Republic of the Philippines

CAMARINES SUR POLYTECHNIC

DRUG STUDY

Name of Drug Dosage/Frequency Mechanism Indication Contraindication Adverse Effect Nursing Responsibilities
of Action
/Timing/Route
Glyburide is available in Increasing Glyburide is indicated Glyburide therapy should - Hypoglycemia and weight gain Close monitoring for signs and
1.25 mg, 2.5 mg, and 5 insulin alone or as part of not be re-initiated if the are the most frequently symptoms of declining blood glucose
mg tablets. secretion from combination product patient has a history of encountered adverse effects levels is required
beta cells in
with metformin, as an allergic reaction to the of glyburide.
Dosage for type 2 the pancreas.
Specifically, adjunct to diet and medication. However, - Nausea
diabetes: 1.25 mg to 20 exercise, to improve patients with previous - upper abdominal fullness
sulfonylureas Monitoring glyburide is also necessary
mg orally, once or glycemic control in adults allergic reactions to drugs - heartburn
bind to the for patients in circumstances that
GLYBURIDE divided twice daily. SUR1 receptors with type 2 diabetes of the same class may not - rash provoke the onset of hypoglycemia,
in the mellitus necessarily react to
Formulation note: non- Some side effects can be serious. If including exercise, lack of eating, and
membranes of glyburide.
micronized and the beta cells - Management of you experience any of these accidental overdosage
micronized glyburide of potassium Gestational symptoms, call your doctor
formulations are not ATP-dependent Diabetes Mellitus immediately:
bioequivalent. Dosing channels. Also, prescribers must use
- Used in Ensure patient safety, it is crucial to be
must be re-titrated These agents caution with glyburide in - yellowing of the skin or eyes
block these combination to aware of the signs and symptoms of
when switching manage glycemic hospitalized patients, who - light-colored stools hypoglycemia when initiating
channels,
between formulations. control: are malnourished, misuse - dark urine glyburide therapy
releasing
insulin after metformin alcohol, have renal and - pain in the upper right part of
Glyburide is orally cardiac dysfunctions, or the stomach
the cell - Management of
administered in typical depolarizes. At with gastrointestinal - unusual bruising or bleeding
initial dosages of 2.5 mg Type 2 Diabetes Educate patient on self-monitoring of
times, disease - diarrhea
to 5 mg, with a mellitus blood glucose levels and adhere to
sulfonylureas - fever
maximum of 40 mg daily bind to SUR2 regularly scheduled blood glucose and
- sore throat
—the maximum dosage receptors on HbA1C testing
cells in cardiac - swelling of the eyes, face, lips,
is rarely used, as many This focuses who do not tongue, or throat
tissue and the
patients with type 2 have atherosclerotic
endothelium.
diabetes do not require After the initial cardiovascular disease or In patients with liver dysfunction,
dosages higher than 10 chronic kidney disease
 Republic of the Philippines
CAMARINES SUR POLYTECHNIC
Republic of th COLLEGES
Nabua, Camarines Sur
mg per day. Clinical insulin and have not achieved monitoring of liver function tests may
effects are also secretion, their HbA1C target be necessary.
insignificant beyond sulfonylureas despite exhausting first-
can also
dosages of 10 to 15 mg line treatment options.
decrease
daily. insulin However, recent updates Educate the patient about the
clearance in in recommendations for importance of positive lifestyle
Hepatic dosing: Start first-line therapy
the liver, modifications, including smoking
dosing at 1.25 mg in increasing emphasize the
patients with hepatic cessation, adopting a healthy diet,
plasma insulin importance of tailoring
impairment. participating in an exercise program,
levels. treatment based on
Glyburide, and maintaining healthy body weight,
patient-specific factors, as ample evidence supports the
along with
glipizide, is including comorbidities benefits of lower body weight in
classified as a such as atherosclerotic achieving better diabetes control.
second- cardiovascular disease,
generation heart failure, or chronic
sulfonylurea kidney disease, as well as
due to its individual management
increased
needs
potency and
difference in
elimination,
allowing their
use in patients
with renal and
hepatic
dysfunction.
 Republic of the Philippines
CAMARINES SUR POLYTECHNIC
Republic of th COLLEGES
Nabua, Camarines Sur

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