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Objective: To evaluate the ability of short-wavelength automated perimetry (SWAP) for the detection of visual impairment in patients with type I diabetes without retinopathy or with minor retinal vascular changes. Design: Comparative... more
Objective: To evaluate the ability of short-wavelength automated perimetry (SWAP) for the detection of visual impairment in patients with type I diabetes without retinopathy or with minor retinal vascular changes. Design: Comparative cross-sectional study. Participants: 30 eyes of 30 healthy subjects and 73 eyes of 73 patients with type I diabetes mellitus were studied. Methods: Ophthalmic examination of diabetic patients showed no retinopathy or minimal changes (less than 5 microaneurisms in each eye) with no previous laser treatment. All patients were examined by means of the SWAP 24-2 strategy. Mean Deviation (MD) and Pattern Standard Deviation (PSD) were compared between both groups. Results: There were differences in the clusters of altered points between both groups (p=0.004). SWAP MD was lower in the diabetic group than in the controls (-2.89 dB vs. -0.20 dB, p<0.001). SWAP PSD also differed between both groups (2.50 dB in control group, 3.12 dB in the diabetic group, p=0....
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Trois membres d'une famille ayant une incidence elevee de myopie forte sont presentes, avec des decouvertes au niveau corneen compatibles avec une dystrophie cristallienne centrale de Schnyder. On inclut une exploration... more
Trois membres d'une famille ayant une incidence elevee de myopie forte sont presentes, avec des decouvertes au niveau corneen compatibles avec une dystrophie cristallienne centrale de Schnyder. On inclut une exploration ophtalmologique, ainsi qu'analytique, avec elevation des niveaux du cholesterol et des triglycerides et PEV avec alteration dans conduite
Research Interests: Art and Ophtalmologie
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A randomized, prospective, double-blind, placebo-controlled study was performed to examine the effects of mitomycin-C in glaucoma filtering surgery. In the study, 32 pigmented rabbits (64 eyes) divided into 4 different groups of treatment... more
A randomized, prospective, double-blind, placebo-controlled study was performed to examine the effects of mitomycin-C in glaucoma filtering surgery. In the study, 32 pigmented rabbits (64 eyes) divided into 4 different groups of treatment were used. In the first group, ...
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This article presents the results of a study comparing retinal nerve fiber layer defects and automated perimetry (C-30-2 Humphrey program). The authors (EA, IP, MLG, LEP, and FMH) selected normotensive (control ; 40 eyes) and ocular... more
This article presents the results of a study comparing retinal nerve fiber layer defects and automated perimetry (C-30-2 Humphrey program). The authors (EA, IP, MLG, LEP, and FMH) selected normotensive (control ; 40 eyes) and ocular hypertensive eyes (173 eyes) at random and carried out a ...
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Research Interests: Ophthalmology and Biology
Sobre un modelo de cirugia filtrante en el conejo aplicamos una inyeccion subconjuntival de mitomicina-C postoperatoria valorando la evolucion clinica y la aparicion de complicaciones frente a un grupo control elegido de forma aleatoria y... more
Sobre un modelo de cirugia filtrante en el conejo aplicamos una inyeccion subconjuntival de mitomicina-C postoperatoria valorando la evolucion clinica y la aparicion de complicaciones frente a un grupo control elegido de forma aleatoria y compuesto por los ojos contralaterales de los mismos conejos. Los resultados demostraron una buena respuesta de la disminucion de la presion intraocular y mantenimiento de la ampolla en el grupo tratado, significativamente muy superiores al grupo control. Las complicaciones fueron minimas y sin diferencias significativas entre ambos grupos. Incluyeron una endoftalmitis en el grupo control y un caso de hipertension mantenida en el grupo tratado.
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LDLR, GYPA, HBGG, D7S8, GC (PM loci) and D1S80 are widely used in forensic casework analyses and population data are required to estimate the frequency of a DNA profile. This paper presents the results of a survey aimed at investigating... more
LDLR, GYPA, HBGG, D7S8, GC (PM loci) and D1S80 are widely used in forensic casework analyses and population data are required to estimate the frequency of a DNA profile. This paper presents the results of a survey aimed at investigating the allele and genotype frequency distribution of these loci in an important Spanish population (Zaragoza, North Spain). Statistical analysis to determine whether allele frequencies were in Hardy-Weinberg equilibrium was carried out as well as to obtain some parameters of medicolegal interest. There was no evidence of association between the alleles of the loci. The Zaragoza sample does not differ substantially from other Caucasian populations.
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Central nervous system depression is the predominant response to acute trichloroethylene exposure. Cranial or peripheral nerves are also affected. The paper is a case report of a bilateral retrobulbar optic neuritis caused by occupational... more
Central nervous system depression is the predominant response to acute trichloroethylene exposure. Cranial or peripheral nerves are also affected. The paper is a case report of a bilateral retrobulbar optic neuritis caused by occupational trichloroethylene poisoning. The urinary concentration of trichloroacetic acid one week after the onset of symptoms was positive. Visual fields and visual evoked potentials recovered eight months later. Other neurological diseases, such as multiple sclerosis were excluded.
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Population data were generated for the STR loci D18S535, D1S1656 and D12S391 in a population sample of unrelated healthy individuals born and living in Aragon (North Spain). The three loci were amplified using a fluorescence-based PCR... more
Population data were generated for the STR loci D18S535, D1S1656 and D12S391 in a population sample of unrelated healthy individuals born and living in Aragon (North Spain). The three loci were amplified using a fluorescence-based PCR method and were typed automatically. No deviation from Hardy-Weinberg expectations were observed. The three loci proved to be highly discriminating and valuable polymorphisms for forensic analyses.
Research Interests: Polymorphism, Biology, Medicine, Spain, Discriminant Analysis, and 12 morePopulation, Humans, Fluorescence in situ hybridization, Polymerase Chain Reaction, DNA fingerprinting, Microsatellite, Legal Medicine, Genotype, Genetic Polymorphism, Reproducibility of Results, Likelihood Functions, and Gene frequency
This article reports on a study of the effect of subconjunctival injection of mitomycin-C on fibroblast viability. Pigmented rabbits were exposed to subconjunctival injection, and tissue samples were taken 1 hour after the injection. The... more
This article reports on a study of the effect of subconjunctival injection of mitomycin-C on fibroblast viability. Pigmented rabbits were exposed to subconjunctival injection, and tissue samples were taken 1 hour after the injection. The average scleral and conjunctival proliferations from the mitomycin-C-treated tissues were found to be significantly less than the outgrowth of the eyes treated with balanced saline solution. We conclude that mitomycin-C has an important inhibitory effect on conjunctival and scleral fibroblast populations.
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Research Interests:
Copyright © 2013 Isabel Pinilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is... more
Copyright © 2013 Isabel Pinilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To evaluate the ability of frequency-doubling technology (FDT) perimetry in detecting visual field defects in young adults with type I diabetes prior to retinopathy or with minor retinovascular changes. Methods. This comparative cross-sectional study included 30 healthy subjects and 73 age-matched patients with type I diabetes mellitus. All subjects underwent a full ocular examination including an FDTwith the threshold C-20-5 strategy. Only one eye per subject was randomly included in the statistical analysis. FDT results and time to perform the test were compared between the groups. Results. The mean age was 27.1 years in the control group and 26.6 years in the diabetic group (
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We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS). One... more
We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS). One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated. Normal ranges of absolute interocular differences were established as the 95th percentile. The mean ± SD subfoveal CT (SFCT) and total CV values in the right and left eyes were 342.03 ± 77.38 versus 361.64 ± 76.45 µm (correlation coefficient ρ = 0.820; p < 0.001) and 0.27 ± 0.06 versus 0.28 ± 0.06 mm3 (ρ = 0.830; p < 0.001), respectively. Differences in 5 of the 9 areas of the ETDRS map were statistically significant (p < 0.05), but with a strong interocular correlation (ρ > 0.8; p < 0.001). The 95th percentile of interocular ...
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To describe the presumed retinal toxicity after using specific batches of perfluorocarbon liquid ALA OCTA (Alamedics, Dornstadt, Germany) in pars plana vitrectomy. This is an observational retrospective consecutive case series analyses of... more
To describe the presumed retinal toxicity after using specific batches of perfluorocarbon liquid ALA OCTA (Alamedics, Dornstadt, Germany) in pars plana vitrectomy. This is an observational retrospective consecutive case series analyses of patients operated on pars plana vitrectomy for retinal detachment or intraocular lens subluxation, using the 150141 or 200114 batches of perfluorocarbon liquid ALA OCTA as assistance during the surgery in a single center. Patients were included in this report if they manifested retinal toxicity signs throughout the follow-up, such as retinal and retinal pigment epithelium atrophy, disk paleness, and intensive macular fibrosis. Spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany) and Ultra-Wide Field 200° retinal camera (Optos P200Tx; Optos, Scotland, United Kingdom) images, electrophysiological tests, and visual fields were performed to analyze the retinal structure and functionality. Seven of 80 patients showed all the described signs of toxicity, after a mean follow-up of 34.29 days (range: 10-87) since surgery. Four patients needed a second pars plana vitrectomy because of tractional retinal detachment and proliferative vitreoretinopathy, and two of them underwent a third surgery because of redetachment. All patients experienced amaurosis or central scotoma, with a final best-corrected visual acuity ranging from 20/200 to light perception. Presumed toxic batches of perfluorocarbon liquid may cause massive retinal toxicity. A rapid suspicion, a correct traceability of surgical products, and informing health authorities are fundamental to prevent further cases of toxicity.
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PURPOSE To assess the prevalence of vitreoretinal interface abnormalities in a general population of healthy adults ≥45 years of age. DESIGN Cross-sectional study carried out at 17 ophthalmology services throughout Spain. PARTICIPANTS... more
PURPOSE To assess the prevalence of vitreoretinal interface abnormalities in a general population of healthy adults ≥45 years of age. DESIGN Cross-sectional study carried out at 17 ophthalmology services throughout Spain. PARTICIPANTS Between September 2015 and March 2016, all consecutive healthy persons aged ≥45 years who were accompanying patients to ophthalmology services were invited to take part in the study. Exclusion criteria were known retinal disease, uveitis, history of ocular trauma or previous intraocular surgery (including cataract surgery and intravitreal injections), severe myopia (>-6 dioptres), and poor ocular media transparency. METHODS Spectral-domain OCT or swept-source OCT was performed on all participants. Diseases of the vitreomacular interface were classified according to the OCT-based anatomic classification system of the International Vitreomacular Traction Study Group. All pathologic and borderline images as well as doubtful cases were evaluated blindly in a central reading center. MAIN OUTCOME MEASURES Prevalence of vitreomacular interface abnormalities (vitreomacular traction epiretinal membrane, lamellar hole). RESULTS The study included 2257 participants with a mean age of 59.5 years (range 45-90), and a total of 4490 eyes (right eyes 2242, left eyes 2248). Vitreoretinal interface abnormalities were detected in 70 eyes, with a prevalence of 1.6%. Vitreomacular adhesion was observed in 1317 eyes (29.3%). Results of spectral-domain OCT or swept-source OCT examination were unrevealing in 3103 eyes. Vitreoretinal interface abnormalities were found in 61 participants, with a prevalence in the study population of 2.7%. Vitreomacular traction was observed in 14 participants (0.6%), epiretinal membrane in 44 (1.9%), and lamellar macular hole in 3 (0.1%). The prevalence of both vitreomacular traction and epiretinal membrane increased significantly with age. The presence of vitreoretinal interface abnormalities was unrelated to concomitant diabetes mellitus or hypertension. CONCLUSIONS An important percentage of healthy participants from the general population ≥45 years of age showed vitreoretinal interface abnormalities. Screening with OCT is advisable at any first routine consultation or preoperative assessment, particularly in older participants.
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The PCR-based DNA loci LDLR, GYPA, HBGG, D7S8, GC and HLA DQA1 are widely used in forensic casework analyses. Population data on the distribution of allele frequencies are desired to estimate the rarity of a DNA profile. We studied the... more
The PCR-based DNA loci LDLR, GYPA, HBGG, D7S8, GC and HLA DQA1 are widely used in forensic casework analyses. Population data on the distribution of allele frequencies are desired to estimate the rarity of a DNA profile. We studied the allele distributions at these forensically important DNA markers in two Spanish populations (Central Pyrenees and Teruel). Results were in agreement with Hardy-Weinberg expectations. Furthermore, there was little evidence for departures from expectation of independence between loci within the two sample populations. Tests for homogeneity were carried out between the two Spanish populations and a U.S. Caucasian population.
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Whole blood samples were collected from healthy unrelated donors born and living in Aragon (n = 136) and Asturias (n = 120). DNA was isolated using standard phenol-cloroform extraction method. Amplification was carried out according to... more
Whole blood samples were collected from healthy unrelated donors born and living in Aragon (n = 136) and Asturias (n = 120). DNA was isolated using standard phenol-cloroform extraction method. Amplification was carried out according to Nievas (1) in a PE 2400 thermocycler (PE Biosystems). Each locus was amplified individually, except DYS389I/II and DYS385 (two loci each with the same set of primers). The recommendations of the International Society for Forensic Genetics were followed for typing and interpretation (2). In addition, we successfully took part in the quality control exercise for Y-STRs organized by Dr. Lutz Roewer, Institute of Legal Medicine, Humboldt University, Berlin, Germany (3). Y-STR haplotype variability was evaluated by means of Analysis of Molecular Variance (AMOVA) (4,5).
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&m$?56 : Tha use Of antlmitotk agents I " flllerlno surgery has increased the rate of ~~Yx.?s In Ihose oases consIdered as havi " g a pear preoperative pmgnosis. MitOmydnC k an antiMotlc-antimelebolfte agent that inhibits... more
&m$?56 : Tha use Of antlmitotk agents I " flllerlno surgery has increased the rate of ~~Yx.?s In Ihose oases consIdered as havi " g a pear preoperative pmgnosis. MitOmydnC k an antiMotlc-antimelebolfte agent that inhibits DNA C@llWUO ". The aim of this study is to evaluate cellular eltemtions induced by the anlimnotlc In previously treated sderal PRas. w The kfl eye of twelve he&y plgmenled rabbits went under filtering surgery. and were whsequenUy separated Into two different treatment groups. During the surgical procedure the finl group (6 eyes) received MMC 0.4 mg/ml and the mcond * " Iup (5 Eyes) BSS. Sderedonly was performed one hour after surgery and the biopsies were placed in tissue cullore media. Two pdatm of each group were fixed in 97O alcohol MI days 6. 3 and 12, routinely stained with hemaloxylin and eosi " and studied through optic microscopy. &ff&: The samples of tissue treated with MMC showed a considerable cellular atypla. Fibmbiasl were bigger, Irregularly ananged. and their nuclei were fmquenuy convoluted and indented wilh savoral nucleoli. The cyloplasm also showed multiple vacuoles. ~onclwkn~ The cyl~loxic effed of MMC can be clearly observed in scleral areas sfler tlltedng wrgery. Mlawoopk studies In cellular wllure might be useful In order lo improve our knowledge about Ihe lnlfinsic effed of this anlimetabolite. PURPOSE: A previous study has shown that extracapsulaa cataract extraction (ECCE) can be performed safely with a full-thickness filtering procedure. 1le reviewed 13 cases of combined phakoemulsification, posterior chamber lens implantation and posterior lip sclerectomy and 100 control cases of phakoemulsification and posterior chamber implant to compare the safetv and efficacv of the two rxocedures MEiTiiOOS: Seven oi 13 eyes undergoing the tkiple procedure had advanced visual field loss. Four patients who underwent the triple procedure had useful vision in only one eye. The anterior chamber was filled with viscoelastic at the end of the gl;'Ct~~~fa~~~'lEs~igmatisrn was measured with a revent post-operative shallowinq keratometer, and induced astigmatism was calculated at intervals post-operatively. RESULTS: The mean intraocular pressure (IOP) of eyes-which the triple procedure was done was 19 pre-operatively on maximally tolerated medical therapy, and 13 after one year. One patient used 1 drop daily of a beta-blocker post-operatively; all others required no medications post-operatively. Maximun visual acuity was attained by one month post-operatively in all patients. NO patient lost visual acuity or visual field; and induced astiqmatism was minimal at 6 and …
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To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO). The clinical presentation is described, and the likely causes are analyzed. New biological methods for... more
To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO). The clinical presentation is described, and the likely causes are analyzed. New biological methods for testing safety of intraocular medical devices are proposed. Information regarding a series of eyes suffering acute severe events after intraocular use of a toxic PFO was analyzed. Four types of spectroscopy, nuclear magnetic resonance, and chromatography were used to identify the potential PFO contaminants. Cultures of human retinal pigment epithelial cells (ARPE-19) and porcine neuroretina were used to quantify the toxicity of the suspect PFO lots. Of 117 cases of intraocular toxicity, 96 were considered clearly related to the use of PFO. Fifty-three cases had no light perception, and 97 had no measurable visual acuity. Retinal necrosis (n = 38) and vascular occlusion (n = 33) were the most characteristic findings. Two hydroxyl compounds, perfluoroo...
Research Interests: Mass Spectrometry, Magnetic Resonance Spectroscopy, Medicine, Retinal Pigment Epithelium, Visual acuity, and 11 moreVitreoretinal Surgery, Humans, Animals, Retinal detachment, Retina, Optometry and Ophthalmology, Fourier transform infrared spectroscopy, Swine, Retrospective Studies, Gas Chromatography/mass Spectrometry, and Acute Disease
Research Interests: Archives, High Frequency, Prospective studies, Humans, Optic Nerve, and 14 moreFemale, Male, Retina, Intraocular Pressure, Technique, Exploration, Short wavelength automated perimetry, Middle Aged, Optometry and Ophthalmology, Adult, Vision Disorders, Visual Fields, Perimetry, and Ocular Hypertension
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A case of mixed carcinoma of the parotid gland (an epidermoid carcinoma located in a pleomorphic adenoma) metastatic to the choroid is presented. The histopathology of the tumor is discussed. A 65-year-old man was admitted complaining of... more
A case of mixed carcinoma of the parotid gland (an epidermoid carcinoma located in a pleomorphic adenoma) metastatic to the choroid is presented. The histopathology of the tumor is discussed. A 65-year-old man was admitted complaining of blurred vision in his right eye for 1 day. He underwent parotidectomy for mixed carcinoma of the parotid gland (an epidermoid carcinoma located in a pleomorphic adenoma that was completely excised) 6 months before. Funduscopic examination showed a nasal retinal detachment, with gray-whitish, minimally elevated nodular choroidal lesions. Fluorescein angiography and contact B-scan ultrasonography confirmed the presence of an underlying mass. The right eye was enucleated and an epidermoid infiltrating carcinoma was identified. Metastatic tumors are the most common intraocular malignancies, and the choroid is by far the most common location for intraocular metastases. There are few cases reported of parotid tumors metastatic to the orbit. To the best of our knowledge, no histological examination of an ocular metastatic mixed carcinoma of the parotid gland has yet been reported.
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Research Interests: Risk, Probability, Visual acuity, Prospective studies, Humans, and 15 moreGlaucoma, Intraocular Pressure, SWAP, Risk factors, Clinical Sciences, Middle Aged, Optometry and Ophthalmology, Adult, ACTA, Vision Disorders, Retinal Ganglion Cells, Visual Fields, Risk Factors, Neurosciences, and Ocular Hypertension
Research Interests: Treatment Outcome, Endophthalmitis, Visual acuity, Aspergillus, Humans, and 18 moreGlucose, Female, Retinal detachment, Candida, Fluconazole, Male, Retina, Follow-up studies, Risk factors, Middle Aged, Optometry and Ophthalmology, Adult, Antifungal Agents, Itraconazole, Risk Factors, Cryosurgery, Vitrectomy, and Postoperative Complications
Research Interests: Adolescent, Humans, Diabetic Retinopathy, Female, Male, and 3 moreBiomed, Adult, and Type 2 Diabetes Mellitus
Research Interests: Optical coherence tomography, Prospective studies, Humans, Diabetic Retinopathy, Female, and 11 moreMale, Three Dimensional Imaging, Young Adult, Risk factors, Clinical Sciences, Optometry and Ophthalmology, Adult, Public health systems and services research, Sex Factors, Prognosis, and Risk Factors
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Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section,... more
Preliminary results of a larger investigation on correlation between Retinal Nerve Fiber Layer Defects (RNFL) and Automated Perimetry (AP) are presented. A group of ocular hypertensive patients was recruited and a cross-section, randomized study was carried out. The group was composed of 54 eyes from 28 patients; 15 men and 13 women, mean age 42.76 year, mean visual acuity 0.95 (Snellen cart) and mean visual defect expressed in diopters was +0.514 (from -2.5 to +5). A total of 17 (31.48%) refractive fields were pathologic according to our criteria, one from a normal RNFL and the others from nerve fiber defects. We observed 6 no reliable RNFL photographs, 18 normal, 11 slits, 6 wedge, 11 diffuse and 2 mixed defects. Comparing RNFL and AP, 53.33% of eyes with fiber defects had abnormal perimetries. The more evolutioned the defect, the larger percentage of abnormal visual fields were observed: 36.36% in slit defects, 66.66% in wedge, 54.55% in diffuse and 100% in mixed ones. Comparing location of defects with location of cluster of decreased sensibility points in visual field, a higher correlation in inferior than superior defects was found.
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We know very little about the relationship between the diurnal intraocular pressure variations and the progression of visual field loss. A prospective study of 149 eyes of 149 patients suffering from intraocular hypertension has been... more
We know very little about the relationship between the diurnal intraocular pressure variations and the progression of visual field loss. A prospective study of 149 eyes of 149 patients suffering from intraocular hypertension has been carried out through a minimum period of five years. At least 4 years before the appearance of field defects, we detected significant oscillations of IOP in the 64% of the cases prone to develop visual field loss. Likewise, we have found a statistically significant relationship between the presence of defects in the RNFL (retinal nerve fiber layer) and the existence of significant oscillations of IOP.
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To determine a practical method for quantifying in vivo lens absorption by human crystalline, obtaining an index of lens density in our population. 62 normal subjects were evaluated in this study (ages ranging from 20 to 71 years).... more
To determine a practical method for quantifying in vivo lens absorption by human crystalline, obtaining an index of lens density in our population. 62 normal subjects were evaluated in this study (ages ranging from 20 to 71 years). TESTING PROCEDURE: Measurements of dark-adapted scotopic thresholds for 450 nm and 656 nm stimuli were obtained (Tubinger perimeter) in order to determine ocular media absorption. Van Norren and Vos&amp;amp;#39;s procedure was used to calculate ocular media absorption transmission loss. Least-squares linear regressions were used to correlate lens density to age. A gradual and approximately linear increase in average lens absorbance was found under 55 years of age. Elder subjects showed a higher increase in this absorbance with higher variability. A correction factor for age-related ocular media absorption was obtained from the calculated curve. The range was approximately 1 to 5 dB. Determination of the transmission characteristics of the preretinal media is essential for interpreting threshold sensitivity values. Increase in lens absorption has been shown to be selective for short wavelengths. Due to this fact, a correction factor for the age-related ocular media absorption should be applied to avoid misinterpretation of the Blue-on-Yellow perimetry absolute results. That factor may discriminate sensitivity losses due to changes in the lens from those due to retinal or neuronal dysfunction.
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Research Interests:
To determine if short-wavelength automated perimetry (SWAP) provides evidence that indicates early functional losses in ocular hypertensive subjects and to establish a direct comparison with early structural abnormalities in the retinal... more
To determine if short-wavelength automated perimetry (SWAP) provides evidence that indicates early functional losses in ocular hypertensive subjects and to establish a direct comparison with early structural abnormalities in the retinal nerve fiber layer (RNFL). A total of 160 eyes belonging to 83 patients with ocular hypertension (intraocular pressure &amp;amp;gt;21 mm Hg and normal results on standard automated perimetry evaluation), on which a SWAP and RNFL study were performed, were examined. One hundred twenty-eight age-matched subjects without ocular hypertension were evaluated to establish the 95% and 99% confidence intervals at each of the 76 exploration points of the SWAP test. The RNFL study results were normal in 83 cases (51.8%) and pathologic in 77 cases (48.1%). The SWAP results were pathologic in 57 cases (35.6%). Significant differences (P&amp;amp;lt;.001) were observed when comparing the distribution of normal and pathologic SWAP results among the types of defects in the RNFL (focal wedge, diffuse atrophy, and mixed atrophy). Short-wavelength automated perimetry is a useful test for the early detection of visual field losses. It is more sensitive than standard automated perimetry and provides a high association with RNFL assessment, which has proved capable of detecting signs of glaucomatous damage several years before the onset of the typical visual field defects.
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ABSTRACT Purpose To evaluate the ability of Fourier-domain (FD) OCT to detect retinal alterations in epiretinal membrane (ERM) eyes. To test the intra-session reproducibility of macular thickness measurements in ERM and healthy subjects... more
ABSTRACT Purpose To evaluate the ability of Fourier-domain (FD) OCT to detect retinal alterations in epiretinal membrane (ERM) eyes. To test the intra-session reproducibility of macular thickness measurements in ERM and healthy subjects using Cirrus and Spectralis OCT.Methods Two hundred and nine of 209 subjects (87 ERM patients and 122 healthy subjects) underwent three macular scans by the same experienced examiner using Cirrus and Spectralis OCT . Differences between healthy and ERM eyes were studied. The relationship between average thicknesses with both instruments was evaluated. Repeatability was studied by intra-class correlation coefficients and coefficients of variation (COV) for the nine areas corresponding to the ETDRS.Results Macular thickness increase was detected in ERM eyes for all OCT parameters (p