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Article
Open AccessDecreasing trend in destructive potential of tropical cyclones in the South Indian Ocean since the mid-1990s
Tropical cyclone activity often leads to many adverse impacts and assessing their destructiveness is a crucial scientific concern. Here we investigated changes in the destructiveness of tropical cyclones world...
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Article
Open AccessHigh-Resolution Simulation of the Near-Field Pollutant Dispersion in a Nuclear Power Plant Community with High-Performance Computing
This study aims to employ numerical simulations to understand the dynamics of wind fields and air pollutant dispersion in the proximity of a nuclear plant, situated within a specified urban environment. By lev...
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Article
Open AccessLarge-scale photovoltaic solar farms in the Sahara affect solar power generation potential globally
Globally, solar projects are being rapidly built or planned, particularly in high solar potential regions with high energy demand. However, their energy generation potential is highly related to the weather co...
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Article
Open AccessAbnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway
Myocardial ischemia-reperfusion injury (MIRI) is one of the main reasons for poor prognosis in patients with ischemic cardiomyopathy (ICM). To date, the mechanism remains unknown. As members of the silent info...
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Article
Open AccessIncrease in tropical cyclone rain rate with translation speed
In general, tropical cyclone (TC) rainfall accumulation usually decreases with faster TC translation speed but increases with heavier rain rate. However, how the TC rain rate changes with translation speed is ...
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Article
Open AccessHerbicidal secondary metabolites from Bacillus velezensis JTB8-2 against Orobanche aegyptiaca
Egyptian broomrape (Orobanche aegyptiaca) is a parasitic plants that cause significant losses to important crops. The effective methods for controlling this weed are rare. Biological control could be one of the p...
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Article
Open AccessHigh PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma
Adaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC). Palmitoyl-protein thioesterase 1 (PPT1) plays a critical role in prog...
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Article
Open AccessChemo-photodynamic therapy with light-triggered disassembly of theranostic nanoplatform in combination with checkpoint blockade for immunotherapy of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor with high rate of metastasis and recurrence. Although immune checkpoint blockade (ICB) has emerged as a promising type of immunotherapy in advanced HC...
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Article
Open AccessLoss of exosomal LncRNA HCG15 prevents acute myocardial ischemic injury through the NF-κB/p65 and p38 pathways
Exosomes are nanosized bilayer membrane vesicles that may mediate intercellular communication by transporting bioactive molecules, including noncoding RNAs, mRNAs, and proteins. Research has shown that exosome...
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Article
Open AccessRecent global decrease in the inner-core rain rate of tropical cyclones
Heavy rainfall is one of the major aspects of tropical cyclones (TC) and can cause substantial damages. Here, we show, based on satellite observational rainfall data and numerical model results, that between 1...
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Article
Open AccessVariability in the global energy budget and transports 1985–2017
The study of energy flows in the Earth system is essential for understanding current climate change. To understand how energy is accumulating and being distributed within the climate system, an updated reconst...
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Article
Open AccessLaparoscopic resection of hepatic epithelioid hemangioendothelioma: report of eleven rare cases and literature review
Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare borderline tumor of vascular endothelial origin. Laparoscopic resection of HEHE has never been reported.
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Article
Open AccessSystematic review and meta-analysis of video-assisted thoracoscopic surgery segmentectomy versus lobectomy for stage I non–small cell lung cancer
Whether video-assisted thoracoscopic surgery (VATS) segmentectomy and VATS lobectomy provide similar perioperative and oncological outcomes in stage I non–small cell lung cancer (NSCLC) is still controversial.
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Article
Open AccessMicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction
Sepsis leads to severe inflammatory and cardiac dysfunction. This study aimed to explore the clinical value of miR-495 in sepsis, as well as its role in sepsis-induced inflammation and cardiac dysfunction.
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Article
Open AccessEfficacy of bevacizumab combined with erlotinib for advanced hepatocellular carcinoma: a single-arm meta-analysis based on prospective studies
The efficacy of bevacizumab combined with erlotinib (B + E) for the treatment of advanced hepatocellular carcinoma, especially for sorafenib-refractory patients, has been observed and evaluated in several tria...
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Article
Open AccessGefitinib provides similar effectiveness and improved safety than erlotinib for east Asian populations with advanced non–small cell lung cancer: a meta-analysis
The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non–small cell lung cancer (NSCLC), especially in ...
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Open AccessMinimally access via left anterior mini-thoracotomy for repair of adult subarterial ventricular septal defects
Minimally invasive cardiac surgical techniques are increasingly applied in the treatment and management of a variety of adult ventricular septal defects (VSDs). However, repair of adult subarterial VSDs via le...
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Article
Open AccessA chemical chaperone improves muscle function in mice with a RyR1 mutation
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and atrophy, but the underlying mechanisms are...
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Article
Open AccessA systematic review and meta-analysis of T2, T3 or T4, to evaluate the best denervation level for palmar hyperhidrosis
We systematically reviewed and compared the clinical outcomes of thoracoscopic sympathectomy (TS) at different denervation levels for palmar hyperhidrosis. We searched PubMed, Ovid MEDLINE, EMBASE, Web of Scie...
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Article
Open AccessThoracotomy is better than thoracoscopic lobectomy in the lymph node dissection of lung cancer: a systematic review and meta-analysis
The aim of this study was to investigate which surgical method is better in lymph node (LN) dissection of lung cancer.