- Currently at Reunion Island University, France. 1995-2006 Lecturer at the Université de Bretagne Occidentale, Quimper... moreCurrently at Reunion Island University, France. 1995-2006 Lecturer at the Université de Bretagne Occidentale, Quimper, Fra. PhD in Food Science (1993) from University of Burgundy, Dijon. Involved in the field of Biotechnology of Food Ingredients for more than 30 years. Main research now focused on microbial production of pigments. This activity started 20 years ago and studies were and are mainly devoted to aryl carotenoids, such as isorenieratene, C50 carotenoids, anthraquinones, azaphilones.edit
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Research Interests: Chemistry, Food Science, Medicine, Pigment, Yeast, and 4 moreFoods, Agar, Ripening, and Arthrobacter
Research Interests: Biotechnology, Food, Peptide, Food Industry, Bacteriocin, and 4 moreEnzyme, Fermentation, Thaumatin, and Colorant
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Microbial pigments have great interest within the healthcare industry, as they possess immunosuppressive, antifungal, antiproliferative properties, induce apoptosis, and may have potential for medical applications. The microbes such as... more
Microbial pigments have great interest within the healthcare industry, as they possess immunosuppressive, antifungal, antiproliferative properties, induce apoptosis, and may have potential for medical applications. The microbes such as Micrococcus, Bacillus, Rhodotorula, Monascus, Phaffia, Sarcina, and Achromobacter have the capability to produce different pigments. Biosynthesis of microbial pigments has been greatly underexplored and a multitude of potentially useful pigments still await discovery. Only less than 1% of the microbial community is estimated to be cultivated in the laboratory and vast diversity of microbial pigments and their encoding biosynthetic gene clusters remain to be exploited. The expansion of eco-friendly technologies in pigment synthesis is of considerable importance to expand their biological applications. Nanotechnology is presently employed as a tool to explore the darkest avenues of medical sciences to combat diseases caused by drug-resistant microbes. This chapter provides the state-of-art knowledge on the synthesis of nanoparticles from pigments and their pharmacological applications. The current limits and future forecasts for the synthesis of pigment-mediated nanoparticles by microorganisms are discussed.
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Les lactones sont des composes d'aromes largement distribues dans les aliments. Leur presence a ete decrite dans plus de 120 produits alimentaires ou elles apportent des notes peche, abricot, noix de coco, beurre. . . Certains... more
Les lactones sont des composes d'aromes largement distribues dans les aliments. Leur presence a ete decrite dans plus de 120 produits alimentaires ou elles apportent des notes peche, abricot, noix de coco, beurre. . . Certains microorganismes sont capables de synthetiser des lactones a partir de sources simples de carbone et d'azote. De nombreux parametres permettent d'influencer les niveaux atteints mais ceux-ci sont generalement compris entre 1 et 10 mg/l. L'addition de precurseurs hydroxyles a une culture microbienne augmente fortement la formation de lactones, il s'agit de conversion. La degradation de l'acide ricinoleique et d'autres acides gras hydroxyles par des levures appartenant au genre sporidiobolus a permis de mieux comprendre les relations entre la structure du precurseur et la lactone obtenue. La beta-oxydation du precurseur ne s'accompagne pas obligatoirement du maintien de l'enantiomerie du carbone porteur de l'hydroxyle. Les levures sporidiobolus ont des comportements extremement variables pour la production de gamma-decalactone. Le point crucial semble resider dans le rapport des vitesses de formation de l'acide 4-hydroxy decanoique et de degradation de ce stade vers l'acetyl-coa terminal. Sp. Salmonicolor est une levure performante mais celle-ci est tres sensible a la toxicite des lactones. Divers procedes ont ete envisages pour lever l'inhibition et favoriser la conversion. La perstraction semble etre la technique la plus adaptee au couplage reacteur/extracteur. Son emploi peut etre envisage pour maitriser la production de gamma-decalactone avec une seconde levure, sp. Ruinenii, notamment pour minimiser les phenomenes de reconsommation
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Within the genus Sporidiobolus, S. odorus has been widely reported as having the ability to convert castor oil or its derivatives to γ-decalactone, but other species have also shown potential for lactone production. In this work, the... more
Within the genus Sporidiobolus, S. odorus has been widely reported as having the ability to convert castor oil or its derivatives to γ-decalactone, but other species have also shown potential for lactone production. In this work, the bioconversion of ricinoleic acid methyl ester to γ-decalactone was studied with four species of Sporidiobolus: S. salmonicolor, S. ruinenii, S. johnsonii, and S.
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In the plant kingdom, numerous pigments have already been identified, but only a minority of them is allowed by legal regulations for textile dyeing, food coloring or cosmetic and pharmaceutics’ manufacturing. Anthraquinones, produced as... more
In the plant kingdom, numerous pigments have already been identified, but only a minority of them is allowed by legal regulations for textile dyeing, food coloring or cosmetic and pharmaceutics’ manufacturing. Anthraquinones, produced as secondary metabolites in plants, constitute a large structural variety of compounds among the quinone family. Derivatives that contain hydroxyl groups, namely hydroxy-anthraquinones, are colored. They have attracted the attention of many researchers due to their large spectrum of possible applications especially in the fields of dyeing. These dyes produce a wide range of nuances in shades (red, orange and yellow). Fifteen anthraquinones’ derivatives from madder color roots (Rubia tinctorium L.) play an important role in dyeing (CI Natural Red 8). Purpurin (CI Natural Red 16) is a minor component in the madder color, but is the main dye in addition with munjistin in Indian madder (Rubia cordifolia). Alizarin (Pigment Red 83, CI Mordant Red 11) is the...
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Les extraits enrichis en phycocyanine de Spirulina platensis (spiruline) peuvent trouver de nombreuses applications dans les domaines de l’alimentaire, de la pharmacologie, de la cosmetique et de la recherche. Seul colorant bleu naturel... more
Les extraits enrichis en phycocyanine de Spirulina platensis (spiruline) peuvent trouver de nombreuses applications dans les domaines de l’alimentaire, de la pharmacologie, de la cosmetique et de la recherche. Seul colorant bleu naturel compatible avec l’alimentaire, la phycocyanine est egalement reconnue pour ses vertus antioxydantes, anti-inflammatoires et hepatoprotectrices. Cette etude a pour objectif de comparer differentes methodes d’extraction de la phycocyanine de Spirulina platensis et d’analyser la stabilite de ces colorants dans les extraits. Les extraits enrichis en phycocyanine ont ete obtenus a l’aide de methodes physiques (congelation/decongelation, vortex, ultrasons, micro-ondes, methode acceleree par solvant - ASE), chimiques (HCl) et biochimiques (lysozymes, levures) a partir de spiruline seche ou fraiche produite au laboratoire et les resultats ont ete compares a des echantillons de spiruline commerciale. Les extraits ont ete analyses par spectrophotometrie et par...
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Common salt, i.e. table salt, commonly employed in cooking, is cheaper than specialty marine salt ob-tained by evaporation of seawater in solar salterns. For a decade some European producers intended to access Protected Geographical... more
Common salt, i.e. table salt, commonly employed in cooking, is cheaper than specialty marine salt ob-tained by evaporation of seawater in solar salterns. For a decade some European producers intended to access Protected Geographical Indication (PGI) or Traditional Specialty Guaranteed (TSG) status in order to protect and value coarse salt, ground (fine) salt and salt flower, based on the quality policy for the products of European Union (EU) agriculture. The PGI associates a product with a region, to confirm its authentic origin whereas TSG highlights the traditional character, either in the composition or means of production. The first success in this field was obtained by marine salt producers of Guerande, France that received a PGI label on March 20, 2012. In Europe, consumers are, for example, attracted by high price salt products that could be used in gourmet cooking. Moreover, empirical observation highlighted a con-cept of revenue linked with territorial qualities, that is to...
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Talaromyces albobiverticillius-is a pigment producing ascomycete fungi isolated from the marine biodiversity of Reunion Island, Indian Ocean, France. Due to the extensive interest in process development for pigment production from natural... more
Talaromyces albobiverticillius-is a pigment producing ascomycete fungi isolated from the marine biodiversity of Reunion Island, Indian Ocean, France. Due to the extensive interest in process development for pigment production from natural microbial sources among scientists and manufacturers, much attention has to be paid to unfold marine treasure to find some novel pigment producers. Media composition and growth conditions influence culture growth and thus have an effect on pigment production. The production of pigment(s) can be improved by optimizing the culture conditions. Traditional optimization techniques such as " One factor at a time " fail to identify the variables that give rise to maximum response, and also consume labor and time. Statistical methods are an alternate to traditional methods, a process by considering the mutual interactions among the variables to optimize responses. Response Surface Methodology (RSM) is one such technique which simplifies optimizat...
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Astaxanthin (AXT) is a natural xanthophyll with strong antioxidant, anticancer and antimicrobial activities, widely used in the food, feed, pharmaceutical and nutraceutical industries. So far, 95% of the AXT global market is produced by... more
Astaxanthin (AXT) is a natural xanthophyll with strong antioxidant, anticancer and antimicrobial activities, widely used in the food, feed, pharmaceutical and nutraceutical industries. So far, 95% of the AXT global market is produced by chemical synthesis, but growing customer preferences for natural products are currently changing the market for natural AXT, highlighting the production from microbially-based sources such as the yeast Phaffia rhodozyma. The AXT production by P. rhodozyma has been studied for a long time at a laboratory scale, but its use in industrial-scale processes is still very scarce. The optimization of growing conditions as well as an effective integration of upstream-downstream operations into P. rhodozyma-based AXT processes has not yet been fully achieved. With this critical review, we scrutinized the main approaches for producing AXT using P. rhodozyma strains, highlighting the impact of using conventional and non-conventional procedures for the extraction of AXT from yeast cells. In addition, we also pinpointed research directions, for example, the use of low-cost residues to improve the economic and environmental sustainability of the bioprocess, the use of environmentally/friendly and low-energetic integrative operations for the extraction and purification of AXT, as well as the need of further human clinical trials using yeast-based AXT.
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Filamentous fungi have gained growing interest as sources of diverse pigmented secondary metabolites. Some specific polyketides from Ascomycetous species have demonstrated a wide range of industrial applications in food, cosmetic,... more
Filamentous fungi have gained growing interest as sources of diverse pigmented secondary metabolites. Some specific polyketides from Ascomycetous species have demonstrated a wide range of industrial applications in food, cosmetic, textile, and in the design of pharmaceutical products. The formulation of recipes containing fungal polyketides has increased over recent years. Fusarium strains were proven useful to mankind in a variety of technologies. Nevertheless, there is still need of new isolates of Fusarium for use in emerging and already existing fields. In this article, we report the concomitant production of the bioactive red bikaverin along with two novel purple pigments by the phytopathogenic Fusarium oxysporum LCP531 strain isolated from soil. In literature, the production of purple pigment had only been described in cultures of Fusarium Fujikuroi, Fusarium verticillioides, and Fusarium graminearum. The production of these naphthoquinonic pigments, their distribution (either...
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Research Interests: Fungi, Biodiversity, Fusarium, HPLC, Color, and 12 moreMarine, Dyeing, Colour, Pigment, EXTRACTION, Carotenoid, Biosynthesis, QR, Metabolite, Colorant, Fungal, and polyketide
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ABSTRACT
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Spectrocolorimetry was used for the evaluation of Brevibacterium linens pigmentation. A total of 23 strains of Brevibacterium linens, from various sources, were plated onto solid agar media and their color coordinates were measured and... more
Spectrocolorimetry was used for the evaluation of Brevibacterium linens pigmentation. A total of 23 strains of Brevibacterium linens, from various sources, were plated onto solid agar media and their color coordinates were measured and expressed by the L*a*b* colorimetric system. All the strains were located along a straight line with a hue of 66 degrees (orange color). The effect of light exposure versus storage in the dark was also investigated using this approach. Three groups with distinct behaviors were demonstrated for the 23 B. linens strains.
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Synthetic coloring agents have been broadly utilized in several industries such as food, pharmaceuticals, cosmetic and textile. Recent surveys on the potential of teratogenicity and carcinogenicity of synthetic dyes have expressed... more
Synthetic coloring agents have been broadly utilized in several industries such as food, pharmaceuticals, cosmetic and textile. Recent surveys on the potential of teratogenicity and carcinogenicity of synthetic dyes have expressed concerns regarding their use in foods. Worldwide, food industries have need for safe, natural and new colorings to add variety to foods and make them appealing to consumers. Natural colorings not only expand the marketability of the food product, but also add further healthful features such as antibacterial, antioxidant, anticancer and antiviral properties. Novel microbial strains should be explored to meet the increasing global search of natural pigments and suitable techniques must be developed for the marketable production of new pigments, using microbial cultures, viz., fungi, and bacteria. To address the issue of the natural coloring agents, this review presents the recent trends in several studies of microbial pigments, their biological properties and industrial applications.
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Prevention of concrete structure from premature deterioration has become a major challenge around the world, and its high maintenance cost demands an eco-friendly and economical alternative. Apart from the conventional healing of cracks... more
Prevention of concrete structure from premature deterioration has become a major challenge around the world, and its high maintenance cost demands an eco-friendly and economical alternative. Apart from the conventional healing of cracks using chemicals, a microbial crack repairing strategy has given promising results. The concept of bio-concrete or bio-cement is based on microbially induced calcium carbonate precipitation (MICCP) which involves the usage of microorganisms (direct or encapsulated) to increase the durability of concrete structure, reduce its water permeability, and provoke self-healing of cracks. MICCP involves autotrophic and heterotrophic pathways of bio-mineralization, while calcite is the most common and stable polytype of calcium carbonate. Bacteria possess various coding and regulatory genes for enzymes (urease and carbonic anhydrase) involved in calcite precipitation; however, most of the genetic studies in this perspective are done on pathogenic organisms. The respective technique is now being successfully employed in the fields of geo-technology and civil engineering for concrete strengthening, soil consolidation, monument restitution, and low energy construction. The formulation of smart cement and space bricks are some recent developments. The efficacy of different bacteria for fortification of concrete and aggregates, auto-repairing of cracks, restoration architecture, and potential properties of smart cement are focused on, in this review article.