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Mayyada Wazaify

    Mayyada Wazaify

    This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. Methods: A cross-sectional study was conducted... more
    This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. Methods: A cross-sectional study was conducted in Jordan, using a self-administered online questionnaire. The questionnaire consisted of three main parts: demographics, the experience of pharmacists with abusers’ behavior, as well as their perspectives toward loperamide abuse. Results: A total of 250 community pharmacists completed the survey, 54% (135) of which were female. Almost one-third (33.2%; 83) of the participants reported exposure to suspected cases of loperamide abuse during the last six months. Pharmacists declared that most of the suspected loperamide abusers were male (60.2%), of middle–low socioeconomic status (69.9%), and between 20 and 30 years of age (57.8%). The largest quantity (packs) of loperamide requested by a single patient was around 33.2 ± 14.9 at once. As reported by ...
    This study aimed to assess the ability of community pharmacists to recognize cases of Loperamide abuse at the point of sale, their perspective of and experience towards potential abuse cases. Methods: A cross-sectional study was conducted... more
    This study aimed to assess the ability of community pharmacists to recognize cases of Loperamide abuse at the point of sale, their perspective of and experience towards potential abuse cases. Methods: A cross-sectional study was conducted in Jordan, using a self-administered online questionnaire. The questionnaire consisted of 3 main parts: demographics, the experience of pharmacists with abusers' behavior, as well as their perspectives towards Loperamide abuse. Results: A total of 250 community pharmacists completed the survey, 54% (135) of which were female. Almost one-third (33.2%; 83) of the participants reported exposure to suspected cases of Loperamide abuse during the last six months. Pharmacists declared that most of the suspected Loperamide abusers were male (60.2%), of middle-low socioeconomic status (69.9%), and between 20-30 years of age (57.8%). The largest quantity (packs) of Loperamide requested by a single patient was around 33.2±14.9 at once. As reported by phar...
    Introduction Pharmacy education and practice have developed rapidly worldwide in the past few years. This has prompted a re-evaluation of pharmaceutical education in Jordan. This study explored final year pharmacy students‘ experiences... more
    Introduction Pharmacy education and practice have developed rapidly worldwide in the past few years. This has prompted a re-evaluation of pharmaceutical education in Jordan. This study explored final year pharmacy students‘ experiences and expectations of pharmacy education as a prelude for designing delivery of a revised pharmacy curriculum. Methods A validated and pre-tested questionnaire was administered to final-year students at the two public faculties of pharmacy in Jordan. Data then was coded and statistically analyzed. Responses from open questions were subjected to thematic analysis. Results and Discussion A total of 308 students completed questionnaires from the 2 universities (JU, n=191 and JUST, n=117). Students still mainly relied on classroom teaching and devoted little time to self-directed study. They were receptive to change and offered some suggestions to improve the curriculum.For some of the questions, there was a significant different between the responses of st...
    Objectives To describe and map what is known about unconventional uses of paracetamol through a scoping review of published literature by adopting adopted a PRISMA systematic approach methodology. Key findings Four themes for... more
    Objectives To describe and map what is known about unconventional uses of paracetamol through a scoping review of published literature by adopting adopted a PRISMA systematic approach methodology. Key findings Four themes for unconventional uses of paracetamol emerged: (a) use of paracetamol in sleep (a-1) positive effect of paracetamol on sleep (n = 9) or (a-2) neutral or negative effect of paracetamol on sleep (n = 9); (b) use of paracetamol in sport (n = 13); (c) mixing paracetamol with drinks, waterpipe and illicit drugs (n = 5); and (d) miscellaneous uses (n = 4). Forty records were reviewed and charted. Available literature supports concern around the potential of harmful or non-medical use of paracetamol, especially among patients with a history of substance use, parents of young children or athletes. Summary Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It is considered remarkably safe if used within instruc...
    Background: This study is the first of its kind in Jordan to survey knowledge, attitude and participation of health sciences students at The University of Jordan (UJ) towards clinical research. Aim. To investigate UJ undergraduate Health... more
    Background: This study is the first of its kind in Jordan to survey knowledge, attitude and participation of health sciences students at The University of Jordan (UJ) towards clinical research. Aim. To investigate UJ undergraduate Health Sciences final year students’ knowledge, attitudes towards and participation of students in clinical research. Methods: A self-administered structured questionnaire, composed of 28 questions with pre-formulated answers was used. The questionnaire contained questions that examined the knowledge, attitudes towards and participation of students in clinical research. Target sample was 250 students of the 5 health sciences faculties (Medicine, Pharmacy, Dentistry, Nursing and Rehabilitation sciences). Data was coded and entered into SPSS database for Windows-version 17 for analysis. Results: out of 250 questionnaires distributed, 240 were completed (response rate= 96.0%). The majority of respondents (84.5%) reported that they had heard of the term 'c...
    Background: This study aimed to describe the situation of psychoactive substance use in Jordan during the period of 2014–2018, recorded by Anti-narcotic Department (AND).Methods: A retrospective de...
    Abstract Background: This study aimed to identify pattern of substance use among patients at two public addiction rehabilitation centers in Amman. It provided a description of substance use career and assessment of addiction severity,... more
    Abstract Background: This study aimed to identify pattern of substance use among patients at two public addiction rehabilitation centers in Amman. It provided a description of substance use career and assessment of addiction severity, quality of life and quality of sleep among participants. Methods: A quantitative cross-sectional study using a structured data collection form consisting of 4 parts: 1. General data including the demographic characteristics, medical history and career of drug abuse. 2. Severity of addiction using the severity of dependence scale (SDS). 3. Quality of life measured by the EQ-5D and 4. Quality of sleep measured by the insomnia severity index (ISI) scale. Results: A total of 93 patients from 2 treatment settings were recruited over 5 months. The total number of actively used substances was 196, with an average of 2 substances per patient. Alcohol and synthetic cannabinoids were the two most commonly used substances (39.8% and 38.7% respectively) followed by benzodiazepines (33.4%). A notable drop in heroin use was observed (5.4%, 5 out of 23 opioid user) compared to the years 2007-2009. The mean SDS score among patients was 11.43 (SD ± 3.48) indicating high dependence. Sleep problems were reported by 45% of patients. Data showed a significant role of community pharmacies in supplying drugs of abuse for users. Conclusion: Pattern of substance use changed significantly in Jordan with synthetic cannabinoids being of the top substances used and heroin use dropping. Actions should be taken to reframe the legalization of dispensing certain drugs by pharmacists without a prescription.
    Background Community pharmacists are the most accessible health professionals for patients seeking advice on minor ailments and over the counter supply. Objectives To assess the management of patients seeking advice for headache in... more
    Background Community pharmacists are the most accessible health professionals for patients seeking advice on minor ailments and over the counter supply. Objectives To assess the management of patients seeking advice for headache in community pharmacies in Jordan. Method A cross-sectional study was conducted using simulated patient in three cities in Jordan. A trained simulated patient enacted an advice-seeking scenario for the treatment of a headache. The visits were evaluated using pre-defined criteria relating to content and communication skills. Results Of 72 community pharmacies invited, 50 (69.4%) agreed to participate. Of these, 38 (76%) pharmacies were visited. The median duration of the visit was 2 min (20 s-4 min). All visits resulted in selling a drug. Paracetamol combinations often with caffeine were recommended in over 50% of visits. Drug sale recommendations were often made without obtaining essential information about symptoms or patient medical history. Only brand nam...
    This study explores the prevalence, type, frequency, purpose and pattern of herbal preparation use as complementary and alternative medicine (CAM) in a cohort of patients with diabetes in Jordan. The study took the form of a... more
    This study explores the prevalence, type, frequency, purpose and pattern of herbal preparation use as complementary and alternative medicine (CAM) in a cohort of patients with diabetes in Jordan. The study took the form of a cross-sectional survey of patients attending the outpatient departments at The National Centre for Diabetes, Endocrine and Genetics (NCDEG), in Amman. The method was based on semi-structured questionnaire. A total of 1000 diabetes patients were interviewed. Of the participants, 16.6% (n=166) reported using herbs. Most of CAM users were in the age group 51-60 years (n=73, 44.0%) and predominantly female (59.6%). 139 of the CAM users (83.7%) had at least obtained a high school degree. The most common herbal product to be used was green tea (20.5%). This study confirmed that there is an appreciable prevalence of herbal use among patients with diabetes in Jordan.
    This thesis considers the appropriate use of over-the-counter (OTC) products (also known as non-prescription drugs) from the perspective of community pharmacy, the general public and the impact of OTC drug consumption on attendance at... more
    This thesis considers the appropriate use of over-the-counter (OTC) products (also known as non-prescription drugs) from the perspective of community pharmacy, the general public and the impact of OTC drug consumption on attendance at Accident and Emergency (A & E) departments. A community pharmacy-based awareness campaign was used to ascertain if an extensive information campaign on the safe use of OTC medicines increased public awareness and helped pharmacists identify those who abuse/misuse OTC drugs. The campaign appeared to have little effect on patients' advice seeking behaviour, which could be due to a number of reasons. A harm-minimisation model for the identification and treatment of OTC drug abuse/misuse by community pharmacists was tested in six community pharmacies. Each pharmacist identified clients suspected of abusing/misusing OTC products and attempted to recruit and treat these individuals according to the study protocol. Success was noted with some cases, with clients agreeing to stop using the products and/or try safer alternatives. Difficulties were encountered such as lack of time and confidence on the pharmacists' part and lack of co-operation on the part of the clients. All participating pharmacists were interviewed to obtain feedback on the harm minimisation model and to identify any problems they had encountered. Strategies for improving the model have been recommended. Research was carried out to investigate the general public's (n=1000) opinion and perceptions of OTC medicines, with a focus on their knowledge and opinion of the misuse/abuse of such preparations. The survey revealed that OTC drugs and the community pharmacist were central to self-care. Furthermore, general public in Northern Ireland were highly aware of the abuse potential of some of OTC drugs.
    Research Interests:
    The myriad changes in pharmacy practice in Jordan have transformed the pharmacist's role to be more focused on the patient and... more
    The myriad changes in pharmacy practice in Jordan have transformed the pharmacist's role to be more focused on the patient and his/her therapeutic needs than on just the traditional dispensing. This, in addition to other possible factors, is believed to have influenced pharmacists' job satisfaction and stress level in different practice settings in Jordan. This study aimed to determine the level of job satisfaction and job related stress among pharmacists in Amman. Moreover, the main causes of dissatisfaction and stress-related factors affecting pharmacists at their working positions were also explored. The study was conducted in four pharmacy practice settings: independent and chain community pharmacies as well as private and public hospital pharmacies. The study adopted the self-administered survey methodology technique using a pre-validated pre-piloted questionnaire. The questionnaire was adapted from one previously used in Northern Ireland. Data were entered into SAS database and analysed using descriptive statistics, Chi square and regression analysis. The significance level was set at P < 0.05. The level and factors affecting job satisfaction and job related stress as reported by participating pharmacists. A total of 235 registered pharmacists in Amman were involved. The pharmacists' job satisfaction was significantly affected by the type of pharmacy practice settings (P = 0.038), pharmacists' registration year (P = 0.048) and marital status (P = 0.023). Moreover, job related stress situations like patient care responsibility have been associated significantly with the type of pharmacy practice settings (P = 0.043) and pharmacists' registration year (P = 0.013). Other job stressors like long working hours, lack of advancement, promotion opportunities and poor physician pharmacists' relationship have also been reported by participants. The study concluded that community pharmacists in Amman are found to be less satisfied with their jobs than their hospital counterparts. Pharmacists' job satisfaction should be enhanced to improve pharmacists' motivation and competence. Consequently, this will improve their productivity and provision of pharmaceutical care.
    Objectives The aim of this study was to investigate the drug information resources available in community pharmacies in Amman, Jordan. Methods A total of 156 private community (retail) pharmacies in different parts of Amman, the capital... more
    Objectives The aim of this study was to investigate the drug information resources available in community pharmacies in Amman, Jordan. Methods A total of 156 private community (retail) pharmacies in different parts of Amman, the capital of Jordan, were recruited by personal contact. Pharmacists at the sample pharmacies completed a self-administered questionnaire that consisted of two sections. The first section elicited the drug information resources available in their pharmacies. The second section presented five mock medicines information scenarios and asked respondents to identify the most suitable information resource to be used from a given list. Answers then were coded and entered into SPSS for Windows for statistical analysis. Key findings All pharmacies had at least one reference book, but most were outdated. The Monthly Index of Medical Specialties (MIMS) was the most commonly found (n =101; 64.7%), and 40.4% (n = 63) had internet access. Only 19.2% (n = 30) of the responde...
    Background We conducted a scoping review focused on various forms of substance use amid the pandemic, looking at both the impact of substance use on COVID-19 infection, severity, and vaccine uptake, as well as the impact that COVID-19 has... more
    Background We conducted a scoping review focused on various forms of substance use amid the pandemic, looking at both the impact of substance use on COVID-19 infection, severity, and vaccine uptake, as well as the impact that COVID-19 has had on substance use treatment and rates. Methods A scoping review, compiling both peer-reviewed and grey literature, focusing on substance use and COVID-19 was conducted on September 15 2020 and again in April 15 2021 to capture any new studies. Three bibliographic databases (Web of Science Core Collection, Embase, PubMed) and several preprint servers (EuropePMC, bioRxiv, medRxiv, F1000, PeerJ Preprints, PsyArXiv, Research Square) were searched. We included English language original studies only. Results Of 1564 articles screened in the abstract and title screening phase, we included 111 research studies (peer-reviewed: 98, grey literature: 13) that met inclusion criteria. There was limited research on substance use other than those involving tobacco or alcohol. We noted that individuals engaging in substance use had increased risk for COVID-19 severity, and Black Americans with COVID-19 and who engaged in substance use had worse outcomes than white Americans. There were issues with treatment provision earlier in the pandemic, but increased use of telehealth as the pandemic progressed. COVID-19 anxiety was associated with increased substance use. Conclusions Our scoping review of studies to date during COVID-19 uncovered notable research gaps namely the need for research efforts on vaccines, COVID-19 concerns such as anxiety and worry, and low- to middle-income countries (LMICs) and under-researched topics within substance use, and to explore the use of qualitative techniques and interventions where ap- propriate. We also noted that clinicians can screen and treat individuals exhibiting substance use to mitigate effects of the pandemic. Funding Study was funded by the Institution for Social and Policy Studies, Yale University and The Horowitz Foundation for Social Policy. DH was funded by a NIDA grant (R01DA048860). The funding body had no role in the design, analysis, or interpretation of the data in the study.
    It is believed that psychiatry clerkship can improve communication of pharmacists with psychiatric patients. This pilot study aimed to assess and describe the effect of psychiatry clerkship on student’s attitudes and perceptions towards... more
    It is believed that psychiatry clerkship can improve communication of pharmacists with psychiatric patients. This pilot study aimed to assess and describe the effect of psychiatry clerkship on student’s attitudes and perceptions towards psychiatry, psychiatric patients and the surrounding stigma. A prospective survey was conducted at The University of Jordan to assess: 1. PharmD students’ feedback regarding: (a) the 2-week psychiatry clerkship; (b) psychopharmacology games and 2. Students' perceptions, attitudes and stigma regarding mental health. The questionnaire was adopted from three commonly used tools: Balon Attitudes towards Psychiatry, Mental Illness Clinicians Attitudes Scale (MICA) and Attitudes toward Psychiatry-30 (ATP-30). All students in the rotation filled the questionnaire (n=29). Students were highly satisfied with the clerkship and psychopharmacology games. Students had shown positive attitude towards psychiatry at the baseline, which further improved at the en...
    Abstract Background Substance Use Disorder is a chronic relapsing disease that is characterized by compulsive drug seeking and use, despite harmful consequences. The aim of this study was to evaluate the impact of clinical pharmacist... more
    Abstract Background Substance Use Disorder is a chronic relapsing disease that is characterized by compulsive drug seeking and use, despite harmful consequences. The aim of this study was to evaluate the impact of clinical pharmacist intervention/recommendation on the treatment of patients admitted to addiction rehabilitation centers in Jordan. Methods A randomized controlled trial was conducted in two public addiction treatment centers in Amman. Patients (n = 93) were randomized into 2 groups (control and intervention). Medication review was conducted for both groups at baseline, during stay and at discharge. Treatment related problems (TRPs) were identified by the clinical pharmacist and recommendations provided to the therapeutic team in the intervention group. Additionally, quality of life and quality of sleep were assessed at baseline and 2 weeks later. Results A total of 392 TRPs were identified during the study period. The mean number of TRPs ± SD was 4.22 ± 2.58 per patient. The clinical pharmacist intervention led to a reduction in the mean number of TRPs at discharge by 2.2 ± 0.85 (p < 0.001) in comparison to the control group (by 0.23 ± 0.27, p = 0.066). After 2 weeks of admission, there was an improvement of physical health (p = 0.035) and of the overall sleep status (p = 0.048) in the intervention vs. control groups. Conclusion Clinical pharmacy services provided to patients with substance use disorder reduced the number of TRPs and improved other outcomes such as physical health and quality of sleep during detoxification. Long term studies with larger sample sizes are needed.
    Background The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, such as people who... more
    Background The COVID-19 pandemic is creating severe issues for healthcare and broad social structures, exposing societal vulnerabilities. Among the populations affected by COVID-19 are people engaged in substance use, such as people who smoke; vape (e-cigarette use); use opioids, cannabis, alcohol, or psychoactive prescription drugs; or have a substance use disorder (SUD). Monitoring substance use and SUD during the pandemic is essential, as people who engage in substance use or present with SUD are at greater risk for COVID-19, and the economic and social changes resulting from the pandemic may aggravate SUD. There have been several reviews focused on COVID-19 in relation to substance use and SUD. Reviews generally did not consider on a large range of substance use variants or SUDs. We plan a scoping review that seeks to fill gaps in our current understanding of substance use and SUD, in the COVID-19 era. Methods A scoping review focused on substance use and SUD, in relation to COV...
    Appropriate household storage and use of drug products can reduce drug wastage and unnecessary hazards. We aimed to quantify the amounts and types of medications that were stored in Jordanian households and the extent of drug wastage in... more
    Appropriate household storage and use of drug products can reduce drug wastage and unnecessary hazards. We aimed to quantify the amounts and types of medications that were stored in Jordanian households and the extent of drug wastage in terms of the amount and cost of these medications. The setting was households in Amman, Jordan. This was a cross-sectional survey study using a pre-piloted questionnaire. Family members were interviewed in person about use of drug products, and where drug products were stored. The main outcomes were types, storage methods, cost and quantities of drug products in every household. Two hundred and forty-three households were approached, out of which 219 agreed to participate. A total of 2393 (mean 10.9, SD 5.2) drug products were recorded from the 219 households surveyed. A significant positive correlation was noted between the number of drug products in a household and family size (r = 0.19, P < 0.01), the level of the mother's education (r = 0....
    Antimicrobial prophylaxis in cardiac surgery has been demonstrated to lower the incidence of surgical site infection (SSI). Inappropriate antimicrobial prophylaxis, such as inappropriate selection of the antimicrobial agent or... more
    Antimicrobial prophylaxis in cardiac surgery has been demonstrated to lower the incidence of surgical site infection (SSI). Inappropriate antimicrobial prophylaxis, such as inappropriate selection of the antimicrobial agent or inappropriate dosing regimen, can increase the prevalence of antibiotic resistant strains, prolong hospital stay, cause adverse reactions, and negatively affect an institution's pharmacy budget for antibiotics. In developing countries such as Jordan, where the role of clinical pharmacists is still in its primary stages, the first step in establishing an organized clinical pharmacy service is the evaluation of current practice to determine the need for improvement. To assess the degree of adherence to international guidelines for antimicrobial prophylaxis practice in cardiac surgery performed at Queen Alia Heart Institute (QAHI) in Amman, Jordan, as part of an attempt to determine opportunities for clinical pharmacist intervention. For a total of 236 patien...
    Purpose: To explore Jordanian Pharm.D students' career choices, perceptions and expectations.Methods: This observational study was conducted during June 2013 at the University of Jordan. A total of 192 undergraduate Pharm.D students... more
    Purpose: To explore Jordanian Pharm.D students' career choices, perceptions and expectations.Methods: This observational study was conducted during June 2013 at the University of Jordan. A total of 192 undergraduate Pharm.D students were invited to complete a questionnaire prepared and validated by the research team. The questionnaire investigated student’s demographics, the reasons behind choosing to study Pharm.D, satisfaction with the Pharm.D course, student’s future plans following graduation, and student’s perceptions about the Pharm.D specialty. Data collected were encoded and analyzed by SPSS database for Windows version17.Results:The majority (93%) of respondents was females,aspired to work as hospital clinical pharmacists (83%) and many (68%) believed that Pharm.D graduates are well respected by the general public. Results indicated that students are unaware of the current Pharm.D salaries and have higher expectations than what is being currently offered in the country....
    This study investigated the abuse of over-the-counter (OTC) products (e.g., proteins, dietary supplements) and prescription drugs (e.g., hormones) in gymnasiums in Amman by random distribution of a structured questionnaire to 375 gym... more
    This study investigated the abuse of over-the-counter (OTC) products (e.g., proteins, dietary supplements) and prescription drugs (e.g., hormones) in gymnasiums in Amman by random distribution of a structured questionnaire to 375 gym clients (November 2012-February 2013). Data were analyzed using SPSS for Windows (version 17.0). A total of 31 (8.8%) clients admitted to using 21 products (mentioned 71 times) of anabolic steroids and other hormones (e.g., growth hormone and thyroxine) to increase muscular power at the gym or build muscle mass. Abuse of different prescription and OTC drugs among gymnasium clients is present in Jordan, but current methods for controlling the problem are ineffective. Better methods should be developed. The study's limitations are noted.
    The aim of this study was to investigate abuse/misuse of prescription and nonprescription drugs in community pharmacies in Jordan by random distribution of a structured questionnaire to 405 pharmacies (November 2005-January 2006). Data... more
    The aim of this study was to investigate abuse/misuse of prescription and nonprescription drugs in community pharmacies in Jordan by random distribution of a structured questionnaire to 405 pharmacies (November 2005-January 2006). Data were analyzed using SPSS for windows (version 14.0). Most respondents (94.1%) suspected that some level of abuse/misuse occurred in their pharmacy, which was highest for decongestants, cough/cold preparations, benzodiazepines, and antibiotics. Abuse/misuse of prescription and nonprescription drugs is present in Jordan, but current methods for controlling the problem are ineffective, and better methods should be developed. The study's limitations are noted..
    This study sought to describe the type, frequency, purpose and pattern of herbal preparation use as complementary medicine in a sample of patients with cancer in Jordan. The study took the form of a cross-sectional survey of patients... more
    This study sought to describe the type, frequency, purpose and pattern of herbal preparation use as complementary medicine in a sample of patients with cancer in Jordan. The study took the form of a cross-sectional survey of patients attending the outpatient departments at King Hussein Cancer Centre (KHCC), a specialist cancer centre in Amman. The method was based on using a semi-structured questionnaire. A total of 1138 patients with cancer were interviewed, out of which 404 (35.5%) reported using botanicals based complementary and alternative medicine (CAM) primarily bought form Jordan (85.1%) and used in the crude form as infusions (73.3%). Only 6.8% used herbal products in a dosage form. Most of CAM users were above 40 years of age (63.1%). Recommendation of a friend was the main factor that prompted them to use CAM (41.8%). This study revealed that CAM use is common among patients with cancer in Jordan.

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