Josep Casanova
Universitat de Lleida, Medicina, Department Member
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Sr. Director: El dermatofibrosarcoma protuberans (DFSP) es un tumor cutáneo poco común que se caracteriza p.
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... Sorolla, A., Yeramian, A., Dolcet, X., Pérez de Santos, A., Llobet, D., Schoenenberger, J., Casanova, J., Soria, X ... Absorbance was measured at 595 nm in a microplate reader (Bio-Rad, Richmond, CA, USA ... with 2 mol L −1 HCl for 30... more
... Sorolla, A., Yeramian, A., Dolcet, X., Pérez de Santos, A., Llobet, D., Schoenenberger, J., Casanova, J., Soria, X ... Absorbance was measured at 595 nm in a microplate reader (Bio-Rad, Richmond, CA, USA ... with 2 mol L −1 HCl for 30 min and neutralization with 0·1 mol L −1 Na 2 ...
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... A la Dra Carme Pinol, con la que he compartido muchas horas de ordenador, al DrXavi Gómez y al Dr Manel Baradad por su ayuda en el trabajo estadístico y al Dr Ramón Egido por su trabajo en el diagnóstico anatomopatológico. ...
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Información del artículo Temperaturas de emplazamiento de depósitos basálticos freamagmáticos deducidas a partir de datos paleomagnéticos.
Research Interests: Adolescent, Spain, Prospective studies, Humans, Child, and 22 moreINTENSIVE CARE, Female, Male, Statistical Significance, Infant, Differential Diagnosis, Incidence, Length of Stay, Skin Diseases, Clinical Sciences, Aged, Middle Aged, Adult, Public health systems and services research, Intensive Care Medicine, Skin Disease, Intensive Care Units, Prospective Study, Critical Illness, Mortality rate, Severity of Illness Index, and Child preschool
Comment.We present this case for the following teaching points: (1) Curvularia and Bipolaris are difficult to distinguish, and, therefore, could coexist more often than previously recognized; (2) this is the second report of a case... more
Comment.We present this case for the following teaching points: (1) Curvularia and Bipolaris are difficult to distinguish, and, therefore, could coexist more often than previously recognized; (2) this is the second report of a case involving these two organ¬ isms; and ...
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The worldwide incidence of malignant melanoma is increasing. The number of pigmented naevi and amount of solar exposure are important risk factors. The aim of this study was to characterize a paediatric population (from Lleida, Catalonia,... more
The worldwide incidence of malignant melanoma is increasing. The number of pigmented naevi and amount of solar exposure are important risk factors. The aim of this study was to characterize a paediatric population (from Lleida, Catalonia, Spain) in terms of phenotype, sun behaviour and naevi prevalence. Data on the numbers and distributions of acquired naevi in 369 children, aged 4, 8 and 14 years, were collected and correlated with age, sex, skin phototype and environmental factors (annual/lifetime intermittent and chronic sun exposure, sunburns and sunscreen use). The density of naevi increased with age. Boys had more naevi on the trunk and girls had more naevi on the legs. Children with light skin phototype had more naevi. A higher level of accumulated sun exposure correlated with a higher number of naevi in children with non-adequate sunscreen use. In conclusion, several risk factors associated with naevi density and distribution were found, as previously reported by others. Mul...
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We review the literature on benign chronic bullous dermatosis of childhood and the criterions for its diagnosis and differentiation from dermatitis herpetiformis and bullous pemphigoid. The diagnosis among these conditions should be based... more
We review the literature on benign chronic bullous dermatosis of childhood and the criterions for its diagnosis and differentiation from dermatitis herpetiformis and bullous pemphigoid. The diagnosis among these conditions should be based on immunofluorescence data. BCBDC shows linear IgA on the basal membrane zone. Its course is benign and there is not enteropathy. In dermatitis herpetiformis we find granular IgA and complement in the tips of dermal papillae. It is a chronic illness and the patients have a gluten-sensitive enteropathy. The bullous pemphigoid is a severe condition which needs corticosteroids for its control. Direct immunofluorescent studies reveal IgG and complement in a linear pattern in the membrane basal zone. It is associated with circulating antibasement membrane zone IgG.
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A 37 year-old woman presented with type D2 familial dysplastic nevus syndrome with melanoma. A melanoma was excised of her back and more than one hundred pigmented lesions, four of which presented histologic characteristics of dysplastic... more
A 37 year-old woman presented with type D2 familial dysplastic nevus syndrome with melanoma. A melanoma was excised of her back and more than one hundred pigmented lesions, four of which presented histologic characteristics of dysplastic nevus were observed. Several relatives of her presented multiple nevi and a sister of her mother and a brother of the patient had been diagnosed of melanoma. It is well established that such kind of nevi are precursor for melanomas, particularly familial forms. The clinical identification of such lesions is very simple and facilitates the diagnosis and early treatment of melanoma.
Research Interests: Humans, Female, Pedigree, Risk factors, Adult, and 3 moreRisk Factors, Medicina Clinica, and Skin Neoplasms
Porphyria cutanea tarda is treated with phlebotomies in the absence of renal failure. However, in patients on maintenance hemodialysis, this will lead to the need for high doses of erythropoietin. We describe the case of a 63-year-old... more
Porphyria cutanea tarda is treated with phlebotomies in the absence of renal failure. However, in patients on maintenance hemodialysis, this will lead to the need for high doses of erythropoietin. We describe the case of a 63-year-old hemodialysis patient who had chronic hepatitis C virus and developed porphyria cutanea tarda after iron overload due to repeated transfusions. She was treated with erythropoietin and phlebotomies reaching clinical remission 4 months after beginning treatment.
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Cutaneous metastases as internal neoplasm manifestation are not very frequent. However, the lung cancer in male, is the first cause of cutaneous metastases. The skin metastases may be the first clinical manifestation of cancer in these... more
Cutaneous metastases as internal neoplasm manifestation are not very frequent. However, the lung cancer in male, is the first cause of cutaneous metastases. The skin metastases may be the first clinical manifestation of cancer in these patients. We report two cases of lung neoplasm in whose first manifestation was metastases of skin. We have reviewed the literature.
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Giant basal cell carcinoma (BCC) is defined as a tumor with a diameter of 5 cm or more. Surgery, the treatment of choice for any type of BCC, can cause considerable anatomical damage in large tumors. In 2 patients with giant BCC we... more
Giant basal cell carcinoma (BCC) is defined as a tumor with a diameter of 5 cm or more. Surgery, the treatment of choice for any type of BCC, can cause considerable anatomical damage in large tumors. In 2 patients with giant BCC we therefore provided neoadjuvant treatment with a combination of oral acitretin and topical 5% imiquimod. Acitretin is a systemic retinoid used for primary prevention of nonmelanoma skin cancer. Imiquimod is an immunomodulator whose approved indications include treatment of nonfacial superficial BCC less than 2 cm in diameter. Previous studies have demonstrated a synergic anticancer effect of both drugs in vitro and in vivo. This combination produced a marked reduction in tumor mass in our patients. Later we were able to provide definitive treatment, which achieved complete remission of the tumors.
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We present the case of a newborn with congenital absence of skin in the anterior part of the left leg that shortly after developed bulla and erosions in hands, feet, ears, buttocks and mouth. The cutaneous biopsy and ultrastructural and... more
We present the case of a newborn with congenital absence of skin in the anterior part of the left leg that shortly after developed bulla and erosions in hands, feet, ears, buttocks and mouth. The cutaneous biopsy and ultrastructural and immunohistochemical studies showed a subepidermal bulla in the lamina lucida, absence of hemidesmosomes and marked decrease of laminin 5, thus establishing the diagnosis of Bart syndrome associated to the Herlitz form of lethal junctional epidermolysis bullosa. Bart syndrome consists of congenital and localized absence of skin, nail abnormalities and mucoc-cutaneous bullae. It is usually associated to dystrophic epidermolysis bullosa. The Herlitz form of junctional epidermolysis bullosa is a rare variant, usually lethal that is produced by mutations in the genes coding for the anchor protein laminin 5. To our knowledge this is the second case that reports an association between Bart syndrome and lethal junctional epidermolysis bullosa and the first i...
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We present a case of Sweet's syndrome with atypical lesions, characterized by erythematous plaques, vesicles and bullous lesions. Skin lesions in patients with an underlying malignancy are more frequently atypical and with vesicular,... more
We present a case of Sweet's syndrome with atypical lesions, characterized by erythematous plaques, vesicles and bullous lesions. Skin lesions in patients with an underlying malignancy are more frequently atypical and with vesicular, bullous or even ulcerative characteristics, in addition to the typical plaques and nodules. However, the case presented is not associated with malignancy, despite the fact that these processes, particularly hematologic ones, should be suspected.
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Research Interests: Adolescent, Spain, Humans, Child, Infant, and 3 moreSkin Diseases, Epidemiologic Studies, and Child preschool
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Dermatoweb is a website to aid undergraduate dermatology training. It includes the dermatology program of the Lerida Faculty of Medicine, and is based principally on clinical presentations, tables with the differential diagnosis of the 20... more
Dermatoweb is a website to aid undergraduate dermatology training. It includes the dermatology program of the Lerida Faculty of Medicine, and is based principally on clinical presentations, tables with the differential diagnosis of the 20 most common reasons for dermatologic consultation, about 200 clinical test cases to stimulate self-training, and a subject list with the 32 topics that make up the dermatology syllabus in many faculties of medicine. Thanks to this website, some of our students achieve high marks in dermatology despite hardly coming to classes. In addition, therapeutic guidelines for the common dermatoses can be found on the site, and an atlas with more than 5,300 photographs and almost 100 videos on the more common dermatological procedures; these can serve as a visual aid for family doctors, residents in dermatology in the initial years, and practicing dermatologists.