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    Addison's Disease

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    ash ash
    Addison's disease is caused by insufficient production of cortisol and aldosterone by the adrenal glands due to autoimmune destruction or other causes. It can be primary, resulting from problems with the adrenal glands themselves, or secondary, due to issues with the pituitary or hypothalamus. Symptoms include fatigue, weight loss, low blood pressure, and skin pigmentation. Treatment involves lifelong hormone replacement therapy to supplement cortisol and mineralocorticoid levels.

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    Addison's Disease

    Uploaded by

    ash ash
    99 views9 pages
    Addison's disease is caused by insufficient production of cortisol and aldosterone by the adrenal glands due to autoimmune destruction or other causes. It can be primary, resulting from problems with the adrenal glands themselves, or secondary, due to issues with the pituitary or hypothalamus. Symptoms include fatigue, weight loss, low blood pressure, and skin pigmentation. Treatment involves lifelong hormone replacement therapy to supplement cortisol and mineralocorticoid levels.

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    PHYSIOLOGY

    Original Title

    ADDISON’S DISEASE

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    Addison's disease is caused by insufficient production of cortisol and aldosterone by the adrenal glands due to autoimmune destruction or other causes. It can be primary, resulting from problems with the adrenal glands themselves, or secondary, due to issues with the pituitary or hypothalamus. Symptoms include fatigue, weight loss, low blood pressure, and skin pigmentation. Treatment involves lifelong hormone replacement therapy to supplement cortisol and mineralocorticoid levels.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    99 views9 pages

    Addison's Disease

    Uploaded by

    ash ash
    Addison's disease is caused by insufficient production of cortisol and aldosterone by the adrenal glands due to autoimmune destruction or other causes. It can be primary, resulting from problems with the adrenal glands themselves, or secondary, due to issues with the pituitary or hypothalamus. Symptoms include fatigue, weight loss, low blood pressure, and skin pigmentation. Treatment involves lifelong hormone replacement therapy to supplement cortisol and mineralocorticoid levels.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 9

    ADDISONS DISEASE

    AFIF BIN AIDIT 082013100004 IMS BANGALORE

    LEARNING OUTCOMES
    What is Addisons disease

    Pathogenesis
    Causes Clinical manifestation

    Investigations
    Treatments

    DEFINITION
    Body produces insufficient amount of cortisol or

    aldesterone an autoimmune inflammation of adrenal gland resulting in gradual destruction inability to make sufficient amounts of adrenal hormones. Fatal Known as adrenal insufficiency Occurs in all groups and both sexes

    PATHOGENESIS
    Occurs when more than 90% of adrenal gland tissue

    is destroyed Primary Addisons disease Due to autoimmune system, tuberculosis

    CAUSES
    PRIMARY SECONDARY

    1) 2) 3) 4) 5) 6) 7)

    Polyglandular syndrome Tuberculosis HIV/AIDS Metastatic carcinoma Bilateral adrenalectomy Amyloidosis Intra-adrenal haemorrhage

    1) Withdrawal of suppressive glucocorticoid therapy 2) Hypothalamic or pituitary disease

    CLINICAL MANIFESTATIONS
    GLUCOCORTIC OID INSUFFICINEC Y 1) 2) 3) 4) 5) MINERALCORT ICOID INSUFFICIENC Y ACTH EXCESS ADRENAL ANDROGEN INSUFFICIENC Y 1) Decreased body hair 2) Loss of libido, especially in female

    Weight loss 1) Hypotension Malaise 2) Hyponatremia Weakness 3) Hyperkalemia Diarrohea Postural hypotension 6) Hypoglycaemia 7) Hyponatremia 8) Hypercalcaemi a

    1) Pigmentation : - palmar crease - knuckles - conjunctivae

    INVESTIGATIONS
    Random blood sample ( cortisol )

    ACTH stimulation test


    Assessment of mineralcorticoids Plain x-ray

    Ultrasound
    HIV test

    TREATMENTS
    Glucocorticoid replacement therapy

    Adrenal androgen ( women )


    Mineralocorticoid replacement

    REFERENCE
    http://www.mayoclinic.org/diseases-

    conditions/addisons-disease/basics/definition/con20021340 http://autoimmune.pathology.jhmi.edu/diseases.cf m?systemID=3&DiseaseID=16

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