- I am a infectious diseases and clinical microbiology specialist.edit
WOS: 000437783100003The aim of this study was to determine the microorganisms in playgrounds and sport complexes and to offer solutions for prevention methods. For this reason, equipment used by many people and toys in the playgrounds,... more
WOS: 000437783100003The aim of this study was to determine the microorganisms in playgrounds and sport complexes and to offer solutions for prevention methods. For this reason, equipment used by many people and toys in the playgrounds, especially the parts that handled and contacting to body, and swimming pools were preferred. The samples were put into bloody EMB and Sabouraud Medium, waited in 37 degree incubator and they were evaluated after 24, 48 and 72 hours. As a result of the study 218 (77,03 %) microorganisms were reproduced (217 bacteria and 1 fungus). The surfaces that bacteria were obtained from: 50 from plastic surfaces, 46 from ceramic surfaces, 43 from rubber surfaces, 31 from metallic surfaces, 25 from wooden surfaces, 17 from swimming pools, and 6 from others. 175 (80,64 %) reproduced bacteria were specified as human pathogen. The bacteria that reproduced the most were Staphylococcus hominis ssp hominis (17). As a group, the bacteria group that reproduced the most wa...
Research Interests:
Amaç: Timolol maleat'ın prezervan içeren (Timoptic %0.5) ve içermeyen (Timo-COMOD %0.5) preparatlarınm bakteriyle kontaminasyon risklerini karşılaştırmak. Yöntem: Kliniğimizde glokom nedeni ile ilaç başlanması planlanan 32 hasta... more
Amaç: Timolol maleat'ın prezervan içeren (Timoptic %0.5) ve içermeyen (Timo-COMOD %0.5) preparatlarınm bakteriyle kontaminasyon risklerini karşılaştırmak. Yöntem: Kliniğimizde glokom nedeni ile ilaç başlanması planlanan 32 hasta rasgele iki gruba ayrıldı. Grup l'de yer alan 16 hastaya prezervan (Benzalkonium klorür) içeren timolol preparatı (Timoptic %Ö.5), Grup 2'de yer alan 16 hastaya ise prezervan içermeyen timolol preparatı (Timo-COMOD %0.5) önerildi. En az 15 gün ilaç kullanımı sonrasında hastaların konjonktivalarından ve damlalarından standart mikrobiyolojik tekniklerle bakteriyolojik örnekler alındı. Sonuçlar, Student t testi ve ki-kare kullanılarak karşılaştırıldı. Bulgular: Her iki grup yaş ve cins açısından benzerdi (P0.6, P0.5, sırasıyla). Grup l'de yer alan 16 hastanın konjonktiva kültürlerinin sadece 3'ünde koagülaz negatif stafilokok'un ürediği, damlalıkların uç ve içeriklerinden alman diğer kültürlerde ise üreme olmadığı gözlendi. Grup 2'de...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Hastane enfeksiyonlarının önemli bir, etkeni olan S. auerus suşlarının kaynaklarından birisi de hastane personelidir. Metisiline dirençli S. auerus (MRSA) kökenlerinin giderek artması tedavisi zor enfeksiyonlara neden olmaktadır. Bu... more
Hastane enfeksiyonlarının önemli bir, etkeni olan S. auerus suşlarının kaynaklarından birisi de hastane personelidir. Metisiline dirençli S. auerus (MRSA) kökenlerinin giderek artması tedavisi zor enfeksiyonlara neden olmaktadır. Bu çalışmada hastane personeli ile hasta ziyaretçileri arasında burunda S.aureus taşıyıcılık oranı bakımından fark olup olmadığının ve taşıyıcılığa etkili olası faktörlerle ilişkisinin araştırılması amaçlandı. Kırıkkale Üniversitesi Tıp Fakültesi Hastanesinde görevli 219 sağlık personelinin 34'ünde (%İ5) nazal S.aureus taşıyıcılığı saptanırken (29 MSSA (Metisilin sensitif S. Auerus), 5 MRSA'); bu oran 100 hasta yakınının 10'unda (%10) (5 MSSA, 5 MRSA) tespit edildi. Hastane personelinde S. aureus taşıyıcılığı hasta yakınlarına göre anlamlı oranda yüksek bulundu (p0.044). Taşıyıcılığı etkileyen risk faktörleri (hâlen damar içi antibiötik kullanımı, son 6 ayda hastanede yatış, son 6 ayda cerrahi operasyon geçirme ve kronik hastalık öyküsü) ile taş...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Amac: Bu arastirma Kirikkale Universitesi Tip Fakultesi hastanesine ayaktan basvuran 310 gonullu diyabetes mellitus hastasi ile 200 saglikli kontrol grubunda yapildi. Hastalar ve kontrol grubuna demografik bilgileri ve asilama hikâyesini... more
Amac: Bu arastirma Kirikkale Universitesi Tip Fakultesi hastanesine ayaktan basvuran 310 gonullu diyabetes mellitus hastasi ile 200 saglikli kontrol grubunda yapildi. Hastalar ve kontrol grubuna demografik bilgileri ve asilama hikâyesini de iceren standart anket uygulandi. Arastirma Dizayni ve Metot: Serum ornekleri alinarak -20 0C ‘de saklandi. Toksin notralizasyon (TN) metodu ile serum orneklerinde difteri antikor duzeyleri olculdu. Bu metotla, < 0.01 IU/ml duzeyler hassa; ≥ 0.01 - < 0.1 IU/ml duzeyler temel koruyucu ve ≥ 0.1 IU/ml seviyeler tam koruyucu duzeyler olarak degerlendirildi. Istatistiksel analiz SPSS 8.0 programi kullanilarak yapildi. Sonuclar: Hassasiyet, temel koruyucu ve tam koruyucu duzeyler hasta ve kontrol grubunda sirasiyla %18.1, %42.5, %81.9 ve %16.5, %36.5, %83.5 olarak olculdu. Sonuclar tum titre araliguinda incelendiginde hasta ve kontrol grubu arasinda fark bulunmadi (x2=2.966, p=0.227). Sadece daha yasli hasta bireyler arasinda, istatistiksel olarak...
Research Interests:
Research Interests:
In spite of developments in the diagnosis and management of infective endocarditis, this disease still carries high rates of morbidity and mortality. Between 1997-2001, 32 episodes of endocarditis in 30 patients were treated in our... more
In spite of developments in the diagnosis and management of infective endocarditis, this disease still carries high rates of morbidity and mortality. Between 1997-2001, 32 episodes of endocarditis in 30 patients were treated in our department. Twenty-two patients were male and eight female; their ages ranged from 21-84 (mean years). Of these episodes 78% associated with native valve and 21% with prosthetic valve. Fever, fatigue, chills, dyspnea were the most common clinical findings. Blood cultures were positive in 78.1% (25/32) of the episodes, revealing Staphylococcus spp. (12), Streptococcus spp. (6), Enterococcus spp. (3), Stenotrophomonas maltophilia (2), Pseudomonas aeruginosa (1), Listeria spp. (1). During follow-up 34.3% of the episodes were complicated by emboli and the overall mortality rate was 40.6%. The presence of congestive heart failure was found as the major risk factor affecting the prognosis of the disease. In view of this grave outcome of this disease, prompt dia...
In this prospective study, 7 viral and 3 atypical bacteria antigens were investigated by immunofluorescence method during January 1999-May 2000 for the etiological diagnossis of respiratory tract infections. Respiratory tract secretions... more
In this prospective study, 7 viral and 3 atypical bacteria antigens were investigated by immunofluorescence method during January 1999-May 2000 for the etiological diagnossis of respiratory tract infections. Respiratory tract secretions were obtained from children (group I, 76 cases) and adults (group II, 135 cases) who had symptoms of respiratory tract infections. Etiological diagnosis was reported as 45.4% in pediatric cases and 67.3% in adults. In group I and group II; the rates of Chlamydia pneumoniae was 17.8%, 13.3%; Mycoplasma pneumoniae 0%, 9.6%; influenza A virus 3.9%, 16.3%; adenovirus 3.9%, 14.8%; parainfluenza virus type I 5.3%, 7.4%; respiratory syncytial virus 9.2%, 1.5%; parainfluenza virus type 2 3.9%, 3.0%; and influenza B virus 1.3%, 1.5% respectively. In 2.6% and 3.9% of the patients in two groups two or more etiological agents were identified. Parainfluenza virus type 3 and Legionella pneumophila antigens could not be determined in any of the patients. The advant...
Research Interests:
and Leptospira infections in Microtus
Coronavirus disease 2019 (COVID-19) disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus, which has affected the whole world, can cause clinical pictures ranging from mild cold symptoms to severe lower... more
Coronavirus disease 2019 (COVID-19) disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus, which has affected the whole world, can cause clinical pictures ranging from mild cold symptoms to severe lower respiratory tract infections that can cause mortality. Recently, reports of dermatological findings associated with COVID-19 such as urticaria has been increasing. Here, a COVID-19 case presenting with urticaria and angioedema is described. A 26-year-old female patient, who was found to be SARS-CoV-2 positive by polymerase chain reaction performed for being in contact, presented to our outpatient clinic with complaints of itchy, erythematous lesions on her body and swelling in the eyes and throat for four days. The patient received favipiravir treatment for 5 days and these complaints started 4 days after the treatment ended. History of food and other drug allergies, insect bites and chemicals were questioned in the differential diagnosis for etiolo...
Research Interests:
Research Interests: Medicine and Amoebiasis
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
To investigate the effects of treatments of 'mad honey', blossom honey and nitrofurazone on infected wound healing. Male albino Wistar rats were randomly divided into four groups: 'mad honey' (MH), blossom honey (BH),... more
To investigate the effects of treatments of 'mad honey', blossom honey and nitrofurazone on infected wound healing. Male albino Wistar rats were randomly divided into four groups: 'mad honey' (MH), blossom honey (BH), nitrofurazone (N) and control (C). All rats were anaesthetised intraperitoneally. A circular skin incision was made to the back regions. Grafts containing slime-producing Staphylococcus epidermidis were placed on the incision area and then sutured to the skin. Infection in the wound area was confirmed after 48 hours. Wounds were dressed twice daily with the various treatment materials. Rats were randomly euthanised on days 7 or 14, and tissue samples taken. Tissue samples were assessed for hydroxyproline (HP), tensile strength (TS) and macroscopic measurement (area and intensity). HP levels were higher in the treatment groups (MH, BH, N) at days 7 and 14 compared with the control group. 'Group x day' interaction was found in the HP levels (p=0.0...
Research Interests:
This study aims to evaluate approaches and knowledge level for tuberculosis (TB) diagnosis and treatment among infectious diseases and clinical microbiology research assistants and specialist physicians. This was a descriptive study on... more
This study aims to evaluate approaches and knowledge level for tuberculosis (TB) diagnosis and treatment among infectious diseases and clinical microbiology research assistants and specialist physicians. This was a descriptive study on the research assistants and specialist physicians. A questionnaire consisting of 24 questions prepared by the researchers was used. Data were analyzed using SPSS, version 22.0. In this study, 116 physicians participated. The average age of participants was 41.07 ± 8.65 years, and 64.7% were female. The proportion of physicians with no pulmonary and non-pulmonary TB experience was calculated as 6.9% and 3.4%, respectively. Acid-fast-bacilli (AFB) tests were most frequently used in the diagnosis of pulmonary TB. On the other hand, the tuberculin skin test (TST) + chest radiography (CR) was most frequently used for latent TB in immunosuppressed subjects (91.4% and 69%, respectively). The most common non-pulmonary TB clinic form encountered was lymphadeni...
Research Interests:
Objectives: To determine whether trace elements that are essential for neural function play a role in the pathophsiology and etiology of auditory neuropathy (AN).. Materials and methods: Patients diagnosed with auditory neuropathy... more
Objectives: To determine whether trace elements that are essential for neural function play a role in the pathophsiology and etiology of auditory neuropathy (AN).. Materials and methods: Patients diagnosed with auditory neuropathy consisted of eight children (two male, six female). The blood tests including the measurement of sodium, potassium, chloride, calcium, phosphorus, iron, copper and magnesium were done in children with AN during their routine care. Results: Of the eight children with AN, many had serum levels outside the normal range: one had low sodium, two had low potassium, one had low chloride, two had high zinc and three had low zinc, two had low calcium and two had higher than normal phosphorus. Conclusion: Although some serum trace element levels in our patients were higher or lower than normal values, the mean values were within normal limits. Thus, we were unable to detect a relationship between serum trace element levels and AN-. In the future, larger studies shou...
Research Interests:
Research Interests:
Kan dolasimi enfeksiyonlarinin saptanabilmesi icin kan kulturu alinmasi gereklidir. Kan kulturleri sise sayisi ile ureme oranlari arasinda kanitlanmis bir iliski mevcuttur. R ehberler 24 saatlik sure icinde iki-dort sise kan kulturu... more
Kan dolasimi enfeksiyonlarinin saptanabilmesi icin kan kulturu alinmasi gereklidir. Kan kulturleri sise sayisi ile ureme oranlari arasinda kanitlanmis bir iliski mevcuttur. R ehberler 24 saatlik sure icinde iki-dort sise kan kulturu alinmasini onermislerdir. Bu calismada kan kultur siselerinin sayilarinin uygunlugu arastirilmistir. Bu calisma Kirikkale Universitesi Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji laboratuarinda yurutulmustur. Mart 2013-Mart 2014 tarihleri arasinda gelen her hastaya ait kan kultur siselerinin sayisi degerlendirilmistir. Rehberlere dayanarak iki ila dort kan kultur sisesi uygun olarak dusunulmustur. Kan kulturleri hastalarin cerrahi veya dahili kliniklere basvurmasina gore iki gruba ayrilmistir. Verilerin analizi icin SPSS 15.0 programi, gruplarin karsilastirilmasi icinde ki kare testi kullanilmistir. p<0.05 anlamli kabul edilmistir. Calisma suresi boyunca laboratuarimiza 621 hastadan 1095 kan kultur sisesi gonderilmistir. 435 hastanin uygun sayida (iki-dort) kan kultur sisesine sahip oldugu bulunmustur. 185 hastada sadece tek, bir hastada dortten fazla kan kultur sisesinin gonderildigi saptanmistir. Uygunsuz alim oranlari cerrahi klinikler icin %34.4 (66/192), dahili klinikler icin %27.9 (120/429) olarak saptanmistir (p= 0.107). Sonuclarimiza gore her hastane uygun kan kultur sisesi oranlarini arastirmali ve buna gore gerekli egitim programlarini yurutmelidir. Anahtar kelimeler: kan kulturu, sise sayisi Abstract For detecting blood stream infections blood cultures are essential. There is a proven relation between the number of blood cultures and growing rates. Guidelines offer that two to four blood cultures be obtained over a 24 hours period. The aim of this study was to examine the appropriateness of number of blood cultures. The study was conducted in Infectious Diseases Laboratory of Kirikkale University Hospital. From March 2013 to March 2014, the number of blood cultures obtained from each hospitalized patients and admitted to our laboratory were evaluated. In accordance with guidelines, two to four blood cultures were accepted as appropriate. Blood cultures were divided into two groups according to admission from internal diseases clinics or surgical clinics. SPSS 15.0 program was used for data analysis and chi-square test was used for comparing groups. p<0.05 was accepted as significant. During the study period, 1095 blood cultures from 621 patients had been admitted to our laboratory. 192 patients were staying in surgical clinics and 429 were in internal diseases clinics. 435 patients had an appropriate number (two to four) of blood cultures. While a single blood culture was obtained from 185 patients, more than four cultures were obtained from one patient. Inappropriateness number of blood cultures was 66 in surgical clinics and 120 in internal diseases clinics (p=0.107). According to our results all hospitals should detect their appropriateness of number of blood cultures and education programs ought to be conducted accordingly. Keywords: blood culture, number of bottle
Research Interests: Medicine and Gynecology
Research Interests:
Research Interests:
Research Interests:
Research Interests:
The aim of present study was to evaluate the occurrence of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum in non-gonococcal urethritis (NGU) and to determine the bacterial resistance to six antibiotics in order to... more
The aim of present study was to evaluate the occurrence of Chlamydia trachomatis, Mycoplasma hominis, and Ureaplasma urealyticum in non-gonococcal urethritis (NGU) and to determine the bacterial resistance to six antibiotics in order to determine the most suitable treatment strategy. A total of 50 patients were enrolled into the study. Urethral samples were taken with a dacron swab placed into urethra 2 - 3 cm in males, and vaginal samples were taken from the endocervical region in women. The patient samples that did not grow Neisseria gonorrhoeae were accepted as NGU. Direct immunofluorescence technique was used for the investigation of C. trachomatis. Mycoplasma IST was used for the isolation of M. hominis and U. urealyticum. U. urealyticum was isolated from 24 patients. Thirteen of them had only U. urealyticum, and the rest had mixed pathogen organisms (7 U. urealyticum + M. hominis; 3 U. urealyticum + C. trachomatis, and 1 U. urealyticum + M. hominis + C. trachomatis). C. tracho...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
... Ülkemizde, Ankara yöresinde Haexcavatum' un sığır ve koyunlarda Mart-Kasım ayları arasında sıklıkla görüldüğü, Elazığ yöresinde sığır, koyun ve keçilerde 12 kene türünün varlığı, Van yöresinde sığır ve koyunlarda en çok... more
... Ülkemizde, Ankara yöresinde Haexcavatum' un sığır ve koyunlarda Mart-Kasım ayları arasında sıklıkla görüldüğü, Elazığ yöresinde sığır, koyun ve keçilerde 12 kene türünün varlığı, Van yöresinde sığır ve koyunlarda en çok Rhipicephalus türleri olmak üzere 11 kene türünün ...
Turkish Journal. of. Medical Sciences. ...
Research Interests:
In this study an immunofluorescence (IF) method was used to investigate the antigens of viruses and atypical bacteria in respiratory tract infections (RTI) in pediatric and adult age groups. In this prospective study of 2 years... more
In this study an immunofluorescence (IF) method was used to investigate the antigens of viruses and atypical bacteria in respiratory tract infections (RTI) in pediatric and adult age groups. In this prospective study of 2 years (1998-2000), IF was used to investigate the antigens of 7 viral and 3 atypical bacteria to be used for the etiological diagnosis of RTI. Sputum (33.6%) and nasopharyngeal aspirate specimens were obtained from pediatric patients (Group I, 76 cases) and adults (Group II, 135 cases) with RTI symptoms. Antigen detection rates were found to be 44.7% in Group I and 67.4% in Group II (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). The following rates for specific antigens in Groups I and II, respectively, were as follows: Chlamydia pneumoniae, 17.1 and 13.3% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05); Mycoplasma pneumoniae, 0 and 9.6% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); influenza A virus, 3.9 and 16.3% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); adenovirus, 3.9 and 14.8% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); parainfluenza virus type 1, 5.3 and 7.4% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05); respiratory syncytial virus, 9.2 and 1.5% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); parainfluenza virus type 2, 3.9 and 3%(P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05); and influenza B virus, 1.3 and 1.5% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Mixed agents were found at a rate of 2.6 and 3.7% (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05) in Groups I and II, respectively. Parainfluenza virus type 3 and Legionella pneumophila antigens were not found. Since detecting etiological agents provides an important guide for determining the most appropriate antibiotic therapy, this IF method could be applied in clinical practice for arriving at a correct diagnosis and administration of effective treatment.
Research Interests: Turkey, Adolescent, Chlamydia pneumoniae, Clinical Practice, Prospective studies, and 19 moreHumans, Child, Female, Male, Infant, Monoclonal Antibodies, Respiratory Syncytial Virus, Aged, Middle Aged, Adult, Respiratory Tract Infections, influenza A virus, Bacterial infections, Sputum, Respiratory Tract Infection, Virus diseases, Detection Rate, Prospective Study, and Age Groups
Recent reports have demonstrated that automated continous monitoring blood culture systems are fast and efficent in the detection of Brucella spp. In this retrospective study, the detection of these slow-growing bacteria by BACTEC 9050... more
Recent reports have demonstrated that automated continous monitoring blood culture systems are fast and efficent in the detection of Brucella spp. In this retrospective study, the detection of these slow-growing bacteria by BACTEC 9050 blood culture system was evaluated. For this purpose, 60 patients, whose blood cultures were monitored by using BACTEC 9050 system were included into the study. Brucella spp. were isolated in 26 of 31 patients from whom two blood cultures were obtained and in 17 of 29 patients from whom single blood culture were obtained. The majority of isolates (84.1%) were detected within 7 days of incubation while the earliest detection was on the 3rd day in two samples. However, the bacteria were isolated by subcultures after 30 days of incubation in 8 of the samples. In conclusion, the routine 5 or 7 days-incubation protocols with BACTEC 9050 system were not efficient for the isolation of Brucella spp. Obtaining two blood cultures and prolonged incubation followed by subcultures increased the probability of bacterial isolation.
Research Interests: Adolescent, Humans, Child, Female, Brucella, and 9 moreMale, Mikrobiyoloji, Brucellosis, Aged, Middle Aged, Adult, Time Factors, Retrospective Studies, and Bacteremia
Abstract: Background: In this study, because of genomic mimicry of viruses and resemblance in transmission route of HCV and GBV-C/HGV infection, we aimed to investigate possible relationships between chronic GBV-C/HGV infection and NIDDM... more
Abstract: Background: In this study, because of genomic mimicry of viruses and resemblance in transmission route of HCV and GBV-C/HGV infection, we aimed to investigate possible relationships between chronic GBV-C/HGV infection and NIDDM in 88 patients with type-2 ...