Bipolar Affective Disorder

We have examined a structural variant of the 5-HT2C receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5 ...

Background: There are major health care implications of Quality of Life and Disability in long-standing disorders such as bipolar affective disorder and recurrent depressive disorder. Objectives: To compare the inter episode Quality of life (QOL) and Disability in patients with the diagnosis of Bipolar affective disorder or Recurrent depressive disorder in remission. Methods: The two groups were assessed cross-sectionally. Euthymic bipolar or recurrent depressive disorder subjects were included in the study. QOL assessment was done using the World Health Organisation (WHO) QOL – Bref Kannada version. Disability was assessed using the Schedule for assessment of psychiatric disability (SAPD), which is an Indian modification of the WHO Disability assessment schedule-II. Results: There were 80 patients enrolled into the study. The mean QOL scores did not differ significantly in the two groups except for the RDD subjects experiencing higher environmental domain QOL (p=.05). The mean disa...

Background Cryptic structural abnormalities within the subtelomeric regions of chromosomes have been the focus of much recent research because of their discovery in a percentage of people with mental retardation (UK terminology: learning disability). These studies focused on subjects (largely children) with various severities of intellectual impairment with or without additional physical clinical features such as dysmorphisms. However it is well established that prevalence of schizophrenia is around three times greater in those with mild mental retardation. The rates of bipolar disorder and major depressive disorder have also been reported as increased in people with mental retardation. We describe here a screen for telomeric abnormalities in a cohort of 69 patients in which mental retardation co-exists with severe psychiatric illness. Methods We have applied two techniques, subtelomeric fluorescence in situ hybridisation (FISH) and multiplex amplifiable probe hybridisation (MAPH) to detect abnormalities in the patient group. Results A subtelomeric deletion was discovered involving loss of 4q in a patient with co-morbid schizoaffective disorder and mental retardation. Conclusion The precise region of loss has been defined allowing us to identify genes that may contribute to the clinical phenotype through hemizygosity. Interestingly, the region of 4q loss exactly matches that linked to bipolar affective disorder in a large multiply affected Australian kindred.

1 , Gülsel Yalç›n ABSTRACT: Behçet's disease and late onset rapidly cycling bipolar affective disorder: a case report A 48-year old woman who is suffering from Behcet's disease (BD) for 16 years was diagnosed as having bipolar affective disorder (BAD) at the age of 41. Correlative effects of her both illness have been examined when she has been treated in our hospital because of her new mixed episode. It has known that these kind of illnesses have different correlative effects about each other and therefore they might influence the patient's quality of life adversely. In our patient, bipolar disorder which developed about 9-10 years after the first physical manifestations of BD has come in to rapidly cycling in last 2 years, the exact opposite of this situation, the BD ameliorated after beginning of bipolar disorder , practically it was in the remission. Rapidly cycling feature of her BP illness deteriorated patient's life and comprimised her treatment. There are onl...