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    Sitoskeleton

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    zatunniqy

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    © All Rights Reserved
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    Sitoskeleton

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    zatunniqy
    54 views43 pages

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    sitoskeleton.ppt

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    54 views43 pages

    Sitoskeleton

    Uploaded by

    zatunniqy

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 43

    Cell Motility

    Copyright (c) by W. H. Freeman and Company


    Pergerakan sel

    Cytoskeleton
    -serabut protein yg ditemukan di sel
    eukariotik
    -support bentuk sel
    -menjaga organela pada lokasi yg tetap
    -membantu perpindahan material ke
    dalam sel

    Copyright (c) by W. H. Freeman and Company


    Bagian sitoplasma, di antara organela
    penuh anyaman benang2 halus
    Disebut jala2 mikrotrabekula (mirip bunga
    karang)
    Krn membentuk kerangka sel shg disebut
    sitoskeleton

    Copyright (c) by W. H. Freeman and Company


    Cytoskeleton

    Copyright (c) by W. H. Freeman and Company


    The
    Cytoskeleton
    in Action

    Sel darah
    putih
    menggunakan
    sitokeleton
    untuk
    “meraih”
    bacteri.

    Copyright (c) by W. H. Freeman and Company


    The Cytoskeleton

    An animal cell cytoskeleton

    Copyright (c) by W. H. Freeman and Company


    The Cytoskeleton in Action

    Cilia on a protozoan Beating sperm tail at fertilization

    Smoker’s cough is due to destruction of cilia linking the airways.


    During blood clotting, platelets change shape
    due to changes in the actin cytoskeleton

    Figure 18-8
    Copyright (c) by W. H. Freeman and Company
    Komponen Penyusun
    Sitoskeleton

    Protein yg di sitosol mmbentuk benang


    halus disbut filamen
    Ada 3 macam (berdasar struktur dan garis
    tengah)
    : mikrotubula (24 nm), mikrofilamen (60
    Ao), filamen intermedia (8-10 nm)

    Copyright (c) by W. H. Freeman and Company


    19.6 Functions and structure of intermediate filaments
    distinguish them from other cytoskeletal fibers

    Copyright (c) by W. H. Freeman and Company Figure 19-50


    mikrotubula

    Filamen dgn diameter trbesar (24 nm)


    Trsusun atas 13 protofilamen
    Tiap protofilamen tdr dr molekul2 tubulin
    (tubulin alfa dan beta)
    Punya kutub positif yg pertumbuhannya
    cepat, kutub negatif prtumbuhannya
    lambat

    Copyright (c) by W. H. Freeman and Company


    Heterodimeric tubulin subunits compose the
    wall of a microtubule

    Figure 19-2
    Copyright (c) by W. H. Freeman and Company
    19.1 Arrangement of protofilaments in
    singlet, doublet, and triplet microtubules

    Figure 19-3
    Copyright (c) by W. H. Freeman and Company
    Berfungsi memberi bentuk sel, gerakan
    sel, menentukan bidng pembelahan sel
    Membentuk flagela, silia, sentriol

    Copyright (c) by W. H. Freeman and Company


    Mikrofilamen

    Trdiri dr mikrofilamen aktin, meosin dan


    tropomeosin (byk di otot)
    Aktin
     aktin mrpkan protein kontraktil terbanyak
    di sel eukariotik
    Dalam bentuk monomer disebut Aktin G
    Dalam bentuk filamen disebut Aktin F

    Copyright (c) by W. H. Freeman and Company


    Bersifat labil (mudah terakit dan terurai)
    Terlibat dlm proses sitokinesis, aliran
    plasma, gerakan sel, gerakan mikrovili
    intestinal

    Copyright (c) by W. H. Freeman and Company


    The actin cytoskeleton
     Filamen aktin(or microfilaments) adalah salah satu dr 3
    filamen protein yg menyusun system cytoskeleton
     Eukaryotic cells contain abundant amounts of highly
    conserved actin

    Copyright (c) by W. H. Freeman and Company Figure 18-1


    18.1 The actin cytoskeleton is organized
    into bundles and networks of filaments

    Figure 18-4
    Copyright (c) by W. H. Freeman and Company
    Actin cross-linking proteins bridge actin
    filaments to form bundles and networks

    Figure 18-5
    Copyright (c) by W. H. Freeman and Company
    Filamen Intermedia

    Bersifat liat
    Punya daya rentang tinggi.
    Benang berongga terdiri 5 protofilamen
    Diameter 8-10 nm
    Banyak terdapat di inti, dan sel yg alami
    stress mekanik spt epitelium, akson sel
    saraf dan otot polos

    Copyright (c) by W. H. Freeman and Company


    Pergerakan otot/muscle

    Copyright (c) by W. H. Freeman and Company


    Microanatomy of Skeletal
    Muscle

    sel otot =
    serabut otot
    yg mengandung
    myofibril

    Copyright (c) by W. H. Freeman and Company


    Muscle: a specialized contractile machine

    Figure 18-26
    Copyright (c) by W. H. Freeman and Company
    Tiap serabut otot terdiri dari ribuan
    myofibril
    Tiap myofibril terdapat 1500 filamen
    meosin dan 3000 filamen aktin
    Tiap filamen meosin terdiri dari molekul
    meosin BM 33.200 dan molekul aktin BM
    70.000

    Copyright (c) by W. H. Freeman and Company


    Dengan mikroskup cahaya : nampak
    gambaran gelap terang kepadatan
    relatif dan ada bagian yang tumpah
    tindih dr aktin dan miosin

    Copyright (c) by W. H. Freeman and Company


    Pita cahaya I
    Terdiri filamen aktin saja (nampak terang)
    Sifat terhadap cahaya yg terpolarisasi
    (berkas cahaya yg datang dipancarkan ke
    semua jurusan krn kepadatan sama)

    I band

    Copyright (c) by W. H. Freeman and Company


    Pita A
    Terletak dimana aktin dan meosin
    tumpang tindih (shg nampak gelap)
    Sifat anisotropik (cahaya dipancarkan
    tdk merata)

    A band
    Copyright (c) by W. H. Freeman and Company
    Sarkomer
    Terbentuk oleh 2 garis Z (protein
    nonkontraktil) atau sebuah pita A dan 2
    belahan pita I

    Sarkoplasma
    Sitoplasma sel2 otot
    Terdapat retikulum sarkopasma agranuler

    Copyright (c) by W. H. Freeman and Company


    Z line Z line

    H band

    Copyright (c) by W. H. Freeman and Company


    Copyright (c) by W. H. Freeman and Company
    Filamen meosin
    Tediri 2 utas peptid yg satu sama lainnya saling melilit
    dalam suatu heliks yg ujungnya membntuk kepala.

    Copyright (c) by W. H. Freeman and Company


    Copyright (c) by W. H. Freeman and Company
    Filamen aktin
    Terdiri 3 unsur : troponin, tropomeosin, aktin

    Copyright (c) by W. H. Freeman and Company


    Active site : suatu molekul ADP dimana
    filamen meosin saling mengadakan interaksi
    dgn filamen aktin shg terjadi kontraksi otot
    Tropomeosin : merupakan protein yg akan
    “menutupi” active site shg tdk terjadi kontraksi
    Troponin : akan berikatan dgn Ca utk
    permulaan kontraksi

    Copyright (c) by W. H. Freeman and Company


    Ilustrasi sarkomer
    H Band

    Copyright (c) by W. H. Freeman and Company


    18.4 Capping proteins stabilize the ends
    of actin thin filaments in the sarcomere

    Figure 18-28
    Copyright (c) by W. H. Freeman and Company
    18.4 Thick and thin filaments slide past
    one another during contraction

    Figure 18-29
    Copyright (c) by W. H. Freeman and Company
    18.4 Titin and nebulin filaments organize
    the sarcomere

    Figure 18-30
    Copyright (c) by W. H. Freeman and Company
    18.4 A rise in cytosolic Ca2+ triggers
    muscle contraction (part I)

    Figure 18-31a
    Copyright (c) by W. H. Freeman and Company
    18.4 A rise in cytosolic Ca2+ triggers
    muscle contraction (part II)

    Figure 18-31b
    Copyright (c) by W. H. Freeman and Company
    18.4 Tropomyosin and troponin regulate contraction in
    skeletal muscle

    Figure 18-32
    Copyright (c) by W. H. Freeman and Company
    18.4 Ca2+-dependent mechanisms for regulating
    contraction in skeletal and smooth muscle

    Figure 18-33
    Copyright (c) by W. H. Freeman and Company
    18.4 Myosin-dependent mechanisms also
    control contraction in some muscles

    Figure 18-34
    Copyright (c) by W. H. Freeman and Company

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