Lactoferrin is a member of the high affinity to glycoprotein family of transferrin for iron and plays a role in natural immunity as well as antibacterial, antifungal, antiviral, antiparasitic, antioxidant, anticancer, antiinflammatory,... more
Lactoferrin is a member of the high affinity to glycoprotein family of transferrin for iron and plays a role in natural immunity as well as antibacterial, antifungal, antiviral, antiparasitic, antioxidant, anticancer, antiinflammatory, bone health and immunomodulation. The aim this study was to investigate of the acute effect of lactoferrin on paraoxonase activity, oxidant/antioxidant system and total protein, albumin and globulin. This study was carried out on 6-month Sprague Dawley rats in a total number of 20 subjects. Paraoxonase activity, total antioxidant capacity (TAC), total oxidant capacity (TOC), total protein, albumin and globulin levels were measured through the spectrophotometer. When the lactoferrin group was compared with the control group, it was found that TAC levels were statistically higher (P<0.05), TOC levels were statistically lower (P<0.01) and paraoxonase activity was statistically higher (P<0.05). There was no difference in total protein and globuli...
Research Interests:
Research Interests:
The aim of this study was to investigate the potential for the treatment of thromboembolic diseases by determining the fibrinolytic, fibrinogenolytic activities and substrate specificity of the recombinant subtilisin from Bacillus... more
The aim of this study was to investigate the potential for the treatment of thromboembolic diseases by determining the fibrinolytic, fibrinogenolytic activities and substrate specificity of the recombinant subtilisin from Bacillus subtilis strain PTTC 1023. The subtilisin gene from Bacillus sp. was synthesized, cloned into the vector pD441-NH and expressed in E. coli BL21 (DE3). Recombinant subtilisin (~40 kDa) was purified in a single-step procedure by affinity chromatography. The fibrinolytic, fibrinogenolytic activities and substrate specificity of the pure recombinant enzyme was determined. The recombinant protease of B. subtilis displayed an optimum fibrinolytic activity at pH 7.5 and 37°C.The α, β and Υ-Υ chains of fibrinogen were totally degraded by the recombinant enzymes at 37°C for 30 min. However, the Υ chains were more resistant to enzyme digestion in all times. The clear zones produced by recombinant enzyme and plasmin on the fibrin plate did not significant difference ...
OBJECTIVES In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver... more
OBJECTIVES In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats. MATERIALS AND METHODS Forty male Wistar albino rats were used as animal materials. Animals were divided into 4 groups and treated as follows: Rats in group 1 (control) were intraperitoneally (i.p) injected with single dose of saline; rats in group 2 were i.p. injected with DEN at a dose of 150 mg/kg/body weight; rats in group 3 were treated with DEN (via single i.p. injection at 150 mg/kg/body weight) plus n-3 FA (at a dose of 0.4 g /kg/day via subcutaneous route in fish oil) for 7 days, and group 4 received n-3 FA via s.c. route at a dose of 0.4 g/kg/day in fish oil for 7 days. The plasma samples were analyzed for...
Research Interests:
The disadvantage of the conventional protein-inorganic hybrid nanoflower production method is the long incubation period of the synthesis method. This period is not suitable for practical industrial use. Herein, protein-inorganic hybrid... more
The disadvantage of the conventional protein-inorganic hybrid nanoflower production method is the long incubation period of the synthesis method. This period is not suitable for practical industrial use. Herein, protein-inorganic hybrid nanoflowers were synthesized using hemoglobin and copper ion by fast sonication method for 10 min. The synthesized nanoflowers were characterized via scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and Fouirer-transform infrared spectroscopy. The activity and stability of the nanoflowers in the presence of different metal ions, organic solvents, inhibitors, and storage conditions were also evaluated by comparing with free hemoglobin. According to obtained results, the optimum pH and temperatures of both hybrid nanoflower and free hemoglobin were pH 5 and 40 °C, respectively. At all pH levels, nanoflower was more stable than free protein and it was also more stable than the free hemoglobin at temperatures ranging between 50 °C and 80 °C. The free protein lost more than half of its activity in the presence of acetone, benzene, and N,N-dimethylformamide, while the hybrid nanoflower retained more than 70% of its activity for 2 h at 40 °C. The hybrid nanoflower activity was essentially increased in the presence of Ca2+, Zn2+, Fe2+, Cu2+ and Ni2+ (132%, 161%, 175%, 185% and 106%, respectively) at 5 mM concentration. The nanoflower retained more than 85% of its initial activity in the presence of all inhibitors. In addition, it retained all its activity for 3 days under different storage conditions, unlike free hemoglobin. The results demonstrated that new hybrid nanoflowers may be promising in different biotechnological applications such as catalytic biosensors and environmental or industrial catalytic processes.
Research Interests:
The main goal of this study was to find a link between colostrum and the 1-day-old lamb serum γ-glutamyltransferase (GGT) activity and immunoglobulin G (IgG) concentration and their relation with neonatal diseases and beyond. Further,... more
The main goal of this study was to find a link between colostrum and the 1-day-old lamb serum γ-glutamyltransferase (GGT) activity and immunoglobulin G (IgG) concentration and their relation with neonatal diseases and beyond. Further, to set a linear relationship between the serum GGT activity (SGGTA) and the IgG concentration (SIgGC) in different days of the neonatal period, thereby determining the feasibility of the GGT activity in the prediction of the colostrum quality and passive immunity and to define a cut-off point for the SGGTA associated with an increased risk of illness or death in lambs. For this purpose, blood samples were obtained from the lambs before the colostrum intake (day 0) and on different days (1, 2, 4, 7, 14 and 28) in the neonatal period. The colostrum was collected from the respective ewes (n = 254) related to the lambs. The most accurate (R2 = 0.652) model for predicting the SIgGC or passive immune status was the multiple regression model developed to calc...
Research Interests:
Research Interests:
. The aim of this study was to investigate the effects of boric acid (BA) and borax (BX) on live weight and obesity associated molecules including leptin, L-carnitine, insulin-like growth factor 1 (IGF-I), and heat shock proteins 70... more
. The aim of this study was to investigate the effects of boric acid (BA) and borax (BX) on live weight and obesity associated molecules including leptin, L-carnitine, insulin-like growth factor 1 (IGF-I), and heat shock proteins 70 (HSP70) in rats fed with high-fat diet. A total of 60 rats were equally allocated as ND (normal diet), HF (high-fat diet), HF+BA, HF+BX, ND+BX, ND+BA. Body weight increases in HF+BA (85 g) and HF+BX (86 g) were significantly lower (p&lt;0.05) compared to HF group (126 g). Boron treatment decreased serum L-carnitine level in high-fat diet (HF+BA 11.12 mg/L, HF+BX 10.51 mg/L, p&lt;0.05) compared to HF group (15.57 mg/L), while no change was observed in groups ND+BA (7.55 mg/L) and ND+BX (7.57 mg/L) compared to group ND (8.29 mg/L). Neither BA nor BX supplementation in ND and HF groups altered the serum levels of HSP70 and leptin. BA and BX supplementation in rats fed HF resulted in a significant reduction in live weight. Boron compounds altered L-carnitine and IGF-1 levels in rats. These results indicate that boron compounds are beneficial in the treatment of obesity as well as in the prevention of high-fat diet-induced weight increase. Alterations in serum L-carnitine and IGF-1 levels in boron treated rats also indicate possible role of boron compounds in energy metabolism in response to high fat diet.
Research Interests:
Research Interests:
In this study, enzyme-inorganic hybrid nanoflowers were synthesized using proteinase K and Cu ions. The synthesized proteinase K-Cu hybrid nanoflowers (P-hNFs) were characterized by their morphology and chemical point of view by using... more
In this study, enzyme-inorganic hybrid nanoflowers were synthesized using proteinase K and Cu ions. The synthesized proteinase K-Cu hybrid nanoflowers (P-hNFs) were characterized by their morphology and chemical point of view by using different techniques such as SEM, FTIR, EDX, and XRD. The proteolytic activities and some important characteristics such as optimum pH and temperature of the P-hNFs were also evaluated by comparison with free proteinase K. Optimum pH values of free proteinase K and P-hNFs were determined as pH 10 and pH 11, respectively. Optimum temperatures recorded for both free proteinase K (at pH 10) and P-hNFs (at pH 11) were 40 °C. In our study, for the first time, using some commercial detergents and surfactants, the utility of the P-hNFs as a detergent additive was also systematically evaluated. In these studies, the P-hNFs exhibited better activity than free proteinase K in the presence of all surfactants (CHAPS, DOC, SDS, Triton X-100 and Tergitol) except for...
Research Interests:
Research Interests:
Research Interests:
Tamoxifen is a synthetic non steroidal anti-estrogen used to treat patients with breast cancer and healthy subjects with high risk of breast cancer. It was aimed to study the short term effects of tamoxifen on the plasma total antioxidant... more
Tamoxifen is a synthetic non steroidal anti-estrogen used to treat patients with breast cancer and healthy subjects with high risk of breast cancer. It was aimed to study the short term effects of tamoxifen on the plasma total antioxidant capacity (TAC), nitric oxide (NO) and the adenosine deaminase activity (ADA) in healthy rabbits. Sixteen healthy New Zealand rabbits were allocated to 2 groups including controls and tamoxifen treated animals. Controls received a single application of 0.9% saline via oral route while the treated rabbits received orally tamoxifen (dissolved in 0.9% saline, at a dose of 5 mg/kg). Blood samples were collected at 6 and 24 hours following the treatments. Plasma TAC and ADA were not affected by Tamoxifen treatment. However, NO level in tamoxifen treated group was increased at 24 hours following tamoxifen treatment as compared to controls. In conclusion, acute tamoxifen treatment may not affect the antioxidant status and cellular immunity, as evidenced by...
Research Interests:
Research Interests: Chemistry, Food Science, Biology, Glutathione, Retinol, and 3 moreBeta Carotene, Carotene, and Malondialdehyde
Research Interests: Engineering, Chemistry, Animal Science, Immunology, Gastroenterology, and 15 moreBiology, Medicine, Internal Medicine, Correlation, Disease, Blood sampling, Luminescence, Hydrogen Peroxide, C reactive protein, Cerebral Ischemia, Erythrocyte Sedimentation Rate, Individual Difference, Carotid Artery, Blood Plasma, and Mechanical Property
Research Interests:
Research Interests:
Research Interests:
Research Interests: Chemistry, Biology, Medicine, Toxicity, Glutathione, and 3 moreSialic Acid, Malondialdehyde, and Carnitine
Research Interests:
Research Interests:
Research Interests:
ABSTRACT This study was designed to evaluate the potential of lactoferrin (Lf) as predictor of passive immunity by establishing correlation between serum Lf and IgG concentration determined by ELISA in healthy lambs before and after... more
ABSTRACT This study was designed to evaluate the potential of lactoferrin (Lf) as predictor of passive immunity by establishing correlation between serum Lf and IgG concentration determined by ELISA in healthy lambs before and after colostrums intake at various days of neonatal period, to determine the presumptive effect of serum Lf along with serum IgG levels on neonatal lamb health through comparison of values measured for healthy and diseased lambs and to evaluate the impact of colostral Lf and IgG concentrations on passive immunity and lamb health. For this purpose, blood samples were obtained from the fifty healthy lambs at birth and 1, 2, 4, 7, 14 and 28 days of birth. Additionally first day blood samples were also collected from 286 lambs. Health status of all lambs (n = 336) was monitored from birth to 12 weeks of life. Colostrums samples were obtained within 0–4 hours of parturition from 193 the respective ewes related to the lambs tested in this study. Serum Lf and IgG concentrations of day 1, 2, 4, 7, 14 and 28 were significantly higher than the values of pre-suckling time in healthy lambs. There was a weak linear relationship between serum Lf and IgG concentrations in only 1, 2, 4 and 7 day-old healthy lambs (r2 = 0.073 to 0.079) except for the first day (r2 = 0.213). The multiple linear regression model moderately (r2 = 0.375) estimated the serum IgG concentration as a function of the serum Lf concentration and of the age of lambs at the time of sampling [day 1, 2, 4, 7, 14 and 28] in healthy lambs during the neonatal period. The healthy lambs had significantly higher Lf concentration at 24th hour after the birth (SLfC-24) than ill lambs in the neonatal period (P &lt; 0.01) and the period covering 5 to 12 weeks of life (P &lt; 0.01). Similar results were found for SIgGC-24. The morbidity rate of lambs with SLfC-24 &lt;800 ng/mL was 3.2 times higher in neonatal period and 1.7 times higher in the period covering 5-12 weeks of life when compared with lambs having SLfC-24 above 800 ng/ml. There was a significant (P &lt; 0.01) and positive (R = 0.261) correlation between CIgGC and CLfC. In conclusion, our study revealed the importance of serum Lf in prevention of disease development in lambs and in prediction of passive immunity. In addition the positive correlation between colostral Lf and IgG values may be of use in evaluation of colostrums quality.
Research Interests:
Research Interests:
Research Interests:
RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...
Research Interests:
Oxidative stress, which is characterized by disruption of the oxidant/antioxidant balance, causes pathological processes, including toxicities induced by certain mycotoxins. The present study was designed to investigate the effects of... more
Oxidative stress, which is characterized by disruption of the oxidant/antioxidant balance, causes pathological processes, including toxicities induced by certain mycotoxins. The present study was designed to investigate the effects of resveratrol on sirtuin deacetylases (SIRT2 and SIRT3), nitric oxide (NO), reduced glutathione (GSH) and malondialdehyde (MDA) in fumonisin B1-induced hepatotoxicity. Regarding the experimental design, forty BALB/c mice were divided into four groups corresponding to the control, resveratrol (10 mg/kg, i.p), fumonisin B1 (2.25 mg/kg, i.p) and resveratrol + fumonisin B1 (10 mg/kg + 2.25 mg/kg) groups. At the end of the 14 day-treatment, expression levels of SIRT2 and SIRT3 protein in the serum and liver were revealed by western blotting and antioxidant/oxidant activity analysis. SIRT2 and SIRT3 expression levels in the liver were significantly decreased by fumonisin B1 in comparison to the control. However, resveratrol supplementation coupled with fumonis...
Research Interests: Chemistry, Oxidative Stress, Glutathione, Resveratrol, Fumonisin, and 3 moreSirtuin, Malondialdehyde, and SIRT
Background: Incoming anaesthesia created by the use of many drugs with different physicochemical properties is a source of stress and trauma for the body. This event increases the oxidative response and changes the balance between... more
Background: Incoming anaesthesia created by the use of many drugs with different physicochemical properties is a source of stress and trauma for the body. This event increases the oxidative response and changes the balance between oxidant/antioxidant capacity in the organism in favor of oxidant capacity. This situation is defined as oxidative stress. For these reasons, studies are conducted to determine the effects of general anaesthetic agents on oxidant and antioxidant systems in the organism. In this study, it was aimed to determine the effects of isoflurane and sevoflurane used for general anaesthesia in humans and animals on lipid peroxidation and antioxidant defense system in calves.Materials, Methods & Results: The study included 14 calves of different breeds, ages, sexes, and weighing, average 2 weeks old. The cases randomly were divided into 2 groups, the isoflurane group (group I), and the sevoflurane group (group II), and each group included 7 animals. Before general anae...
Research Interests:
Protein‐inorganic hybrid nanoflowers have tremendous potential in bionanotechnology due to their simple method of preparation, high stability and superior properties. Considering these features, the present study was designed to... more
Protein‐inorganic hybrid nanoflowers have tremendous potential in bionanotechnology due to their simple method of preparation, high stability and superior properties. Considering these features, the present study was designed to investigate the artificial blood substitution potentials of hemoglobin‐inorganic hybrid nanoflowers. In this context, hemoglobin‐inorganic hybrid nanoflowers (Cu‐NF, Co‐NF and Zn‐NF) were synthesized using with different metal ions (copper, cobalt and zinc), then their oxygen carrying capacity, the hemolytic studies, in vitro oxidant/antioxidant capacity levels and oxidative stress index were reported for the first time. The present findings have revealed that Zn‐NF had significant oxygen content and artificial oxygen carriers (AOC), as well as a significantly low percent hemolysis rate and a safe standard value. Also, hemolysis rate decreased along with the increases in hemoglobin content coupled with increments in nanoflower concentrations. The percentage hemolysis rate was lower than all nanoflowers at low free hemoglobin concentration, but hemolysis rates also increased with increments in concentration. The results showed that in general, Zn‐NF stands out with its high total antioxidant capacity and low total oxidant capacity and oxidative stress index. The obtained results showed that Cu‐NF and Co‐NF, especially Zn‐NF might be considered as a potential superior artificial oxygen carrier. Therefore, this nanoflower system might be act as an efficient material as a blood substitute in the near future.
Research Interests:
Aim: In order to reveal the scientific evidence for its antioxidant and metabolic activities known in folk medicine, the present study was aimed to investigate the effect of bud and fruit parts of Capparis ovata plant on some antioxidant... more
Aim: In order to reveal the scientific evidence for its antioxidant and metabolic activities known in folk medicine, the present study was aimed to investigate the effect of bud and fruit parts of Capparis ovata plant on some antioxidant parameters and nesfatin-1 and irisin hormones in mus musculus mice for the first time.Materials and Methods: The dry extract was obtained from bud and fruit parts of C.ovata. Twenty mus musculus mice were divided into two groups as control and C.ovata treatment group. C.ovata group was fed with 500 mg/kg C.ovata plant extract via gavage for 21 days. The nesfatin-1 and irisin levels in tissue were determined using enzyme-linked Immunosorbent assay methods. The total oxidant capacity (TOC), total antioxidant capacity (TAC), nitric oxide (NO), reduced glutathione (GSH) and gamma glutamyl transpeptidase activity levels were measured spectrophotometrically.Results: Results showed that both irisin and nesfatin-1 levels were higher in liver and kidney of C.ovata group compared to the control groups. The liver TOC level was lower and the reduced GSH level was higher in group given C.ovata. The kidney NO levels were higher in C.ovata group. The extract increased synthesis of energy regulatory hormones and also exhibited antioxidant characteristics by reducing free radicals in the liver and affecting glutathione synthesis.Conclusion: As a result, C.ovata can be used as a valuable phytotherapeutic agent in processes associated with the energy regulation and oxidative stress related many disease conditions.
Research Interests:
Research Interests:
Research Interests:
In the present work, subtilisin gene from Bacillus subtilis PTTC 1023 was synthesized, cloned into the vector pD441-NH and expressed in E. coli BL21 (DE3). Recombinant subtilisin was purified in a single-step procedure by affinity... more
In the present work, subtilisin gene from Bacillus subtilis PTTC 1023 was synthesized, cloned into the vector pD441-NH and expressed in E. coli BL21 (DE3). Recombinant subtilisin was purified in a single-step procedure by affinity chromatography. The molecular mass of the purified protein was determined to be about 40kDa by SDS-PAGE. The optimum pH and temperature values of its proteolytic activity were 10.5 and 50°C, respectively and retained more than 70% and 89% of its activity in pH range of 7-12 and 30-60°C, respectively. Enzyme purity was estimated to be about 200- fold greater than that of the crude extract and subtilisin had a specific activity of 56.16U/mg, with a yield of about 87.9%. It was completely inhibited by phenylmethanesulfonyl fluoride, which strongly suggests its belonging to serine protease family. Interestingly, subtilisin protease displayed a significant compatibility with commercial detergents, and tolerance organic solvents, metallic ions and surfactants. The findings obtained demonstrated that protease of B. subtilis could potentially be used in future applications as an additive in detergent formulations.
Research Interests:
Research Interests:
Research Interests:
The aim of this study was to determine the effect of exogenous GSH, an important antioxidant containing thiol group, on total antioxidant capacity (TAC) and total oxidant capacity (TOC), adenosine deaminase (ADA), a significant indicator... more
The aim of this study was to determine the effect of exogenous GSH, an important antioxidant containing thiol group, on total antioxidant capacity (TAC) and total oxidant capacity (TOC), adenosine deaminase (ADA), a significant indicator of cellular immunity, and nitric oxide (NO) concentrations in rabbits. Sixteen healthy New Zealand rabbits were divided into 2 groups as control and GSH-treated group. Animals in control group received single intraperitoneal (ip) administration of 0.9% saline. Rabbits in GSH-treated group received reduced L-glutathione (10 mg/kg) (ip). Blood samples were taken from the marginal ear vein 0, 3, 6 and 12 hours after injection. Plasma TAC and NO levels were not statistically different between control and GSH group at 0 and 12 hours. Plasma TAC level was found to be significantly higher (p < 0.05) while NO level was found to be significantly lower (p < 0.05) in GSH treated group when compared to control group at 3 and 6 hours. Plasma TOC and ADA ac...
Research Interests: Chemistry, Medicine, Antioxidants, Nitric oxide, Female, and 7 moreAnimals, Antioxidant, Male, Glutathione, Rabbits, Adenosine Deaminase, and Oxidants
Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The... more
Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals. It was aimed to study the effects of therapeutic doses of ivermectin on the plasma adenosine deaminase (ADA) and gamma glutamyl transpeptidase activities (GGT), total antioxidant capacity (TAC), nitric oxide (NO) and total protein, albumin, globulin levels in rabbits. Twenty healthy New Zealand rabbits were allocated to 2 equal groups. Group I received 0.5 mg/kg and Group II received 1 mg/kg of ivermectin via subcutaneous injection. Blood samples were collected before the experiment, at 24 and 120 hours following the treatments. Ivermectin at therapeutic doses increased plasma NO level at 24 h while decreased TAC at 120 h and did not ...
Research Interests: Pharmacology, Medicine, Antioxidants, Nitric oxide, Female, and 4 moreAnimals, Male, Rabbits, and Ivermectin
Research Interests:
Research Interests:
Research Interests: Chemistry, Medicine, Antioxidants, Blood Glucose, Nitric oxide, and 15 moreAnimals, Antioxidant, Dietary Supplements, Japanese Quail, Triglycerides, Lipid peroxidation, Arginine, Egg White, Egg Weight, Antioxidant Capacity, Malondialdehyde, Total Antioxidant Capacity, Blood Chemistry, Serum albumin, and Total protein
Research Interests:
Research Interests:
... American Journal of Physiology 265, 862867. ↵: Gokce HI &; Woldehiwet Z. (2002) Production of tumor necrosis factor-alpha (TNF-α) and reactive ... Turkish Journal of Medical Sciences 39, 1319. ↵: Yanik M.,; Erel O. &; Kati... more
... American Journal of Physiology 265, 862867. ↵: Gokce HI &; Woldehiwet Z. (2002) Production of tumor necrosis factor-alpha (TNF-α) and reactive ... Turkish Journal of Medical Sciences 39, 1319. ↵: Yanik M.,; Erel O. &; Kati M. (2004) The relationship between potency of oxidative ...
Research Interests:
... growth rate and especially the utilization of amino acids from the maternal circulation for protein synthesis in the foetal muscles (Jainudeen and Hafez, 1994). ... Utilization of energy for lactation is regulated by many endocrine... more
... growth rate and especially the utilization of amino acids from the maternal circulation for protein synthesis in the foetal muscles (Jainudeen and Hafez, 1994). ... Utilization of energy for lactation is regulated by many endocrine factors, including growth hormone (Hatfield et al., 1999 ...
Research Interests:
The effect of orally administered l-carnitine on biochemical parameters was examined in lactating Tuj-ewes. Ewes were orally given 500 mg of l-carnitine daily for 3 weeks. To evaluate the changes on selected blood indicators (total... more
The effect of orally administered l-carnitine on biochemical parameters was examined in lactating Tuj-ewes. Ewes were orally given 500 mg of l-carnitine daily for 3 weeks. To evaluate the changes on selected blood indicators (total protein, albumin, glucose, triglyceride, cholesterol, ...
Research Interests:
Research Interests:
ABSTRACT Ozcan, A., Kaya, N., Atakisi, O., Karapehlivan, M., Atakisi, E. and Cenesiz, S. 2009. Effect of kefir on the oxidative stress due to lead in rats. J. Appl. Anim. Res., 35: 91–93.To study the effect of kefir given to the rats,... more
ABSTRACT Ozcan, A., Kaya, N., Atakisi, O., Karapehlivan, M., Atakisi, E. and Cenesiz, S. 2009. Effect of kefir on the oxidative stress due to lead in rats. J. Appl. Anim. Res., 35: 91–93.To study the effect of kefir given to the rats, which have been developed oxidative stress through administration of lead, 36 rats were divided into 4 groups, the control group, the lead group, lead and kefir group and kefir group. After 6 weeks of treatment, blood levels of the glutathione (GSH), malondialdehyde (MDA), vitamin E, β-carotene and retinol were determined. The GSH level in the lead group was significantly lower (P