ABSTRACT The objective of this paper is to present an algorithm that allows us to record the movements and metrics that the surgeon does for placement of intrapedicular screw in lumbar region, and also provides de visual feedback that... more
ABSTRACT The objective of this paper is to present an algorithm that allows us to record the movements and metrics that the surgeon does for placement of intrapedicular screw in lumbar region, and also provides de visual feedback that simulates the fluoroscope imagery. This algorithm is intended for be used with a model of the lumbar area in order to develop a simulator of a minimum invasive surgery,
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1b 1c 1528 Brain Activity in Ateles geoffroyi: Resting-state fMRI of working memory in medial prefrontal cortex. Diana Platas, Benito de Celis Alonso, Silvia Hidalgo Tobón, Fernando Chico, Jairo Muñoz-Delgado, and Kimberley Phillips... more
1b 1c 1528 Brain Activity in Ateles geoffroyi: Resting-state fMRI of working memory in medial prefrontal cortex. Diana Platas, Benito de Celis Alonso, Silvia Hidalgo Tobón, Fernando Chico, Jairo Muñoz-Delgado, and Kimberley Phillips Universidad Nacional Autónoma de México, Mexico DF, Mexico DF, Mexico, Trinity University, Texas, United States, Faculty of Physics and Mathematics, BUAP, Puebla, Mexico, Hospital Infantil de Mexico, Federico Gómez, Mexico DF, Mexico, Universidad Autónoma Metropolitana, Campus Iztapalpa, Mexico DF, Mexico, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico DF, Mexico
Introduction. Leukemia and lymphoma are the commonest neoplasm in childhood; in a second place are intracranial tumors (ICT); meningiomas represent 0.4 to 4.6% ofICT of children, while in adults are observed in 13 to 27%. Surgical... more
Introduction. Leukemia and lymphoma are the commonest neoplasm in childhood; in a second place are intracranial tumors (ICT); meningiomas represent 0.4 to 4.6% ofICT of children, while in adults are observed in 13 to 27%. Surgical resection is the treatment of choice, and a survival of 100% can be achieved in low-grade malignancy cases; however, for malignant meningiomas survival is poor (1.5 years). Material and methods. Clinical data were obtained from clinical charts; the histopathological material were reviewed and meningiomas were classified using the WHO formulation. Descriptive statistics, using SPSS 9, were employed; results were compared with data informed in the literature. Results. From 622 ICT resected in the period analyzed, 18 intracraneal meningiomas were found which represent 2.89% of all ICT managed in our Hospital; 11 were males, age varied from 10 months to 17 years with a mean of 8.6 years; vomiting and headache were the most frequent clinical manifestation obser...
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SUMMARY Action of GABA agonists and antagonists on memory. The θ rhythm. Muscimol may directly alter memory. Recently, a modified matching to position (MTP) paradigm was employed aimed at influencing the type of associations a rat may use... more
SUMMARY Action of GABA agonists and antagonists on memory. The θ rhythm. Muscimol may directly alter memory. Recently, a modified matching to position (MTP) paradigm was employed aimed at influencing the type of associations a rat may use to solve the task. The main behavioral manipulation was the application of a differential outcomes procedure (DOP). DOP implies correlating each event to be remembered with a different reward condition. This procedure will result in the development of specific reward expectations which will in turn increase and guide choice behavior. Such different reward expectations will not be present when the reward assignation used is either common or random (non-differential outcomes procedure, NOP). Intraventricular infusion of muscimol or CSF in rats carrying out a delayed MTP using either a MOP or an NOP protocol will affect both groups of rats, but the nature of the deficit will differ depending on the reinforcement contingencies. Rats trained in DOP will...
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On behave of my commentary of the book "El enigma de Goya: La personalized de Goya y su pintura tenebrous" (The goya enigma: Goya's personality an his tenebrous painting), written by Doctor Francisco Alonso Hernández, I... more
On behave of my commentary of the book "El enigma de Goya: La personalized de Goya y su pintura tenebrous" (The goya enigma: Goya's personality an his tenebrous painting), written by Doctor Francisco Alonso Hernández, I proposed some complementary concepts for this book. The clinical manifestations of Goya's disease in 1792, and his ulterior dramatically behavioral and artistic change, are suggestive of a damage of thje limbic system, raised during his illness. The clinical features of Goya's disease are relieved, and moreover the functions and disfunction's of the limbic system an his correlation with the sickness
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In this second part of the Review Article on craniosynostosis, different types of syndromatic craniosynostosis are analyzed along with clinical and imaging aspects and, in known cases, embryogenetic alterations. Different types of... more
In this second part of the Review Article on craniosynostosis, different types of syndromatic craniosynostosis are analyzed along with clinical and imaging aspects and, in known cases, embryogenetic alterations. Different types of treatments are also described for both syndromic and nonsyndromic craniosynostosis. These range from the classic surgical treatments for achieving brain decompression, restoring the anatomy and providing the highest degree of aesthetics for the child. Last, but not least, information on cutting-edge treatments such as techniques in tissue engineering, use of bioabsorbable bone distractors and even endoscopic surgical systems are included. It is expected that in the near future there should be a greater number of publications that report the success of these new techniques.
An uncommon case, probably the first in Mexico, of fibromuscular dysplasia involving the internal, extra and intracranial carotid artery, histologically demonstrated in an 18-year old young man is presented. The few bibliographical... more
An uncommon case, probably the first in Mexico, of fibromuscular dysplasia involving the internal, extra and intracranial carotid artery, histologically demonstrated in an 18-year old young man is presented. The few bibliographical references on the subject are reviewed and emphasis is placed on the importance of angiographic studies for the establishment of the aethiology of the disease in all cases of occlusive cerebrovascular accident.
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... His contribution to cardiovascular surgery and transplants as well as organ preservation and cultures of tissues. Auteur(s) / Author(s). PONCE-DE LEON Fernando Chico (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ...
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RESUMEN La callosotomía ha sido desarrollada para reducir frecuencia y severidad de las crisis epilépticas refractarias. En México, la evolución de las clínicas de cirugía de epilepsia es incipiente. En el paciente pediátrico, es posible... more
RESUMEN La callosotomía ha sido desarrollada para reducir frecuencia y severidad de las crisis epilépticas refractarias. En México, la evolución de las clínicas de cirugía de epilepsia es incipiente. En el paciente pediátrico, es posible diagnosticar desde los primeros seis ...
Research Interests: Humanities and Art
Craniosynostoses are defined as closure, ossification and sclerosis of one or more cranial sutures. This condition causes different grades of brain compression, intracranial hypertension and detriment of intellectual coefficient and... more
Craniosynostoses are defined as closure, ossification and sclerosis of one or more cranial sutures. This condition causes different grades of brain compression, intracranial hypertension and detriment of intellectual coefficient and vision. In the first part ...
Salvo algunos casos aislados, la cirugía de tumores cerebrales y de la epilepsia se inicia formalmente en la segunda mitad el siglo XIX, tanto en los Estados Unidos de América como en Europa. Se presenta en este trabajo la actividad... more
Salvo algunos casos aislados, la cirugía de tumores cerebrales y de la epilepsia se inicia formalmente en la segunda mitad el siglo XIX, tanto en los Estados Unidos de América como en Europa. Se presenta en este trabajo la actividad neuroquirúrgica del doctor Rafael Lavista, quien en ...
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Base de dados : LILACS. Pesquisa : 568740 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Texto completo.... more
Base de dados : LILACS. Pesquisa : 568740 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Texto completo. experimental, Documentos relacionados. Id: 568740 ...
Matrix metalloproteinases (MMPs) are enzymes responsible for extracellular matrix degradation and contribute to local and distant cell invasion during cancer progression or metastasis. The effects of chromatin structure on gene expression... more
Matrix metalloproteinases (MMPs) are enzymes responsible for extracellular matrix degradation and contribute to local and distant cell invasion during cancer progression or metastasis. The effects of chromatin structure on gene expression and the use of histone deacetylase inhibitors such as sodium butyrate (NaBu) may directly influence pro-MMPs secretion. In the present study, we evaluated the effect of NaBu on pro-MMP-9 and pro-MMP-2 secretion in human Jurkat and HT1080 cells, and in 36 pediatric solid tumors. Cell lines and samples were exposed to 8 mM of NaBu and proteinase activity was evaluated in the supernatant by gelatin zymograms. Our results showed, for Jurkat cells treated with NaBu, increases of 2-fold and 1.5-fold in pro-MMP-9 and pro-MMP-2 secretion, respectively. A 50% decrease in pro-MMP-9 secretion due to NaBu was observed in HT1080 cells. NaBu induced a 0.62 reduction in levels of pro-MMP-9 secretion in untreated tumors. For cell lines and some NaBu-treated tumors...
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An aspect of early Mexican surgery in the sixteenth century is presented. The treatment of facial wounds by Alonso Lopez de Hinojosos and Agustin Farfán is reviewed. Farfán proposed total nose reconstruction, with a cutaneous arm flap, 18... more
An aspect of early Mexican surgery in the sixteenth century is presented. The treatment of facial wounds by Alonso Lopez de Hinojosos and Agustin Farfán is reviewed. Farfán proposed total nose reconstruction, with a cutaneous arm flap, 18 years before its description in De Curtorum Chirurgia, by Tagliacozzi, in 1597 in Venice, Italy. The chapter on facial wounds by Lopez de Hinojosos and Farfán shows their concern for the final aesthetic results and should be considered the first Mexican publication in the field of plastic surgery.
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The first published account of a neurosurgical intervention performed on the North American continent is described. The operation took place in Mexico City in 1561. The neurosurgical intervention was performed by a Spanish surgeon, Pedro... more
The first published account of a neurosurgical intervention performed on the North American continent is described. The operation took place in Mexico City in 1561. The neurosurgical intervention was performed by a Spanish surgeon, Pedro Arias de Benavides, on a 13-year-old boy who had sustained head trauma that caused an open depressed cranial fracture and exposed the cerebrum. A description of this case was first published in Valladolid, Spain, 6 years after the event, in a book entitled Secretos de Chirurgia ("Secrets of Surgery").
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The first nine clinical cases using endoscopie dissection of dura and craniotomy with minimal trephines were performed from June to August 1997 after trial dissection of 19 fresh cadavers conducted at the University of Brno's... more
The first nine clinical cases using endoscopie dissection of dura and craniotomy with minimal trephines were performed from June to August 1997 after trial dissection of 19 fresh cadavers conducted at the University of Brno's Pathology Institute in the Czech Republic. These procedures involved the refinement of craniofacial and intracranial surgical techniques using the endoscope and prototype instruments. These dissections demonstrated that intracranial structures can be explored using an endoscope without encumbrance, and that major craniofacial surgeries may also be performed with minor incisions and minimal craniotomies. Furthermore, we seek to illustrate that use of the endoscope in craniofacial surgery provides improved visualization and protection of vital structures while simultaneously allowing the surgeon to perform delicate maneuvers. This permits minimal brain retraction with less subsequent morbidity. This minimally invasive craniofacial-intracranial surgical technique using the endoscope is performed with minimal cutaneous incisions, avoiding wide exposure of subcutaneous tissue, cranium, and meningeal structures. The ultimate goal is to perform endoscopie intracranial osteotomies and obtain advancement of craniofacial skeleton with gradual distraction. Potential neurosurgical advantages include improved postoperative recovery, decreased cerebral edema, and decreased risk of hemorrhage and infection.
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This study addressed the integration of sensory short-term memory (SSTM) and motor planning (MP) in the lateral cerebellar region, where the dentate nucleus is localized, and in the prefrontal cortex (PF). Boucher and... more
This study addressed the integration of sensory short-term memory (SSTM) and motor planning (MP) in the lateral cerebellar region, where the dentate nucleus is localized, and in the prefrontal cortex (PF). Boucher and Lewis's test of SSTM and MP was administered pre- and postsurgically to 8 patients of either sex, between 5 and 19 years of age, with tumors of the cerebellum, PF (area 9 medial) or the parieto-occipital region, and on one occasion to 8 corresponding controls. Whereas lesions of the midline portions of the cerebellum and of the parietal-occipital region did not appear to cause any cognitive defects, patients with lesions affecting either the lateral cerebellar region or PF exhibited statistically significant deficits of SSTM and MP. The lateral cerebellum seems to act in concert with PF to integrate different cognitive activities related to holding objects in SSTM and planning motor strategies in reference to them.
Research Interests: Neuroscience, Neurosurgery, Auditory Perception, Adolescent, Medicine, and 15 morePrefrontal Cortex, Motor planning, Brain Mapping, Humans, Child, Cerebellum, Female, Male, Clinical Sciences, Adult, Cognition disorders, Functional Laterality, Postoperative Complications, Neuropsychological Tests, and Child preschool
To evaluate clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM) at Hospital Infantil de México Federico Gómez. Cases of patients treated from January to May, 2007, were included in this study. Variables... more
To evaluate clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM) at Hospital Infantil de México Federico Gómez. Cases of patients treated from January to May, 2007, were included in this study. Variables analyzed were: age, diagnosis, size of tumor, histopathological description, degree of resection, time of stay in hospital, complications and outcome using Pearson's chi-squared test and logistic regression. Sixteen patients were identified. Mean age of presentation was 8.8. An increased frequency of complications was observed in younger patients and longer survival rates in patients with greater resections; main mode of presentation was directly related to intracranial hypertension; size of tumor was not related to evolution or outcome. Modern histological classifications especially designed for children are deemed necessary to accurately diagnose GBM.
Research Interests: Neurosurgery, Medicine, Logistic Regression, Multivariate Analysis, Mexico, and 15 moreBrain Tumor, Humans, Child, Glioblastoma, Female, Male, Clinical Sciences, Glioblastoma Multiforme, Age Factors, Chi Square Distribution, MEXICO, Chi Square Test, Intracranial Hypertension, Logistic Models, and Brain Neoplasms
Holoprosencephaly with cyclocephaly is an early disturbance of organogenesis and has been classified as a severe brain malformation starting in 1755 by Eller in Germany, then in 1822 by Etienne Geoffroy de Saint-Hilaire in France, and... more
Holoprosencephaly with cyclocephaly is an early disturbance of organogenesis and has been classified as a severe brain malformation starting in 1755 by Eller in Germany, then in 1822 by Etienne Geoffroy de Saint-Hilaire in France, and finally in 1828 by Tiedemann in Germany. In 1839, Dr. Arellano published in Mexico a necropsy case of holoprosencephaly. This was the fourth publication worldwide on this kind of pathological alteration. Furthermore, in reference to diaphragmatic herniation, Arellano's paper is the fourth world report, having appeared 9 years before Bochdalek's publication. We have not found any other report that appeared before 1839 in the Americas on this particular malformation, and we consider that Arellano's paper was the first of its kind on the American continent. As is well known, the publications of this Mexican medical researcher were, for his time, at the level of those of the most developed countries. It is also important to know that the medical journal where Arellano's work was published, the "Periódico de la Academia de Medicina de Mégico(sic)," founded and directed by Dr. Manuel Carpio in 1836, is the direct forerunner of the present Gaceta Médica de México, the oldest currently published journal in the Americas.
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DETAILS OF PUBLICATION: The first neuroanatomy text published on the American continent was included in the Tractado de Anothomia y Chirugia by Fr. Agustín Farfán, O.S.A., who received his M.D. in 1569 from the Royal and Pontifical... more
DETAILS OF PUBLICATION: The first neuroanatomy text published on the American continent was included in the Tractado de Anothomia y Chirugia by Fr. Agustín Farfán, O.S.A., who received his M.D. in 1569 from the Royal and Pontifical University of Mexico. It was printed in 1579 by Antonio Ricardo, a Piedmontese who had settled in Mexico City, capital of New Spain. . This text encompasses a very correct and complete neuroanatomy of an eminently Galenic type.
Research Interests: Neurosurgery, Publishing, Neuroanatomy, Medicine, Mexico, and 4 moreHumans, Mexico City, Clinical Sciences, and MEXICO
More than 10 years ago, the goal of our work had been to obtain a tissue sample of infiltrating lesions of the brainstem that had been diagnosed using computerized axial tomography (CAT). At that time, biopsies were believed to be... more
More than 10 years ago, the goal of our work had been to obtain a tissue sample of infiltrating lesions of the brainstem that had been diagnosed using computerized axial tomography (CAT). At that time, biopsies were believed to be indispensable when starting treatment of tumors. With time our objectives changed. Biopsies remained necessary, since until 1 year before the writing of this article we had not had the benefits of magnetic resonance imaging (MRI) at our Hospital. We also decided that carrying out sound statistics, confirmed by biopsies, was in itself a good procedure, especially in a country in which, to date, no serial studies of brainstem tumors had been undertaken. We analyzed all of the patients diagnosed with posterior fossa tumors between March 1989 and March 2002 at the Hospital Infantil de México Federico Gómez (HIM). A preoperative TAC of the cranium was performed on every patient. Stereotactically-guided biopsies during tomography allowed precise control of penetration. Material obtained was sent to the Department of Pathology for analysis. Fifty patients were diagnosed with infiltrating tumors of the brainstem: 30 cases of low-grade astrocytomas, 13 cases of high-grade astrocytomas, 2 cases of primitive neuroectodermic tumors, 2 cases of rhabdoid tumors, 1 case of ependymoma, and 2 patients had non-specified tumors. The most frequent symptoms and signs were ataxia and disturbances of the cranial nerves. There was no mortality caused by penetration, and follow-up studies of more than 5 years were carried out. The results from our series were similar to those in the literature. In our case, follow-up studies were undertaken for longer periods. In the first section of our work, we suggest the need for stereotactic biopsies in order to arrive at a precise diagnosis in environments in which MRI may be unavailable. At present, presumptive diagnosis of infiltrating brainstem lesions may be adequately undertaken with imaging methods, such as MRI. However, we believe that a stereotactically-guided biopsy provides an accurate method for diagnosing lesions of the brainstem. In our case, this procedure has been carried out entirely in the tomography room, without any complications of disease or mortality.
Research Interests: Radiology, Neurosurgery, Magnetic Resonance Imaging, Radiosurgery, Adolescent, and 15 moreMedicine, Biopsy, Humans, Child, Medulloblastoma, Female, Brainstem, Male, Infant, Clinical Sciences, Retrospective Studies, Astrocytoma, X ray Computed Tomography, Magnetic resonance image, and Child preschool
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Bites by house pets can be lethal or cause a series of catastrophic events with severe sequels, such as the loss of a limb or a systemic infection which may be life-endangering, especially in the case of children being bitten. A... more
Bites by house pets can be lethal or cause a series of catastrophic events with severe sequels, such as the loss of a limb or a systemic infection which may be life-endangering, especially in the case of children being bitten. A 2-year-old girl was attacked by a dog, causing lesions at the occipital region. This was treated initially as a superficial wound that became further complicated with two cerebellar abscesses. These abscesses required neurosurgical and antimicrobial treatment, with a satisfactory outcome. The precise and diligent evaluation of a lesion caused by an animal bite may prevent further life-endangering complications. To the best of our knowledge, there are no reports about cerebellar abscess caused by a dog bite. When cranial lesions are penetrating, an abscess must to be considered. We insist on the importance of medical evaluation and adequate treatment of such lesions.