Hakan H . Kadıoğlu
Ataturk University, Neurosurgery, Faculty Member
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OBJECTIVE The authors of this study aimed to define the microanatomy of the interthalamic adhesion (ITA) using microfiber dissection, magnetic resonance (MR) tractography, and histological analysis. METHODS Sagittal, coronal, and axial MR... more
OBJECTIVE The authors of this study aimed to define the microanatomy of the interthalamic adhesion (ITA) using microfiber dissection, magnetic resonance (MR) tractography, and histological analysis. METHODS Sagittal, coronal, and axial MR images from 160 healthy individuals 2–82 years of age were examined. The relationships between age range and ITA morphology as well as between gender and ITA morphology were evaluated statistically. Among these 160 individuals, 100 who had undergone MR tractography were examined. In this group, the presence of fiber tracts in the ITA and the relationship with ITA morphological types were examined. Thirty formalin-fixed human cadaveric brains were also examined endoscopically, and 6 hemispheres were dissected from the medial to lateral and superior to inferior directions under the microscope. Sections taken from one of the brains with an ITA type 2 with both thalami were examined histologically. Anti-neurofilament antibody was used in the histological examination. RESULTS Four morphological types of ITA were observed. Type 1 had an adhesion/adherent appearance, type 2 had a bridge/commissure appearance, type 3 showed no adhesion, and type 4 had a double bridge. Tractographic examination revealed that 28% had no fiber tract transition in the ITA, 21% had a significant transition, and 51% had an indistinct transition. Statistically, the presence of the ITA was significantly higher in the pediatric (age) and female (gender) groups. In specimens with ITAs of a bridge/commissure appearance (type 2), fiber tracts showed clear transitions between thalami. In type 1 (adherent/adhesive appearance), fiber tracts were observed within the ITA, but a reciprocal transition was unclear. Dissection showed that these fiber tracts in the ITA reach the nucleus accumbens, caudate nucleus, and frontoorbital region anteriorly and the lateral habenula and posterior commissure posteriorly. Some fibers also joined the ansa peduncularis. In histological studies, axonal fibers moving in the ITA were observed with anti-neurofilament antibody staining. CONCLUSIONS This is the first study to demonstrate fiber tracts of the ITA through fiber dissection and transillumination techniques as well as radiological and histological study. Statistical data were obtained by comparing the morphological group with age and gender groups. The anatomy of this structure, which has been neglected for many years, was reexamined. This study showed that the ITA has fibers connecting different parts of the brain, in contrast to previous studies suggesting that it was a simple massa.
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Tumors of the pineal region (TPRs) are rare neoplasms that are surgically challenging to resect. Conventional treatment strategies are available, but gamma knife radiosurgery (GKRS) is an alternative approach. This study presents a... more
Tumors of the pineal region (TPRs) are rare neoplasms that are surgically challenging to resect. Conventional treatment strategies are available, but gamma knife radiosurgery (GKRS) is an alternative approach. This study presents a single-center experience with GKRS performed for TPR with and without histopathological diagnoses. The cases of 25 patients with TPRs treated with GKRS were retrospectively analyzed. Thirteen of these 25 patients had histopathological confirmation, and 13 had elevated serum alpha-fetoprotein and beta-human chorionic gonadotropin levels. The 25 patients had a mean follow-up duration of 61 months. The total response rate to GKRS was 60%, and a 53.8% decrease in the alpha-fetoprotein and beta human chorionic gonadotropin levels was observed. The findings of this study indicate that GKRS is a safe procedure for TPRs, even in the event of insufficient histopathological findings. This treatment approach provides increased Karnofsky performance scores and an ext...
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OBJECTIVE It is difficult to demonstrate the success of the procedure in patients with third ventriculostomy. We evaluated that optic nerve sheath diameter (ONSD) measurement, which can reflect intracranial pressure, may be a criterion... more
OBJECTIVE It is difficult to demonstrate the success of the procedure in patients with third ventriculostomy. We evaluated that optic nerve sheath diameter (ONSD) measurement, which can reflect intracranial pressure, may be a criterion for decision of endoscopic third ventriculostomy (ETV) success. METHODS 28 adult patients suffering long overt standing ventriculomegaly (LOVA) who performed ETV were included in this retrospective study. The patients were divided into two groups as successful (group A) and failed ETV group (group B) according to their postoperative evaluation. ONSD was measured on pre- and post-operative computed tomography (CT) and Evan's index (EI), diameter of third ventricule (V3), the patency of ETV stoma and periventricular edema were evaluated by magnetic resonance imaging (MRI). RESULTS The mean ONSD was measured as 6.39±0.92mm for the right eye, 6.50±0.91mm for the left eye on preoperative CT. The mean ONSD by CT (after surgery) was 4.89±0.87mm for the right eye, 5.02±0.1mm for the left eye (p<0.05). Postoperative group A and group B were compared according to ONSD measurement; mean ONSD in group A was 4.52±0.69mm for the right and 4.59±0.9mm for the left, mean ONSD in group B was 5.82±0.51mm for the right and 6.1±0.32mm for the left (p<0.05). The best ONSD value for detecting failed ETV was 5.40mm (sensitivity 90%, specifity 75%, AUROC 0.938) for right and 5.91mm (sensitivity 90%, specifity 75%, AUROC 0.950) for left. EE was measured as 0.39±0.12mm on preoperative MRI and 0.39±0.12mm on postoperative MRI (p=0.3). V3 was measured as 14.7±2.47mm on preoperative MRI and 10.47±1.99mm on postoperative MRI (p<0.05). CONCLUSION The statistical values obtained from study show that the ONSD measurement can help in the postoperative evaluation of patients, who had a ETV surgery.
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ABSTRACT BackgroundThis study aims to investigate experimentally the noradrenaline mediated responses of common carotid artery (CCA) helical strips in tissue bath in the presence of periarterial blood and blood products for varying... more
ABSTRACT BackgroundThis study aims to investigate experimentally the noradrenaline mediated responses of common carotid artery (CCA) helical strips in tissue bath in the presence of periarterial blood and blood products for varying durations. MethodNinety hybrid albino male rabbits were randomly assigned to three main groups. In the first group, following the exposure, a mixture of 0.3 saline and 0.3 g polyvinyl alcohol (PVA) was applied around the CCAs by using a silastic sheath. For the second group, 0.3 ml blood and 0.3 g PVA, and for the third group 0.3 ml thrombocyte rich plasma (TRP) and 0.3 g PVA were applied. All subjects were sacrificed at the end of a predetermined follow-up period, CCAs were prepared in the shape of helical strips and positioned on the isometric contraction measurement device, then contraction amplitudes and time to the achievement of a plateau level were measured. FindingsContraction amplitude seemed to decrease significantly in the whole blood and TRP groups, compared to the normal vessel and saline groups. Moreover, the time to plateau was significantly decreased in the whole blood and TRP groups. ConclusionsIt can be suggested that the decrease in vascular contractility may have the unfavorable effect of cerebral vascular autoregulation following subarachnoid haemorrhage, depending on the amount of and contact duration with blood.
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A case presented in which a intraparencymal epidermoid cyst localized in the left temporo-parietal lobe and complicated with brain abscess after removing the epidermoid cyst. Because the localization of epidermoid cyts is very rare, and... more
A case presented in which a intraparencymal epidermoid cyst localized in the left temporo-parietal lobe and complicated with brain abscess after removing the epidermoid cyst. Because the localization of epidermoid cyts is very rare, and it caused aseptic meningitis in early postoperative period and characteristic brain abscess that it could not isolated any microorganism this case is discussed within literature knowlegde.
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Research Interests: Microsurgery, Adolescent, Medicine, Anatomy, Humans, and 15 moreNeuroradiology, Female, Male, Interventional Radiology, Artery, Clinical Sciences, Aged, Middle Aged, Adult, Intracranial Arteriovenous Malformations, Neurosciences, Anterior communicating artery, Intracranial aneurysm, cerebral arteries, and anterior cerebral artery
The anatomical variations of sylvian vein and cistern were investigated during the pterional approach in 750 operative cases with different pathologies. All patients were operated on at the Neurosurgical Department of Ataturk University... more
The anatomical variations of sylvian vein and cistern were investigated during the pterional approach in 750 operative cases with different pathologies. All patients were operated on at the Neurosurgical Department of Ataturk University Medical School, Erzurum, Turkiye. The patients underwent surgery for the lesions necessitating the right or left pterional approach. The findings were recorded during surgical intervention and observed through the operative sketches of the pathologies, the slides, and videotapes of the operations. In our study, we surgically classified the variations of sylvian vein, according to its branching and draining patterns. Type I: The fronto-orbital (frontosylvian), fronto-parietal (parietosylvian) and anterior temporal (temporosylvian) veins drain into one sylvian vein. Type II: Two superficial sylvian veins with separated basal vein draining into the sphenoparietal and Rosenthal&#39;s basal vein. Type III: Two superficial sylvian veins draining into the sphenoparietal and the superior petrosal veins. Type IV: Hypoplastic superficial sylvian vein and the deep one. Four types of sylvian vein variations were defined as follows. The type I was seen in 52.8% (n = 396), the type II was found in 19.2% (n = 144), type III was recorded in 18.2% (n = 137), and type IV, or hypoplastic and deep form was discovered in 9.8% (n = 73) of patients. The coursing of sylvian vein was in the temporal side (Temporal Coursing) in 62.4 percent of the cases (n = 469), in the frontal side (Frontal Coursing) in 25 % of the patients (n = 187) and in 9 percent of the cases (n = 67) in the deep localization (Deep Coursing). Only 3.6% of the cases (n = 27) showed Mixed Coursing. The variations of the sylvian cisterns were classified into three types, according to the relationships between the lateral fronto-orbital gyrus and the superior temporal gyrus. In Sylvian type, the frontal and temporal lobes are loosely (Sylvian Type A, wide and large) or tightly (Sylvian Type B, close and narrow) approximated on the surface thereby covering the substance of the sylvian cistern. In Frontal Type, the proximal part of the lateral fronto-orbital gyrus herniated into the temporal lobe. In Temporal Type, the proximal part of the superior temporal gyrus herniated into the lateral fronto-orbital gyrus. The variations of the sylvian cisterns in 750 patients with different pathologies, were as follows: in 47.7% (n = 358) Sylvian type A, in 27.2% percent (n = 204) Sylvian type B, in 16.3% (n = 122) frontal type and in 8.8% (n = 66) temporal type. We concluded that venous perfusion discorder of the brain is the most important factor during the pterional approach. Careful intraoperative assessment and protection of the sylvian vein, which is a surgical pitfall, is an indispensable part of the operation. The recognition of the anatomical variations of the sylvian vein and cistern, and the detailed knowledge of the microvascular relationships and the importance of preservation of this vein at that level, will allow the neurosurgeon, believing in the minimally invasive neurosurgical techniques, to construct a better and safer microdissection plan, to save time, and can prevent postoperative neurological deficits.
Research Interests: Microsurgery, Adolescent, Medicine, Anatomy, Prospective studies, and 15 moreHumans, Female, Male, Clinical Sciences, Aged, Middle Aged, Adult, Anatomical Variation, Cistern, Neurosciences, Frontal Lobe, Craniotomy, minimally invasive neurosurgery, minimally invasive surgical procedures, and Intracranial Embolism and Thrombosis
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Amac: Turk kulturunde yer adlandirmasi, genellikle boy, asiret, oymak veya cemaatlerin adlarinin kullanimiyla yapilmaktadir. Bu dusunceden hareketle Erzurum cografyasindaki bazi yerlesim yerlerinin adlariyla eski inanclarin ve ona mensup... more
Amac: Turk kulturunde yer adlandirmasi, genellikle boy, asiret, oymak veya cemaatlerin adlarinin kullanimiyla yapilmaktadir. Bu dusunceden hareketle Erzurum cografyasindaki bazi yerlesim yerlerinin adlariyla eski inanclarin ve ona mensup olan topluluklarin kulturel kodlari incelendi. Gerec yontem: Calisma Erzurum siyasi sinirlari dâhilinde tutulmaya calisildi. Yerlesim yerleri hâlihazirdaki adlari ve daha onceki isimleri ile birlikte belirlenerek adlarinin arka planindaki kulturel kodlara ulasilmaya calisildi. Bulgular: Yaklasik on bes yerlesim yeri adinda yedi civarinda inanc toplulugu saptandi. Bunlarin birbirleriyle kendi mantik orgusu icinde ilis-kili olduklari belirlendi. Belirlenen yer adlarindaki inanc kodlariyla yerle-sim yerinin gunumuzdeki sakinlerinin hicbir bicimde iliskilerinin kalma-digi goruldu. Sonuc: Turkler, kadim caglardan beri sikca Turkeli’nden Anadolu’ya hareket halinde olmuslardir. Turkler, IX-X. yuzyildan baslayarak karsilas-tiklari yeni inanc sistemi ile sah...
Research Interests: Art and Gynecology
Erzurum ve cevresinde fiziki temizlik ve sifa elde etmek amaciyla hamam ve kaplicalardan yaygin bicimde yararlanilmaktadir. Bu yararlanma esnasinda gecmisten gunumuze uzanan birtakim gelenekler yerine getirilmektedir. Bu hamam... more
Erzurum ve cevresinde fiziki temizlik ve sifa elde etmek amaciyla hamam ve kaplicalardan yaygin bicimde yararlanilmaktadir. Bu yararlanma esnasinda gecmisten gunumuze uzanan birtakim gelenekler yerine getirilmektedir. Bu hamam uygulamalarinin vazgecilmez ogelerinden biri de hamam tasidir. Calismamizda Erzurumlu ve Erzurum’da yerlesik kisilerden ve Erzurum Muzesinden temin edilen on hamam tasi boyut ve gorunum bakimindan incelendi. Bircok yerel adetin yerine getirilmesinde vazgecilmez bir oge olarak karsimiza cikan hamam tasinin, bizzat islevleri ve uzerindeki motifler ile kadim inanclardan gunumuze kalitlar tasidigi; eski su kultunun cermik/ hamam adetleri, dugun ve dogum gorenekleri icinde varligini surdurdugu sonucuna varildi.
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“Sunnet” kelimesiyle Islam Peygamberi Hz. Muhammed’in yaptigi butun soz ve eylemleri kast edilmesinin yaninda, erkeklik organinin ucundaki derinin kesilmesi anlamini da ifade etmek icin de dilimizde ayni kelime kullanilmaktadir. Bununla... more
“Sunnet” kelimesiyle Islam Peygamberi Hz. Muhammed’in yaptigi butun soz ve eylemleri kast edilmesinin yaninda, erkeklik organinin ucundaki derinin kesilmesi anlamini da ifade etmek icin de dilimizde ayni kelime kullanilmaktadir. Bununla Islam Peygamberi Hz. Muhammed’in yaptigi uygulama kast edilmektedir. Bu uygulamaya pek cok dinde yer verildigi gibi cok farkli milletlerin kulturunde de karsimiza cikmaktadir. Gunumuzdeki uygulamayi daha cok Yahudi ve Islam dinindeki algilanisi sekillendirmistir. Sunnetin dinsel anlaminin yani sira tibbi acidan tasidigi onem eski tarihlerden gunumuze kadar cesitli yonlerden ele alinmasini gerekli kilmistir. Bu yazida ozellikle erkeklerde uygulanan sunnet, tarihi, dini ve guncel yonleriyle irdelenecektir.
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✓ In an attempt to investigate the role of tissue fibrinolytic activity in the resolution of intracerebral hematoma, an experimental model of intracerebral hematoma was developed in the rat. The fibrinolytic activity was studied using a... more
✓ In an attempt to investigate the role of tissue fibrinolytic activity in the resolution of intracerebral hematoma, an experimental model of intracerebral hematoma was developed in the rat. The fibrinolytic activity was studied using a histochemical fibrin slide technique. A total of 59 adult male rats were studied. Twenty-nine rats were used for developing the intracerebral hematoma model via injection of autologous whole blood into the left frontal lobe; in the remaining 30 rats, the intracerebral hematomas were studied sequentially. Intracerebral hematoma formation was unsuccessful in six (21%) of 29 rats. Four rats died in the immediate postoperative period and two showed no intraparenchymal clot. Intense fibrinolytic activity was demonstrated in the blood vessel walls of the normal brain, especially in the meninges, choroid plexus, and ependymal cell layer. In the initial stages of hematoma resolution, fibrinolytic activity was not seen in the hematoma or parenchyma except in ...
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In this report, 35 pediatric patients having symptomatic subdural fluid collection treated at Neurosurgery Department of Medical School of Ataturk University from 1987 to 1997 were clinically analysed. Patients were treated with serial... more
In this report, 35 pediatric patients having symptomatic subdural fluid collection treated at Neurosurgery Department of Medical School of Ataturk University from 1987 to 1997 were clinically analysed. Patients were treated with serial percutaneous tapping, drainage into a closed external drainage system, observation, craniotomy and removal of membranes or subdural -peritoneal shunt. If the initial treatment was not effective, subdural to peritoneal shunt treatment was instituted. In those patients, the subdural fluid collection 60 % bilateral and 40 % unilateral. All of patients with bilateral or unilateral collections were treated unilateral shunts. One patient was treated with craniotomy and removal of tight membranes. This study demonstrates that the most efficacious treatment of symptomatic subdural collection in children is inserted an unilateral subdural - peritoneal shunt
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An optochiasmatic tuberculoma, encasing the chiasm and optic nerves, was found in a 58-year-old woman complaining of sudden beginning and progressive visual failure. The patient was treated by surgery and prolonged corticosteroids and... more
An optochiasmatic tuberculoma, encasing the chiasm and optic nerves, was found in a 58-year-old woman complaining of sudden beginning and progressive visual failure. The patient was treated by surgery and prolonged corticosteroids and continued triple antituberculous therapy. Pathological diagnosis was a tuberculoma confirmed by postoperative positive polymerase chain reaction against M. tuberculosis. Because the incidence of tuberculomas has increased, especially in developing countries, in recent years and they also involve optic nerves and chiasm, it is important to include optochiasmatic tuberculoma in the differential diagnosis of optic nerve and chiasm tumors. Including this case, only 31 instances of optochiasmatic tuberculoma have been reported in the literature.
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Hydatid disease involving the vertebral body and paravertebral soft tissues is a rare disease with poor prognosis. We report a case of spinal cord compression caused by secondary extradural cysts.
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Ninety white hybrid rabbits, each weighing 2.5 to 3.5 kg, were used for this experimental model. Thirty rabbits were used for control, and sixty other rabbits were investigated for the response of host to the dural graft. In all animals,... more
Ninety white hybrid rabbits, each weighing 2.5 to 3.5 kg, were used for this experimental model. Thirty rabbits were used for control, and sixty other rabbits were investigated for the response of host to the dural graft. In all animals, a dural defect, 1 x 1 cm in size, was created on the left parietal area following craniotomy. In the control group the excised free dural piece was then sutured again to the area from which it had been excised before. The dural defect was closed with dehydrated human dura mater (DHD) in the half of the rabbits in the group of study, and with autogenous fascia lata (AFL) in the other half. After operation, animals in each group were then subjected to one of five different groups comprising of 3,14,30,60 and 90 days follow-up periods. At the end of follow-up periods, histological, parameters such as cellular inflammatory response, development of fibrous tissue, capsulation, and calcification were examined in specimens obtained from the animals. There ...
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In this article, a quite rare giant cavernous hemangioma located in right frontoparietal region of a 16 year-old boy is presented. Cavernous hemangiomas are commonly seen in extremities, neck, face and sometimes scalp, cutaneous or... more
In this article, a quite rare giant cavernous hemangioma located in right frontoparietal region of a 16 year-old boy is presented. Cavernous hemangiomas are commonly seen in extremities, neck, face and sometimes scalp, cutaneous or subcutaneous in localization. Giant cavernous hemangioma in the right frontoparietal region have been seen in two cases so far. In this article, we discussed the differential diagnosis, characteristics and therapy methods of giant cavernous hemangioma of the scalp.
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10 giant intracranial aneurysms in children were treated consecutively in Neurosurgical Department of Atatürk University, Erzurum, Turkey between 1985-1989. A total of 60 aneurysms of normal size were operated on in the same period. Of... more
10 giant intracranial aneurysms in children were treated consecutively in Neurosurgical Department of Atatürk University, Erzurum, Turkey between 1985-1989. A total of 60 aneurysms of normal size were operated on in the same period. Of the ten cases 6 were male and 4 were female. All the patients were under 17-years old. In 6 cases, the onset of symptoms was sudden subarachnoid hemorrhage, in 3 cases presenting symptoms were insidious imitating a intracranial mass, and in one case, clinical manifestation was epileptic seizure. Among 6 cases with subarachnoid hemorrhage, 3 were in IV grade according to Hunt-Hess scale, 2 were in III grade and one in II grade. Angiographic localisation of the aneurysms was in the middle cerebral artery in 9 cases and in the anterior communicating artery in one case. During the operation, blood pressure was not lowered. All the patients were operated on with normal blood pressure without hypotension. In 4 cases, intramural thrombosis was detected. The ...
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Intracerebral-intraventricular haematoma was created experimentally by injecting coagulated autologous blood into the left cerebral hemispheres of rats, stereotactically 2200 U. Urokinase was injected into the haematomas of the treated... more
Intracerebral-intraventricular haematoma was created experimentally by injecting coagulated autologous blood into the left cerebral hemispheres of rats, stereotactically 2200 U. Urokinase was injected into the haematomas of the treated group and the same volume of physiologic saline solution into the control group. Macroscopic evaluations were made at the end of 24 and 48 hours and lysis of the haematoma was observed in 90% of cases in the group treated with Urokinase. This ratio was 20% in the control group (P < 0.00001). In microscopical evaluation, no histopathological changes were observed in surrounding tissues in either group. It is concluded that local Urokinase administration may be an effective method of treatment in intracerebral aematomas.
Research Interests: Medicine, Brain, Female, Animals, Male, and 8 moreUrokinase, Rats, Saline, Intracerebral Hemorrhage, Wistar Rats, Hematoma, Cerebral Hemorrhage, and Hemolysis
42 patients with cerebral abscesses were treated from 1979 until the end of the first six months of 1987 at the Neurosurgical Department of the Faculty of Medicine, Atatürk University, Erzurum, Turkey. The present study aims at studying... more
42 patients with cerebral abscesses were treated from 1979 until the end of the first six months of 1987 at the Neurosurgical Department of the Faculty of Medicine, Atatürk University, Erzurum, Turkey. The present study aims at studying these patients to determine the factors affecting on prognosis. The patients were studied for the duration of complaints, pre-operational condition, the location of the abscesses, the microorganisms responsible for them, and the techniques of operation applied, by taking their sex and age into consideration. All of the cases were treated operatively. Of these, 18 were treated by excision and 24 were applied drainage, whose percentage was 43 and 57 respectively, 85% of the cases were under 60 years of age. The rate of mortality of the cases with cerebral abscesses was 19%. This rate was between 15% and 37.5% in the cases of several age groups whose complaints lasted less than two months. This rate reached 100% with a sudden increase in the cases who h...
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Aggressive fibromatosis is a rare soft tissue tumor. Although it lacks metastatic potential, it can grow aggressively in a locally infiltrating pattern. The tumors frequently recur after surgical excision, which remains the treatment of... more
Aggressive fibromatosis is a rare soft tissue tumor. Although it lacks metastatic potential, it can grow aggressively in a locally infiltrating pattern. The tumors frequently recur after surgical excision, which remains the treatment of choice. Optional combinations of radiotherapy and/or chemotherapy have been used postoperatively for recurrent disease and/or inoperable cases. A palpable mass was detected in the popliteal fossa of the right lower extremity in a 48-year-old man. Magnetic resonance imaging showed a contrast-enhancing noncalcified lesion initially felt to represent a vascular tumor. An invasive mass adherent to the surrounding tissue was visualized intraoperatively and extensively debulked. The patient's postoperative course was uneventful. Histologic examination of the surgical specimen was consistent with an extra-abdominal desmoid tumor. After appropriate recognition, wide local excision may be the most appropriate treatment for fibromatosis of the extremity. H...
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ABSTRACT BackgroundThis study aims to investigate experimentally the noradrenaline mediated responses of common carotid artery (CCA) helical strips in tissue bath in the presence of periarterial blood and blood products for varying... more
ABSTRACT BackgroundThis study aims to investigate experimentally the noradrenaline mediated responses of common carotid artery (CCA) helical strips in tissue bath in the presence of periarterial blood and blood products for varying durations. MethodNinety hybrid albino male rabbits were randomly assigned to three main groups. In the first group, following the exposure, a mixture of 0.3 saline and 0.3 g polyvinyl alcohol (PVA) was applied around the CCAs by using a silastic sheath. For the second group, 0.3 ml blood and 0.3 g PVA, and for the third group 0.3 ml thrombocyte rich plasma (TRP) and 0.3 g PVA were applied. All subjects were sacrificed at the end of a predetermined follow-up period, CCAs were prepared in the shape of helical strips and positioned on the isometric contraction measurement device, then contraction amplitudes and time to the achievement of a plateau level were measured. FindingsContraction amplitude seemed to decrease significantly in the whole blood and TRP groups, compared to the normal vessel and saline groups. Moreover, the time to plateau was significantly decreased in the whole blood and TRP groups. ConclusionsIt can be suggested that the decrease in vascular contractility may have the unfavorable effect of cerebral vascular autoregulation following subarachnoid haemorrhage, depending on the amount of and contact duration with blood.