Ozlem Yavuz
Balikesir University, Medical Biochemistry, Faculty Member
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Introduction This study aimed to reveal the utility of age-platelet (AP) index and aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR), which are non-invasive markers, in patients with chronic Hepatitis C virus... more
Introduction This study aimed to reveal the utility of age-platelet (AP) index and aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR), which are non-invasive markers, in patients with chronic Hepatitis C virus (HCV) infection in prediction of fibrosis and evaluate whether viral markers could be used for that purpose or not. Methods A total of treatment-naïve 49 patients with chronic HCV who underwent liver biopsy were included in this retrospective study. Anti-HCV S/CO and HCV-RNA viral load (copy/ml) values measured simultaneously with biopsy were determined. AP index and AAR score were calculated and compared. Results Staging of liver biopsy samples of 49 HCV patients was assessed. Comparable diagnostic accuracies of AP index and AAR in prediction of significant fibrosis (F≥2) were showed with ROC curve analysis. The areas under the ROC (AUROCs) were 0.713 and 0.506 respectively. Diagnostic accuracy of API in prediction of significant fibrosis was super...
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In this study, it was aimed to combine laboratory data of COVID-19 patients with CT segmentation-volume analysis (CT-SVA) and is the first research on this subject. Patients were divided into two groups according to disease severity as... more
In this study, it was aimed to combine laboratory data of COVID-19 patients with CT segmentation-volume analysis (CT-SVA) and is the first research on this subject. Patients were divided into two groups according to disease severity as mild/moderate (n = 41) and severe/critical (n = 42). The initial laboratory parameters of the patients at admission like sodium, albumin, CRP, D-dimer, ferritin, fibrinogen, IL-6, procalcitonine, venous blood gas and complete blood count (WBC, lymphocyte, neutrophile, NLR) were recorded and evaluated together with CT-SVA. CT scans of the patients were integrated into ITH Snap Software and damaged tissue volume in ratio to total lung volume was calculated as percent ratio. The results of the study have shown that sodium, CRP, D-dimer, ferritin, fibrinogen, IL-6, procalcitonine, WBC, neutrophile, NLR values were significantly higher at first admission in the severe/critical patient group (p
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The urinary glycosaminoglycan (GAG) excretion in 35 patients with bladder cancer was significantly greater than that in 30 normal persons. In the cancer patients, the results were analysed according to tumour characteristics.... more
The urinary glycosaminoglycan (GAG) excretion in 35 patients with bladder cancer was significantly greater than that in 30 normal persons. In the cancer patients, the results were analysed according to tumour characteristics. Statistically significant differences were found, with increased GAG levels paralleling tumour size, multifocality, stage and grade. These preliminary data suggest that, parallel with established clinical parameters, measurement of urinary GAG excretion provides an indicator of repair of the bladder epithelium.
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The effects of a high fat diet on the development of diabetes mellitus, insulin resistance and secretion have been widely investigated. We investigated the effects of a high fat diet on the pancreas and skeletal muscle of normal rats to... more
The effects of a high fat diet on the development of diabetes mellitus, insulin resistance and secretion have been widely investigated. We investigated the effects of a high fat diet on the pancreas and skeletal muscle of normal rats to explore diet-induced insulin resistance mechanisms. Forty-four male Wistar rats were divided into six groups: a control group fed standard chow, a group fed a 45% fat diet and a group fed a 60% fat diet for 3 weeks to measure acute effects; an additional three groups were fed the same diet regimens for 8 weeks to measure chronic effects. The morphological effects of the two high fat diets were examined by light microscopy. Insulin in pancreatic islets was detected using immunohistochemistry. The homeostasis model assessment of insulin resistance index and insulin staining intensity in islets increased significantly with acute administration of high fat diets, whereas staining intensity decreased with chronic administration of the 45% fat diet. Islet areas increased significantly with chronic administration. High fat diet administration led to islet degeneration, interlobular adipocyte accumulation and vacuolization in the pancreatic tissue, as well as degeneration and lipid droplet accumulation in the skeletal muscle tissue. Vacuolization in the pancreas and lipid droplets in skeletal muscle tissue increased significantly with chronic high fat diet administration. We suggest that the glucolipotoxic effects of high fat diet administration depend on the ratio of saturated to unsaturated fatty acid content in the diet and to the total fat content of the diet.
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In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA)... more
In this study, alterations in the liver antioxidant enzymes status and lipid peroxidation in short-term (8-weeks) and long-term (24-weeks) diabetic rats were examined. Glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA) levels were significantly increased, but superoxide dismutase (SOD) activity was significantly reduced in 8-weeks diabetic rats, compared to control. Catalase (CAT) activity, however, was found unchanged. In 24-weeks diabetic rats, while GSH-Px activity was unchanged, but SOD and CAT activities and MDA levels were significantly increased, compared to control. These results suggest that diabetes-induced alterations in tissue antioxidant system may reflect a generalized increase in tissue oxidative stress. It can be concluded that lipid peroxidation and antioxidant enzyme levels are elevated in diabetic condition. Hence, diabetes mellitus, if left untreated, may increase degenerative processes due to accumulation of oxidative free radicals.
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To evaluate the protective effect of l-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW plus l-carnitine group. Retrieved... more
To evaluate the protective effect of l-carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW plus l-carnitine group. Retrieved liver grafts were preserved in UW and UW plus l-carnitine solutions at +4 degrees C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. No micro or macrovacuolar fat droplets were observed in the tissue slices. l-Carnitine effectively decreased enzyme release when added to UW solution (P < 0.05). In addition to fatty liver, l-carnitine might be a metabolic adjunct in preservation solutions for non-fatty liver within UW solution.
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BACKGROUND: Commercial energy drink usage is reported to be higher in athletes and adolescents. However, the impact of pre-exercise consumption of energy beverages on hematologic and biochemical responses and skeletal muscle contractile... more
BACKGROUND: Commercial energy drink usage is reported to be higher in athletes and adolescents. However, the impact of pre-exercise consumption of energy beverages on hematologic and biochemical responses and skeletal muscle contractile properties has not been fully elucidated. METHOD: Ten male subjects performed 50 maximal eccentric actions on an isokinetic dynamometer at 90 ◦ /sec followed by two identical trials that were preceded by consuming either a placebo (P) or energy drink (ED) beverage. The test was repeated after 7–10 days while consuming the alternate beverage. Complete blood counts and chemistry profile was conducted before and immediately after exercise. RESULTS: Eccentric contractions resulted in an increased number of neutrophils (Neut) and decreased lymphocytes (Lymph), decreased eosinophils (EOS) and did not change basophil (BASO) levels in control. However, the BASO levels increased immediately after the exercise with P and ED beverage consumption. In contrast, P and ED beverage consumption had no effect on Neut, Lymph, MONO or EOS counts after exercise compared to pre-exercise values. Acute exercise increased creatinine kinase (CK) and decreased phosphorus (Pi) but did not have any effect on other blood chemistry parameters. The biochemical profile and eccentric muscle contractile properties were not significantly affected by any of the beverages. CONCLUSIONS: Consumption of pre-exercise energy drink does not have a favorable effect on immune blood cells induced in the acute eccentric exercise model.
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A comparative study on isolated guinea pig hearts was carried out to determine the effect of calcium entry blocking agents: nifedipine- and verapamil-added reperfusion solutions on myocardial recovery after global ischemia. After 20 min... more
A comparative study on isolated guinea pig hearts was carried out to determine the effect of calcium entry blocking agents: nifedipine- and verapamil-added reperfusion solutions on myocardial recovery after global ischemia. After 20 min of normothermic ischemia, three groups of solutions were used for reperfusion (10 animals each): (1) Nifedipine-added (10--8 mmol L(minus sign1)) Krebs--Henseleit solution; (2) verapamil-added (10--8 mmol L(minus sign)) Krebs-Henseleit solution; (3) Krebs--Henseleit solution. Postischemic myocardial functions (ventricular contractile force and heart work) and enzyme activities were compared with their preischemic values. The addition of calcium entry blocking agents does not have any significant advantage over control solutions in myocardial recovery.
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Page 1. Düzce Tıp Fakültesi Dergisi 2003; 5 (1): 17-19. Role of Growth Hormone for Colonic Polyps in Non-Acromegalic Patients Yaşar SERTBAŞ1, Esin KORKUT1, Zerrin BİCİK1, Sibel ERSAN1, Özlem YAVUZ2, Murat ALPER3 ...
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In this study, the effects of intraperitoneal applications N-acetyl cysteine (NAC) an glutathione (GSH) precursor, on GSH and related enzymes, lipid peroxidation activities in the erythrocyte and liver tissue were investigated. For this... more
In this study, the effects of intraperitoneal applications N-acetyl cysteine (NAC) an glutathione (GSH) precursor, on GSH and related enzymes, lipid peroxidation activities in the erythrocyte and liver tissue were investigated. For this purpose, effects of the NAS were investigated on playing an important role in detoxification reactions of biomolecules; GSH/GSSG, GSH reductase, GSH-px, NADP/NADPH activity, superoxide dismutase (SOD) and as an indicator of lipid peroxidation malondialdehyde (MDA) in liver toxicity formed by carbon tetrachloride (CCl4). In this study in order to create liver toxicity in rats, CCl4 was applied 3 times with an interval of one day 1 ml/kg intraperitoneal (ip) in 1/1 ratio of olive oil in the form of solution. In order to determine the protective effect of the NAS, NAS application was started 3 days before (ip 50 mg /kg/day) that CCl4 injected to tested group and continued during the experiment. 24 hours after the last injection of CCl4, blood and liver ...
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Abstract It has been reported that asthma might develop due to the exposure of excessive diesel exhaust and exacerbations might be seen in asthmatic patients. In a cross-sectional study the levels of serum eosinophilic cationic protein... more
Abstract It has been reported that asthma might develop due to the exposure of excessive diesel exhaust and exacerbations might be seen in asthmatic patients. In a cross-sectional study the levels of serum eosinophilic cationic protein (ECP), the rates of respiratory symptoms, the mean levels of FVC predicted%, FEV1 predicted %, FEV1/FVC, MMEF predicted%, smoking status and the variabilities of PEF in weekends and working days were compared between 70 toll collectors (TC) (mean age, SD; 37.17±7.77 years) and 29 controls (mean age, SD; 37.72±9.05). All of the subjects in study group were men. The mean level of serum ECP was 32.18±32.36 ng/ml in TC whereas it was 21.04±18.61 ng/ml in controls (p=0.086). Chest tightness was observed in 21.4% (15/70) of TC while it was seen in 24.1% (7/29) of controls. Thirty percent (21/70) of TC and 34.5% (10/29) of controls had wheezing. Chest tightness [21.4% (15/70) vs. 24.1% (7/29)], wheezing [30% (21/70) vs. 34.5% (10/29)], sputum [%37.1 (26/70) ...
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Page 1. / Thematic Poster Session / Tuesday, May 18/8:15 AM-4:00 PM / Area E, Hall C50 UPDATE ON OCCUPATIONAL LUNG DISEASES G (First Level), Morial Convention Center SMOKING STATUS AND RESPIRATORY ...
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Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the... more
Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg(-1) varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg(-1) groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.
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To investigate whether Chlamydia pneumoniae (Cpn) seropositivity in patients with suspected coronary artery disease (CAD) (n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and... more
To investigate whether Chlamydia pneumoniae (Cpn) seropositivity in patients with suspected coronary artery disease (CAD) (n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and traditional risk factors for cardiovascular events. The severity of coronary atherosclerosis was ranked by Gensini score. Inflammation and endothelial dysfunction were evaluated using white blood cell counts and levels of high-sensitivity C-reactive protein (hs-CRP), ferritin, tumour necrosis factor-alpha (TNF-alpha), interleukins 1beta and 6 (IL-1beta, IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin and oxidized LDL (oxLDL), and these were compared between Cpn-seropositive and seronegative individuals. IgA and IgG Cpn seropositivity were significantly associated with the presence of CAD (p = 0.005) and were independent predictive factors for the severity of coronary atherosclerosis (p = 0.005). Elevated levels of IL-6 (p = 0.027) and triglyceride (p = 0.038) and low levels of high-density lipoprotein cholesterol (HDL-C) (p = 0.038) were significantly predicted by Cpn IgA and IgG seropositivity. Seropositivity for Cpn is a risk factor for patients with significant angiographically documented coronary stenosis. Additionally, Cpn seropositivity was significantly associated with dyslipidemia and elevated IL-6, known risk factors for CAD. These observations indicate that Cpn infection may be one entry point to the causal or contributory pathways that lead to atherosclerosis and its clinical manifestations.
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Research Interests: Humans, Female, Male, Theophylline, Aged, and 9 morePublic health systems and services research, Analysis of Variance, Chronic obstructive pulmonary disease, Pulmonary Function, Pulmonary function test, Carcinoembryonic Antigen, Glucocorticoids, Severity of Illness Index, and Cholinergic antagonists
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Research Interests: Occupational Health, Turkey, Oxidative Stress, Humans, Smoking, and 15 moreNitric oxide, Vehicle Emissions, Male, Nitrates, Vitamin E, Lipid peroxidation, Occupational, Adult, Occupational Exposure, Public health systems and services research, Cross Sectional Studies, Malondialdehyde, Nitrites, Case Control Studies, and Respiratory function tests
Oxygen free radicals may be implicated in the pathogenesis of ischemia-reperfusion damage. It is known that 2-chloroadenosine (2-CADO) has neuromodulatory effects and prevents the neuronal damage seen in the period of postischemia... more
Oxygen free radicals may be implicated in the pathogenesis of ischemia-reperfusion damage. It is known that 2-chloroadenosine (2-CADO) has neuromodulatory effects and prevents the neuronal damage seen in the period of postischemia reperfusion. However, direct effects of 2-CADO on lipid peroxidation have not been investigated previously. The attack on the cell membrane by free radicals leads to lipid peroxidation, which can be assayed by the malondialdehyde (MDA) level. The aim of this study was to determine the effect of 2-CADO therapy on lipid peroxidation in experimental forebrain ischemia and postischemia reperfusion in Mongolian gerbils. Cerebral ischemia was induced by a bilateral 30-mm occlusion of the common carotid arteries. 2-Chloroadenosine (0.6 mg/kg, IV) was administered 5 min subsequent to ischemia. Ischemia was followed by reperfusion for 30 min. The MDA level was measured by the thiobarbituric acid (TBA) test. Bilateral carotid artery occlusion for 30 min in gerbils resulted in no significant change in MDA level in the brain. The MDA level was higher in postischemia reperfusion than in the ischemic group. 2-Chloroadenosine treatment did not change the MDA level in the ischemic period. However, the MDA level recovered significantly upon 2-CADO therapy during reperfusion following ischemia. These results suggest that 2-CADO may offer some degree of protection against oxidative stress in cerebral ischemia-reperfusion damage.
Research Interests: Free Radicals, Free Radical, Female, Animals, Male, and 14 moreLipid peroxidation, Oxidative stress and free radical biology and medicine, Group, Cerebral Ischemia, Reperfusion injury, Carotid Artery, Ischemia–reperfusion, Malondialdehyde, Biochemistry and cell biology, Neuroprotective Agents, Cell Membrane, Free Radical Biology, Gerbillinae, and Lipid peroxides
We determined the sensitivity, specificity, receiver operating characteristics and correlation between cystatin C (cysC) and two widely used markers of renal function, creatinine clearance and serum creatinine, in 244 patients (84... more
We determined the sensitivity, specificity, receiver operating characteristics and correlation between cystatin C (cysC) and two widely used markers of renal function, creatinine clearance and serum creatinine, in 244 patients (84 diabetics, 84 hypertensive and 76 healthy subjects). Renal failure was defined as creatinine clearance of less than either 80 or 60mL/min. Variables were evaluated for two definitions of renal failure and compared between patient groups. Correlation coefficients with cysC were −0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; −0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and −0.61 for creatinine clearance and 0.94 for creatinine in the control group. The receiver operating characteristic curves with a cut-off value of 60mL/min were similar for creatinine and cysC, while at 80mL/min they were 0.626 for creatinine and 0.813 for cysC levels. We classified the patients into three groups with respect to...
Research Interests: Cognitive Science, Clinical Chemistry, Humans, Hypertension, Female, and 14 moreRenal failure, Male, Clinical Sciences, Middle Aged, Adult, cystatin C, Biological markers, Sensitivity and Specificity, Cross Sectional Studies, Chronic Kidney Failure, Predictive value of tests, Creatinine, Case Control Studies, and Glomerular Filtration Rate
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The aim of the study was to investigate the acute and subacute dose and the dose regime of thiamphenicol-induced changes in serum biochemical parameters in mice. Thiamphenicol was given to the trial groups at a dosage of 100 mg/kg bw... more
The aim of the study was to investigate the acute and subacute dose and the dose regime of thiamphenicol-induced changes in serum biochemical parameters in mice. Thiamphenicol was given to the trial groups at a dosage of 100 mg/kg bw (group 2) and 200 mg/kg bw ( ...
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Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shock wave therapy (ESWT) (500 shock waves at 14 kV) on the healing poten-tial of tendon injuries that may accompany fractures. Methods: The... more
Objectives: A rat model was designed to investigate the effect of low-energy extra-corporeal shock wave therapy (ESWT) (500 shock waves at 14 kV) on the healing poten-tial of tendon injuries that may accompany fractures. Methods: The study included 48 rats for histopathologic (n= ...