- box 354300
CHID
University of Washington
Seattle, Wa 98195
Phillip Thurtle
University of Washington, Comparative History of Ideas, Faculty Member
- Film Theory, Animation, Critical Medical Studies, Human-Animal Relations, Marxism, Installation Art, and 47 moreInformation Society, Death Studies, Cellular Biology, Book History, Mobility/Mobilities, Conservation Biology, Material Culture Studies, Gerontology, Anthropology, Gender Studies, Psychology, Philosophy, World Literatures, Music, Digital Divide, Visual Studies, Humanities, Intellectual Property, Biomedicine, Biology, Digital Humanities, Informatics, Art, Medical Imaging, Critical Theory, Bioinformatics, Genetics, Zoology, Cultural Studies, Cognitive Psychology, Comparative Literature, Biological Anthropology, Human Evolution, New Media, Developmental Biology, Feminist Theory, Immunology, Memory (Cognitive Psychology), Postcolonial Studies, Technology (Gerontology), Women's Studies, History, Frankfurt School, Science and Technology Studies, Computer Networks, Databases, and Softwareedit
By investigating the practices and beliefs of Gilded Agetrotting horse breeders, this article demonstrates therelationship between industrial economic development and thegrowth of genetic reasoning in the United States. As mosthistorians... more
By investigating the practices and beliefs of Gilded Agetrotting horse breeders, this article demonstrates therelationship between industrial economic development and thegrowth of genetic reasoning in the United States. As mosthistorians of biology already know, E.H. Harriman, LelandStanford, and John D. Rockefeller not only transformed Americanbusiness practice, they donated heavily to institutions thatpromoted eugenic research programs. What is not widely known,
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Research Interests: Art and Naturalism
The HLA-DQ region contains highly polymorphic alpha and beta loci, so that a diverse set of cis- and trans-associated class II alpha/beta dimers are potentially generated in heterozygous individuals. To evaluate the extent of this... more
The HLA-DQ region contains highly polymorphic alpha and beta loci, so that a diverse set of cis- and trans-associated class II alpha/beta dimers are potentially generated in heterozygous individuals. To evaluate the extent of this predicted diversity, DQ2 beta or DQ3.2 beta cDNA were introduced into a panel of homozygous B cell lines that expressed different DQ alpha alleles. Restricted patterns of alpha/beta pairing were observed in which DQ2 beta and DQ3 beta molecules were unable to pair efficiently with DQ1 alpha chains. This pairing anomaly may contribute to altered class II phenotypes in heterozygous individuals, and is reflected in the absence of either DQ1 alpha, DQ2 beta or DQ1 alpha, DQ3 beta haplotypes in the known human gene pool.
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HLA-DQ class II molecules are complex heterodimers in which polymorphic alpha- and beta-polypeptides form noncovalent associations leading to cell surface expression. Using gene transfer with retroviral vectors, we demonstrate that... more
HLA-DQ class II molecules are complex heterodimers in which polymorphic alpha- and beta-polypeptides form noncovalent associations leading to cell surface expression. Using gene transfer with retroviral vectors, we demonstrate that surface expression of heterodimers among various DQ alpha and -beta polypeptides is not universal. Two types of allele-specific constraints were found: DQ beta chains that are associated with the DQw1 specificities do not form stable cell surface heterodimers with DQ alpha chains encoded on haplotypes that are associated with DQw2, DQw3, or DQw4. Similarly, surface expression of heterodimers composed of DQw2- or DQw3-associated DQ beta chains and DQw1 DQ alpha chains were not detected. The formation of mixed isotype heterodimers also showed allelic preference: DR alpha/DQw1 beta dimers were detected on the cell surface, but DR alpha/DQw3 beta dimers were not. Failure to express class II heterodimers on the cell surface was apparently due to either ineffic...
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Retroviral vectors with an internal cytomegalovirus major immediate-early gene enhancer/promoter regulating HLA class II gene expression were used to transfer HLA cDNA into human EBV-transformed B-lymphoblastoid cell lines. HLA-DQ2 beta... more
Retroviral vectors with an internal cytomegalovirus major immediate-early gene enhancer/promoter regulating HLA class II gene expression were used to transfer HLA cDNA into human EBV-transformed B-lymphoblastoid cell lines. HLA-DQ2 beta and DQ3.2 beta cDNA were transferred into DQ3.2 and DQ2 homozygous lymphoblastoid cell lines, respectively. Serologic analysis of the infected cell lines with allospecific mAb demonstrated surface expression of these exogenous DQ molecules implying that DQ alpha-chains from DR3, DQ2-positive cells can pair with DQ3.2 beta-chains and, similarly, DQ alpha-chains from DR4, DQ3.2-positive cells can pair with DQ2 beta-chains. Immunoprecipitation of the introduced DQ3.2 beta molecule resulted in co-purification of the allotype-mismatched endogenous DQ2 alpha polypeptide. We also show that vectors with a cytomegalovirus major immediate-early gene enhancer/promoter result in higher levels of expression of the transduced gene compared to previously described ...
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... Thomas Y. Levin (Cambridge, Mass.: Harvard University Press, 1995), pp. ... Mental Life, in Readings in Social Theory: The Classic Tradition to Post-Modernism, 3rd ed ... Deidre Shauna Lynch, The Economy of Character: Novels, Market... more
... Thomas Y. Levin (Cambridge, Mass.: Harvard University Press, 1995), pp. ... Mental Life, in Readings in Social Theory: The Classic Tradition to Post-Modernism, 3rd ed ... Deidre Shauna Lynch, The Economy of Character: Novels, Market Culture, and the Business of Inner Meaning ...
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These comments are assembled from comments commissioned for and published in Techniques Journal, Issue 1, A [Animating], Spring 2021, edited by Adam Nocek and Stacey Moran https://techniquesjournal.com/issue/animating/ I’ve written my... more
These comments are assembled from comments commissioned for and published in Techniques Journal, Issue 1, A [Animating], Spring 2021, edited by Adam Nocek and Stacey Moran
https://techniquesjournal.com/issue/animating/
I’ve written my responses to the pieces below with three goals in mind. To increase understanding by emphasizing specific themes in each of the works; to draw out the relationship of these themes to the topic of the special issue: animation, broadly construed; then to begin weaving the themes of the pieces together in a narrative that is informed by but not wholly indebted to the insights of the pieces in the volume.
You can find the essays at the links provided below. The in-situ comments are distributed across the essays and can be found by following the “Comments” hyperlink provide by the editors.
https://techniquesjournal.com/issue/animating/
I’ve written my responses to the pieces below with three goals in mind. To increase understanding by emphasizing specific themes in each of the works; to draw out the relationship of these themes to the topic of the special issue: animation, broadly construed; then to begin weaving the themes of the pieces together in a narrative that is informed by but not wholly indebted to the insights of the pieces in the volume.
You can find the essays at the links provided below. The in-situ comments are distributed across the essays and can be found by following the “Comments” hyperlink provide by the editors.
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German Idealism still dominates most approaches in theoretical biology. This has led to a conception of organisms as tightly regulated self-forming systems where the demands of the whole organism dominate how the parts are coordinated.... more
German Idealism still dominates most approaches in theoretical biology. This has led to a conception of organisms as tightly regulated self-forming systems where the demands of the whole organism dominate how the parts are coordinated. This article troubles this approach by presenting aspects of biology that refuse to be synthesized into a specific whole. I call this approach “goth biology” as it recognizes the murkiness of systems of knowledge, the loosely composite nature of most living things, and the continual haunting of life by death. Methodologically, I use insights gleaned from the history of post-punk goth music to explore the role of aesthetics, timbres, and forms as elements of lives that bound disparate times and spaces without providing a unified synthesis. A form of biological experience, and a theory of how the body works, goth biology demands that one lose a conception of “self” in order to embrace the complexity of biological interactions. As the goth performance artist Anna-Varney Cantodea recently confessed in an interview: “I have long given up on any goals I might have had,” but this doesn’t keep me from being inspired by everything around me.
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This paper studies the hybridization practices of plant breeder Luther Burbank in order to better understand how the gene theory of heredity emerged from late nineteenth and early twentieth century spatial practices. Although Burbank bred... more
This paper studies the hybridization practices of plant breeder Luther Burbank in order to better understand how the gene theory of heredity emerged from late nineteenth and early twentieth century spatial practices. Although Burbank bred plants that could fit the consumption ...
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Phillip Thurtle and A.J. Nocek. “Vitalizing Thought.” Inflexions 7, “Animating
Biophilosophy” (March 2014). i-xi. www.inflexions.org
Biophilosophy” (March 2014). i-xi. www.inflexions.org
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Phillip Thurtle. “Animation and Vitality.” Inflexions 7, “Animating Biophilosophy” (March 2014). 98-117. www.inflexions.org.
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4 w The EMERGENCE of GENETIC RATIONALITY < < o I I m n 33 > PHILLIP THURTLE ... IN VIVO The Cultural Mediations of Biomedical Science Phillip Thurtle and Robert Mitchell, Series Editors ... IN VIVO The... more
4 w The EMERGENCE of GENETIC RATIONALITY < < o I I m n 33 > PHILLIP THURTLE ... IN VIVO The Cultural Mediations of Biomedical Science Phillip Thurtle and Robert Mitchell, Series Editors ... IN VIVO The Cultural Mediations ofBiomedical Science is dedicated to the ...
How grids paved the way for our biological understanding of organisms Phillip Thurtle explains how the grid came to dominate biology in the twentieth century, transforming biologists’ beliefs about how organisms were constructed. Biology... more
How grids paved the way for our biological understanding of organisms
Phillip Thurtle explains how the grid came to dominate biology in the twentieth century, transforming biologists’ beliefs about how organisms were constructed. Biology in the Grid ultimately suggests that such a grid-organized understanding of natural life inevitably has social and political dimensions, with society recognized as being made of interchangeable, regulated parts rather than as an organic whole.
Phillip Thurtle explains how the grid came to dominate biology in the twentieth century, transforming biologists’ beliefs about how organisms were constructed. Biology in the Grid ultimately suggests that such a grid-organized understanding of natural life inevitably has social and political dimensions, with society recognized as being made of interchangeable, regulated parts rather than as an organic whole.
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German Idealism still dominates most approaches in theoretical biology. This has led to a conception of organisms as tightly regulated self-forming systems where the demands of the whole organism dominate how the parts are coordinated.... more
German Idealism still dominates most approaches in theoretical biology. This has led to a conception of organisms as tightly regulated self-forming systems where the demands of the whole organism dominate how the parts are coordinated. This presentation disturbs this approach by presenting aspects of biology that refuse to be synthesized into a specific whole. I call this approach “goth biology” as it recognizes the murkiness of systems of knowledge, the loosely composite nature of most living things, and the continual haunting of life by death. Methodologically, I use insights gleaned from the history of Gothic architecture and art, gothic literature, and post-punk goth music to explore the role of aesthetics, timbres, and forms as elements of lives that bound disparate times and spaces without providing a unified synthesis.
