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Research Interests: Asthma, Medicine, Heterogeneity, Factor analysis, Humans, and 15 moreCOPD, Internal Medicine, Female, Male, Body Mass Index, Clinical Sciences, Middle Aged, Chronic obstructive pulmonary disease, Pulmonary disease, Acute Disease, Exacerbation, Exacerbations, Cardiovascular medicine and haematology, Bronchodilator agents, and Pulmonary Disease Chronic Obstructive
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Research Interests: Humans, COPD, Female, Lung, Aged, and 15 moreChronic obstructive pulmonary disease, Combination drug therapy, Disease Progression, Budesonide, Glucocorticoids, Logistic Models, Area Under Curve, Formoterol, Bronchodilators, Inhaled corticosteroids, Decision Support Techniques, Albuterol, Exacerbation, Bronchodilator agents, and Drug combinations
Research Interests: Medicine, Humans, COPD, Internal Medicine, Female, and 15 moreMale, Lung, Aged, Middle Aged, Randomized Controlled Trial, Chronic obstructive pulmonary disease, Disease Progression, Budesonide, Glucocorticoids, Formoterol, Randomized Controlled Trials as Topic, Exacerbation, discontinuation, Bronchodilator agents, and Pulmonary Disease Chronic Obstructive
Research Interests: Medicine, Humans, COPD, Internal Medicine, Female, and 15 moreMale, Aged, Middle Aged, Adult, Odds ratio, Prognosis, Chronic obstructive pulmonary disease, Combination drug therapy, Budesonide, Confidence Interval, Formoterol, Exacerbation, Adrenal cortex hormones, Bronchodilator agents, and Pulmonary Disease Chronic Obstructive
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Research Interests: Clinical Trials, Randomization, Medicine, Humans, COPD, and 15 moreInternal Medicine, Placebo, Female, Male, Lung, Aged, Middle Aged, Chronic obstructive pulmonary disease, Disease Progression, Budesonide, Glucocorticoids, Formoterol, Exacerbation, Bronchodilator agents, and Pulmonary Disease Chronic Obstructive
Research Interests: Administration, Medicine, Humans, COPD, Internal Medicine, and 15 moreFemale, Pneumonia, Male, Clinical Sciences, Aged, Middle Aged, Inhalation, Confidence Interval, Fluticasone propionate, Inhaled corticosteroids, Adrenal cortex hormones, Cardiovascular medicine and haematology, Bronchodilator agents, Fluticasone, and hazard ratio
Research Interests: Health Care, Clinical Trial, Global Health, IT Management, Medicine, and 15 moreComorbidity, Humans, COPD, American, Health Care Workers, Burden of Disease, Clinical Sciences, Prevalence, Chronic obstructive pulmonary disease, Intensive Care Medicine, Disease Progression, Disease Management, Delivery of Health Care, Medical and Health Sciences, and Bronchodilator agents
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Exposure to air pollution is a major contributor to the pathogenesis of COPD worldwide. Indeed, most recent estimates suggest that 50% of the total attributable risk of COPD may be related to air pollution. In response, the Global... more
Exposure to air pollution is a major contributor to the pathogenesis of COPD worldwide. Indeed, most recent estimates suggest that 50% of the total attributable risk of COPD may be related to air pollution. In response, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Scientific Committee performed a comprehensive review on this topic, qualitatively synthesised the evidence to date and proffered recommendations to mitigate the risk. The review found that both gaseous and particulate components of air pollution are likely contributors to COPD. There are no absolutely safe levels of ambient air pollution and the relationship between air pollution levels and respiratory events is supra-linear. Wildfires and extreme weather events such as heat waves, which are becoming more common owing to climate change, are major threats to COPD patients and acutely increase their risk of morbidity and mortality. Exposure to air pollution also impairs lung growth in children and as such may lead to developmental COPD. GOLD recommends strong public health policies around the world to reduce ambient air pollution and for implementation of public warning systems and advisories, including where possible the use of personalised apps, to alert patients when ambient air pollution levels exceed acceptable minimal thresholds. When household particulate content exceeds acceptable thresholds, patients should consider using air cleaners and filters where feasible. Air pollution is a major health threat to patients living with COPD and actions are urgently required to reduce the morbidity and mortality related to poor air quality around the world.
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Background Mechanical Ventilation (MV) is a complex and central treatment process in the care of critically ill patients. It influences acid–base balance and can also cause prognostically relevant biotrauma by generating forces and... more
Background Mechanical Ventilation (MV) is a complex and central treatment process in the care of critically ill patients. It influences acid–base balance and can also cause prognostically relevant biotrauma by generating forces and liberating reactive oxygen species, negatively affecting outcomes. In this work we evaluate the use of a Recurrent Neural Network (RNN) modelling to predict outcomes of mechanically ventilated patients, using standard mechanical ventilation parameters. Methods We performed our analysis on VENTILA dataset, an observational, prospective, international, multi-centre study, performed to investigate the effect of baseline characteristics and management changes over time on the all-cause mortality rate in mechanically ventilated patients in ICU. Our cohort includes 12,596 adult patients older than 18, associated with 12,755 distinct admissions in ICUs across 37 countries and receiving invasive and non-invasive mechanical ventilation. We carry out four different...
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Research Interests: Medicine, Logistic Regression, Humans, Congestive Heart Failure, INTENSIVE CARE, and 15 moreFemale, Male, Acute respiratory distress syndrome, Anesthesia, Cohort Study, Length of Stay, Logistic Regression Analysis, Clinical Sciences, Intensive Care Unit, Mechanical Ventilation, Intensive Care Medicine, Intensive Care Units, Logistic Models, Cohort Studies, and Continuous Positive Airway Pressure
Research Interests: Asthma, Medicine, Humans, Chronic Disease, Lung Diseases, and 15 moreAmerican, Liberation, Length of Stay, Intensive Care Unit, Adult, Odds ratio, Mechanical Ventilation, Chronic obstructive pulmonary disease, Intensive Care Units, Intubation, Logistic Models, Confidence Interval, Cohort Studies, Acute Disease, and Medical and Health Sciences
Research Interests: Treatment Outcome, Medicine, Comorbidity, Humans, COPD, and 12 moreBiomedical Research, Consensus, Risk factors, Lung, Medline, Systematic review, Risk Factors, Predictive value of tests, Severity of Illness Index, Respiratory function tests, Medical and Health Sciences, and Pulmonary Disease Chronic Obstructive
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Research Interests: Medicine, Prospective studies, Humans, COPD, Internal Medicine, and 13 moreFemale, Male, Cohort, Health Status, Aged, Middle Aged, Questionnaires, Vital Capacity, Chronic obstructive pulmonary disease, Severity of Illness Index, Prospective Cohort Study, Exacerbation, and Pulmonary Disease Chronic Obstructive
Research Interests: Medicine, Linear models, Multivariate Analysis, Humans, COPD, and 15 moreInternal Medicine, Female, Male, Dyspnea, Lung, Aged, Middle Aged, Bronchitis, Chronic obstructive pulmonary disease, Disease Progression, Cough, Logistic Models, Chronic Bronchitis, Exacerbation, and Pulmonary Disease Chronic Obstructive
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Research Interests: Medicine, Critical Care, Multivariate Analysis, Humans, Female, and 15 moreMale, Aged, Middle Aged, Mechanical Ventilation, Ards, Age Factors, Cardiovascular Diseases, Body Weight, Intensive Care Units, Hospital Mortality, Drug Utilization, Cohort Studies, Heart arrest, Medical and Health Sciences, and Respiration Artificial
Research Interests: Evidence Based Medicine, Medicine, Comorbidity, Humans, COPD, and 15 moreBiomedical Research, Europe, Consensus, Female, Male, Risk factors, Lung, Medline, Prognosis, Risk Factors, Disease Management, Predictive value of tests, Respiratory function tests, Medical and Health Sciences, and Pulmonary Disease Chronic Obstructive
Research Interests: Medicine, Comorbidity, Humans, COPD, Internal Medicine, and 14 moreSmoking, Female, Male, Follow-up studies, Lung, Middle Aged, Spirometry, Vital Capacity, Chronic obstructive pulmonary disease, Disease Progression, Confidence Interval, Exacerbation, Medical and Health Sciences, and Pulmonary Disease Chronic Obstructive
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Research Interests: Clinical Trial, Medicine, Humans, COPD, Smoking, and 15 moreFemale, Classification, Male, Cohort, Aged, Middle Aged, Chronic obstructive pulmonary disease, Budesonide, Proportional Hazards Models, Agonist, Adrenal cortex hormones, Medical and Health Sciences, Corticosteroid, Bronchodilator agents, and Pulmonary Disease Chronic Obstructive
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Research Interests: Evidence Based Medicine, Treatment Outcome, Medicine, Comorbidity, Policy making, and 15 moreHumans, Biomedical Research, Europe, Consensus, United States, Risk factors, Lung, Intensive Care Medicine, Risk Factors, Pulmonary disease, Predictive value of tests, Severity of Illness Index, Respiratory function tests, Medical and Health Sciences, and Pulmonary Disease Chronic Obstructive
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Category B is described as low risk and high symptoms, whereas category C represents low symptoms and high risk. However, the two studies on relation between the risk categories and future exacerbations provide conflicting results, but... more
Category B is described as low risk and high symptoms, whereas category C represents low symptoms and high risk. However, the two studies on relation between the risk categories and future exacerbations provide conflicting results, but indicate that there are high risks in group B. Because management recommendations are based on this risk assessment, they could produce inappropriate advice. For 4,5
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Research Interests: Comparative Study, Medicine, Biological Sciences, DNA, Humans, and 15 moreCOPD, Female, Male, Incidence, Clinical Sciences, Aged, Middle Aged, Genotype, Randomized Controlled Trial, Age Factors, Chronic obstructive pulmonary disease, Multicenter Study, Medical and Health Sciences, Pulmonary Disease Chronic Obstructive, and Genetic predisposition to disease
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Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These features have not been... more
Background Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These features have not been well-studied using large-scale gene expression datasets. We hypothesized that there are divergent gene, pathway, and cellular signatures between COPD and IPF. Methods We performed RNA-sequencing on lung tissues from individuals with IPF (n = 231) and COPD (n = 377) compared to control (n = 267), defined as individuals with normal spirometry. We grouped the overlapping differential expression gene sets based on direction of expression and examined the resultant sets for genes of interest, pathway enrichment, and cell composition. Using gene set variation analysis, we validated the overlap group gene sets in independent COPD and IPF data sets. Results We found 5010 genes differentially expressed between COPD and control, and 11,454 genes differentiall...