Andrea Palma

Lo scopo dello studio è stato quello di valutare gli effetti della terapia parodontale non chirurgica sulla risposta di fase acuta in pazienti affetti da malattia parodontale e diabete mellito di tipo 2. I soggetti inclusi sono stati sottoposti ad un esame parodontale completo, comprendente la profondità di sondaggio, la recessione gengivale, l'indice della placca e il sanguinamento al sondaggio. Sono state inoltre raccolte informazioni riguardanti il fumo, l’indice di massa corporea (BMI) e i parametri vitali quali livelli pressori, frequenza cardiaca e temperatura corporea. Attraverso analisi ematiche sono stati valutati i livelli di glucosio, colesterolo totale, HDL, trigliceridi, emoglobina glicata (HbA1c), insulina, proteina C reattiva (PCR) e IL-6. Per lo studio clinico randomizzato, i soggetti che hanno soddisfatto i criteri di inclusione sono stati sottoposti a trattamento parodontale non chirurgico. Tali pazienti sono stati assegnati tramite randomizzazione a un gruppo ...

a los otros compañeros y amigos que nos han acompañado. A mi entrañable amiga Dolores Ponce, quien llevó a cabo la fórmula alquímica del opus nigrum que remató la forma de esta obra. Por eso y mil cosas más, todo mi agradecimiento. A cada uno de los hombres y mujeres que han hecho el cine mexicano. En especial, y con entrañable afecto, a los que poblaron mi niñez:

La exposición a riesgos psicosociales y violencia laboral se asocia con una mayor presencia de problemas de salud mental en los/as trabajadores/as. El presente estudio tuvo como objetivo indagar el rol mediador de la violencia laboral entre los riesgos psicosociales (ISOSTRAIN, desbalance esfuerzo-recompensa), antecedentes organizacionales (liderazgo tiránico) y problemas de salud mental (distrés) en 1023 trabajadores/as de tres hospitales públicos chilenos de alta complejidad de tres regiones del país. Se hipotetizó que la exposición a riesgos psicosociales y algunas características organizacionales (liderazgo tiránico) se asocia a menores niveles de salud mental y que parte de este efecto se encuentra mediado por la exposición a violencia laboral. Se aplicó un cuestionario incluyendo el Negative Act Questionnaire Revised (NAQ-R), el Screening de Distrés Psicológico, la Escala de Liderazgo Destructivo, el Cuestionario de Desbalance Esfuerzo-Recompensa y el Job Content Questionnaire...

Bile duct injury (BDI) is a dangerous complication of cholecystectomy, with significant postoperative sequelae for the patient in terms of morbidity, mortality, and long-term quality of life. BDIs have an estimated incidence of 0.4–1.5%, but considering the number of cholecystectomies performed worldwide, mostly by laparoscopy, surgeons must be prepared to manage this surgical challenge. Most BDIs are recognized either during the procedure or in the immediate postoperative period. However, some BDIs may be discovered later during the postoperative period, and this may translate to delayed or inappropriate treatments. Providing a specific diagnosis and a precise description of the BDI will expedite the decision-making process and increase the chance of treatment success. Subsequently, the choice and timing of the appropriate reconstructive strategy have a critical role in long-term prognosis. Currently, a wide spectrum of multidisciplinary interventions with different degrees of inva...

Although democracy is no longer the exception in Latin America, in many cases the political feasibility of major social and fiscal covenants remains a standing challenge, which explains the interest that the Economic Commission for Latin America and the Caribbean (ECLAC) has in covering this issue, with the support of the German Agency for International Cooperation (GIZ), in the framework of the project “Social covenant for more inclusive social protection”. This paper opens a line of inquiry into analysis of the emergence of compacts and consensuses in the social policy sector, presenting a methodological proposal to conduct ex post case studies of compacts and consensuses that have emerged in this sector in democratic contexts, as well as ex ante assessments of the possibilities for a broad social accord or consensus in specific contexts. This methodological proposal is built on three case studies on major consensus-based social policy reforms in Chile, Mexico and Uruguay, which w...

El presente documento busca abrir una linea de investigacion en torno al analisis del surgimiento de pactos y consensos en el sector de la politica social, presentando una propuesta metodologica para analizar ex post casos de surgimiento de pactos y consensos en este sector en contextos democraticos, asi como para evaluar ex ante las posibilidades de un pacto o consensos en contextos especificos. Asimismo, esta propuesta metodologica enmarca tres estudios de caso sobre reformas importantes a las politicas sociales en Chile, Mexico y Uruguay que fueron objeto de un consenso, y que seran publicados en el marco de la serie Politicas Sociales. En la introduccion se discute el interes y la relevancia de los consensos y pactos, en general y en el ambito de la politica social en particular, para luego presentar dos enfoques teoricos que ayudan a abordar el surgimiento de pactos y consensos en este sector de politica publica. En primer lugar se revisan algunos paradigmas explicativos acerca...

Se presenta un testeo empirico de la capacidad predictiva de la teoria de la conducta planificada (TCP) de las intenciones de uso del condon con la pareja estable en estudiantes universitarios que no han iniciado su vida sexual. El analisis de datos consistio primero en un analisis factorial exploratorio de las variables de la TCP y luego regresion multiple con los 16 factores obtenidos como variables independientes y las intenciones de uso del condon con la pareja estable como dependiente. Cinco factores resultaron predictores del uso del condon. El modelo de regresion multiple resulto significativo (R = 0,37, F(16, 314) = 2,91, p < 0,001 y R2 = 0,14). Se discuten las implicaciones de los resultados para la prevencion del virus de inmunodeficiencia humana (HIV). Palabras clave Teoria de la conducta planificada, Uso del condon, Prevencion de HIV, Estudiantes universitarios ABSTRACT PREDICTORS OF CONDOM USE INTENTIONS WITH THE MAIN PARTNER WITH THE THEORY OF PLANNED BEHAVIOR IN CO...

4676 Introduction Myeloproliferative diseases (MPDs) are a group of haematological disorders characterized by the hyper proliferation of different blood cells in peripheral blood and other hematopoietic organs. The clinical heterogenity of these neoplasms reflects the different gene pathways involved, most of which are only partially known. Given the genetic homology and the physiological similarity to mammals, zebrafish has emerged as an ideal model to study human normal and malignant haematopoiesis. In the last decade several oncogenes involved in the development of hematopoietic neoplasms have been used to model leukemia in zebrafish with the aim to discovery new molecular pathways involved in malignant transformation. Despite the first encouraging results these experimental models failed to fully recapitulate human myeloproliferative disorders. Methods We took advantage of the Gal4/UAS binary system to induce the expression of human oncogenic HRASV12G in the zebrafish hematopoie...

Background: Although a complete remission (CR) can be achieved in 70-80% of newly diagnosed acute myeloid leukemia (AML) patients, relapses occur in up to the 50% of cases. Thus, minimal residual disease (MRD) monitoring is a major issue for early detection of patients at high-risk of treatment failure and relapse. Aim: to dynamically evaluate WT1 pan-leukemic molecular marker of MRD in patients with AML. Matherial and methods: 107 newly diagnosed AML patients consecutively treated between 2010 and 2013 were monitored with quantitative WT-1 from bone marrow (BM) and peripheral blood (PB) at baseline, after induction, after the first consolidation course, before allogeneic stem cell transplantation (allo-SCT), at the 3rd and the 6th month after transplantation Results: At diagnosis, 104/107 (97%) had increased PB and BM WT1 levels assessed according to the ELN assay. Eighty-eight out of 107 patients (82%) achieved a complete remission (CR) after induction, 30/88 (34%) relapsed during...

Cystic pancreatic lesions (CPLs) are being identified increasingly, and some benefit from surgical treatment. With the increasing use of robotic-assisted surgery (RAS) for neoplasms of the pancreas, the aim of the present comparative study is to establish whether the RAS offered any advantages over conventional open surgery (OS) in the management of CPLs. Twenty-seven out of 37 robot-assisted left-sided pancreatectomy (LSP) performed between January 2010 and April 2017 were carried out for CPLs. The surgical outcome and histopathology were compared retrospectively with a control group of 27 patients who had undergone open LSP for CPLs, selected using a one-to-one case-matched methodology (OS-Group) from the prospectively collected institutional database. The spleen was preserved in a significantly higher percentage of patients in the RAS-group (63% vs. 33.3%, P< 0.05). There was no difference in the post-operative course (pancreatic fistula and morbidity) between the two groups. ...

The aim of this review is to describe and to analyze scientific reports about occupational violence in the health area. A systematic review of the literature on Academic Search Complete (EBSCO Host), Medline, Pubmed, Scielo, Scopus and Web of Science was performed and 23 articles were selected for analysis. Most studies are quantitative, measuring workplace violence and its consequences, including multi-stratum samples. They mainly measure psychological and external violence and their subjects are hospital workers. Violence is conceived as coming from organizational dimensions. Facilitators of violence are related to the nature of the job and the most commonly studied consequences are related to mental health. The main consequences of the phenomenon are depressive symptoms, post-traumatic stress disorder (PTSD) and work stress. The nature of the job as a facilitator of violence relates primarily to the place of work and to the profession. Most of the studies are carried out with mul...

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is burdened by life-threatening complications, with graft-versus-host disease (GvHD) being the major cause of morbility and mortality. Recently, clinical and physiopathologic evidences showed that vascular endothelium can be a target of GvHD in the early phase and circulating endothelial cells (CECs) represent surrogate markers of endothelial damage. Using the CellSearch System (Veridex LLC, Raritan, NJ), CECs were counted before (T1), after conditioning regimen (T2), at engraftment (T3), at GvHD onset (T4), and after steroid treatment (T5) in 40 patients (7 Hodgkin's Disease, 13 Acute Myeloblastic Leukemia, 5 Acute Lymphoblastic Leukemia, 8 Multiple Myeloma, 3 Chronic Lymphocytic Leukemia, 1 Non-Hodgkin Lymphoma, 1 Chronic Myeloid Leukemia, 2 Severe Aplastic Anemia) undergoing allo-HSCT. The median CEC per milliliter at T1 was 20 (n=33, range 4-718), in comparison to a value of 2 (range, 1-14) in controls (P<0.001). At T3, CEC per milliliter were 47 (range, 16-148) in GvHD patients and 92 (range, 23-276) in patients without GvHD (P=0.006). This difference remained significant in multivariate analysis (odds ratio, 0.97; 95% confidence interval, 0.96-0.99; P=0.02). At GvHD onset, the relative increase of CEC counts from time of engraftment (T4 vs. T3) was 44% (range, -43% to 569%) in GvHD patients versus 0% (range, -49% to 2%) in patients without GvHD (P=0.003), being confirmed as significant in multivariate analysis (odds ratio, 1.04; 95% confidence interval, 1.0-1.08; P=0.04). Changes in CEC count can represent a promising marker to monitor endothelial damage in patients undergoing allo-HSCT and could become a valuable tool in the diagnostic definition of GvHD.

To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed WT1 levels on peripheral blood (PB) and bone marrow (BM) before and after allo-SCT in 24 AML patients with WT1 overexpression at diagnosis. Five copies of WT1/ABL × 104from PB were identified as the threshold value that correlated with relapse after allo-SCT. The same correlation was not identified when WT1 expression was assessed from bone marrow (BM). Eight out of 11 (73%) patients with a pre-allo-SCT PB-WT1 ≥ 5 and 4/13 (31%) patients with a pre-allo-SCT PB-WT1 < 5 relapsed, respectively (P= 0.04). The incidence of relapse was higher in patients with PB-WT1 ≥ 5 measured after allo-SCT, at the 3rd (56% versus 38%;P= 0.43) and at the 6th month (71% versus 20%;P= 0.03). Patients with pretransplant PB-WT1 < 5 had significantly better 2-year OS and LFS than patients with a PB-WT1 ≥ 5 (81% versus 0% and 63% versus 20%) (P= 0.02). Our data suggest the usefulness of WT1 monitoring from PB to predict the r...

An improved fluid loss additive for use in well cements, preferably comprising from about 30 to about 70 weight percent polyvinylpyrrolidone, from about 5 to about 19 weight percent carboxymethylhydroxyethyl cellulose, and the sodium salt of naphthalene sulfonate. Improved cement slurries comprising the subject fluid loss additive and an improved method for cementing well bores through use of the novel slurries are also provided. The improved cement slurries of the invention preferably comprise from about 26 to about 60 percent water and from about 0.75 to about 2 percent of the improved fluid loss additive, by weight of the cement.