The surface of Ti3C2 MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their... more
The surface of Ti3C2 MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs in...
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Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical... more
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed nanoemulsions (NEs) using an anti-oxidative polymeric amphiphile, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), hydrogenated soy lecithin (HL), black soldier fly larvae (BSFL) oil, and avocado (AV) oil through pre-homogenization and ultrasonication method. Addition of TPGS (weight ratios 100 and 50% as compared to HL) into NEs effectively reduced particle size and phase transition region area of NEs with pure HL. Incorporation of Apig into NEs made particle size increase and provided a disorder effect on intraparticle molecular packing. Nevertheless, the encapsulation efficiency of NEs for Apig approached to about 99%. The chemical stability of Apig was significantly improved and its an...
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CIGS/ZnS@FA|APBA q-dots were synthesized in an aqueous phase; these quantum dots exhibited great potential as dual-modal nanoprobes for optical/MR imaging.
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Fe3O4-HA-Ce6 nanotheranostic agents demonstrated specific targeting ability toward cancer cells with subsequent improvement in dual modal MR/NIR imaging and photodynamic therapeutic effects.
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δ-MnO2 thin film electrodes (M1) deposited on stainless steel mesh using CBD were used in symmetric supercapacitor device (SSM/M1//M1/SSM) with aqueous 1 M Na2SO4 electrolyte. The device shows 138% retention of specific capacitance after... more
δ-MnO2 thin film electrodes (M1) deposited on stainless steel mesh using CBD were used in symmetric supercapacitor device (SSM/M1//M1/SSM) with aqueous 1 M Na2SO4 electrolyte. The device shows 138% retention of specific capacitance after 2500 cycles.
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In this review, we discuss recent advances of I–III–VI QDs with a major focus on synthesis and biomedical applications; advantages include low toxicity and fluorescent tuning in the biological window.
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Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic... more
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source. Ultrasound-mediated chemical synthesis of hydroxyapatite (HAp) is also carried out using similar approach wherein commercially available calcium hydroxide and ammonium dihydrogen orthophosphate was used as calcium and phosphate precursors, respectively and referred as CHAp for better comparison. The prepared materials were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR) and Raman spectro...
Research Interests: Engineering, Materials Science, Nanoparticles, Nanotechnology, Medicine, and 15 moreBiological Sciences, Cell line, Nanocrystalline Material, Humans, Animals, Hardness, Calcination, Elastic Modulus, Cell Proliferation, Fracture Toughness, Osteoblasts, Durapatite, Biocompatible Materials, Egg shell, and Ammonium Dihydrogen Phosphate
We propose a one-pot microwave-assisted pyrolysis method for fabrication of magnetofluorescent carbon quantum dots (MFCQDs), using a combination of waste crab shell and three different transition-metal ions, Gd(3+), Mn(2+), and Eu(3+),... more
We propose a one-pot microwave-assisted pyrolysis method for fabrication of magnetofluorescent carbon quantum dots (MFCQDs), using a combination of waste crab shell and three different transition-metal ions, Gd(3+), Mn(2+), and Eu(3+), referred to as Gd@CQDs, Mn@CQDs, and Eu@CQDs, respectively. Chitin from waste crab shell acted not only as a carbon source but also as a chelating ligand to form complexes with transition-metal ions. Gd@CQDs exhibited a high r1 relaxivity of 4.78 mM(-1)·s(-1) and a low r2/r1 ratio of 1.33, suggesting that they show excellent potential as a T1 contrast agent. Mn@CQDs and Eu@CQDs showed high r2 relaxivity values of 140.7 and 28.32 mM(-1)·s(-1), respectively, suggesting their potential for use as T2 contrast agents. Further conjugation of Gd@CQDs with folic acid (FA) enabled specific targeting to folate receptor-positive HeLa cells, as confirmed via in vitro magnetic resonance and fluorescence imaging. Doxorubicin (DOX) was selected as a model drug for c...
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The development of gp120 targeted human immunodeficiency virus (HIV) drug has improved antiretroviral therapies owing to its effects on attachment to target cells.
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A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported. The NiWO4-modified electrodes showed excellent sensitivity... more
A facile hydrothermal route for the synthesis of ordered NiWO4 nanocrystals, which show promising applications as high performance non-enzymatic glucose sensor is reported. The NiWO4-modified electrodes showed excellent sensitivity (269.6 μA mM−1 cm−2) and low detection limit (0.18 μM) for detection of glucose with desirable selectivity, stability and tolerance to interference, rendering their prospective applications as cost-effective, enzyme-free glucose sensors.
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3-D ZnFe2O4/FSSM-300 nano-flakes on flexible stainless steel mesh as anode and Ni(OH)2/FSSM-300 as cathode was used to fabricate an asymmetric supercapacitor.
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This paper reports the development of multifunctional nanoparticles as effective dual-modality molecular imaging probes and drug delivery agents for simultaneous cancer diagnosis and chemotherapy.
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Bifunctional superparamagnetic–luminescent core–shell–satellite structured microspheres are prepared by a layer-by-layer assembly between metal cations and thiol groups for magnetodisplay applications.
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Magnetofluorescent nanoclusters containing oil-soluble nanoparticles of MnFe2O4and AgInS2–ZnS QDs are prepared. The nanoclusters possess photoluminescent and magnetic properties as well as an excellent specific targeting and drug delivery... more
Magnetofluorescent nanoclusters containing oil-soluble nanoparticles of MnFe2O4and AgInS2–ZnS QDs are prepared. The nanoclusters possess photoluminescent and magnetic properties as well as an excellent specific targeting and drug delivery capability on HeLa cancer cell.
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Inspired by the gecko foot pad, we fabricated polystyrene-block-poly(N-isopropylacrylamide) (PS-b-PNIPAAm) copolymer pillar array to mimic climbing attitude of a gecko, alternately attach to and detach from a surface. The pillar array... more
Inspired by the gecko foot pad, we fabricated polystyrene-block-poly(N-isopropylacrylamide) (PS-b-PNIPAAm) copolymer pillar array to mimic climbing attitude of a gecko, alternately attach to and detach from a surface. The pillar array structure of the PS segment significantly enhances both of the hydrophilic and hydrophobic property of PNIPAAm segment tips at 25 and 50 °C, respectively, which could generate alternating adhesive forces of approximately 120 and 11 nN. The dramatic change in adhesive and friction force difference at 25 and 50 °C may guide the design of bio-inspired artificial analogues, which could approach gecko's climbing behavior.