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    Pathophysiology of Thrombophlebitis

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    Jennifer Arde
    Thrombophlebitis is caused by Virchow's triad of venous stasis, hypercoagulability, and endothelial damage. Venous stasis occurs due to immobility from conditions like injury, surgery, or obesity. Hypercoagulability results from genetic or acquired factors that increase clotting. Endothelial damage is caused by trauma from procedures, devices, or repetitive motion that exposes connective tissue and triggers clotting. Together, these three factors can initiate the clotting cascade and lead to thrombophlebitis, characterized by tenderness, swelling, and redness in the affected vein.

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    Pathophysiology of Thrombophlebitis

    Uploaded by

    Jennifer Arde
    640 views3 pages
    Thrombophlebitis is caused by Virchow's triad of venous stasis, hypercoagulability, and endothelial damage. Venous stasis occurs due to immobility from conditions like injury, surgery, or obesity. Hypercoagulability results from genetic or acquired factors that increase clotting. Endothelial damage is caused by trauma from procedures, devices, or repetitive motion that exposes connective tissue and triggers clotting. Together, these three factors can initiate the clotting cascade and lead to thrombophlebitis, characterized by tenderness, swelling, and redness in the affected vein.

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    THROMBOPHLEBITIS

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    Thrombophlebitis is caused by Virchow's triad of venous stasis, hypercoagulability, and endothelial damage. Venous stasis occurs due to immobility from conditions like injury, surgery, or obesity. Hypercoagulability results from genetic or acquired factors that increase clotting. Endothelial damage is caused by trauma from procedures, devices, or repetitive motion that exposes connective tissue and triggers clotting. Together, these three factors can initiate the clotting cascade and lead to thrombophlebitis, characterized by tenderness, swelling, and redness in the affected vein.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    640 views3 pages

    Pathophysiology of Thrombophlebitis

    Uploaded by

    Jennifer Arde
    Thrombophlebitis is caused by Virchow's triad of venous stasis, hypercoagulability, and endothelial damage. Venous stasis occurs due to immobility from conditions like injury, surgery, or obesity. Hypercoagulability results from genetic or acquired factors that increase clotting. Endothelial damage is caused by trauma from procedures, devices, or repetitive motion that exposes connective tissue and triggers clotting. Together, these three factors can initiate the clotting cascade and lead to thrombophlebitis, characterized by tenderness, swelling, and redness in the affected vein.

    Copyright:

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    Download as DOC, PDF, TXT or read online from Scribd
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    of 3

    PATHOPHYSIOLOGY OF THROMBOPHLEBITIS

    Venous Stasis

    Virchow’s
    Triad

    Hypercoagulability Endothelial Damage

    VENOUS STASIS

    Spinal injury, Inactivity, Hospitalizati Pregnancy/ Obesity Varicose AMI, HF,


    hip fracture, sedentary on/ surgery childbirth veins late shock
    joint lifestyle
    replacement,
    stroke

    Paralysis of the Increase pressure on Impaired


    extremities lower extremities contractility

    Immobilization Prolonged bed rest Dilation of lower


    extremity veins

    Venous Stasis

    HYPERCOAGULABILITY

    Family history Prenancy/ Oral Cancer Polycythemia


    of blood childbirth contraceptives
    clotting
    disorder
    Release of
    procoagulant from
    cancerous growth. Increased RBC

    Deficiency of antithrombin Increased level of procoagulants Hemoconcentration


    III, protein C and protein S

    Hypercoagulability
    ENDOTHELIAL DAMAGE

    Indwelling venous catheter, Hip surgery/ total hip Fx/ dislocation (repetitive
    IV meds, pacing wires surgery motion injury)

    Direct trauma to the veins (especially


    femoral an iliac) infection/
    inflammatory/ inflammation of the vein

    Endothelial Damage

    Injury to vessel

    Connective tissue exposed,


    chemicals released

    Active clotting factors Inactive clotting factor

    Calcium and platelet chemicals

    Prothrombinase

    Prothrombin Thrombin

    Fibrinogen Fibrin (clot)

    Inflammation is triggered, causing


    THROMBOPHLEBITIS
    tenderness, swelling, and
    erythema

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