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Estimation Risk and Optimal Portfolio Choice. VS Bawa, SJ Brown, RW Klein NORTH-HOLLAND PUBL. CO., NY, 190 pp, 1979. Portfolio theory is important not only for its own sake and for its normative implications, but also ...
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Page 1. Use of R 2 in Accounting Research: Measuring Changes in Value Relevance over the Last Four Decades Stephen Brown Kin Lo Thomas Lys JL Kellogg Graduate School of Management Northwestern University Evanston, IL 60208 ...
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The effects of agricultural improvement by cultivation, re-seeding, lime and fertiliser additions on the soil solution chemistry of acid podzolic soils have been investigated in a field experiment in a mid-Wales catchment. the treatment... more
The effects of agricultural improvement by cultivation, re-seeding, lime and fertiliser additions on the soil solution chemistry of acid podzolic soils have been investigated in a field experiment in a mid-Wales catchment. the treatment resulted in an increase in the pH, alkalinity and calcium content of soil waters from the surface, organic-rich horizon. in the year following treatment, soil waters
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Perpetuum mobile: substance, force and the sociology of translation Steven D, Brown and Rose Capdevila There are optical errors in time as there are in space' Marcel Proust The Fugitive 'One takes force as it is or one produces... more
Perpetuum mobile: substance, force and the sociology of translation Steven D, Brown and Rose Capdevila There are optical errors in time as there are in space' Marcel Proust The Fugitive 'One takes force as it is or one produces it' Michel Serres Turner Translates Carnot Abstract ...
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This work explores the eect of adding a new partitioning step into the traditional complex programmable logic device (CPLD) CAD flow. A novel algorithm based on Rent's rule and simulated an- nealing partitions a design... more
This work explores the eect of adding a new partitioning step into the traditional complex programmable logic device (CPLD) CAD flow. A novel algorithm based on Rent's rule and simulated an- nealing partitions a design before it enters the place and route stage in CPLD CAD. The resulting partitions are then placed using an enhanced placement tool. Experiments conducted on Altera'a APEX20K chips in- dicate that a partitioned placement can provide an average performance gain of 7% over flat placements.
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Historically, radiologists' official written reports have functionally been proprietary communications between radiologists and referring providers. Although never secret, these reports have traditionally been archived in the medical... more
Historically, radiologists' official written reports have functionally been proprietary communications between radiologists and referring providers. Although never secret, these reports have traditionally been archived in the medical record, with tightly controlled access. Patients rarely viewed reports directly. As patient-centered care, transparent communication, and electronic archiving have converged, however, radiologists' reports, like many other medical record components, are increasingly accessible to patients via web-based "portals." Many radiologists harbor justified anxiety about whether and how radiology reports should change in response to these portals. Direct patient access to radiology reports raises several questions, including: who are reports really for, what is their essential purpose, what content should they include or omit, what limits should be…
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We have developed and demonstrated a Hyperspectral Image Projector (HIP) intended for system-level validation testing of hyperspectral imagers, including the instrument and any associated spectral unmixing algorithms. HIP, based on the... more
We have developed and demonstrated a Hyperspectral Image Projector (HIP) intended for system-level validation testing of hyperspectral imagers, including the instrument and any associated spectral unmixing algorithms. HIP, based on the same digital micromirror arrays used in commercial digital light processing (DLP * ) displays, is capable of projecting any combination of many different arbitrarily programmable basis spectra into each
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Researchers have proposed several hypotheses about the neuromodulator systems involved in generating P3 components of the ERP. To test some of these hypotheses, we conducted a randomized placebo-controlled crossover study in which we... more
Researchers have proposed several hypotheses about the neuromodulator systems involved in generating P3 components of the ERP. To test some of these hypotheses, we conducted a randomized placebo-controlled crossover study in which we investigated how the late positive ERP response to deviant stimuli is modulated by (a) clonidine, an α2 agonist that attenuates baseline noradrenergic activity; and (b) scopolamine, a muscarinic antagonist of acetylcholine receptors. We collected EEG data from 18 healthy volunteers during the performance of an auditory oddball task with several active and passive task conditions. We then used temporospatial principal component analysis (PCA) to decompose the ERP waveforms. The PCA revealed two distinct late positive ERP components: the classic parietal P300 and the frontal novelty P3. Statistical analysis of the temporospatial factor scores indicated that in most conditions the amplitude of the classic P300 was increased by clonidine and scopolamine. In...
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Phenotypic analysis of mutant mice is limited by lack of accurate, simple, and nondestructive in utero imaging techniques. This study evaluated the usefulness of ultrasound imaging (US) to stage fetal mouse gestational age (GA) and depict... more
Phenotypic analysis of mutant mice is limited by lack of accurate, simple, and nondestructive in utero imaging techniques. This study evaluated the usefulness of ultrasound imaging (US) to stage fetal mouse gestational age (GA) and depict morphologic de- velopment. We imaged 16 pregnant CD-1 mice and a total of 92 fetuses with a 15-MHz US transducer from 9.5 d postcoitus
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Project Goals: The BioEnergy Science Center (BESC) is focused on the fundamental understanding and elimination of biomass recalcitrance. BESC's approach to improve accessibility to the sugars within biomass involves 1) designing plant... more
Project Goals: The BioEnergy Science Center (BESC) is focused on the fundamental understanding and elimination of biomass recalcitrance. BESC's approach to improve accessibility to the sugars within biomass involves 1) designing plant cell walls for rapid deconstruction and 2) developing multitalented microbes for converting plant biomass into biofuels in a single step (consolidated bioprocessing). BESC research in biomass deconstruction and
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Himmelfarb Health Sciences Library developed a worksheet to aid in making collection development decisions for the George Washington University Medical Center. This worksheet would enable the library to give priority to departments with... more
Himmelfarb Health Sciences Library developed a worksheet to aid in making collection development decisions for the George Washington University Medical Center. This worksheet would enable the library to give priority to departments with less journal coverage. By conducting departmental surveys, the library was able to prioritize purchases regarding the journal collection. This poster presentation explains the development, results, and benefits
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Identification of negation in electronic health records is essential if we are to understand the computable meaning of the records: Our objective is to compare the accuracy of an automated mechanism for assignment of Negation to clinical... more
Identification of negation in electronic health records is essential if we are to understand the computable meaning of the records: Our objective is to compare the accuracy of an automated mechanism for assignment of Negation to clinical concepts within a compositional expression with Human Assigned Negation. Also to perform a failure analysis to identify the causes of poorly identified negation (i.e. Missed Conceptual Representation, Inaccurate Conceptual Representation, Missed Negation, Inaccurate identification of Negation). 41 Clinical Documents (Medical Evaluations; sometimes outside of Mayo these are referred to as History and Physical Examinations) were parsed using the Mayo Vocabulary Server Parsing Engine. SNOMED-C was used to provide concept coverage for the clinical concepts in the record. These records resulted in identification of Concepts and textual clues to Negation. These records were reviewed by an independent medical terminologist, and the results were tallied in ...
Research Interests: Information Systems, Natural Language Processing, Decision Making, Failure Analysis, Electronic Health Record, and 15 moreHumans, Internal Medicine, Baltimore, Diagnosis, Geomatic Engineering, SNOMED CT, Randomised Controlled Trial, Clinical Sciences, IRT-likelihood Ratio, Physical examination, Chi Square Test, Clinical Decision Support Systems, High Sensitivity, Predictive value of tests, and Positive predictive value
The Himmelfarb Health Sciences Library Serials Department implemented revisions to a previously developed worksheet used to aid in more effectively making collection development decisions. The worksheet as developed was used effectively,... more
The Himmelfarb Health Sciences Library Serials Department implemented revisions to a previously developed worksheet used to aid in more effectively making collection development decisions. The worksheet as developed was used effectively, but subsequent questions and further input encouraged the original developer to identify additional parameters to measure, thus improving on the original worksheet. This poster presentation is a summary of
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Page 1. Journal of Counseling Psychology 1997, Vol. 44, No. 1, 44-52 Copyright 1997 by the American Psychological Association, Inc. 0022-0167/97/S3.00 Role of Social-Cognitive Expectations in High School... more
Page 1. Journal of Counseling Psychology 1997, Vol. 44, No. 1, 44-52 Copyright 1997 by the American Psychological Association, Inc. 0022-0167/97/S3.00 Role of Social-Cognitive Expectations in High School Students' Mathematics-Related Interest and Performance ...
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We report on the characterization of a portable, fiber-optic coupled spectroradiometer. The system was tested for radiometric stability and repeatability, wavelength calibration, stray light, linearity with optical flux, and sensitivity... more
We report on the characterization of a portable, fiber-optic coupled spectroradiometer. The system was tested for radiometric stability and repeatability, wavelength calibration, stray light, linearity with optical flux, and sensitivity to ambient temperature. Many of the measurements were performed using the NIST laser-based facility for Spectral Irradiance and Radiance responsivity Calibrations using Uniform Sources (SIRCUS). The goal of this work
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... They can be treated as thin layers of cubic stacking. I1, I2 and E correspond to 3 (eg ABC), 4 (eg ABCA) and 5 (eg ABCAB) bi-atomic layers of cubic structure, respectively. ... It is not very surprising since the I1 sequence has the... more
... They can be treated as thin layers of cubic stacking. I1, I2 and E correspond to 3 (eg ABC), 4 (eg ABCA) and 5 (eg ABCAB) bi-atomic layers of cubic structure, respectively. ... It is not very surprising since the I1 sequence has the lowest stacking fault energy. ...
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Two photometers were calibrated at six different facilities of the PTB and the NIST. At each institute a secondary calibration against other reference photometers at an optical bench, a primary calibration against reference photodiodes at... more
Two photometers were calibrated at six different facilities of the PTB and the NIST. At each institute a secondary calibration against other reference photometers at an optical bench, a primary calibration against reference photodiodes at monochromator facilities and a primary calibration with tunable lasers were performed. All measurements are traceable to the respective cryogenic radiometers used as primary and national
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Age-associated changes in power and maximal oxygen consumption (VO2max) were studied in a cross section of endurance trained cyclists. Subjects (n = 56) performed incremental cycling exercise, during which capillary blood lactate [La(-)]... more
Age-associated changes in power and maximal oxygen consumption (VO2max) were studied in a cross section of endurance trained cyclists. Subjects (n = 56) performed incremental cycling exercise, during which capillary blood lactate [La(-)] was measured. Power output increased by 30 Watts during each 5 minutes stage, with initial power output based on individual ability. When [La(-)] was >4.5 mmol·L(-1), subjects were given a 10 min recovery at a power output approximately 50% below estimated power at [La(-)]4mmol. Subjects then performed an incremental test (1 minute stages) to VO2max. Decline in VO2max was 0.65 ml·kg(-1)·min(-1)·year(-1) (r = -0.72, p < 0.01) for males, and 0.39 ml·kg(-1)·min(-1)·year(-1) (r = -0.54, p < 0.05) for females. Power at VO2max decreased by 0.048 W kg(-1)·year(-1) (r = -0.72, p…
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In this work, we describe radiometric platforms able to produce realistic spectral distributions and spatial scenes for the development of application-specific metrics to quantify the performance of sensors and systems. Using these... more
In this work, we describe radiometric platforms able to produce realistic spectral distributions and spatial scenes for the development of application-specific metrics to quantify the performance of sensors and systems. Using these platforms, sensor and system performance may be quantified in terms of the accuracy of measurements of standardized sets of complex source distributions. The same platforms can also serve
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The Department of Energy site at Hanford, WA, has been historically impacted by U and Cr from the nuclear weapons industry. In an attempt to stimulate microbial remediation of these metals, in-situ lactate enrichment experiments are... more
The Department of Energy site at Hanford, WA, has been historically impacted by U and Cr from the nuclear weapons industry. In an attempt to stimulate microbial remediation of these metals, in-situ lactate enrichment experiments are ongoing. In order to bridge the gap from the laboratory to the field, we inoculated triplicate anaerobic, continuous-flow glass reactors with groundwater collected from
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Pulmonary regurgitation (PR) following surgery of the right ventricular outflow tract (RVOT) is not innocent and leads to significant right heart dysfunction over time. Recent studies have demonstrated that percutaneous valves can be... more
Pulmonary regurgitation (PR) following surgery of the right ventricular outflow tract (RVOT) is not innocent and leads to significant right heart dysfunction over time. Recent studies have demonstrated that percutaneous valves can be implanted in conduit free outflow tracts with good outcomes. To evaluate in patients with severe PR - anticipated to require future pulmonary valve replacement - the feasibility and safety of pre-stenting dilated non-stenotic patched conduit-free right ventricular outflow tracts before excessive dilation occurs, followed by percutaneous pulmonary valve implantation (PPVI). Twenty seven patients were evaluated, but only 23 were deemed suitable based on the presence of an adequate retention zone ≤24mm defined by semi-compliant balloon interrogation of the RVOT. A 2 step procedure was performed: first the landing zone was prepared by deploying a bare stent, followed 2months later by valve implantation. RVOT pre-stenting with an open cell bare metal stent (...
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Seven high affinity antibodies to human serum transferrin which recognize at least four different epitopes are described. Apparent dissociation constants (Kd&#39;s) have been determined for the binding of the antibodies to human... more
Seven high affinity antibodies to human serum transferrin which recognize at least four different epitopes are described. Apparent dissociation constants (Kd&#39;s) have been determined for the binding of the antibodies to human transferrin in the presence and absence of iron. Small differences in reactivity were found. Five of the antibodies bind to the isolated amino-terminal half-molecule of human transferrin. Two of the antibodies appear to be to the C-terminal lobe since they bind to holo-transferrin but do not recognize the N-terminal half-molecule. Immunoblotting shows that six of the antibodies recognize both reduced and nonreduced transferrin. In addition, all of the antibodies bind with sufficiently high avidity to transferrin to make them useful as probes in studies in which binding of transferrin to the specific transferrin receptor is examined.
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We describe a time-resolved, contrast-enhanced carotid MR angiographic technique using a 3D gradient-echo sequence in combination with a sensitivity-encoding scheme. We delineate the steps involved in generating the dynamic MR... more
We describe a time-resolved, contrast-enhanced carotid MR angiographic technique using a 3D gradient-echo sequence in combination with a sensitivity-encoding scheme. We delineate the steps involved in generating the dynamic MR angiographic images, discuss issues related to image quality, and outline differences between this technique and recently reported similar methods that implement multiple parallel receivers to reduce imaging time.
Research Interests: Image Quality, Humans, Female, Male, American, and 14 moreTime Resolved, Contrast-Enhanced Ultrasound, Clinical Sciences, Aged, Middle Aged, Adult, Time Factors, MR Angiography, Sensitivity and Specificity, Reference Values, Neurosciences, Contrast Media, Carotid Stenosis, and Magnetic resonance angiography
Background This article is concerned with professional learning within multi-agency settings. Since the publication of the government document Every child matters in 2003, professionals involved in working with children and young people... more
Background This article is concerned with professional learning within multi-agency settings. Since the publication of the government document Every child matters in 2003, professionals involved in working with children and young people have been moving into newly organized services that are required to deliver improved services for vulnerable children and their families. Although new ways of professional working are described
Research Interests: Education, Professional Identity, Quality of life, Activity Theory, Social Exclusion, and 13 moreProfessional Development, Young People, Teamwork, Professional Learning, Educational, Social theories, Team work, Work in Progress, Division of Labour, Study design, Work Practice, Every Child Matters, and Data Gathering
To systematically compare the results of dobutamine stress echocardiography in matched groups of hypertensive and normotensive patients with anginal chest pain and normal coronary arteriograms (CPNA). University hospital. 33 patients with... more
To systematically compare the results of dobutamine stress echocardiography in matched groups of hypertensive and normotensive patients with anginal chest pain and normal coronary arteriograms (CPNA). University hospital. 33 patients with exertional anginal chest pain, a positive exercise stress ECG, and a completely normal coronary arteriogram; 17 had a history of systemic hypertension (14 women; mean (SD) age 57 (6) years), and 16 had no hypertensive history (12 women; age 54 (9) years). Ambulatory ECG monitoring, dobutamine stress echocardiography, and thallium-201 single photon emission computed tomography (SPECT) were performed in all subjects. All patients had normal left ventricular systolic function at rest and none fulfilled the criteria for ventricular hypertrophy. Eight normotensive patients and 10 hypertensive patients had perfusion abnormalities on thallium SPECT (p = 0.61). Dobutamine infusion reproduced anginal pain in seven normotensive and seven hypertensive patient...
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Obstruction of the venous pathways after Mustard repair for transposition of the great arteries is associated with an increased risk of arrhythmia and sudden death. The purpose of this study was to assess the effectiveness of the largest... more
Obstruction of the venous pathways after Mustard repair for transposition of the great arteries is associated with an increased risk of arrhythmia and sudden death. The purpose of this study was to assess the effectiveness of the largest (tracheal 22 x 40 mm) Wallstents in treating baffle obstructions. Retrospective analysis of patients with stented venous pathways. Eleven patients with baffle obstruction after Mustard repair for transposition of the great arteries. Stenoses were dilated with an 18 or 20 mm balloon. However, recoil was noticed in 11 patients: immediately (n = 7) or on repeat angiography (n = 4). Eighteen stents were implanted (mean (SD)) 18 (3.3) years postoperatively. After dilatation a tracheal Wallstent (11.5 F) was deployed. Relief of obstruction, haemodynamic improvement. In the inferior vena cava, 10 stents were deployed in seven baffle obstructions with an increase in diameter from 9.8 (2.4) mm to 16.5 (1.4) mm (p < 0.01) and a mean (SD) pressure gradient ...
Research Interests: Surgery, Treatment, Treatment Outcome, Adolescent, Stents, and 21 moreCatheterization, Sudden Death, Complication, Humans, Child, Female, Male, Heart, Infant, Follow-up studies, Newborn Infant, Inferior Vena Cava, Adult, Retrospective Studies, Arrhythmia, Pressure Gradient, SUPERIOR VENA CAVA, Nino, Vein, Postoperative Complications, and Child preschool
Page 1. Journal of Counseling Psychology 2000, Vol. 47, No. 1,36-49 Copyright 2000 by the American Psychological Association, Inc. 0022-0167/00/S5.00 DO1: 10.1037//0022-0167.47. 1.36 Contextual Supports and Barriers to Career Choice: A... more
Page 1. Journal of Counseling Psychology 2000, Vol. 47, No. 1,36-49 Copyright 2000 by the American Psychological Association, Inc. 0022-0167/00/S5.00 DO1: 10.1037//0022-0167.47. 1.36 Contextual Supports and Barriers to Career Choice: A Social Cognitive Analysis ...