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The aim of this study is to describe the management of three different complications associated with rhinosinusitis which developed simultaneously in the same patient. A 27-year-old man visited the emergency department with complaints of... more
The aim of this study is to describe the management of three different complications associated with rhinosinusitis which developed simultaneously in the same patient. A 27-year-old man visited the emergency department with complaints of headache and swelling of the left eye. He had sustained a blunt head injury 1 month earlier. He was diagnosed with preseptal cellulitis, subdural abscess, and Pott’s puffy tumor which was shown to be a result of rhinosinusitis after physical examination and imaging. After surgical and medical treatment, he was followed up without further complications. Complications of acute rhinosinusitis are very uncommon in the antibiotic era. Patients may suffer life-threatening outcomes if complications develop. A prompt multidisciplinary approach must be immediately established by otorhinolaryngologists, ophthalmologists and other specialists of relevance in order to diagnose and treat life-threatening complications.
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504 LARENKS VE NAZOFARENKSTE SENKRON MANTLE HÜCRELİ LENFOMA Mantle cell lymphoma is a variant of non-Hodgkin’s lymphoma and is known as a mature peripheral B-cell lymphoid neoplasm. Lymphomas of the larynx and nasopharynx are rare; mantle... more
504 LARENKS VE NAZOFARENKSTE SENKRON MANTLE HÜCRELİ LENFOMA Mantle cell lymphoma is a variant of non-Hodgkin’s lymphoma and is known as a mature peripheral B-cell lymphoid neoplasm. Lymphomas of the larynx and nasopharynx are rare; mantle cell lymphoma is exceedingly rare. In most mantle cell lymphoma cases, the tumoral lymphoid cells express nuclear cyclin D1 due to a t(11;14) chromosomal translocation between an IGH gene and CCND1. This is considered to be an important genetic event in mantle cell lymphoma. There are case reports in the literature on various histologic types of nonHodgkin’s lymphomas which affect the nasopharynx and larynx simultaneously. However, to the best of our knowledge, mantle cell lymphoma involvement of the nasopharynx and larynx simultaneously has not been reported. In this case report, the detailed clinical manifestations and pathological findings of a mantle cell lymphoma patient have been presented along with a literature review of mantle cell lymphoma.
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Turkiye Klinikleri J E N T 2004, 4 109 Parotisin benign lenfoepiteliyal kistleri (BLK), ağrısız, kistik ve genellikle iki taraflı tutulum gösteren lezyonlardır. Çocukluk ve yeti şkin dönemde görülebilen BLK’lar iki taraflı oldu ğunda HIV... more
Turkiye Klinikleri J E N T 2004, 4 109 Parotisin benign lenfoepiteliyal kistleri (BLK), ağrısız, kistik ve genellikle iki taraflı tutulum gösteren lezyonlardır. Çocukluk ve yeti şkin dönemde görülebilen BLK’lar iki taraflı oldu ğunda HIV enfeksiyonu bulgusu olarak ortaya çıkabilmektedir. Parotis bezi kistik kitlelerinin ayırıcı tanısında dü şünülmesi gereken bu patolojinin HIV ile birlikteliğinden dolayı erken tanısı önem arz etmektedir. Olgu Sunumu Kırk iki yaşında, erkek hasta sol parotiste a ğrısız kitle sebebiyle klini ğimize başvurdu. Hastanın sol parotis bezindeki a ğrısız kitlesi yaklaşık bir yıldır mevcut olup giderek büyüme göstermekteymi ş. Hastanın öz ve soy geçmi şinde herhangi bir özellik tespit edilmedi. Yapılan muayenesinde, sol parotis bölgesinde 2 x 5 cm, semisolid, a ğrısız, mobil kitle saptandı. Di ğer kulak burun bo ğaz ve sistemik muayenelerinde patoloji saptanmadı. Rutin biyokimya ve hemogram tetkik sonuçları normaldi. Yapılan boyun USG’da sol parotis süperfisyel lobunda kistik, septasyon içeren 3x5x3 cm boyutlarında kitl e izlendi. Parotis bölgesi bilgisayarlı tomografisind e sol parotis süperfisyel lobunda 22 x 47 mm boyutlarında, kistik, multiloküler kitle tespit edildi ( Şekil 1). OLGU SUNUMU / CASE REPORT.
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Background: The effects of some antioxidant and anti-inflammatory agents on the development of myringosclerosis had been investigated in some previous studies. The aim of this study was to evalute the effects of wound healing agent... more
Background: The effects of some antioxidant and anti-inflammatory agents on the development of myringosclerosis had been investigated in some previous studies. The aim of this study was to evalute the effects of wound healing agent dexpanthenol, oxidant agent H 2 O 2 and ...
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ÖZET Amaç: Alt konkalara ait anatomik varyasyonlar (AKAV) nadir görülen bir durum değildir. Alt konka ile ilgili hipertrofi dışında bildirilmiş varyasyonlar; agenezi, hipogenezi, bifidite ve pnömatizasyondur. Bu çalışmanın amacı AKAV... more
ÖZET Amaç: Alt konkalara ait anatomik varyasyonlar (AKAV) nadir görülen bir durum değildir. Alt konka ile ilgili hipertrofi dışında bildirilmiş varyasyonlar; agenezi, hipogenezi, bifidite ve pnömatizasyondur. Bu çalışmanın amacı AKAV sıklığını belirlemektir. Yöntem ve ...
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Purpose: The variations of inferior turbinates (VIT) are not rare entity. The reported variants of inferior turbinate excluding hypertrophy are agenesis, hypogenesis, bifidity and pneumatization. The aim of this study is to determine the... more
Purpose: The variations of inferior turbinates (VIT) are not rare entity. The reported variants of inferior turbinate excluding hypertrophy are agenesis, hypogenesis, bifidity and pneumatization. The aim of this study is to determine the frequency of VIT.
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Covid 19 enfeksiyonun klinik bulguları tanınmaya başladıkça tat ve koku bozukluklarının da oldukça sık rastlanan semptomlardan oldukları tespit edilmiştir. Mekanizmaları halen kesin olarak ortaya konulmamıştır. Koku bozukluğu içi ilk... more
Covid 19 enfeksiyonun klinik bulguları tanınmaya başladıkça tat ve koku bozukluklarının da oldukça sık rastlanan semptomlardan oldukları tespit edilmiştir. Mekanizmaları halen kesin olarak ortaya konulmamıştır. Koku bozukluğu içi ilk tedavi rehberi yayınlanmış olup geliştirilmesi gerekmektedir. Tat bozukluğu için ise henüz tedavi algoritması yetersizdir.
Fibrous dysplasia, which is a localized pathologic disorder of bone, is characterized by the abnormal proliferation of fibrous tissue that is interspersed with normal or immature bone. Involvement of the temporal bone, which is usually... more
Fibrous dysplasia, which is a localized pathologic disorder of bone, is characterized by the abnormal proliferation of fibrous tissue that is interspersed with normal or immature bone. Involvement of the temporal bone, which is usually unilateral, develops in only 18% of all patients with fibrous dysplasia and occurs more frequently in a monostotic rather than a polyostotic form. To our knowledge, only 3 patients with bilateral temporal bone involvement have been reported in the literature. We present the case of a patient with minimal symptoms who was diagnosed as having bilateral monostotic fibrous dysplasia of the temporal bones and a con-comitant giant cholesteatoma.
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ÖZET Amaç: Ekstraözefageal reflü kulakta östaki tüp hasarı yoluyla otitis mediaya neden olmaktadır. Bu çalışmanın amacı ratlarda deneysel reflünün neden olduğu östaki hasarının histopatolojik özelliklerini multifaktöryel olarak... more
ÖZET Amaç: Ekstraözefageal reflü kulakta östaki tüp hasarı yoluyla otitis mediaya neden olmaktadır. Bu çalışmanın amacı ratlarda deneysel reflünün neden olduğu östaki hasarının histopatolojik özelliklerini multifaktöryel olarak değerlendirmektir. Yöntem: Toplam 19 albino rat HCl/Pepsin göre iki gruba ayrıldı. İnfüzyonları uygulayabilmek amacıyla ratların tümünün nazofarenksine polietilen tüpler yerleştirildi. Tüp yoluyla 7 gün boyunca gruplardan birine HCl/Pepsin diğerine Fosfat tamp. %0.9 NaCl uygulandı. Uygulamanın 7.'nci gününde tüm ratlar sakrifiye edildi. Ratların her iki kulaklarında ve östakinin nazofarenks ve timpanum bölgelerine ait kesitlerde, goblet hücre yoğunluğu, submukozal inflamatuar hücre infiltrasyonu, submukozal bezlerdeki hasar, hipertrofi ve bağ doku artışı gruplar arasında karşılaştırıldı. Elde edilen değerler için gruplar arasındaki çoklu karşılaştırmalarda Mann-Whitney U, grup içindeki kulak (sağ/sol) ve bölgeye (‘N'/ ‘T') göre yapılan istatistikl...
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ÖZET Amaç: Allantoinin nazal mukozada yara iyileşmesi üzerine olan etkilerini incelemek ve böylece nazal yıkama solüsyonları ve nazal tampon materyalleri için kullanılabilecek yeni bir solüsyon elde etmek. Gereç ve yöntem: Çalışmamızda... more
ÖZET Amaç: Allantoinin nazal mukozada yara iyileşmesi üzerine olan etkilerini incelemek ve böylece nazal yıkama solüsyonları ve nazal tampon materyalleri için kullanılabilecek yeni bir solüsyon elde etmek. Gereç ve yöntem: Çalışmamızda ağırlıkları 240-350 gram arasında değişen 36 adet beyaz Spraque Dawley yetişkin erkek rat kullanıldı. Sağ nazal kavitelerine girilerek interdental fırça yardımı ile (brushing technique) septum, konka ve lateral nazal duvarlarında mukozal hasar oluşturuldu. Hayvanlar birinci hafta ve üçüncü hafta olmak üzere iki gruba ve bu iki grup da kontrol, distile su ve allantoin olmak üzere üç alt gruba ayrıldı. Bulgular: Histopatolojik skorlama sonuçlarına göre birinci hafta grubunda ödem ve konjesyon parametreleri açısından istatistiksel olarak anlamlı fark saptandı (p=0.05 ve p=0.005). Üçüncü hafta grubunda ise ödem, konjesyon ve fibrozis parametreleri açısından istatistiksel olarak anlamlı fark saptandı (p=0.05, p=0.027 ve p=0,022). Sonuçlar: Sonuçlarımız all...
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Objective: The definition of sudden sensorineural hearing loss (SSHL) is widely used in the literature. However, there are many cases in clinical practice that do not meet this definition. We aimed to analyze these unclassified patients... more
Objective: The definition of sudden sensorineural hearing loss (SSHL) is widely used in the literature. However, there are many cases in clinical practice that do not meet this definition. We aimed to analyze these unclassified patients to demonstrate their responses to systemic steroid therapy and their clinical features. We also aimed to compare them with the patients in the literature that are compatible with the definition. Methods: Thirty five patients with acute onset hearing loss but not meeting SSHL definition criteria in the literature were analyzed. After statistical analysis of audiometric measurements before and after treatment, two groups were recruited. Patients with hearing loss less than 3 frequencies recruited to group 1 and hearing loss at 3 or more consecutive frequencies, but with an average loss of less than 30 dB were included in group 2. Then these two groups were compared. Results: There were statistically significant differences between the patients at all f...
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Objective: This study aimed to investigate the prognostic value of systemic immune inflammation index (SII) in sudden idiopathic sensorineural hearing loss (SISNHL). Methods: Eighty-nine patients diagnosed with SISNHL were included in... more
Objective: This study aimed to investigate the prognostic value of systemic immune inflammation index (SII) in sudden idiopathic sensorineural hearing loss (SISNHL). Methods: Eighty-nine patients diagnosed with SISNHL were included in this study. SII was calculated from the complete blood count when the patients were hospitalised. The patients were treated in accordance with our routine SISNHL protocol. Hearing recovery was evaluated in accordance with Siegel’s criteria, and two main groups were created (complete and incomplete recovery groups). The control group consisted of patients who were admitted to our clinic for hearing examination. SIIs were statistically analysed amongst these three groups (control, complete recovery and incomplete recovery groups). Results: The mean SII of the three groups significantly differed (p= 0.002). The control group significantly differed from the two other groups (complete recovery group: p= 0.023, incomplete recovery group: p= 0.048). The compl...
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Hemangiomas are the most common masses of the major salivary glands in parotid glands in childhood particularly. They occur more frequently in the parotid gland and rarely the submandibular gland. Changes in blood flow dynamics within... more
Hemangiomas are the most common masses of the major salivary glands in parotid glands in childhood particularly. They occur more frequently in the parotid gland and rarely the submandibular gland. Changes in blood flow dynamics within hemangiomas may induce thrombus formation and phleboliths. Cavernous hemangioma may lead to thrombophlebitis in major salivary glands in adults. To our knowledge, cavernous hemangioma of submandibular glands containing phleboliths in childhood has not been described so far in the literature. In this article, we report the first pediatric case of a cavernous hemangioma containing multiple phleboliths in the submandibular gland mimicking submandibular sialolithiasis in a seven-year-old boy.
Research Interests: Medicine, Humans, Child, Male, Differential Diagnosis, and 3 moreParotid Gland, hemangioma, and Thrombus
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Objective:To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population.Patients and methods:Single... more
Objective:To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population.Patients and methods:Single nucleotide polymorphisms were determined in DNA from the peripheral blood erythrocytes of 48 heavy smokers (25 patients with laryngeal cancer and 23 cancer-free controls), using polymerase chain reaction.Results:There were no significant differences in age, smoking duration or smoking intensity, comparing the two groups. The homozygous AA genotype of MnSOD Val16Ala was significantly more prevalent in the cancer group than the control group (92vs13 per cent, respectively), while the heterozygous AV genotype of MnSOD Val16Ala was more prevalent in the control group than the cancer group (87vs8 per cent, respectively) (p < 0.001). There were no significant differences between the cancer and control groups regarding GPx1 Pro198Leu or CAT-262 C < T poly...
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Wound healing is a highly complex, coordinated, multistep process involving clot formation, inflammatory reaction, immune response, and finally, tissue remodeling and maturation. Many endogenous and exogenous influences, such as... more
Wound healing is a highly complex, coordinated, multistep process involving clot formation, inflammatory reaction, immune response, and finally, tissue remodeling and maturation. Many endogenous and exogenous influences, such as radiation, infection, nutrition, ...
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Endoscopic intranasal interventions are popular approaches for the diagnosis and treatment of paranasal sinus disease. A major limitation of these techniques, however, is the potential for the surgeon to become spatially disoriented and... more
Endoscopic intranasal interventions are popular approaches for the diagnosis and treatment of paranasal sinus disease. A major limitation of these techniques, however, is the potential for the surgeon to become spatially disoriented and thereby increase the risk of serious ...
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Purpose: The variations of inferior turbinates (VIT) are not rare entity. The reported variants of inferior turbinate excluding hypertrophy are agenesis, hypogenesis, bifidity and pneumatization. The aim of this study is to determine the... more
Purpose: The variations of inferior turbinates (VIT) are not rare entity. The reported variants of inferior turbinate excluding hypertrophy are agenesis, hypogenesis, bifidity and pneumatization. The aim of this study is to determine the frequency of VIT.
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Objective: This study aimed to investigate connective tissue and lymphoid tissue ratios in tonsillectomy specimens to determine differences between microanatomical structure. Methods: Tonsillectomy materials were collected from patients... more
Objective: This study aimed to investigate connective tissue and lymphoid tissue ratios in tonsillectomy specimens to determine differences between microanatomical structure. Methods: Tonsillectomy materials were collected from patients aged 3-13 years and three groups were created. Patients with larger tonsils than 3 cc and had recurrent tonsillitis history were included to the Group 1, larger tonsils than 3 cc without recurrent tonsillitis history were included to the Group 2 and tonsil sizes less than 2 cc with recurrent tonsillitis history were included to the Group 3. Masson’s Trichrome stained slides were evaluated to determine the connective and lymphoid tissues. We use Python programming language and count pixels to calculate the approximate ratio of the connective tissue area. Results: The mean connective tissue percentages were 5.45±2.50 in group 1, 5.45±2.42 in group 2 and 10.90±3.41 in group 3. There was significantly higher connective tissue ratios in group 3 compared t...
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Research Interests: Nonparametric Statistics, Immunohistochemistry, Treatment Outcome, Medicine, Animals, and 15 moreMale, Clinical Sciences, Rats, Copper Acetates, Saline, Wistar Rats, Quinolines, Reference Values, Otitis Media with Effusion, Indomethacin, Random Allocation, Methylprednisolone, Montelukast, Paediatrics and reproductive medicine, and Otitis
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The etiology of nasal polyposis and pathophysiological mechanisms of polyp formation is still poorly understood. Experimental models have suggested that nasal polyp growth requires extracellular matrix formation and is associated with... more
The etiology of nasal polyposis and pathophysiological mechanisms of polyp formation is still poorly understood. Experimental models have suggested that nasal polyp growth requires extracellular matrix formation and is associated with fibroblast proliferation. Intranasal corticosteroids appear to be useful in reducing nasal polypoid lesions and the likelihood of polyp recurrence after surgery. Basic fibroblast growth factor (bFGF) is a potent angiogenesis factor and is mitogenic for a wide range of cell types. We investigated the alteration of bFGF levels in nasal polyp tissue after administration of topical corticosteroid. Nasal polyp tissues were obtained from 36 patients with diffuse nasal polyposis before and after topical nasal steroid treatment. As a topical nasal steroid mometasone furoate was given for 4 weeks in a dosage of 200 microg/day. The bFGF levels were measured by competitive enzyme immunoassay method. The mean levels of tissue bFGF, before and after topical nasal s...
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The reasons and frequency of dry tap at myringotomy in pediatric patients with otitis media with effusion Objectives: To determine the frequency and causes of dry tap at myringotomy in pediatric patients myringotomized due to provi-... more
The reasons and frequency of dry tap at myringotomy in pediatric patients with otitis media with effusion Objectives: To determine the frequency and causes of dry tap at myringotomy in pediatric patients myringotomized due to provi- sional diagnosis of otitis media with effusion. Methods: Charts of 435 ears of 256 patients (158 male, 98 female) myringotomized due to otitis media with effusion were reviewed between years 1999-2003. The mean age was 7.1 ± 3.4, ranging between 2-16 years. Preoperative appearance of tympanic mem- brane, tympanogram, acoustic reflex, age, gender, season of oper- ation were all investigated in relation to dry tap at myringotomy. Results: Two-hundred and sixty out of 435 ears were inserted myringotomy tube following fluid aspiration from myringotomy ostium. The number of dry tap at myringotomy was 175 (40.2%). Fourty-eight of these dry ears were inserted myringotomy tube due to adhesion. The total number of tube placement was 308 (70.8%). Dry tap at myring...