G. Kusminsky
Universidad Austral, Medicina, Faculty Member
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Cinquenta y tres pacientes (ptes) recibieron transplante alogenico con celulas progenitoras extraidas de la sangre periferica (PSP); 25 ptes eran mujeres y 28 varones. La edad media del grupo fue de 20 anos, (rango 2-550. Los diagnosticos... more
Cinquenta y tres pacientes (ptes) recibieron transplante alogenico con celulas progenitoras extraidas de la sangre periferica (PSP); 25 ptes eran mujeres y 28 varones. La edad media del grupo fue de 20 anos, (rango 2-550. Los diagnosticos fueron leucemia mieloide aguda (LMA) en 16 ptes, leucemia linfoblastica aguda (LLA) en 15, leucemia mieloide cronica (LMC) en primera fase cronica en 12, aplasia medular en 4, sindrome mielodisplasico en 3 y Enfermedad de Hodgkin en recaida luego de trasplante autologo, talasemia mayor y sindrome de Hunter en 1 caso, respectivamente. Los acondicionamientos fueron en 38 ptes radioterapia corporal total 1200 cGy y ciclofosfamida 120 mg/kg EV; en 10 ptes busulfan 16 mg/kg y ciclosfosfamida 120 mg/kg EV, 3 ptes radioterapia linfoide total (RLT) y ciclosfosfamida, 2 ptes con otros agentes quimioterapicos. Los PSP se infundieron a traves de un cateter sin ningun tipo de manipulacion. La profilaxis de injerto vs huesped (EICH) se realizo con ciclosporina ...
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PREDICTED AND MEASURED ENERGY EXPENDITURE IN MECHANICALLY VENTILATED CRITICALLY ILL CHILDREN – A COMPARISON OF STANDARD EQUATIONS WITH INDIRECT CALORIMETRY L.L. Tietze1, K. Kok1, I.L. Jarnvig2, T. Hartvig Jensen2, C. Molgaard1,3, M.J.... more
PREDICTED AND MEASURED ENERGY EXPENDITURE IN MECHANICALLY VENTILATED CRITICALLY ILL CHILDREN – A COMPARISON OF STANDARD EQUATIONS WITH INDIRECT CALORIMETRY L.L. Tietze1, K. Kok1, I.L. Jarnvig2, T. Hartvig Jensen2, C. Molgaard1,3, M.J. Allingstrup2 1University Hospital CopenhagenRigshospitalet, Pediatric Nutrition Unit, Copenhagen, Denmark 2University Hospital CopenhagenRigshospitalet, Department of Intensive Care, Copenhagen, Denmark 3University of Copenhagen, Pediatric and International NutritionDepartment of NutritionExercise and Sports, Copenhagen, Denmark
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... GLOBULINA ANTILINFOCITARIA EN APLASIA MEDULAR ración del balance normal de las subpoblaciones linfocitarias o inducir la producción de cierta he ... Packed red-cells were transfused when symptoms of anemia developed or when... more
... GLOBULINA ANTILINFOCITARIA EN APLASIA MEDULAR ración del balance normal de las subpoblaciones linfocitarias o inducir la producción de cierta he ... Packed red-cells were transfused when symptoms of anemia developed or when hemoglo-bin was 7 g/dl or less. ...
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Research Interests: Genetics, Biology, Cytogenetic, Calcium, Cytogenetics, and 15 moreHumans, Fluorescence in situ hybridization, Female, Male, Karyotyping, Bone marrow, Aged, Fluorescent in situ hybridization, Adult, Group, Lactate dehydrogenase, Chromosomal abnormalities, Control Group, HEMATOLOGÍA, and Chromosome aberrations
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In vitro studies were performed in a patient with B-cell chronic lymphocytic leukemia who developed pure red cell aplasia (CLL-PRCA). The patient's irradiated circulating mononuclear blood cells and supernatant markedly inhibited... more
In vitro studies were performed in a patient with B-cell chronic lymphocytic leukemia who developed pure red cell aplasia (CLL-PRCA). The patient's irradiated circulating mononuclear blood cells and supernatant markedly inhibited normal marrow erythroid (but not granulocyte-monocyte) progenitor colony proliferation. In contrast, irradiated peripheral blood mononuclear cells and supernatant obtained from a B-CLL patient (Rai stage III) and from a hematologically normal donor, did not affect hematopoietic progenitor colony growth. These findings suggest that the anemia of CLL-PRCA evolves different mechanisms of those causing anemia in CLL, and is mediated through cellular and secretory mechanisms.
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Research Interests: Adolescent, Humans, Child, Medicina, Follow-up studies, and 4 moreBone marrow, Middle Aged, Adult, and Child preschool
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... TALIA HAHN, GUSTAVO KUSMINSKY, LUCETTE BASSOUS and ALAIN BERREBI ... Fernandez, LA, MacSween, JM and Langley, G. R. (1986) lmmunoregulation of B lymphocyte colony formation by T cell subsets in patients with chronic lymphocytic... more
... TALIA HAHN, GUSTAVO KUSMINSKY, LUCETTE BASSOUS and ALAIN BERREBI ... Fernandez, LA, MacSween, JM and Langley, G. R. (1986) lmmunoregulation of B lymphocyte colony formation by T cell subsets in patients with chronic lymphocytic leukemia. Blood. 67,294300. ...
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Results: Patients homozygous for the single nucleotide polymorphism at codon 10 had increased non-relapse mortality (at 3 years: 46.8% versus 29.4%, P=0.014) and reduced overall survival (at 5 years 29.3% versus 42.2%, P=0.013); the... more
Results: Patients homozygous for the single nucleotide polymorphism at codon 10 had increased non-relapse mortality (at 3 years: 46.8% versus 29.4%, P=0.014) and reduced overall survival (at 5 years 29.3% versus 42.2%, P=0.013); the differences remained statistically ...
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We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no... more
We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P=0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P=0.18), and for grades III-IV was 2.6% vs 11.6% (P=0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P=0.002) and extensive 5% vs 23.6% (P=0.01). OS was 74% vs 76% for BM vs PBSCs (P=0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P=0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P=0.005) respectively. In multivariate analysis, aGvHD II-IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1-5.6, P=0.02) and aGvHD III-IV (HR 8.3 CI 3.4-20.2, P<0.001) proved to be independent negativ...