Lcnews227 - Nexera Series

LC News No.
227
March 15, 2019
Release of the new Nexera series and new product portfolio of the modular LC system
This Product News is being issued due to the release of the new Nexera series and the new
product portfolio of the modular LC system. Please also refer to the following related LC news.
(Related LC News)
LC News No. 228 Shimadzu UHPLC System "Nexera X3" model release
LC News No. 229 Shimadzu UHPLC System "Nexera XS" model release
LC News No. 230 Shimadzu UHPLC System "Nexera XR" model launch
LC News No. 231 Shimadzu HPLC System "Nexera Lite" model launch
LC News No. 232 New Nexera series: release of related products
LC News No. 233 Announcement of sales termination
For more than 40 years, Shimadzu Corporation has refined the technological capabilities of
high-speed and ultra-high performance liquid chromatograph, and has provided products with
outstanding performance, such as autosamplers with low carryover and detectors which support
stable signal intensity during ambient temperature fluctuations. The new Nexera series aims to
set new standards for high performance liquid chromatography in the world of analysis,
combining a solid foundation of technological know-how with new functions involving M2M,
IoT and AI. A variety of sensors update operating status and instrument configuration to cloud
servers in real time, including data related to consumable parts such as columns and UV lamps,
guaranteeing data integrity and traceability. Sensor data is also used to predict problems such as
mobile phase depletion and wear-and-tear of consumable parts. Pumping issues that can be
caused by air bubbles are automatically detected and resolved via the autopurge function. The
integration of these technologies allows users to generate accurate and reliable chromatographs
without the need for extensive technical knowledge or experience.
New features contribute to more efficient workflow in the lab as a whole. The installation
area required for the LC has been further reduced, and continuous analysis of thousands of
samples has been enabled. It is now possible to collect data from two different analysis paths in
a single system. Basic performance has also been improved thanks to the addition of a UV cut-
off filter to prevent degradation of compounds and three-way temperature control in the optical
system to ensure baseline stability.
These features are shared by all four models in the new Nexera series, which have a
maximum pressure of 130, 105, 70 and 44 MPa respectively, allowing customers with various
analysis needs to experience the benefits of these new technologies.
LC News No. 227 Page 1

We hope that the release of the new Nexera series will boost Shimadzu LC sales across the
board. Information about LabSolutions updates for the new Nexera series will be provided
separately.
Plate-changer mounting system for ultra-large batch

High pressure gradient system
analysis
Fig 1: The Nexera series outer design
1. Release date
March 15, 2019
Delivery start date: April 2019 onwards (including optional components and separate parts)
2. Key features and system configuration

2.1. Key features
The new Nexera Series is an entirely new LC system that represents a new step in the
development of basic HPLC performance, while also incorporating a number of new
features involving the latest digital and information technologies, such as M2M, IoT and
AI.
Main slogan: Experience New Benchmarks
Taglines: A New Benchmark of Intelligence
A New Benchmark of Efficiency
A New Benchmark of Design
2.1.1. A New Benchmark of Intelligence

This tagline represents the most notable difference between the new Nexera series and
previous Shimadzu LCs. New features allow the simple management of resources in the
lab and automatic optimization of analysis. Data from various sensors is collected in the

cloud, and thanks to advanced information processing technologies, the status of the
instrument and all consumable parts is recorded during every stage of analysis, and
instrument problems can be forecast and prevented. In the case that an error does occur,
the user can be notified by email, and there are options for the instrument to attempt auto-
recovery without the need for user intervention.
These advances in automation allow for smoother analysis and allow more
inexperienced users to collect reliable data consistently. The system contributes to a more
efficient laboratory by centralizing the management of consumable parts.
Features:
 FlowPilot function during start-up and new shutdown
 Mobile phase monitor (optional)
 Auto-diagnostics and auto-recovery
 Remote maintenance and laboratory management using Smart Service Net
2.1.2. A New Benchmark of Efficiency

The autosampler’s ultra-fast injection cycle and the ability to input thousands of samples
into the plate-changers (up to 16,896 samples when using 384-well MTPs) allows for
ultra-high-speed multi-sample analysis without requiring the user to replace plates
manually. Standard autosampler functions for automated pretreatment and mobile phase
blending improve the overall efficiency of analysis and method development, and ACTO
functions support simple method transfer.
Features:
 Ultra-high-speed injection cycle
 Continuous analysis of thousands of samples
 Auto-pretreatment function
 Method development support functions (Method scouting, ACTO Function)
2.1.3. A New Benchmark of Design

The new Nexera series retains the 260mm width of the previous modular model;
however, the height of the autosampler has been reduced, and the slim oven and newly-
designed dial pump have reduced the LC’s installation space and energy consumption.
Power consumption in standby mode is reduced by up to 81%.
In addition, previously-available features have been improved through new designs.
An auto-cooling function results in zero condensation on the autosampler, and triple
temperature-control in the optical system ensures a more stable baseline than ever. The
PDA shows increased linearity over a wide range and a UV filter improves quantitation
results for photodegradable compounds.

Features:
 More compact design
 Intuitive controls via touch panel
 Dual injection
 New cooling mechanism for the autosampler prevents condensation from forming
 Quantitation of low concentration compounds is accurate thanks to the stable
baseline
 Quantitative accuracy of the photodegradable compounds are improved with the
UV filter

2.2. Configuration of the new Nexera system
Shown are the standard configuration overview and main option of the new Nexera
series systems.
System controller Solvent Delivery Pump
The SCL-40 system In addition to the four
controller features a touch parallel double plunger
panel and allows the user to models to raise the upper
control the instrument and pressure limit, the XR and
carry out analysis X3 models have a dual
preparation directly without pump that reduces gradient
the need for a PC. A delay volume and enables
graphical UI makes the an ultra-fast high-pressure
controller easy to use. gradient. Other pumping
environments (low-pressure
gradient, mobile phase
blending) can also be
provided.
Degassing Unit Mobile phase monitor
3-channel and 5-channel (optional)
types available. Since the The monitoring device can
degassing unit is built into be placed in the reservoir
LC-40B X3 pump, a tray. The volume of liquid
separate unit is not remaining in each mobile
required. phase bottle is measured in
real time and can be
checked from a PC or
mobile device. Before a
batch analysis is started, the
amount of mobile phase
required is calculated and a
warning is displayed if the
amount remaining is
insufficient.
Autosampler Detector
The autosampler boasts A new PDA detector and
ultra-low carryover, less UV-VIS detector have been
than 0.0003% (*1). Its developed. Baseline
ultra-fast injection cycle stability and linearity have
and auto pretreatment been improved, and
functions also contribute to stability remains even
more efficient analysis. The under fluctuating
optional dual-injection temperatures.
system consists of two The PDA detector is
separate injection ports and equipped with a UV-cut off
flow lines, enabling filter to improve the
different analyses to be quantitation accuracy of
carried out simultaneously. photodegradable
compounds. The cell and
lamp are traceable via
individual IDs.

Plate-changer Column Oven
The installation area has The circulation oven has a
been greatly reduced to 170 maximum temperature
mm. It is possible to load setting of 90oC. A slim 130
up to 7 racks of 1.5ml vials mm model and a standard
or 14 microtiter plates. Up 260 mm model are
to 3 plate-changers can be available, both able to
connected, allowing up to accommodate a 300 mm
44 MTPs with up to 16896 column. Both have one
samples to be loaded at connection port for CMD
once (using 384-well or mixer ID recognition.
MTPs). Preheater tubing is
available as an option.
(*1) under specified conditions.
Other changes from the existing Prominence and the existing Nexera series are:
 The power cable and photo-link cable will not be packaged together with each unit but
will be provided separately.
 Optimal pre-cut tubing kits for each model are available.
2.3. New Nexera lineup

The new Nexera series has four models:
 Nexera X3 model (maximum pressure 130 MPa)
This is Shimadzu’s new flagship UHPLC model. The dual pump reduces the
gradient delay volume and creates a high pressure gradient, enabling ultra-high-
speed analysis using a packed column with a particle size of under 2 μm. This is
ideal for large-batch analysis and MS coupling. A low pressure gradient can be
achieved by installing an LPGE valve.
 Nexera XS model (maximum pressure 105 MPa)
This is a model designed with competitors’ LC specifications in mind (see Fig. 2
below). It is possible to use a low pressure gradient, the same as that of
competitors, or to install two pumps for a high pressure gradient. There is no dual
pump.
 Nexera XR model (maximum pressure 70 MPa)
This is Shimadzu’s new standard UHPLC model. It can be used both for analysis
with columns with >3μm particle size and for ultra-fast high-level separation
analysis with core-shell columns with less than 3μm particle size. The dual pump
reduces the gradient delay volume and creates a high pressure gradient for ultra-
fast large-batch analysis. A low pressure gradient can be achieved by installing an
LPGE valve. The LC can also be used coupled to an MS.

 Nexera lite model (maximum pressure 44 MPa)
This model is for conventional HPLC analysis with columns or core-shell
columns with a particle size of >3μm. Unlike the other 3 models, the standard
needle for the autosampler is uncoated. If a coated needle is required, it should be
ordered separately. This model will not be actively promoted on the company
website or in catalogues. Materials and information shall be provided to individual
customers at the discretion of the salesperson.
Figure 1 Lineup and market position of the Nexera series
3. Overview of newly-developed units

This section describes the features of newly-developed units of the new Nexera series, their
updates from previous products, and their main specifications. Please reference the other
documents for the details and optional parts related to each unit.

3.1. System controller
Model Name SCL-40 CBM-40 CBM-40lite
Appearance ---
Color screen with touch System controller without The electronic circuit board-
panel and system controller touch panel and reservoir only system controller. It is
with reservoir tray. System tray. LEDs are used for error embedded in the solvent
login, start-up/shutdown, notification. Not data store. delivery unit. In the case of
system check, auto-purge, No data storage. Updated error occur, the bulk solvent
Features method creation, batch from units for Prominence delivery unit LEDs will be
registration/processing, etc. etc. Separate reservoir tray is used to inform them. No
are controllable from the required. data storage. Updated from
system controller unit. No units for Prominence etc.
data storage. Updated from Separate reservoir tray is
units for Prominence etc. required.
Touch panel; LabSolutions LabSolutions and LabSolutions and
and environment settings environment settings can be environment settings can be
Control options
can be controlled from the controlled from the web controlled from the web
web monitor monitor monitor
Touch panel, LabSolutions,
Monitoring LabSolutions, web monitor LabSolutions, web monitor
web monitor
Max.
8 units (12 units with use of 8 units (12 units with use of 4 (excluding stored solvent
controllable
optional parts) optional parts) delivery unit)
modules
Analogue signal Maximum 2Ch Maximum 1Ch
Not available
input (Requires AD board option) (Requires AD board option)
Connection Ethernet Ethernet Ethernet
Dimensions
260×140×500 mm 260×71×500 mm 141×49×130 mm
(W×H×D)
Weight 6 kg 5 kg <1 kg
Power Supply DC 5V1A (supplied by
AC 100-240V AC 100-240V
Voltage built-in unit)
Power
50 VA 50 VA ―
Consumption
Frequency 50 / 60 Hz 50 / 60 Hz ―

3.2. Solvent Delivery Pump
Model Name LC-40D, LC-40D XR / XS / X3 LC-40B XR / X3
LC-40B XR
Appearance LC-40B X3
This is a parallel double-plunger solvent This dual pump system incorporates two
delivery unit. LPGE unit can be contained parallel double plunger solvent delivery
here. Low pressure gradient and blending pumps. It is possible to create a high
functions can be used. pressure gradient with the pump system, or
use the two pumps independently.
Features Unlike LC-20AB, there is no point at

which the flow lines meet, which greatly
reduces the amount of liquid reaching the
mixer and column. On the system
configuration chart, these pumps are
shown as two independent pumps (there
are also two optical link cables).
LC-40D: 44 MPa, LC-40D XR:70 MPa,
LC-40B XR: 70 MPa, LC-40B X3:130
Maximum pressure LC-40D XS: 105 MPa, LC-40D X3:130
MPa
MPa
LC-40D / LC-40D XR: Constant flow
delivery and constant-pressure pumping
Pumping method Constant flow delivery
LC-40D XS / LC-40D X 3: Constant flow
delivery
LC-40D
0.0001~5.0000 mL/min (1.0~44 MPa)
5.0001~10.0000 mL/min (1.0~22 MPa)
LC-40D XR / LC-40B XR
Flow rate settings 0.0001~3.0000 mL/min (1.0~70 MPa)
range 3.0001~5.0000 mL/min (1.0~44 MPa)
5.0001~10.0000 mL/min (1.0~22 MPa)
LC-40D XS
0.0001~3.0000 mL/min (1.0~105 MPa)
3.0001~5.0000 mL/min (1.0~80 MPa)

5.0001~10.0000 mL/min (1.0~22 MPa)
LC-40D X3 / LC-40B X3
0.0001~3.0000 mL/min (1.0~130 MPa)
3.0001~5.0000 mL/min (1.0~80 MPa)
5.0001~10.0000 mL/min (1.0~22 MPa)
LC-40D
±1% or ±2 μL/min, whichever is larger (0.01-2 mL/min)
±2% (2-5 mL/min)
LC-40D XR / LC-40B XR
Flow rate accuracy
LC-40D XS / LC-40D X3 / LC-40B X3
±1% (1 mL/min, 80 MPa)
Flow rate precision Within either 0.06% RSD or 0.02 minSD, whichever is the greater
No. of pressure
1 2
sensors
LC-40D: optional
LC-40B XR: standard
Plunger rinse LC-40D XR /LC-40D XS /LC-40D X3:
LC-40B X3: standard (peristaltic pumps)
standard
Low pressure Available (low pressure gradient unit
No
gradient required)
Available (low pressure gradient unit
Blending function No
required)
LC-40B XR: Optional as exterior unit
Degassing unit Optional as exterior unit LC-40B X3: 5 flow line standard built-in
degassing unit
Dimensions 260×140×500 mm (LC-40B XR)
260×140×500 mm
(W×H×D) 260×210×500 mm (LC-40B X3)
LC-40D / LC-40D XR: 10 kg LC-40B XR: 13 kg
Weight
LC-40D XS / LC-40D X3: 12 kg LC-40B X3: 21 kg
Power supply
AC 100-240V
voltage
Power consumption 150 VA 180 VA
Frequency 50 / 60 Hz

3.3. Degassing Unit
Model Name DGU-403 DGU-405
Appearance
Connecting this device to the solvent delivery unit allows the sequential degassing of
dissolved gases in the HPLC without changing the mobile phase composition, thus
Features
enhancing analysis stability and reproducibility. There are two types available, three-
channel and five-channel.
Stream 3-channel 5-channel
Using the UV-absorption detector, at wavelength 210nm, sensitivity 0.5AU, is used to
Degassing
pump oxygen-saturated methanol (HPLC-grade, 25oC) at a flow-rate of 1 mL/min, the
performance
UV absorbance range is 300 mAU or more.
Dimensions
260×72×500 mm 260×72×500 mm
(W×H×D)
Weight 4 kg 4 kg
Power supply
Supplied by solvent delivery unit
voltage
3.4. Autosampler
SIL-40 SIL-40 XR
Model Name SIL-40C XS SIL-40C X3
SIL-40C SIL-40C XR
Appearance, etc.
Even with a height 67% of the previous design, the increased plate capacity from 2 to 3
Features allows the analysis of up to 1,152 samples using 384-well MTPs. Airflow-based
temperature control gives a more stable and accurate temperature.
Maximum pressure 44 MPa 80 MPa 105 MPa 130 MPa
Normal injection Total injection, variable injection volume (sample loss at injection is zero), and loop
method injection method (option)
0.1~100 μL 0.1~50 μL
Injection Volume
1~2000μL (option)、0.1μL (step)
Injection volume
±1% (n=10 at 5μL injection)
accuracy
Linearity 0.9999% GB min.
Injection volume RSD≦1.0% (0.5~0.9 μL injected)
reproducibility RSD≦0.5% (1.0 ~1.9 μL injected)

RSD≦0.25% (2.0~4.9 μL injected)
RSD≦0.15% (5.0μL upwards)
Not more than
0.0025% (rinse
mode)
Not more than 0.0015% (rinse mode)
Not more than
Carryover Not more than 0.0003% (with rinse, typically)
0.0005% (with
* under specified conditions
rinse, typically)
* under specified
conditions
External rinsing (dip rinsing), injection port rinsing
Optional External rinsing (pumping rinse)
Rinse function
Internal rinsing
Optional
(3 dil)
Needle material Stainless steel Stainless steel (with special coating)
Output tubing for ID0.3 mm×600
ID0.1 mm×600 mm
standard kits mm
252 (With 1 mL sample vial plates × 3, × 84 vials)
162 (With 1.5 mL sample vial plates × 3, × 54 vials)
Max. samples 36 (With 10 mL sample vial plates × 3, × 12 tubes)
72 (With micro tube plates × 3, × 24 samples)
288 (With microtiter plates × 3, × 96 wells)
1,152 (With microtiter plates × 3, × 384 wells)
Cell temperature
Air-circulation temperature control type
control
Temperature setting
4°C to 45°C (4°C is possible with room temperature 30°C, humidity 70% or less)
range
Temperature control
±0.5°C (temperature at a sensor), ±2°C (for liquid in 1.5 mL glass sample vial)
accuracy
Temperature stability ±0.5°C/15 min (liquid in 1.5 mL glass sample vial)
pH range 1-14
Pretreatment function Yes
Overlapping
Yes
injection function
Dual injection
Optional, loop injection method only
function
Dimensions 260 x 280 x 500 mm (for model with temperature control function: 140 mm protrusion
(W×H×D) depth)
Weight Model without temperature control:17 kg, model with temperature control:24 kg
Power supply voltage AC 100-240V (100-240V~)
Power consumption Model without temperature control: 150 VA, model with temperature control: 400 VA

3.5. Plate-changer
Model Name Plate-Changer
Appearance, etc.
This is a compact plate changer with approx.. 1/3 the width of the previous Rack
Features Changer II. The type of plate can be auto-identified just by inserting it. It is possible to
analyze up to 16,896 samples (MTP384) by connecting three plate changers together.
▼ With two plates in the autosampler
1,536 (With microtiter plates × 16
, × 96 wells)
864 (With deep-well plates × 9, × 96 wells)
3,456 (With deep-well plates × 9, × 384 wells)
486 (With 1.5 mL sample vial plates × 9, × 54 vials)
Samples for
216 (With micro tube plates × 9, × 24 tubes)
Processing
▼With two plates in the autosampler and three plate-changers connected.
4,224 sheets (With microtiter plates ×44, × 96 wells)
1,932 (With 1 mL sample vial plates × 23, × 84 vials)
1,242 (With 1.5 mL sample vial plates × 23, × 54 vials)
552 (With micro tube plates × 23, × 24 tubes)
Cell temperature
Air circulation temperature control type
control
Temperature setting
4°C to 45°C (4°C is possible with room temperature 30°C, humidity 70% or less)
range
Temperature control
±0.5°C (temperature at a sensor), ±2°C (for liquid in 1.5 mL glass sample vial)
accuracy
Temperature
±0.5°C/15 min (liquid in 1.5 mL glass sample vial)
stability
Dimensions
170 x 560 x 500 mm (for model with temperature control: 140 mm protruding part)
(W×H×D)
Weight 27 kg
Power supply
AC 100-240V(100-240V~)
voltage
Power consumption 400 VA

3.6. Column Oven
Model Name CTO-40S CTO-40
Appearance
・An active pre-heater (optional) can ・An active pre-heater (optional) can
control the temperature of the mobile control the temperature of the mobile
phase before it enters the column, phase before it enters the column,
improving the separation of components improving the separation of components
with short retention times. with short retention times.
・The Column Management Device ・The Column Management Device keeps
keeps track of columns easily, and the track of columns easily, and the gradient
gradient mixer recognition function mixer recognition function manages mixer
Features
manages mixer data. Together these data. Together these maintain data
maintain data integrity by linking integrity by linking analysis data to
analysis data to information about information about consumable parts.
consumable parts. ・Provides temperature control from 10°C
・This slim oven is only 130 mm wide, below room temperature up to 100°C.
but offers a large temperature-controlled Supports method validation for e.g. sugar
space that can fit three 300-mm analysis.
columns.
Cell temperature
Air-temperature control type
control
Temperature setting
Room temperature -10°C ~ 85°C Room temperature -10°C ~ 100°C
range
Temperature control
±0.1°C
accuracy
300 mm×3 300 mm×3
Column capacity
100 mm×6 150 mm×6
Active preheater
Active preheater Gradient Mixer with Recognition Device
Gradient Mixer with Recognition ×1
Device × 1 FCV-0206 series
Available options FCV-0206 series FCV-0207 series
FCV-0207 series FCV-DR
FCV-DR FCV-36AH
FCV-36AH FCV-12AHi
FCV-14AHi
Dimensions (W×H×D) 130×553×500 mm 260×415×500 mm
Weight 15 kg 21 kg
Power supply voltage AC 100-240V

3.7. UV-VIS Detector, photodiode array detector

Model Name SPD-40, SPD-40V SPD-M40
Appearance
This cost-effective detector features low This detector achieves industry-leading

noise and high stability in the face of linearity of 2.5 AU and noise of 4.5 µAU,
ambient temperature changes. A variety of expanding its dynamic range to 1.7 times
cell options are available for a wide range that of the previous model. It is possible to
of analysis tasks. Cells and lamps are analyze low-level impurities in high-
managed via their individual IDs, concentration compounds. The three-way
contributing to improved traceability. The temperature control (Advanced TC-Optics)
SPD-40V extends the long wavelength of the spectrometer and source lamp
Features
range up to 1000 nm. ensures high baseline stability regardless
of ambient temperature fluctuations.
A new UV cut-off filter has also been
installed to improve the quantitation
accuracy of photodegradable compounds.
Cells and lamps are managed via
individual IDs, contributing to improved
traceability.
SPD-40: 190~700 nm
Wavelength settings 190~800 nm
SPD-40V: 190~1000 nm
Cell temperature
19~50°C, in 1°C steps 19~50°C, in 1°C steps
settings
Slit width ― 1.2 nm, 8 nm
PDA elements ― 1024
SPD40: D2
Lamp D2, W
SPD-40V: D2, W
1-wavelength mode: 4.0 × 10-6 AU*2
2-wavelength mode*3: 10.0 × 10-6 AU*2
Noise 4.5×10-6 AU*1
(Sampling interval in 2-wavelength mode:
0.5 sec.)
Drift 0.1 × 10-3 AU/hour*4 or less*1 0.4 × 10-3 AU/hour or less*1
Standard cell (L=10 mm, V=12 μL, temperature control)
UHPLC cell (L=10 mm, V=8 μL, temperature control)
Cell Semi-micro cell (L=5 mm, V=2.5 μL, temperature control)
※L = optical path Conventional cell (L=10, V=12 µL, temperature control)
length, V = cell Inert cell (L=10 mm, V=12 μL, temperature control)
volume Preparative cell (L=0.1/0.2/0.5 mm, V=0.8/1.6/4.0 μL, no temperature control)
Micro flow cell (L=3 mm, V=0.21 μL, no temperature control)
Pressure-resistant cell (L=10 mm, V=12 μL, no temperature control)
Dimensions
260×140×500 mm 260×140×500 mm
(W×H×D)
Weight 11 kg (Without accessary) 10 kg (Without accessary)

Power supply
AC 100-240V
voltage
*1: Perform SPD-40 / 40V lamp replacement from the top of the device (same as SPD-20A / 20AV).
*2: Noise measurement conditions (SPD-40 / 40V 1 wavelength mode): 230 nm methanol feed 1 mL / min,
response 2 sec
*3: Noise measurement conditions (SPD-40 / 40V) 2 wavelength mode): 250/280 nm methanol feed 1 mL /
min, response 2 sec
*4: Drift measurement conditions (SPD-40 / 40V, 1 wavelength mode): 250 nm, room temperature constant,
methanol feed 1 mL / min, response 2 sec
*5: Measurement condition of noise drift (SPD-M40):
Measurement wavelength: 250 nm, reference wavelength 350 nm, reference wavelength bandwidth ± 20
nm,
Cell: Methanol delivery 1 mL / min, time constant: 2 sec, slit width: 8 nm
*6: This is a cell with a thicker IN piping inner diameter than standard cells. Each has the following
differences. Standard cell: 0.13mm ID x 1040mmL (14 µL), Conventional cell: 0.25 mm ID x 870 mm L
(43 µL)
*7: If the cell temperature adjustment range of SPD-M40 is less than 40 ° C, set room temperature + 15 ° C or
higher (as for SPD-M20A, it set room temperature + 5 ° C or higher)
3.8. Major newly-developed options

Model Name Features, updates, etc. Appearance
Tubing kits Tubes and fittings are provided as a set according
to the system configuration. The number and
inner diameter of the tubes vary. Available tubes
are:
・ 0.3 mm diameter for high-pressure gradients
・ 0.1 mm diameter for high-pressure gradients
・ 0.3 mm diameter for low-pressure gradients
・ 0.1 mm diameter for low-pressure gradients
See the document "4.10 Piping kits" for details.
Wiring kit Optical fiber cables and parts for adjusting cables
at the rear of the instrument are provided as a set
according to the system configuration.
See the document "4.11 Wiring kit" for details.
Mixer A gradient mixer with a "mixer device" that
provides automatic volume recognition. The
mixer capacity is automatically recognized by
connecting to the port in the CTO storage with
the optional CMD cable, and it is displayed and
recorded on LabSolution. The 40 μL size
recommended as a low pressure gradient mixer
for XR, XS, and X3 is supplied with a pump
internal mounting plate. ※ However, please
select a larger size when sufficient mixing is
required, such as when using THF.
For high pressure gradients:
20 μL, 40 μL, 100 μL, 180 μL
For low pressure gradients:
40 μL (with liquid pump internal kit), 300 μL

FCV-DR
Control board and drive section that can be built
into CTOs.
※Flow-line selection valve sold separately
FCV-0206 Series
2-position 6-port valve for use with the drive
section mentioned above.
FCV-0206: 44MPa
FCV-0206H: 80 MPa
FCV-0206H3: 130 MPa
FCV-0607 Series
6 position 7 port valve for use with the drive
section mentioned above.
FCV-0607: 44MPa
FCV-0607H: 80 MPa
FCV-0607H3: 130 MPa
Reservoir tray Necessary when using CBM-40/40lite use. Up to

eight 1 L bottles are stored
Mobile phase This device measures the remaining mobile

monitor phase volume in real time. The measurement
data can be checked via the system controller,
LabSolutions, or dedicated software included in
the mobile phase monitor. In coordination with
the Nexera series, mobile phase levels are
monitored in real time and pumping is stopped
when the remaining volume is insufficient. Prior
to starting the batch analysis, the remaining
volume is checked against the volume required
for analysis, and if there is a shortage then a
warning is displayed to alert the user. The
monitoring system consists of a controller and
bottle holders for holding two 1L bottles, which
are set up for use on the reservoir tray. This
optional monitoring system can also be used with
previous LC models or competitor’s products (in
these cases, it is not possible to check whether
mobile phase levels are sufficient prior to batch
analysis).
Controller:
A device to collect sensor signals and send them
to the cloud server. Up to six bottle holders can
be connected.

Bottle holder:
For holding 1L mobile phase bottles. Two bottles
are set in one holder.
Reservoir bottle 228-38583-42
5-bottle set of 1 L mobile phase bottles
Power cable 071-60821-08
*There are no power cables provided with the
main device. Please prepare the required cables.
Outlet Strip 6P 228-65523-41
This is a power outlet strip that allows the main
power for all units to be turned off in one go. The
switch can be installed on the front of the
reservoir tray. It has six power sockets.
* The switches can only be installed on reservoir
trays for the 40 series or for the SCL-40.
Outlet Strip 2PS 228-65524-58
This is an outlet for supplying power to units
such as SIL-10A and FRC-10A that need to be
connected to service outlets. It has two power
sockets.
* The SCL-40 and CBM-40 do not have service
outlet installed on the reverse.
Tool kit 228-57647-43
This is a tool kit common to the whole Nexera
series. It includes the main tools for each model
such as the pump, autosampler, column oven,
and detector.
*Maintenance tools for each instrument are not
included.

4. Ordering guide
4.1. System Controller
4.1.1. System Controller Unit
P/N Description Code Remarks
228-65500-58 SCL-40 L2
228-65502-58 CBM-40 L2
228-65501-58 CBM-40lite L2
<Components Provided with the SCL-40>

P/N Description Qty Remarks
－ SCL-40 Unit 1
Cautions when Using the New This contains cautions regarding the use of
228-92326 Nexera Series (booklet) 1 the product.
The instruction manual or New Nexera
Instruction Manual / New Nexera
228-92350-41 1 Series System Guide for this product is
Series System Guide (CD-ROM)
available for a fee.
New Nexera Series Quick Guide
228-92853 1 This is a table of operations.
(summary sheet)
228-61083-41 LAN Cable 1 2m
228-75144-03 Tray Guide Bar S 2
228-75144-04 Tray Guide Bar L 2
228-75145 Tube Clamp Label 1
228-75147 Tube Clamp 10
228-25162-03 Drain Tube, Silicon 1
228-42204 Drain Adapter 1
228-42205 Drain OUT, STD 1
228-42206 Drain OUT, CTO 1
035-61561-12 L-Type Fitting 1
228-28163 Straight Joint 1
These are used when fastening the tray
020-37508 Guide Bar Fastening Screws 8 guide bar to the reservoir tray with screws.

<Components Provided with the CBM-40>
－ CBM-40 Unit 1
This contains cautions regarding
228-92326 Safety guideline (booklet), Nexera series (JP/EN) 1 the use of the product.
The instruction manual or New
Instruction Manual / New Nexera Series System Nexera Series System Guide for
228-92350-41 Guide (CD-ROM) 1 this product is available for a
fee.
228-92853 Nexera series Quick Guide 1 This is a table of operations.
228-61083-41 LAN Cable 1 2m
<Components Provided with the CBM-40lite>

－ CBM-40lite Unit 1
Safety guideline (booklet), Nexera This contains cautions regarding the use of
228-92326 series (JP/EN) 1 the product.
The instruction manual or New Nexera
Instruction Manual / New Nexera
228-92350-41 1 Series System Guide for this product is
Series System Guide (CD-ROM)
available for a fee.
228-92853 Nexera series Quick Guide 1 This is a table of operations.
228-61083-41 LAN Cable 1 2m
This cable is used when incorporating the
Control Cable (for the new Nexera
228-70155-41 1 CBM-40lite into the new Nexera series
series)
pump.
This cable is used when incorporating the
Control Cable (for the Prominence /
CBM-40lite into the Prominence or old
228-70157-41 old Nexera series) 1 Nexera series instruments.

4.1.2. Optional Parts for the System Controller
228-77025-06 Optical Fiber Cable 0.6m L9
228-77025-08 Optical Fiber Cable 0.8m L9
228-77025-10 Optical Fiber Cable 1m L9
228-28253-91 Remote Cable L9
228-70481-41 Optical cable connector expansion board (up to 4) L9
228-55519-41 A/D Board L9
228-58619-41 Touch Pen L9
228-59212-41 Touch Panel Protective Sheet L9
228-92361 Instruction Manual EN (booklet) L9
228-92352 New Nexera Series System Guide (booklet) L9
228-92853 Nexera series Quick Guide L9
071-60821-08 Power Cord L9
4.1.3. System Controller Consumables and Maintenance Parts

072-02004-23 Fuse, 0218005.MXP L9

074-73306-33 Button-Type Battery, CR2032 L9
074-80441-47 Power Supply, LFA15F-5-J1Y L9
228-75000-42 PCB ASSY,CBM40 CPU L9
228-75010-41 PCB ASSY,CBM40 OPT8 L9
228-63590-44 PCB-A,FUSE-SW 5A L9
228-75050-41 PCB ASSY,CBM40 LED L9
228-75101-42 Front Panel (with LCDs) L9
4.2. Solvent Delivery Unit

4.2.1. Solvent Delivery Unit
228-65076-58 LC-40D X3 L2
228-65078-58 LC-40B X3 L2
228-65077-58 LC-40D XS L2
228-65000-58 LC-40D XR L2
228-65001-58 LC-40B XR L2
228-65002-58 LC-40D L2

<Components Provided with the LC-40D XR / LC-40D X3 / LC-40D XS>
228-92350-41 Instruction Manual (CD-ROM), Nexera Series 1

228-92326 Safety guideline (booklet), Nexera series (JP/EN) 1
228-45708-91 Suction Filter 1
228-28253-91 Remote Cable 1
228-25162-03 Drain Tube (L1000) 1
228-46054-91 STOP JOINT ASSY,B,D 1
228-46055-91 SYRINGE TUBE ASSY,B,D 1
046-00038-01 Syringe, SS-20ESZ 1
228-18216-91 Syringe Needle ASSY 1
046-05522-02 Clamp, One-Touch Type, M_9120 1
228-42205 Drain, OUT 1
228-42206 Drain, CTO 1
228-28163 Joint, Straight 1
035-61561-12 Coupling, L 2005-10 1
038-00522-02 Bottle, 250ml 1 Glass screw cap bottle
<Components Provided with the LC-40D>

228-25162-03 Drain Tube (L1000) 1
046-00038-01 Syringe, SS-20ESZ 1
228-42205 Drain, OUT 1
228-42206 Drain, CTO 1
035-61561-12 Coupling, L 2005-10 1

<Components Provided with the LC-40B XR>
228-25162-03 Drain Tube (L1000) 1
046-00038-01 Syringe, SS-20ESZ 1
228-42205 Drain, OUT 1
228-42206 Drain, CTO 1
035-61561-12 Coupling, L 2005-10 1
228-70156-41 Cable, PUMP CJ19-LITE 1
<Components Provided with the LC-40B X3>

228-25162-03 Drain Tube (L1000) 1
046-00038-01 Syringe, SS-20ESZ 1
228-42205 Drain, OUT 1
228-42206 Drain, CTO 1
035-61561-12 Coupling, L 2005-10 1
228-70156-41 Cable, PUMP CJ19-LITE 1
228-56687-42 SF Nut,1/8 1
228-56687-43 SF Ferrule,1/8 1

4.2.2. Optional Parts for the Solvent Delivery Unit
228-65016-58 Low Pressure Gradient Kit L2 *1

228-65611-58 Reservoir Switching Valve L2
FCV-11AL
228-65610-58 Reservoir Switching Valve L2
FCV-11ALS
228-65017-58 Reservoir Switching Valve L2 *1
Mixer, SS316L
228-72654-41 L2
(with mixer recognition device)
Mixer, PEEK
228-72654-42 L2
Mixer, MR 20 uL
228-72652-41 L2
228-72652-42 Mixer, MR 40 uL
L2
228-72652-43 Mixer, MR 100 uL
L2
228-72652-44 Mixer, MR 180 uL
L2
228-65020-41 Mixer Attachment Kit, MR 40 uL
LPGE L9 *1
228-72653-42 Mixer, MR 300 uL L LPGE
L2
228-45093-93 Mixer, SS316L ASSY L2
228-45210-41 Mixer, MR40 LPGE L2
228-45210-42 Mixer, MR300 LPGE L2
228-45209-41 Mixer, MR 20 uL TP L2
228-45209-42 Mixer, MR 40 uL TP L2
228-45209-43 Mixer, MR 100 uL TP L2
228-45209-44 Mixer, MR 180 uL II TP L2
228-45292-41 MIXER,MR40,180uLII ,2pc set L2
228-45292-42 MIXER,MR100,180uLII,2pc set L2
228-45292-43 MIXER,MR40,100,180uLII,3pc set L2
228-39625-42 Rinse Pump XR L9
228-35655-94 Column Holder L9
228-53184-51 SUS Piping, 0.3mmIDx500mm L9
228-52711-94 Plunger Seal back up ring GFP L9
228-45593-49 Maintenance Kit LC-40D XR L9
228-45593-50 Maintenance Kit LC-40D L9
228-56201-41 Washing pump seal kit L9
038-00522-02 Bottle, 250 mL L9
*1: This cannot be equipped with a dual pump (LC-40B XR, LC-40B X3).

4.2.3. Solvent Delivery Unit Consumables and Maintenance Parts
■Consumables

228-52711-93 Plunger Seal UFP L9 *2, 3, 4
228-35146 Plunger Seal L9 *1
228-35871-96 SUS Line Filter L9 *1,2,3,4
228-45707-91 Suction Filter L9 *1,2,3, 4,6
228-52069-44 Plunger Holder ASSY UHP L9 *2,*3, 4, 7
228-35281-97 Plunger Holder ASSY L9 *1, 7
228-48249-96 Check Valve IN ASSY L9 *1, 2
228-48249-97 Check Valve IN ASSY L9
*1, 2
(2 pc.)
228-52964-42 Check Valve IN-UHP L9 *3, 4
228-45705-43 Check Valve OUT ASSY, XR L9 *1, 2
228-53334-96 Check Valve OUT-UHP-F L9 *3, 4
228-55272-41 Diaphragm (2 pc.) L9 *1, 2, 3, 4
228-53924-06 Protective Dust Filter for the Light L9
*5
Panel
■ Maintenance Parts
228-55230-45 Pump Head XR L9 *2, 3, 4

228-34541-01 Pump head L9 *1
228-38022-01 Head Holder L9 *1, 2, 3, 4
228-45708-91 Suction Filter ASSY L9 *5
228-56200-48 Suction Filter ASSY L9 *4
228-39084 Coupling, 3PEEK L9 *5, 8
228-12493 Ferrule, 3.0F-T L9 *5, 8
670-10321-05 FEP Tube, 3x1.5 L9 *5, 8
228-47518 Inlet Block, PEEK L9 *5
228-51229-93 Drain Valve ASSY, TP L9 *2, 3, 4
228-45574-95 Drain Valve ASSY, 20ABD L9 *1
228-70026-01 SUS Pipe L L9 *1, 2, 9
228-70026-02 SUS Pipe R L9 *1, 2, 10
228-70472-01 SUS Pipe L, D XS / X3 L9 *3, 9
228-70472-02 SUS Pipe R, D XS / X3 L9 *3, 10
228-67336-01 SUS Pipe L, B X3 L9 *4, 9
228-67336-02 SUS Pipe R, B X3 L9 *4, 10
228-70044 Tube holder L9 *1, 2, 3, 4
228-25495-93 Drain Tube ASSY L9 *1, 2, 3, 4
228-18495-01 ETFE Tube, 1.6x0.8 L9 *1, 2, 3,4,11
228-35403 Male Nut, 1.6MN PEEK L9 *1, 2, 3,4,11
*1: This is for the LC-40D.

*2: This is for the LC-40D XR / B XR.
*3: This is for the LC-40D XS / X3.
*4: This is for the LC-40B X3.
*5: This is for a single pump (LC-40D / XR / XS / X3).
*6: This is only a filter.
*7: This includes a diaphragm.
*8: This part is for the suction filter assembly.
*9: This is for the left pump head.
*10: This is for the right pump head
*11: This is for the piping between the inlet block and the check valve.
4.3. Degassing Unit

4.3.1. Degassing Unit
228-65019-58 Degassing Unit (5 Flow Channels), DGU-405 L2

228-65018-58 Degassing Unit (3 Flow Channels), DGU-403 L2
4.4. Autosampler
4.4.1. Autosampler Unit
228-65120-58 SIL-40C X3 L2
228-65119-58 SIL-40C XS L2
228-65102-58 SIL-40 XR L2
228-65103-58 SIL-40C XR L2
228-65100-58 SIL-40 L2
228-65101-58 SIL-40C L2

<Components Provided with the SIL-40C X3>
228-92350-41 Instruction Manual (CD-ROM) 1

Safety guideline (booklet), Nexera series
228-92326 1
(JP/EN)
228-38446-93 1.5 mL Sample Vial (7 pc.) 1
228-71762-46 1.5 mL Sample Vial Plate 1
228-66695 Drain Tube 1
016-31350-02 Drain Tube, Silicon 2m
228-62077 Drain Tube Clamper 1
228-45708-91 Suction Filter ASSY 4
228-18495-04 ETFE Tube, OD. 1.6 x ID. 0.5 3m
228-39084 Coupling, 3PEEK 1
228-12493 Ferrule, Teflon, 3.0F-T 1
228-44449-26 SF Ferrule, P259 1/16 3
228-44449-28 SF Nut, P255, PK, 1/16 3
228-16007 Teflon Ferrule, 1.6F-T 3
228-67688 Male Nut, PEEK HEAD 3
228-64276 Rinse port cover 1
228-64277-02 Rinse port cap (with hole) 2
228-64277-01 Rinse port cap (no hole) 2
228-67795 USB Cable 1
228-66274-06 Clamp, RWCS-20B 1

<Components Provided with the SIL-40C XS/SIL-40C XR/SIL-40 XR>
228-92326 1
(JP/EN)
228-38446-93 1.5 mL Sample Vial (7 pc.) 1
228-18495-04 ETFE Tube, OD. 1.6 x ID. 0.5 1m
228-39084 Coupling, 3PEEK 1
228-12493 Ferrule, Teflon, 3.0F-T 1
228-35403 Male Nut 1.6MN PEEK 1
228-44449-26 SF Ferrule, P259 1/16 1
228-44449-28 SF Nut, P255, PK, 1/16 1
228-67795 USB Cable 1
072-60319-01 Clamp, DKN-10GSP 1 SIL-40 XR
SIL-40C XS/SIL-40C
228-66274-06 Clamp, RWCS-20B 1
XR

<Components Provided with the SIL-40C/SIL-40>

228-92326 1
(JP/EN)
228-38446-93 1.5 mL Sample Vial (7 pc.) 1
228-18495-04 ETFE Tube, OD. 1.6 x ID. 0.5 1m
228-44449-26 SF Ferrule, P259 1/16 1
228-44449-28 SF Nut, P255, PK, 1/16 1
228-67795 USB Cable 1
072-60319-01 Clamp, DKN-10GSP 1 SIL-40
228-66274-06 Clamp, RWCS-20B 1 SIL-40C
4.4.2. Optional Parts for the Autosampler
228-65110-58 PLATE CHANGER L9

228-71767-44 Two-Liquid Cleaning Option L9
228-71767-45 Multi Rinse Option L9
228-67723-42 Solenoid valve for drain (Teflon, for GPC) L9
228-21975-91 Plunger Seal, Polyethylene L9
228-72568-41 Multi Injection Kit (For CTO-40S) L9 For CTO-40S
228-72568-42 Multi Injection Kit (For CTO-40C) L9 For CTO-40C
228-64106-46 INJ-HPV pipe, inner diameter 0.17 L9
228-71759-42 Sample Loop for Loop Injection, 5 uL L9
228-63132-44 Sample Loop, 50 uL L9
228-63132-45 Sample Loop, 100 uL L9
228-45405-45 Sample Loop, 500 uL L9
228-45405-46 Sample Loop, 2ML L9

228-45717-01 Male Nut Fitting L9

228-56867-41 UHPLC Fitting 2 S L9
228-62544-11 Nexlock SS ID0.1mm X 600mm L9
228-62544-90 Nexlock Fitting (1 pc.) L9
228-35217-91 Vial, 0.2 mL (PP) L9
228-16847-92 Vial, 0.3 mL L9
228-31600-91 Vial, 1 mL (PP) L9
228-21283-91 Vial, 1.1 mL (glass) L9
228-15652-92 Vial, 1.5 mL (glass) L9
228-21287-91 Vial, 4 mL (glass) L9
228-71762-42 Vial Plate, 1 mL L9
228-71762-46 Vial Plate, 1.5 mL L9
228-71762-43 Vial Plate, 4 mL L9
228-71762-44 Vial Plate, 10 mL L9
228-71762-45 Micro Tube Plate L9
228-71840-41 Recognition Labels for 96 Well Microplates L9
(100 pc. set)
228-71840-42 Recognition Labels for 96 Well Deep Well L9
Plates (100 pc. set)
228-71840-43 Recognition Labels for 384 Well Microplates L9
(100 pc. set)
228-71840-44 Recognition Labels for 384 Well Deep Well
L9
Plates (100 pc. set)
4.4.3. Autosampler Consumables and Maintenance Parts

228-64909-93 Needle (NC) L9
228-64909-94 Needle L9
228-64364-42 Needle Seal L9
228-63132-44 Sample Loop, 50 uL L9
228-63132-45 Sample Loop, 100 uL L9
228-71780-41 High Pressure Valve Rotor, FCV0206 L9 Except for XS and X3
228-56253-44 High Pressure Valve Stator, FCV0206 L9 Except for XS and X3
228-71780-42 High Pressure Valve Rotor, FCV0206H L9 For XS and X3
228-48858-42 High Pressure Valve Stator, FCV0206H L9 For XS and X3
228-35145 Plunger Seal L9
228-35010-92 Plunger L9
228-71782-41 Low Pressure Valve Stator L9
228-71780-43 Low Pressure Valve Rotor L9

4.5. Plate Changer
4.5.1. Plate Changer Unit
228-65110-58 PLATE CHANGER L2
<Components Provided with the Plate Changer>

228-66752-42 Stack Plates 1
228-25162-04 Drain Tube (L=2000) 1
035-61561-11 Coupling, L1252 2
035-61561-03 Coupling, Y466 1
020-37509 Screw, SS Bind M3x4 4
022-27706 Bottle, SS Socket Head P2 M4x16 3
022-27750-13 Bottle, SS Socket Head P4 M4x8 2
4.5.2. Optional Parts for the Plate Changer

228-71766-41 Plate changer connection kit L9
228-71766-42 Plate changer connection kit for 3rd unit L9
4.5.3. Plate Changer Consumables and Maintenance Parts

228-53924-06 Protective Filter for the Light Panel (Filter only) L9
4.6. Column Oven

4.6.1. Column Oven Unit
228-65201-58 CTO-40S L2
228-65202-58 CTO-40C L2

<Components Provided with the CTO-40S>
228-25162-03 Drain Tube 1
228-72552 Drain Elbow Tube 1
228-72009 Column, Stay 1
228-63758 Knurled Screws 1
228-15617-91 Column Clamp, B5 2
038-01214-12 Plug 1
228-72584-41 Connection Kit 1
<Components Provided with the CTO-40C>

228-72234 Filter Holder 1
228-72570-01 Protective Dust Filter 1
228-25162-03 Drain Tube 1
228--72586 Column Clamp 2
072-60330-53 Clamp, CKN-10-R 1
072-60319-01 Clamp, DKN-10GSP 1
4.6.2. Optional Parts for the Column Oven

228-72084-41 Active Pre-Heater L9
228-72084-43 Active Pre-Heater Nexlock SS L9 *3
228-15617-41 Column Clamp, B5, 40C L9
228-15617-42 Column Clamp, B8, 40C L9
228-72586 Column Clamp L9
228-28637-91 Column Catch L9 *2
228-28253-91 Remote Cable L9
228-72391-41 Single Stand L9 *1
228-65622-58 FCV-12AHi L2 *2
228-65623-58 FCV-14AHi L2 *2
228-45206-41 FCV-36AH L2
228-65602-58 FCV-DR L2
228-65603-58 FCV-0206 L2
228-65604-58 FCV-0607 L2
228-65607-58 FCV-0206H L2
228-65608-58 FCV-0607H L2
228-65624-58 FCV-0206H3 L2
228-65625-58 FCV-0607H3 L2
228-72436-41 Manifold Attachment Kit L9
228-72438-41 FCV Attachment Kit (CTO-40S) L9 *1
228-72589-41 FCV Attachment Kit (CTO-40C) L9 *2
228-72437-41 FCV Piping, 2 pc. Kit (ID. 0.3) L9

FCV Piping, 2 pc. Kit
228-72437-49 L9 *3
Nexlock SS ID 0.1mm X 300 mm
228-72437-50 L9 *3
228-72437-51 L9 *1, 3
228-32210-91 Manual Injector, 7725 L2
228-32210-93 Manual Injector, 7725I L2
228-23200-91 Manual Injector, 8125 L9
228-32650-93 Manual Injector, 9725I L9
228-72432-41 Manual Injector Attachment Kit L9
*1: This is exclusively for the CTO-40S.
*2: This is exclusively for the CTO-40C.
*3: This is stainless steel piping that can be tightened by hand. (ID. 0.1 mm)
4.6.3. Column Oven Consumables and Maintenance Parts

228-72570 Protective Dust Filter L9 For CTO-40S

228-72570-01 Protective Dust Filter L9 For CTO-40C
4.7. UV-VIS Detector

4.7.1. UV-VIS Detector Unit
228-65312-58 SPD-40 L2
228-65313-58 SPD-40V L2

<Components Provided with the SPD-40 and SPD-40V>
228-57027 Syringe Needle 1
228-57028 Syringe 1 mL 1
228-18565 Male Nut PEEK 2
228-18495-06 ETFE Tube 2
228-25162-03 Drain Tube 1
228-70057 Cap, Hinge Bracket 1
228-40998-10 Coupling 1.6-0.8C 316L 1
228-92326 1
(JP/EN)
4.7.2. Optional Parts for the UV-VIS Detector

228-62156-42 Standard Cell L9 *1

228-64724-42 UHPLC Cell L9 *2
228-64725-42 Semi-Micro Cell L9 *3
228-64728-42 Inert Cell L9 *4
228-68250-42 Conventional cell L9 *5
228-64727-42 Preparative Cell L9 *6
228-64737-42 Micro Cell L9 *7
228-64726-42 SFC Pressure Resistant Cell L9 *8
228-56808-42 Recycle Valve L9 *9
*1: A cell installed as standard on the SPD-40. Optical path length: 10 mm, cell capacity: 12 μL With
temperature control function.
*2: Low diffusion cell for high-speed high-resolution analysis. Optical path length: 10 mm, cell capacity: 8 μL
With temperature control function.
*3: Low diffusion cell used for low flow rates such as MS (equivalent to SPD-20A UFLC). Optical path length:
5 mm, cell capacity: 2.5 μL With temperature control function.
*4: Necessary for passing high concentration salts, halogens, and alkaline solutions that corrode SUS. Optical
path length: 10 mm, cell capacity: 12 μL, with temperature control function.
*5: A cell with IN piping capacity equal to that of the conventional SPD-20A / V. Although diffusion is
attempted in the standard cell, select this when you need the same characteristics as SPD-20A / V, and
when you need low noise at high flow rates exceeding 1.5 mL / min. Optical path length: 10 mm, cell
capacity: 12 μL With temperature control function.
*6: Required for the preparative LC system. Prevents signal saturation by high concentration samples. Optical
path length: 0.1 / 0.2 / 0.5 (switchable: 0.5 mm at shipment), cell capacity: 0.8 / 1.6 / 4.0 μL (changes in
conjunction with optical path length). No temperature control function.
*7: Low diffusion flow cell for micro LC. Optical path length: 3 mm, cell capacity: 0.21 μL. No temperature
control function. When using this cell, it is necessary to replace the main detector board with the micro
compatible board attached to the cell (FE operation required. The cost will be estimated separately).
*8: Required for Nexera UC system. Optical path length: 10 mm, cell capacity: 12 μL. No temperature control
function.

*9: A kit required to recycle the mobile phase. Built in the front panel of this detector. The valve is switched
automatically to recover the mobile phase.
4.7.3. UV-VIS Detector Consumables and Maintenance Parts

228-73407 D2 Lamp L9
228-73443 W Lamp L9
4.8. Photodiode Array Detector

4.8.1. Photodiode Array Detector Unit
228-65302-58 SPD-M40 L2
<Components Provided with the SPD-M40>

228-15672-91 Syringe Adapter 1
046-00017-01 Syringe 1
228-18565 Male Nut PEEK 4
228-18495-06 ETFE Tube 1
228-25162-03 Drain Tube 1
228-61083-41 Ethernet Cable, 2 m 1
228-92326 1
(JP/EN)
4.8.2. Optional Parts for the Photodiode Array Detector

228-62156-42 Standard Cell L9 *1
228-64724-41 UHPLC Cell L9 *2
228-64725-41 Semi-Micro Cell L9 *3
228-68250-41 Conventional Cell L9 *4
228-64728-41 Inert Cell L9 *5
228-64727-41 Preparative Cell L9 *5
228-64737-41 Micro Cell L9 *6
228-64726-41 SFC Pressure Resistant Cell L9 *7
*1: This cell is provided as standard with the unit. Optical path length: 10 mm; cell capacity: 12 uL;
equipped with heat regulation function.
*2: This is a low diffusion cell for high speed, high separation analysis. Optical path length: 10 mm; cell
capacity: 8 uL; equipped with heat regulation function.
*3: This is a low diffusion cell for MS and other low flowrate types. Optical path length: 5 mm; cell capacity:

2.5 uL; equipped with heat regulation function.
*4: A cell with IN piping capacity equal to that of the conventional SPD-20A / V. Although diffusion is
attempted in the standard cell, select this when you need the same characteristics as SPD-20A / V, and
when you need low noise at high flow rates exceeding 1.5 mL / min. Optical path length: 10 mm, cell
capacity: 12 μL With temperature control function.
*5: This is required when circulating liquids with high concentrations of salts that would corrode SS, as well
as halogens, and alkaline solutions. Optical path length: 10 mm; cell capacity: 12 uL; equipped with heat
regulation function.
*6: This is required for preparative systems. It protects against signal saturation by high concentration
samples. Optical path length: 0.1 / 0.2 / 0.5 (switchable: 0.5 mm at time of shipment); cell capacity:
0.8 / 1.6 / 4.0 uL (changes in sync with the optical path length) Not equipped with a temperature
regulation function.
*7: This is a low diffusion flow cell for micro LC. Optical path length: 3mm; cell capacity: 0.21 uL; not
equipped with a temperature regulation function.
*8: This is required for the Nexera UC system. Optical path length: 10 mm; cell capacity: 12 uL;
not equipped with heat regulation function.
4.8.3. Photodiode Array Detector Consumables and Maintenance Parts

228-63621-02 D2 Lamp L9
228-73309 W Lamp L9
228-53924-03 Protective Dust Filter L9
4.9. Reservoir Tray Unit

4.9.1. Reservoir Tray Unit
228-65508-58 Reservoir Tray L2
<Components Provided with the Reservoir Tray>

228-75145 Label, Tube Clamp 1
228-75147 Tube Clamp 10
228-75144-03 Tray Guide Bar S 2
228-75144-04 Tray Guide Bar L 2
228-75145 Tube Clamp Label 1
228-75147 Tube Clamp 10
These are used when
fastening the tray guide bar
020-37508 Guide Bar Fastening Screws 8
to the reservoir tray with
screws.

4.9.2. Optional Parts for the Reservoir Tray
228-77027-41 Bottle Holder Kit, Earthquake-R L9
4.10. Piping Kit

4.10.1. Piping Kit
228-70254-41 Piping Kit A, for High Pressure GE, ID0.3 L9 *1
228-70254-42 Piping Kit B, for High Pressure GE, ID0.1 L9 *2
228-70254-43 Piping Kit C, for Low Pressure GE, ID0.3 L9 *3
228-70254-44 Piping Kit D, for Low Pressure GE, ID0.1 L9 *4
*1: This is for the Nexera lite high pressure gradient. It includes 0.3 x 600 mm (2 pc.), 0.3 x 300 mm (1 pc.),
and 0.3 x 600 mm (1 pc.)
*2: This is for the Nexera XR / XS / X3 high pressure gradient. It includes 0.3 x 600 mm (2 pc.),
0.3 x 300 mm (1 pc.), and 0.1 x 600 mm (1 pc.)
*3: This is for the Nexera lite low pressure gradient. It includes 0.3 x 600 mm (1 pc.), 0.3 x 300 mm (1 pc.),
and 0.3 x 600 mm (1 pc.)
*4: This is for the Nexera XR low pressure gradient. It includes 0.3 x 600 mm (1 pc.), 0.3 x 300 mm (1 pc.),
and 0.1 x 600 mm (1 pc.)
<Components Provided with the 228-70254-41>

228-53137-54 SS Piping (ID 0.3×600) 2 *1

228-53137-61 SS Piping (ID 0.3×300) 1 *2
228-53137-50 SS Piping (ID 0.3×600) 1 *3
228-16001 Male Nuts 1.6MN 5
228-16001-03 Male Nuts 1.6MN, W6 1
228-56867-41 UHPLC FITTING 2 S 2
228-16000-10 Ferrule 1.6F 316L 6
228-16004-15 Coupling 1.6C-0.3 1

228-53137-54 SS Piping (ID 0.3×600) 2 *1

228-53137-61 SS Piping (ID 0.3×300) 1 *2
228-53137-95 SS Pipe 0.1x600 OUT 1 *4
228-16001 Male Nuts 1.6MN 5
228-16001-03 Male Nuts 1.6MN, W6 1
228-16000-10 Ferrule 1.6F 316L 6
228-16004-15 Coupling 1.6C-0.3 1

228-53137-54 SS Piping (ID 0.3×600) 1 *1

228-53137-61 SS Piping (ID 0.3×300) 1 *2
228-53137-50 SS Piping (ID 0.3×600) 1 *3
228-16001 Male Nuts 1.6MN 3
228-16001-03 Male Nuts 1.6MN, W6 1
228-16000-10 Ferrule 1.6F 316L 4
228-16004-15 Coupling 1.6C-0.3 1

228-53137-54 SS Piping (ID 0.3×600) 1 *1

228-53137-61 SS Piping (ID 0.3×300) 1 *2
228-53137-95 SS Pipe 0.1x600 OUT 1 *4
228-16001 Male Nuts 1.6MN 3
228-16001-03 Male Nuts 1.6MN, W6 1
228-16000-10 Ferrule 1.6F 316L 4
228-16004-15 Coupling 1.6C-0.3 1
* 1: This is the stainless steel piping connecting the pump outlet and the mixer inlet (ID. 0.3 mm).
* 2: This is the stainless steel piping connecting the mixer outlet and the autosampler inlet (ID. 0.3 mm).
* 3: This is the stainless steel piping connecting the autosampler outlet and the column inlet (ID. 0.3 mm).
* 4: This is the stainless steel piping connecting the autosampler outlet and the column inlet (ID. 0.1 mm).
4.10.2. Piping Kit Consumables and Maintenance Parts

228-53184-51 SS Piping (ID 0.3×500) L9 *1

228-53184-54 SS Piping (ID 0.3×600) *1
228-53184-93 SS Piping (ID 0.3×700) *1
228-53184-96 SS Piping (ID 0.3×1000) *1
228-53184-41 SS Piping (ID 0.3×1200) *1
228-53184-61 SS Piping (ID 0.3×300) L9 *2
228-53184-49 SS Piping (ID 0.3×600) L9 *3
228-53184-48 SS Piping (ID 0.17x600) *4
228-53184-91 SS Pipe 0.1x600 OUT L9 *5
Nexlock SS ID 0.3 mm X 600 mm (with
228-62544-22 L9 *6
fitting)
228-62544-23 L9 *7
fitting)
228-62544-11 L9 *8
fitting)
*1: This is the stainless steel piping connecting the pump outlet and the mixer inlet (ID. 0.3 mm).
*2: This is the stainless steel piping connecting the mixer outlet and the autosampler inlet (ID. 0.3 mm).
*3: This is the stainless steel piping connecting the autosampler outlet and the column inlet (ID. 0.3 mm).
*6: This is stainless steel piping that can be tightened by hand. (ID. 0.3 mm) Use a column with
a maximum ID. of 0.4 mm.

4.11. Cable Kit
4.11.1. Cable Kit Unit
228-70247-41 Cable kit for Nexera series, A L9

228-70247-42 Cable kit for Nexera series, B L9
228-70247-43 Cable kit for Nexera series, C L9
228-70247-44 Cable kit for Nexera series, D L9

228-77025-06 Optical Fiber Cable, 0.6 m 1
018-20197-02 Fastener, L8913L 20MM, Black 0.5MT
228-64829 Wiring Cover, Body 1
228-64091 Wiring Cover, Lid 2
072-60658-01 Clamp, EA947FA-10A 1


072-60658-01 Clamp, EA947FA-10A 1


072-60658-01 Clamp, EA947FA-10A 1


072-60658-01 Clamp, EA947FA-10A 1
4.11.2. Optional Parts for the Cable Kit

228-70247-49 Cable Cover Set L9
4.11.3. Cable Kit Consumables and Maintenance Parts

228-77025-06 Optical Fiber Cable, 0.6 m L9

4.12. Flow Channel Switching Valve

4.12.1. Optional Parts for the Flow Channel Switching Valve
228-65602-58 FCV-DR L9
228-65603-58 FCV-0206 L9 44 MPa
228-65604-58 FCV-0607 L9 44 MPa
228-65607-58 FCV-0206H L9 80 MPa
228-65608-58 FCV-0607H L9 80 MPa
228-65624-58 FCV-0206H3 L9 130 MPa
228-65625-58 FCV-0607H3 L9 130 MPa
4.12.2. Flow Channel Switching Valve Consumables and Maintenance Parts

228-71780-41 Rotor, 2 Position 6 Port L9
228-56253-44 Stator, 2 Position 6 Port L9

228-71781-41 Packing, 2 Position 6 Port L9
228-71781-44 Packing, 6 Position 7 Port L9
4.13. Mobile Phase Monitor

4.13.1. Mobile Phase Monitor Unit
228-65525-58 Main Unit Controller L2 *1
228-65526-58 Main Unit Bottle Holder L9 *2
*1: Up to 6 bottle holders can be connected.
*2: Two mobile phase bottles can be measured by each.
Note: Order separately an AC adapter that can supply power (at least 500 mA) via a USB cable. The
following recommended item can be supplied by the Parts Center.
AC Adapter,
074-83019-01 L9
6A-054WP05B
<Components Provided with the Mobile Phase Monitor>

088-50825-50 USB Cable 1 2m

Instruction manual, and
application software for
228-93089-41 CD-ROM 1 the mobile phase monitor
settings and monitor
Fastens the bottle holder

072-60314-02 Clamp 6 cable
228-61083-41 LAN Cable 1 2m
This is for error contact
228-28253-91 Event Cable 1 signal output.
228-76032-41 Mark Band Set 1
228-76026 Bottle Number Labels 1
4.13.2. Optional Parts for the Mobile Phase Monitor

228-76011-41 MPM Mounting Kit L9
228-77027-41 Bottle Holder Kit, Earthquake-R L9

4.13.3. Mobile Phase Monitor Consumables and Maintenance Parts
228-75060-41 Controller Board L9
228-75070-41 Bottle Holder Board L9
228-75620-41 Bottle Holder Cable L9
4.14. Power Supply

4.14.1. Power Cord and Outlet Unit
071-60821-08 Power Cord, Length: 2.5 m L9
228-65523-41 Outlet Unit, 6 Plugs L9
228-65524-58 Outlet Unit, 2 Plugs L9
4.15. Other Optional Parts

228-38583-42 Mobile Phase Bottles L9
228-57647-43 Tool Kit L9
228-77036-41 System base kit, A
228-77036-42 System base kit, B
228-77036-43 System base kit, C
228-77027-41 Bottle Holder Kit, Earthquake-R
228-54791-91 Reservoir net, Earthquake resistant
228-54756-02 System fixing belt
228-77035-41 Belt fixing plate for earthquake resistant
5. Handling of Existing Products

In accordance with the release of the new Nexera series, some existing products will be
changed or discontinued. For details, refer to LC News No. 232 and LC News No.233.
6. Instrument Installation Guidelines

・Instrument Units (shared by all instruments)
Width: 400 mm (PDA), 530 mm (UV); Depth: 500 mm; Height: 770 mm (max.)
Size The SIL-40C XR and plate changer have a protrusion from the back of 140 mm.
For the plate changer, the value is the width plus 170 mm.
When installing this product, consider the total weight including each instrument, the
Weight
computer, the monitor, and the printer.
• A room with a temperature between 4 °C and 35 °C, and minimal daily temperature
fluctuations
(When the sample cooler is set to 4 °C, the environmental conditions are a room temperature
Peripheral of 30 °C max., and a relative humidity of 70 % max.)
Environm • A site at which the instruments are not directly exposed to the draft from an air conditioner
ent • A site not exposed to direct sunlight
• Site with no vibrations
• Site where the relative humidity is maintained between 20 % and 85 %
• Site with no condensation

• Site satisfying the installation environment conditions (IEC) (installation category II,
pollution degree 2, altitude of 2000 m or less, indoors)
Required
100 VAC (50/60 Hz)
Power
Install it at a site where the power supply is easy to control.
Supply
*1: Ensure that the desk or stand on which this product is installed is capable of withstanding the total weight
of the equipment. Make sure that it is flat, stable, and has a depth of at least 700 mm.
*2: Keep the back of the instrument at least 100 mm from the wall. If these conditions are not satisfied, there
is a risk that heat might not be dissipated sufficiently through the slits or by the cooling air from the fan,
resulting in overheating of the instrument and a loss of performance.
*3: Ensure that the indoor space is well ventilated. The solvents used by the high-performance liquid
chromatograph are flammable and toxic. A lack of ventilation may lead to poisoning or a fire.
*4: Install this product near a wash stand or other water supply facilities. If solvent gets in the eyes, or
someone touches a toxic solvent, flush it away immediately with water.
*5: Never use open flames near this product. Do NOT install other units that generate sparks within the same
room. The high-performance liquid chromatograph uses large amounts of organic solvents, and a spark
could cause a fire. To be safe, install a fire extinguisher.
*6: In order to maintain system operating life and performance, do NOT install it at a site exposed to
corrosive gases, organic solvents, halogenated substances, gases containing siloxanes, oil mist, or large
amounts of dirt or dust.
*7: Do NOT install it near equipment that generates strong magnetic fields. In addition, if there is a lot of
noise on the power line, take measures for noise blocking (such as adding a noise filter).
*8: When moving the system, do NOT grip it by the opening/closing part on the front. If the system is
inadvertently lifted up while gripping the opening/closing part on the front, there is a risk that it could be
damaged, or come loose.

Sample Estimate for the Nexera Series
For the estimate configuration for each model in the new Nexera series, refer to the
Product News below.
LC News No. 228 Shimadzu UHPLC System "Nexera X3" model release
LC News No. 229 Shimadzu UHPLC System "Nexera XS" model release
LC News No. 230 Shimadzu UHPLC System "Nexera XR" model launch
LC News No. 231 Shimadzu HPLC System "Nexera lite" model launch
7. Sales Materials
Name of Materials Overview Site where Available
Product News These materials, and the separate Product News web pages
documents for each model
Catalog (in Japanese) An explanation of functions and features
shared by all instruments in the new
Nexera series
Instructional PPT for Sales An explanation of each model and the Sales support materials library
features shared by all instruments in the
new Nexera series
Instructional PPT for An explanation of the models except for Sales support materials library
Customers the Nexera lite, and the features shared
by all instruments in the new Nexera
series
Comparison Table Table for comparison with competing Sales support materials library
equivalent instruments (Excel)
Side-by-side An explanation of the features and Sales support materials library
performance shared by all instruments in
the new Nexera series, in comparison to
the Waters, Agilent, and Thermo brands
respectively. This also includes data
collected with competing instruments.
Specifications Sheet Summary of the specifications for each Sales support materials library
unit.
FAQ Sales activities and an FAQ for Sales support materials library
customers This is scheduled to be
updated continuously even after product
release.
Materials Explaining the Introduces the new functions of the new Sales support materials library
New Functions in the New Nexera series in detail in accordance
Nexera Series with the work flow.
Application News A variety of application articles Solution Navigator
introducing the features shared by all the
instruments in the new Nexera series
This is scheduled to be updated
continuously even after product release.
Technical Reports An explanation of new functions and Solution Navigator
features shared by all instruments in the
new Nexera series
Estimate Creation Support These web tools are used to easily create This is under construction.
Tool an estimate for each model.
The user can check the estimate

configuration list, the schematic
diagrams, and the flow channel
diagrams.
Special Website for the New This website is updated periodically with http://www.new-benchmark.com
Nexera Series (for outside information on the new Nexera series,
the company) for about one year from the release date.
Special Website for the New This special website aggregates sales This is under construction.
Nexera Series (in-house in information and customer information
Japan) with respect to the new Nexera series.
Special Website for the New This special website aggregates sales This is under construction.
Nexera Series (for overseas information and customer information
representatives) with respect to the new Nexera series.
Teaser Video This preliminary video is made public Shimadzu public website
before the product release.
(Approximately 30 seconds in length)
Conceptual Video This video introduces the taglines and Specially set-up website
keywords for the new Nexera series.
(Approximately 1 minute in length)
Video to Introduce An introduction to the features shared by Specially set-up website
Functionality all instruments in the new Nexera series,
on a function by function basis
(Approximately 3 minutes in length)
Estimate Creation Support These web tools are used to easily create This is under construction.
Tool an estimate for each model. The user can
check the estimate configuration list, the
schematic diagrams, and the flow
channel diagrams.

Appendix
Names in the New Nexera Series

The name for the new Nexera series, and the names for the models and units are in
accordance with the following rules.
 Series Name
(In Japanese) Nexera シリーズ (ネクセラシリーズ) Note: There is no space
between “Nexera” and シリーズ
(In English) Nexera series Note: The word “series” is not capitalized because it is not
a proper noun.
Examples of Incorrect Notation (Excluding the domain names for special sites)
Nexera Series, Nexera-Series, Nexera-series, NexeraSeries, Nexeraseries
 Model Names
Nexera X3, Nexera XS, Nexera XR, Nexera lite
Note: There is a single-byte space between “Nexera” and the model name (X3, XR
etc.)
X3 (the “X” is capitalized); XS (both are capitalized); XR (both are capitalized); lite
(all lower case)
The font is entirely uniform.
 Unit Model Names

LC-40D, LC-40D XR, LC-40B XR, LC-40D XS, LC-40D X3, LC-40B X3
SIL-40, SIL-40C, SIL-40 XR, SIL-40C XR, SIL-40C XS, SIL-40C X3
Note: For the X3, XS, and XR models, there is a single-byte space before the model
name (such as XR).
A model name is not appended to the “lite” model. The only exception is CBM-
40lite (without the single-byte space).
For detectors, ovens, and other units shared by all models, a model name is not
appended.
(This news is a translation of B105-1750)

Shimadzu Corporation
Global Marketing Department
Analytical & Measuring Instruments Division
E-mail: gcs_ami@group.shimadzu.co.jp

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LC News No.

LC News No. 227 Page 1

Plate-changer mounting system for ultra-large batch

2. Key features and system configuration

2.1.1. A New Benchmark of Intelligence

LC News No. 227 Page 2

2.1.2. A New Benchmark of Efficiency

2.1.3. A New Benchmark of Design

LC News No. 227 Page 3

LC News No. 227 Page 4

LC News No. 227 Page 5

2.3. New Nexera lineup

LC News No. 227 Page 6

Figure 1 Lineup and market position of the Nexera series

3. Overview of newly-developed units

LC News No. 227 Page 7

Model Name SCL-40 CBM-40 CBM-40lite

LC News No. 227 Page 8

Model Name LC-40D, LC-40D XR / XS / X3 LC-40B XR / X3

Features Unlike LC-20AB, there is no point at

LC News No. 227 Page 9

LC News No. 227 Page 10

Model Name DGU-403 DGU-405

LC News No. 227 Page 11

LC News No. 227 Page 12

LC News No. 227 Page 13

LC News No. 227 Page 14

3.7. UV-VIS Detector, photodiode array detector

This cost-effective detector features low This detector achieves industry-leading

LC News No. 227 Page 15

3.8. Major newly-developed options

LC News No. 227 Page 16

Reservoir tray Necessary when using CBM-40/40lite use. Up to

Mobile phase This device measures the remaining mobile

LC News No. 227 Page 17

LC News No. 227 Page 18

<Components Provided with the SCL-40>

LC News No. 227 Page 19

<Components Provided with the CBM-40lite>

LC News No. 227 Page 20

4.1.3. System Controller Consumables and Maintenance Parts

072-02004-23 Fuse, 0218005.MXP L9

4.2. Solvent Delivery Unit

LC News No. 227 Page 21

228-92350-41 Instruction Manual (CD-ROM), Nexera Series 1

<Components Provided with the LC-40D>

LC News No. 227 Page 22

<Components Provided with the LC-40B X3>

LC News No. 227 Page 23

P/N Description Code Remarks

228-65016-58 Low Pressure Gradient Kit L2 *1

LC News No. 227 Page 24

P/N Description Code Remarks

P/N Description Code Remarks

228-55230-45 Pump Head XR L9 *2, 3, 4

LC News No. 227 Page 25

4.3. Degassing Unit

228-65019-58 Degassing Unit (5 Flow Channels), DGU-405 L2

LC News No. 227 Page 26

P/N Description Qty Remarks