Drug Name Classification Mechanism of Action Indication Contraindication Nursing Responsibilities Generic Name CV

Drug Name Classification Mechanism of Indication Contraindication Adverse reaction Nursing responsibilities
action
Generic Alpha-adrenergic Treat the symptoms of Hypersensitivity to Before
name Alpha-blockers antagonist that benign prostatic doxazosin, prazosin, and CV: Orthostatic
Doxazosin selectively inhibits hypertrophy, which may terazosin; hypotension,  Do not breast feed while
alpha-1 adrenergic include urinary syncope. Safe use during
hypotension, edema.
taking this drug.
receptors; Blockages frequency, urgency, and pregnancy (category B) or in  Do not drive or engage in
of the alpha-1 nocturia, among other children is not established other potentially hazardous
adrenergic action on symptoms. In addition, CNS: Vertigo, headache,
activities for 12–24 h after
Brand the vascular smooth doxazosin is indicated the first dose or an increase
dizziness, somnolence,
name muscles lead to a alone or in combination in dosage or when
Cardura decrease in vascular with various fatigue, nervousness, medication is restarted after
resistance and antihypertensive agents an interruption in dosage.
antihypertensive for the management of anxiety.
activity. hypertension. Off-label
uses of doxazosin include During
Actual the treatment of pediatric GI: Nausea, abdominal
dosage, hypertension and the  Monitor BP with patient lying
route, treatment of ureteric pain. down and standing; doses
frequency calculi. above 4 mg increase the risk
Oral, 1- of postural hypotension.
8mg/day PO Hematologic:  Monitor BP 2–6 h after initial
dose or any dose increase.
This is when postural
Leukopenia hypotension is most likely to
occur.
 Use caution when rising from
Skin: Pruritus, eczema. a sitting or supine position in
order to avoid orthostatic
hypotension and syncope;
make position and
directional changes slowly
and in stages.
After
 Report to the physician

episodes of dizziness or
palpitations. These will
require a dosage
adjustment.

Drug Name Classification Mechanism Indication Contraindication Adverse reaction Nursing responsibilities
of action
Generic name A competitive Prescription drug Not recommended Autonomic Nervous System: Before:
Alpha-blockers alpha-1 indicated for the for congestive heart persistent and painful erection of  If first dose is more than 1 mg
Prazosin adrenergic treatment failure due to the penis (priapism) , first dos syncope may occur
receptor of hypertension, mechanical  Elderly patients may be
blocker. By to lower blood obstruction. When Cardiovascular System: sensitive to the drug’s
Brand name blocking pressure. giving first dose stroke, dizziness upon hypotensive effects
alpha-1 Lowering blood monitor for standing, heart attack (myocardial
Minipress receptors on pressure reduce excessive infarction) During :
muscle cesll s the risk of fatal hypotension or give  Monitor patient’s blood
that surround and nonfatal at bedtime. Central and Peripheral Nervous pressure and pulse rate
Actual dosage, blood cardiovascular System:  Monitor patient compliance
route, vessels, prazos events, reduced sense of touch  Full therapeutic effect of drug
frequency in causes primarily strokes (hypoesthesia), numbness and tingling is reached within 4-6 weeks
vasodilation and myocardial  Provide resources for
Oral route (widening) of infarctions. Endocrine System: complementary and alternative
the blood enlarged breast in men therapies to promote positive
Hypertension vessels, and (gynecomastia) coping mechanisms and stress
Initial: 1 mg PO consequently reduction
q8-12hr decreases the Gastrointestinal System: After:
resistance of gastrointestinal obstruction,  Educate the patient about
blood flow. vomiting weight loss, exercise program
PTSD-Related as needed
Nightmares & General Body System:  Educate the patient about
Sleep fatigue, hot flushes, additional methods to lower
Disruption feeling unwell (malaise) blood pressure(low-
(Off-label) sodium,decrease tobacco,and
alcohol consumption)
Initial: 1 mg PO Heart Rate/Rhythm:
qHS
slow heart rate, irregular heartbeats
(cardiac arrhythmias)
Benign
Prostate
Hypertrophy Hematopoietic:
(Off-label) low white blood cell
count, rash with purple spots, low platelet
Initial: 0.5 mg count (thrombocytopenia)
PO q12hr
Liver/Biliary System:
abnormal liver function
tests, inflammation of the liver (hepatitis),
obstruction of bile secretion leading to liver
failure (hepatitis cholestatic),
yellow skin and eyes (jaundice)
Musculoskeletal System:
muscle cramps, muscle weakness
Psychiatric:
agitation, loss of appetite,
nervousness
Respiratory System:
difficulty breathing (bronchospas
m) aggravated
Skin Disorders:
hair loss, hives, skin rash,
severe itching
Special Senses:
blurred
vision ,intraoperative Floppy Iris Syndrome
Urinary System:
blood in the urine, urinary
disorder, urinary frequency, nighttime
urination, excessive urination
Immune System:
allergic reaction
Eye Disorders: Intraoperative Floppy Iris

Syndrome (prolapsed iris during surgery

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Drug Name Classification Mechanism of Indication Contraindication Adverse reaction Nursing responsibilities

 Report to the physician

Eye Disorders: Intraoperative Floppy Iris

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