O artigo aborda o conceito de Corporacao, na obra Filosofia do Direito publicada por Hegel em 1820/21 com o objetivo de lancar luzsobre esta tematica. Afinal, a Corporacao e considerada uma instituicao mediadora, inserida na Sociedade... more
O artigo aborda o conceito de Corporacao, na obra Filosofia do Direito publicada por Hegel em 1820/21 com o objetivo de lancar luzsobre esta tematica. Afinal, a Corporacao e considerada uma instituicao mediadora, inserida na Sociedade Civil-Burguesa, cuja importância se deve, principalmente, as suas caracteristicas de instituicao social e politica. Esta dupla caracteristica motivou a pergunta: como as Corporacoes, consideradas como uma instância da Sociedade Civil-Burguesa, tratadas por Hegel na Filosofia do Direito , efetivam a sociabilidade que tem a forca de formar “a interdependencia e a integracao dos individuos”?
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INTRODUCAO: O derrame pleural (DP) caracteriza-se pelo acumulo de grande quantidade de liquido na cavidade pleural podendo ser identificado como patologia primaria ou secundaria. Este e decorrente de desequilibrios entre mecanismos que... more
INTRODUCAO: O derrame pleural (DP) caracteriza-se pelo acumulo de grande quantidade de liquido na cavidade pleural podendo ser identificado como patologia primaria ou secundaria. Este e decorrente de desequilibrios entre mecanismos que favorecem o aumento da entrada do liquido no espaco pleural e a fatores que dificultam sua absorcao. O quadro clinico pode cursar com dispneia, dor, tosse seca, reducao da expansibilidade pulmonar e ate mesmo o obito em casos mais severos. Com isso, o objetivo deste trabalho e discorrer a respeito da assistencia fisioterapeutica prestada ao paciente com derrame pleural. DESCRICAO DA EXPERIENCIA: Trata-se de um estudo descritivo-observacional realizado na enfermaria do Hospital Universitario Lauro Wanderley - HULW, em Joao Pessoa-PB, com uma paciente do sexo feminino, M.L.S.M. de 56 anos de idade. A atividade consistia em atendimentos desenvolvidos por dois academicos do sexto periodo do curso de fisioterapia sob a supervisao do docente durante a disciplina Fisioterapia nas Disfuncoes do Sistema Respiratorio, no periodo de 04/04/2017 a 27/04/2017. Alem dos nossos atendimentos com duracao media de 35 minutos, duas vezes por semana, a paciente recebia tambem atendimentos dos fisioterapeutas do hospital. Foi admitida no dia 23/02/2017 com queixas de desconforto respiratorio, e diagnosticada com derrame pleural e cirrose hepatica nao alcoolica. No exame fisico percebeu-se: hematoma do lado direito devido as constantes toracocenteses, fremito vocal diminuido no hemitorax direito, dispneia aos pequenos esforcos, edema nos tornozelos, ausculta pulmonar com ruidos adventicios do tipo estertores crepitantes difusos. A paciente ainda fazia uso de ventilacao mecânica nao invasiva (VNI) por meio do aparelho de pressao positiva a dois niveis (BILEVEL - IPAP de 15cmH2O e EPAP de 10cmH2O) quando relatava intenso desconforto respiratorio. Nas condutas destacam-se: o padrao ventilatorio diafragmatico, realizado de forma ativa pela paciente para garantir conscientizacao dos musculos respiratorios e promover incursoes adequadas; manobras de reexpansao pulmonar para aumentar o fluxo expiratorio (tecnica compressao e descompressao bem requisitada); inspiracao fracionada em tempos associada a cinesioterapia motora; alongamento estatico dos principais grupos musculares dos membros superiores, inferiores e acessorios da respiracao para manutencao da flexibilidade; mobilizacoes ativas-assistidas para aumentar amplitude de movimento; fortalecimento muscular com resistencia manual; e administracao de VNI durante toda a sessao para proporcionar alivio da dispneia e drenar o DP. IMPACTOS: A abordagem fisioterapeutica adotada possibilitou: conscientizacao dos musculos responsaveis pela respiracao, com consequente melhora nas incursoes respiratorias (de 26 para 21) e alivio do desconforto respiratorio referido nas posicoes sentada e em pe; diminuicao dos ruidos adventicios auscultados; melhora na amplitude articular e flexibilidade de membros superiores e inferiores, inclusive, possibilitando uma caminhada pelo corredor. Todos estes beneficios foram percebidos por nos academicos, bem como pela paciente e seus familiares, que compartilhavam relatos de melhora significativa. CONSIDERACOES FINAIS: Portanto, a fisioterapia mediante seus recursos terapeuticos mostrou melhora dos sinais clinicos observaveis, sendo o principal parâmetro as consideracoes positivas da paciente acerca de sua evolucao.
Research Interests: Medicine and Gynecology
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Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was... more
Background: Sebaceous carcinoma of the eyelid can clinically mimic benign conditions, such as recurrent chalazion and inflammation and histopathologically squamous cell and basal cell carcinoma (BCC). This retrospective study was undertaken as an attempt to improve the characterization and consequently the diagnosis of these tumors.Methods: Retrospective analysis was performed on eyelid specimens diagnosed as sebaceous carcinoma retrieved from Henry C. Witelson Ophthalmic Pathology Registry, Canada and Hospital Luis S. Bulnes Pathology Registry, Mexico. Two independent, masked pathologists reviewed the H&E microslides.Results: Forty‐four cases were retrieved, 31 from Canada and 13 from Mexico. Cytoplasmic vacuoles were observed in 48% of the cases. Eighty‐four percent of the cases were classified as poorly differentiated lesions. Of these, 75% had features similar to squamous cell carcinoma (SqCC), some with dyskeratosis (30%) and 7% resembled BCC. Solid growth pattern was seen in 26.2% of the cases and lobular growth pattern in 26.2%. Superficial spread resembling Bowen‐like disease was observed in 33% of the cases, pagetoid features in 33% and comedocarcinoma in 31.8%.Conclusion: Sebaceous carcinoma presented as a poorly differentiated lesion in most cases of this series, which suggests a possibility of misdiagnosis because of its similarities to SqCC.
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Research Interests: Philosophy and Medicine
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INTRODUCAO: A Doenca Pulmonar Obstrutiva Cronica (DPOC) caracteriza-se pela obstrucao do fluxo aereo nao totalmente reversivel, progressiva e associada a uma resposta inflamatoria anormal dos pulmoes a inalacao de particulas ou gases... more
INTRODUCAO: A Doenca Pulmonar Obstrutiva Cronica (DPOC) caracteriza-se pela obstrucao do fluxo aereo nao totalmente reversivel, progressiva e associada a uma resposta inflamatoria anormal dos pulmoes a inalacao de particulas ou gases nocivos (Sousa; et. al., 2011). Nos paises industrializados e em certas regioes do Brasil, esta entre as cinco enfermidades mais prevalentes (Varella, 2017). A cada hora tres brasileiros morrem em decorrencia da doenca, o que corresponde a cerca de 40 mil mortes no ano, sendo a principal causa o tabagismo e suas diversas formas. (DATASUS, 2014). DESCRICAO DA EXPERIENCIA: Estudo do tipo descritivo-observacional, realizado no Hospital Universitario Lauro-Wanderley da UFPB, no periodo de 23/03/2017 a 06/04/2017, durante os atendimentos de Fisioterapia ao paciente SMW, de 50 anos, obeso, que alem da DPOC no estagio de bronquite cronica, apresentava hipertensao arterial sistemica e insuficiencia renal. Os atendimentos duravam cerca de 45 minutos, duas vezes na semana. IMPACTOS: Foi percebido que a realizacao de manobras como aceleracao do fluxo expiratorio (AFE), expiracao forcada e tosse ajudavam a expectoracao; ja o uso da ventilacao nao-invasiva (CPAP com pressao de 10 cmH2O) associada a exercicios ativos livres de membros superiores e inferiores, e alongamentos contribuiram para a melhora do condicionamento fisico e dos sintomas de tosse e dispneia, de acordo com o relato do paciente. Destacou-se tambem a necessidade de mudancas nos habitos inadequados de vida, como o tabagismo. CONSIDERACOES FINAIS: A assistencia fisioterapeutica requer continuidade para alem do âmbito hospitalar, uma vez que o quadro clinico da DPOC pode ser estabilizado. Diante deste relato de caso, o atendimento fisioterapeutico no âmbito da enfermaria hospitalar contribuiu para o desenvolvimento de habilidades e competencias de na formacao do profissional fisioterapeuta.
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Research Interests: Microsurgery, Medicine, Adipose tissue, Anatomy, Collagen, and 9 moreAnimals, Male, Fascia, Implant, Time Factors, Vocal Folds, Rabbits, Fascia Lata, and Vocal cords
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INTRODUCAO: A Classificacao Internacional de Funcionalidade, Incapacidade e Saude (CIF), criada em 2001 pela Organizacao Mundial da Saude (OMS), caracteriza-se por abordagem ampla de linguagem padronizada, que incorpora os componentes de... more
INTRODUCAO: A Classificacao Internacional de Funcionalidade, Incapacidade e Saude (CIF), criada em 2001 pela Organizacao Mundial da Saude (OMS), caracteriza-se por abordagem ampla de linguagem padronizada, que incorpora os componentes de saude nos niveis corporais e sociais. Assim, na sua avaliacao o modelo evolui do biomedico (diagnostico etiologico da disfuncao), incorporando tres dimensoes: biologica, psicologica e social. De modo que cada nivel age e sofre acao dos demais, e todos sao influenciados por fatores ambientais. ƒ possivel compreender que e um instrumento eficaz na descricao da saude e dos seus estados, em contrapartida, e notorio alto grau de complexibilidade no manejo e interpretacao, o que provavelmente propicia o afastamento e nao uso pelos profissionais da saude. Logo, a narrativa tem como objetivo discorrer acerca de uma experiencia sobre a construcao de um instrumento de avaliacao baseado na CIF. DESCRICAO DA EXPERIENCIA: Trata-se do relato de academicos realizado a partir da experiencia durante sete encontros da disciplina de Fisioterapia na Saude do Trabalhador, no sexto periodo de Fisioterapia da Universidade Federal da Paraiba, no desenvolvimento de seis instrumentos de avaliacao baseado na CIF, elaborados um por grupo, por meio de atividades processuais elaboradas e dirigidas pelo docente. Sendo elas fragmentadas em etapas, com metas a serem cumpridas. Dentre elas, destacam-se: estudo do caso clinico, cujo objetivo foi compreender acerca do conceito, fatores etiologicos e aspectos fisiopatologicos de patologias com nexo no trabalho (Fibromatose Palmar, Neuropatia do Popliteo Lateral, Estresse Pos-traumatico, Cor Pumonale, Queimadura Solar, Cistite Aguda); em seguida foi usado o checklist da CIF para a selecao de codigos de segundo nivel relacionados a patologia; e adotamos da versao completa da CIF para substituir os codigos de segundo por terceiro e quarto niveis (processos de selecao realizados em tres momentos distintos, sob consenso dos participantes); logo apos, elaborou-se um questionario baseado nestes dominios escolhidos, cujas perguntas serviam para facilitar o processo de aplicacao da CIF, ja que traduziam os codigos de seus componentes (estrutura, funcao, atividade e participacao, e fatores ambientais), alem disso, nas situacoes pertinentes usou-se exames e testes complementares, os quais ajudariam a avaliar com melhor qualidade. Na aplicacao simulada do instrumento, um integrante de cada grupo dramatizou a condicao clinica de outro grupo, com intuito de reproduzir a aplicacao pratica do instrumento. Por fim, exposicao e discussao. IMPACTOS: A construcao do instrumento se mostrou importante pois os discentes tiveram a oportunidade de assimilar o conteudo, muitas vezes enfadonho, de maneira critica, simples e altamente didatica. Tambem desenvolveu-se uma forma de manejar a CIF, que a transformou em uma ferramenta palpavel na investigacao e avaliacao cinetico-funcionais, bem como norteamento para conduta, tornando o instrumento viavel para o profissional fisioterapeuta, independente do campo de atuacao. CONSIDERACOES FINAIS: Neste contexto, e possivel concluir que a experiencia nos remeteu a uma abordagem metodologica eficaz na aquisicao de um conhecimento duradouro, significativo e principalmente de encorajamento do protagonismo discente diante do seu aprendizado, que por sua vez, contribuiu na formacao de um profissional empoderado das ferramentas de sua profissao e, portanto, de melhor qualidade.
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Research Interests: Chemistry, Immunology, Molecular Biology, Medicine, Cell Culture, and 15 moreImmunocytochemistry, Cell line, Humans, Statistical Significance, COX, Clinical Sciences, Eye, Retinoblastoma, Optometry and Ophthalmology, Western blot, Cell Proliferation, Cell Growth, MTT assay, Cell Lines, and Cyclooxygenase
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1. Can J Ophthalmol. 2005 Apr;40(2):188-91. Retinoblastoma in an adult: case report and literature review. Odashiro AN, Pereira PR, de Souza Filho JP, Cruess SR, Burnier MN Jr. Department of Ophthalmology, Federal University of São Paulo,... more
1. Can J Ophthalmol. 2005 Apr;40(2):188-91. Retinoblastoma in an adult: case report and literature review. Odashiro AN, Pereira PR, de Souza Filho JP, Cruess SR, Burnier MN Jr. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. ...
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Trabalho apresentado em II Congresso Internacional Sociedade Portuguesa de Terapia da Fala, 22-26 de setembro 2021, onlineN/
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The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of... more
The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program. Fifty-eight previously inactive men and women, body mass index (BMI) 31.5 ± 2.8 kg/m2, 46.5% (n = 27) genotyped as CC genotype and 53.5% (n = 31) as CA+AA, underwent a 12-week aerobic training (walking/running). Aerobic capacity (ergospirometry), body composition (DXA), and nutritional assessment were made before and 48 h after the experimental protocol. Two-way ANOVA, chi-square test, and logistic regression were used (p < 0.05). Twenty-seven volunteers (46.5%) were identified as CC genotype and 31 (53.5%) as CA+AA genotype. Time-group interaction showed that there was no difference in these between two allele groups. However, differences in distribution of responden...
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Bariatric surgery may lead to metabolic bone disease. In this cross-sectional study, we compared the prevalence of secondary hyperparathyroidism (SHPT), impact on bone mass and turnover markers, and serum leptin after Roux-en-Y gastric... more
Bariatric surgery may lead to metabolic bone disease. In this cross-sectional study, we compared the prevalence of secondary hyperparathyroidism (SHPT), impact on bone mass and turnover markers, and serum leptin after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in 117 patients (91% female, 51% RYGB, age 41.8 ± 6.7 years, time of surgery 4.3 ± 3.4 years) at different times (1–2 years, > 2 and < 5 years and ≥ 5 years). Body composition, bone mineral density (BMD), by dual-energy X-ray absorptiometry, and bone parameters (PTH, serum calcium, 25OHD, alkaline phosphatase (AP), C-telopeptide (CTX)) were analyzed. Prevalence of SHPT (PTH ≥ 65 pg/ml) was 26%, RYGB > SG (18.4% vs. 7.8%, p = 0.039), despite similar 25OHD and calcium levels. Mean PTH, CTX, and AP were higher in RYGB vs. SG (61.3 ± 29.5 vs 49.5 ± 32.3 pg/ml, p = 0.001; 0.596 ± 0.24 vs. 0.463 ± 0.23 ng/ml; 123.9 ± 60.8 vs. 100.7 ± 62.0 U/l). There were 13.5% decreases in femoral neck BMD in all patients, over the study period. In the last group, the RYGB group showed greater bone loss in total body BMD (1.016 vs. 1.151 g/cm2, − 8.1%, p = 0.003) and total femur BMD (1.164 vs. 1.267 g/cm2, − 11.7%, p = 0.007). Mean leptin was lower in the RYGB vs. SG group, with no correlation with BMD in any site. Our data suggest a more deleterious role of RYGB on bone remodeling up to 5 years postoperatively in comparison with SG.
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BACKGROUND & AIMS Low bone mineral density (BMD) for age in people with Cystic Fibrosis (CF) is associated with worse nutritional status. The aim of this study is to assess body composition by anthropometry as a predictor of BMD in... more
BACKGROUND & AIMS Low bone mineral density (BMD) for age in people with Cystic Fibrosis (CF) is associated with worse nutritional status. The aim of this study is to assess body composition by anthropometry as a predictor of BMD in people with CF. METHODS Multicenter cross-sectional study with 39 people aged 5 and 20 years with CF. BMD was assessed by dual energy x-ray emission (DXA) in the incidence of the total body less head (TBLH) and the TBLH Z-score (Z-TBLH) was calculated, adjusted by sex, age, height and ethnicity. Anthropometry was assessed by weight, height, mid-upper arm circumference (MUAC) and triceps skinfold (TSF). Arm muscle area (AMA) and Body Mass Index (BMI) were calculated. Lean mass (LM), fat mass (FM) and free-fat mass (FFM) were identified by DXA. The molecular analysis method by sequencing was used to identify and classify the participants regarding the presence of the F508del pathogenic variant of the CFTR gene. Statistical models of simple and multiple linear regression were created to establish the predictive power of Z-TBLH in the variables. RESULTS Average age of the participants was 13.31 ± 3.86 years, 59% of whom were male. They showed more LM (30.97 Kg ± 11.29) than females (23 Kg ± 6.73). 20 of 30 participants (66.7%) had at least copy of F508del. Among the multiple models, adjusted by height, age and sex, it found BMI (R2 = 0.367), Weight (R2 = 0.220), AMA (R2 = 0.338) as significant predictors of Z-TBLH. The final model composed of AMA, TSF and Age (p = 0.001; R2 = 0.381) had AMA and Age as significant predictors. AMA was associated with an increase in the BMD Z-score in the participants studied. 66.7% of genetically tested participants had the F508del pathogenic variant. The presence of the F508del variant was associated with worse nutritional status. CONCLUSION A statistical model composed of the values of AMA, TSF and Age can predict Z-TBLH, as well as anthropometric variables Weight, or BMI, or AMA associated with height, age and sex, in children and adolescents aged 5-20 years old, of both sexes. Anthropometric markers, as they are easy and relatively inexpensive to obtain, it is a promising alternative to the use of DXA in predicting BMD in these people with CF.
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Aims: Analysis of the relationship between the methylation profile of miR-9-1 or miRs -9-1 / -9-3 and diabetic retinopathy. Background: Diabetic Retinopathy (DR) is a frequent complication of Diabetes mellitus and it has a decisive impact... more
Aims: Analysis of the relationship between the methylation profile of miR-9-1 or miRs -9-1 / -9-3 and diabetic retinopathy. Background: Diabetic Retinopathy (DR) is a frequent complication of Diabetes mellitus and it has a decisive impact on the quality of life, as it is one of the biggest causes of blindness in the adult population. Levels of microRNA-9 have been shown to be related to diabetes but little is known about its involvement with DR in humans. Objective: To analyze the relationship between the methylation profile of miR-9-1 or miRs -9-1/-9-3 and DR. Methods: 103 patients diagnosed with diabetes for 5 to 10 years were analyzed. The data were categorized according to clinical, biochemical, lifestyle and anthropometric parameters. DNA extracted from leukocyte samples was used to determine the methylation profile of miRs-9-1 and -9-3 using a specific methylation PCR assay. Results: miR-9-1 methylation was related to diabetic retinopathy, indicating that methylation of this m...
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IntroductionMTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown.ObjectiveThe aim of this study was to evaluate the influence of physical activity... more
IntroductionMTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown.ObjectiveThe aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 111 patients, 43 men and 68 women diagnosed with DM (7.0 ± 2.3 years), answered the International Physical Activity Questionnaire (IPAQ) and underwent blood collection for biochemical analysis, DNA extraction, and MTHFR gene methylation profile determination.ResultThe comparison of the methylation pattern showed that the partially methylated profile predominates in the insufficiently active group (85%), which does not occur in the sufficiently active group (54%) (p = 0.012). No differences were found in the nutritional status comparison. Logistic regression including overweight, waist circumference, gender, age, t...
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BACKGROUND High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated.... more
BACKGROUND High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated. Therefore, the aim of this study was to verify the influence of a lipidic peroxidation marker (malondialdehyde, MDA) and antioxidant status (total antioxidant capacity marker, TAC) on the magnitude of weight-loss by aerobic-induced exercise in previously sedentary overweight or obese individuals. METHODS Seventy-five physically inactive adults were randomized into experimental (N.=58) and control (N.=17) groups, who engaged in a 12-week program of aerobic training walking and/or running (3 to 5 days/week) or stretching (1 day/week), respectively. Body composition (DXA), aerobic capacity (ergospirometric) and blood collections for oxidative stress analysis (MDA and TAC) were determined before and after the experimental protocol. Two-way ANOVA for repeated measures or Friedman's test were used to evaluate differences in time/group interaction. Pearson correlation was used to verify the relationship between the variables of oxidative stress and of body composition. RESULTS Significant reduction was found in fat body mass of experimental when compared to control group (-1.3±1.9 kg versus -0.3±1.3, P=0.04). Experimental group also altered significantly the total body mass (-1.2±4.7 kg; effect size 0.44), body mass index - BMI (-0.3±1.1 effect size 0.37), fat percentage (1.3±1.6%; effect size 0.50) and lean body mass (0.6±1.5 kg; effect size 0.32).There was increase in MDA of 2.3 μmol/L to 2.7 μmol/L (P=0.00), without changes to TAC (25.6±13.9% to 28.0±10.4%). No correlation was found between these variations in body composition with either the initial values of MDA and TAC or delta variation of these indicators of oxidative stress in response to the training program. CONCLUSIONS Indicators of oxidative stress (MDA and TAC) does not influence the magnitude of weight-loss induced by aerobic training.