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This study is concerned with the new transformed four-dimensional modified Lorenz-Stenflo chaotic system which is obtained from the transformation of state of modified Lorenz-Stenflo system (MLS) which is designed with the help of... more
This study is concerned with the new transformed four-dimensional modified Lorenz-Stenflo chaotic system which is obtained from the transformation of state of modified Lorenz-Stenflo system (MLS) which is designed with the help of Lorenz-Stenflo system by changing its one quadratic nonlinear term by a piecewise linear function to attain strict feedback form which is systematic design approach. Based on adaptive and backstepping control method an adaptive backstepping controller is derived to synchronize as well as stabilize the transformed MLS chaotic system. Error system are reduced by adaptive backstepping method. Complete numerical simulations are performed in order to check the efficacy based on the derived controller.
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Cloud computing, nowadays, is one amongst the rapidly developing technologies around the world which provides a variety of services to its users. One of the salient services offered by the cloud to its users is Storage as a... more
Cloud computing, nowadays, is one amongst the rapidly developing technologies around the world which provides a variety of services to its users. One of the salient services offered by the cloud to its users is Storage as a Service(STaaS). This service makes its user burden free from the task of storing and maintaining data by allowing him to transfer his data to a remote storage server and access it remotely. The user's data is maintained, managed and backed up by the cloud and is made available to him over the internet. But the main concern while using this type of service is the privacy and integrity of stored data. The data stored at remote locations may be accessed, modified or damaged by an attacker. Users require their data to be safe from all such unauthorized activities hence techniques for data integrity verification are needed to check whether the integrity of stored data is intact or not. Integrity verification is a challenging task because the user doesn't posses the data locally. The proposed scheme checks the integrity of data stored at remote location through a third party auditor using bilinear pairing. Later, aggregation is applied over the proposed scheme for further optimization.
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Federated learning is the new tide that is being associated with machine learning territory. It is an attempt to enable smart edge devices to confederate a mutual prediction model while the training data is residing at the respective edge... more
Federated learning is the new tide that is being associated with machine learning territory. It is an attempt to enable smart edge devices to confederate a mutual prediction model while the training data is residing at the respective edge device. This facilitates our data to be more secure, use less bandwidth, lower latency, and power consumption. We exercise the concept of federated learning in our neural network autoencoder model to detect the anomaly. Anomaly detection is finding the unusual pattern in a given data stream which may be a false or mal-entry in the pool of transactions. It helps us to prevent many online theft and scams which are detected using state-of-the-art machine learning and deep learning algorithms. All this has to be implemented in smart edge devices that have enough computing power to train the models provided to them.
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In the last decade, there has been a mounting concern in lipid-based formulations to deliver water-soluble drugs. Lipid-based drug delivery systems are one of the budding and promising technologies designed to tackle the poor... more
In the last decade, there has been a mounting concern in lipid-based formulations to deliver water-soluble drugs. Lipid-based drug delivery systems are one of the budding and promising technologies designed to tackle the poor bioavailability problems. This chapter stresses the different mechanisms of lipophilic drug absorption along with its advantages and limitations. It points out the different mechanisms of how lipid-based excipients and the different formulations interact with the absorption process. This review provides a comprehensive summary about the lipid formulation classification scheme (LFCS), a guide for the selection of appropriate formulation and commonly used excipients for lipid-based formulations, along with the important factors to be considered in formulation design and excipient selection. This review also focuses on the formulation of solid lipid-based formulations, important evaluation aspects, and commercial formulations available for the purpose.
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Management of leave and payroll are critical operations for each institution as it has effect on payment of staff memebers of any institution and also to complete it accurately and on time. The Current Leave and Payroll Manager both are... more
Management of leave and payroll are critical operations for each institution as it has effect on payment of staff memebers of any institution and also to complete it accurately and on time. The Current Leave and Payroll Manager both are paper based systems. Though the attendance is Biometric but still it is not that much efficient in terms of matters related to leave management. Manual payment calculation of staff members is too complex and it even takes lot of time and also requires lot of efforts. So if these processes are automated, it would be of great benefit as it would require less time to calculate the salary of the employees. So, a web application that has a payroll management system is considered as one of the way here. Mmultiple user data access is provided by these system. Users like staff members or administrator can login into the software by writing id and password which are allocated to them from the organization. It involves keeping track of hours worked and can kee...
Collaboration using mixed reality technology is an active area of research, where significant research is done to virtually bridge physical distances. There exist a diverse set of platforms and devices that can be used for a mixed-reality... more
Collaboration using mixed reality technology is an active area of research, where significant research is done to virtually bridge physical distances. There exist a diverse set of platforms and devices that can be used for a mixed-reality collaboration, and is largely focused for indoor scenarios, where, a stable tracking can be assumed. We focus on supporting collaboration between VR and AR users, where AR user is mobile outdoors, and VR user is immersed in true-sized digital twin. This cross-platform solution requires new user experiences for interaction, accurate modelling of the real-world, and working with noisy outdoor tracking sensor such as GPS. In this paper, we present our results and observations of real-time collaboration between cross-platform users, in the context of a geo-referenced virtual environment. We propose a solution for using GPS measurement in VSLAM to localize the AR user in an outdoor environment. The client applications enable VR and AR user to collaborat...
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This paper presents the fabrication and concept of four way hacksaw blade machine mainly carried out for production based industries. Industries are basically meant for production of useful goods and services at low production cost,... more
This paper presents the fabrication and concept of four way hacksaw blade machine mainly carried out for production based industries. Industries are basically meant for production of useful goods and services at low production cost, Machinery cost and low inventory cost. This project consists of a crank and slider mechanism, linear bushing .Today in this world every task have been made quicker and fast due to technology advancement but this advancement also demands huge investment and expenditure, every industry desires to make high productivity rate maintaining the quality and standard of the product at low averag e cost. We have developed a prototype model, we have decided to use almost 1/10 th of the scale for the system. These machines can be used in remote places where electricity is regular. It is designed as a portable one which can be used for cutting in various places. It can be used for operating on materials like thin metals, wood.
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Currently, the OpenCV function library is being used and becoming more common and used in digital images Processing to solve some image processing problems which can improve image processing efficiency. it is a computer vision method that... more
Currently, the OpenCV function library is being used and becoming more common and used in digital images Processing to solve some image processing problems which can improve image processing efficiency. it is a computer vision method that helps to find and visualize the faces in digital images view. This method is a special use in the case for object detection methods that process instances of semantic objects that detect certain classes (for example, people, buildings, or cars, etc.) in digital images and video. this technology plays an important role in Improve the recognition rate of face recognition systems in noise environment and curse Communicate with others. In this research paper, we discussed the use of face detection method in classrooms for attendance as well as for safety, security reasons and method of the detection faces which can adopt the relative positions of every specific face present in the classroom. The experiments show that this method can quickly and efficie...
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Arsenic contamination is turning out to be a major problem these days with its increasing area coverage and the number of people affected directly or indirectly. Now, the level of the contaminant has spread over the soil and sediments... more
Arsenic contamination is turning out to be a major problem these days with its increasing area coverage and the number of people affected directly or indirectly. Now, the level of the contaminant has spread over the soil and sediments from groundwater and other natural sources. Arsenic poisoning in groundwater events is familiar to the world, but the consequences of soil contamination are still unrevealed to the community. Long-term use of arsenic contaminated groundwater to irrigate crops, especially paddy (Oryza sativa L.) has resulted in elevated soil arsenic levels. Now the time is right to take into account the soil contamination of Arsenic and to devise cost effective remedial measures to correct this problem. This article deals with some of the remediation technologies included within broad category of physical, chemical and a few biological methods.
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As we all know that energy consumption has increased a lot and sources of energy are limited so in order to meet the increasing demand of energy use of renewable sources of energy is a must. Keeping this in mind in this paper we are... more
As we all know that energy consumption has increased a lot and sources of energy are limited so in order to meet the increasing demand of energy use of renewable sources of energy is a must. Keeping this in mind in this paper we are discussing about SOLAR LED STREET LIGHT WITH AUTO INTENSITY CONTROL. This street light is driven by solar energy and apart from this it also controls its intensity from dusk to dawn depending upon the brightness. This street light can save a large amount of electricity compared to the tradition one which are alight to their maximum intensity at all times after they are switched on.
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Phagocytosis is an important evolutionary conserved process, essential for clearing pathogens and cellular debris in higher organisms, including humans. This well‐orchestrated innate immunological response is intricately regulated by... more
Phagocytosis is an important evolutionary conserved process, essential for clearing pathogens and cellular debris in higher organisms, including humans. This well‐orchestrated innate immunological response is intricately regulated by numerous cellular factors, important amongst which are the immunomodulatory lysophosphatidylserines (lyso‐PSs) and the pro‐apoptotic oxidized phosphatidylserines (PSs) signalling lipids. Interestingly, in mammals, both these signalling lipids are physiologically regulated by the lipase ABHD12, mutations of which cause the human neurological disorder PHARC. Despite the biomedical significance of this lipase, detailed mechanistic studies and the specific contribution of ABHD12 to innate processes like phagocytosis remain poorly understood. Here, by immunohistochemical and immunofluorescence approaches, using the murine model of PHARC, we show, that upon an inflammatory stimulus, activated microglial cells in the cerebellum of mice deficient in ABHD12 have...
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Cancers of the oral cavity are one of the most common malignancies encountered among cancer patients in India.1 There are different histological variants of oral cavity cancers, and squamous cell carcinoma (SCC) is most common among them.... more
Cancers of the oral cavity are one of the most common malignancies encountered among cancer patients in India.1 There are different histological variants of oral cavity cancers, and squamous cell carcinoma (SCC) is most common among them. The main etiological factors implicated for development of oral cavity cancers are tobacco chewing and alcohol use.2 In India, carcinoma of buccal mucosa has the highest incidence among all the oral cavity cancers.3 The mean age of presentation is 50 years.4 Incidence among males is three times that of females.5 Most of the patients present in advanced stage (Stage III & IV) with majority in stage IV.6 Metastasis from oral cavity cancer takes place by detachment, invasion, proliferation and evasion through lymphatic system and blood vessels. It is regulated at various levels in the body.7 Most common sites of distant metastasis from oral cavity cancers are lungs and liver. Sometimes vertebral bone metastasis is also seen among patients. Metastasis ...
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In this paper, an IoT based women safety device is proposed and implemented for effective self-alert and protection. The proposed device is a three-way safety module for it provides self-defense, evidence recording and tracking... more
In this paper, an IoT based women safety device is proposed and implemented for effective self-alert and protection. The proposed device is a three-way safety module for it provides self-defense, evidence recording and tracking information. Due to increase in the rate of crimes against women, today's age safety of women is a major concern. For self-defence the device produces shock to the attacker through a nerve stimulator and rings a buzzer on pressing a button. It also allows to record evidence via a video camera which gets activated through the button and stores the footage in the Raspberry Pi. The prototype also consists of a GSM and GPS module which is activated by voice command through an Android Application. When the user will say the words "emergency" in his mobile application the device will send SMS alert containing the location of the user and auto dial the pre-set emergency contact number. A microphone and speaker are connected with the GSM module through which the user can hear and speak with the contacted person. Hardware used are Raspberry Pi 3 b+, GSM module, GPS module, relay module, buzzer and nerve stimulator.
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Autosomal dominant polycystic kidney disease (ADPKD) is an inherited chronic kidney disorder (CKD) that is characterized by the development of numerous fluid-filled cysts in kidneys. It is caused either due to the mutations in the PKD1 or... more
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited chronic kidney disorder (CKD) that is characterized by the development of numerous fluid-filled cysts in kidneys. It is caused either due to the mutations in the PKD1 or PKD2 gene that encodes polycystin-1 and polycystin-2, respectively. This condition progresses into end-stage renal disorder if the renal or extra-renal clinical manifestations remain untreated. Several clinical trials with a variety of drugs have failed, and the only Food and Drugs Administration (FDA) approved drug to treat ADPKD to date is tolvaptan that works by antagonizing the vasopressin-2 receptor (V2R). The pathology of ADPKD is complex and involves the malfunction of different signaling pathways like cAMP, Hedgehog, and MAPK/ERK pathway owing to the mutated product that is polycystin-1 or 2. A measured yet substantial number of preclinical studies have found pioglitazone to decrease the cystic burden and improve the renal function in ADPKD...
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Research Interests:
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In cells, the breakdown of arginine to ornithine and ammonium ion plus carbon dioxide is coupled to the generation of metabolic energy in the form of ATP. The arginine breakdown pathway is minimally composed of arginine deiminase,... more
In cells, the breakdown of arginine to ornithine and ammonium ion plus carbon dioxide is coupled to the generation of metabolic energy in the form of ATP. The arginine breakdown pathway is minimally composed of arginine deiminase, ornithine transcarbamoylase, carbamate kinase, and an arginine/ornithine antiporter; ammonia and carbon dioxide most likely diffuse passively across the membrane. The genes for the enzymes and transporter have been cloned and expressed, and the proteins have been purified from Lactococcus lactis IL1403 and incorporated into lipid vesicles for sustained production of ATP. Here, we study the kinetic parameters and biochemical properties of the individual enzymes and the antiporter, and we determine how the physicochemical conditions, effector composition, and effector concentration affect the enzymes. We report the KM and VMAX values for catalysis and the native oligomeric state of all proteins, and we measured the effect of pathway intermediates, pH, temper...
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India has committed for a ‘No First Use Policy’ (NFU) regarding its nuclear warfare strategy. This has continued since the time India became a nuclear state. India's nuclear doctrine has always played an important role in determining... more
India has committed for a ‘No First Use Policy’ (NFU) regarding its nuclear warfare strategy. This has continued since the time India became a nuclear state. India's nuclear doctrine has always played an important role in determining the stability in Asia. Recently the issue has been escalated as India’s Defence Minister gave a statement to media which shows that Indian government could explore other options also regarding its Nuclear Policy. Statement has come at the time when there is abrogation of Article 370 from Jammu and Kashmir has happened letting the tensions to rise between India and Pakistan. This rise in exertion from the side of China and Pakistan has sparked the debate on India's nuclear capability. It raises questions like; does India need to update its doctrine? There is an emerging debate among the strategic community also that India needs to give the NFU policy and even need to make many other changes in the whole doctrine. The NFU policy has often been held as proof of India’s status as a responsible nuclear power. Various factors are to be analyzed before reaching to any conclusion.
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Microbe induced cardiovascular diseases (CVDs) are less studied at present. Host-pathogen interactions (HPIs) between human proteins and microbial proteins associated with CVD can be found dispersed in existing molecular interaction... more
Microbe induced cardiovascular diseases (CVDs) are less studied at present. Host-pathogen interactions (HPIs) between human proteins and microbial proteins associated with CVD can be found dispersed in existing molecular interaction databases. MorCVD database is a curated resource that combines 23,377 protein interactions between human host and 432 unique pathogens involved in CVDs in a single intuitive web application. It covers endocarditis, myocarditis, pericarditis and 16 other microbe induced CVDs. The HPI information has been compiled, curated, and presented in a freely accessible web interface (http://morcvd.sblab-nsit.net/About). Apart from organization, enrichment of the HPI data was done by adding hyperlinked protein ID, PubMed, gene ontology records. For each protein in the database, drug target and interactors (same as well as different species) information has been provided. The database can be searched by disease, protein ID, pathogen name or interaction detection meth...
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Phagocytosis is an evolutionarily conserved biological process where pathogens or cellular debris are cleared by engulfing them in a membrane-enclosed cellular compartment called the phagosome. The formation, maturation, and subsequent... more
Phagocytosis is an evolutionarily conserved biological process where pathogens or cellular debris are cleared by engulfing them in a membrane-enclosed cellular compartment called the phagosome. The formation, maturation, and subsequent degradation of a phagosome is an important immune response essential for protection against many pathogens. Yet, the global lipid profile of phagosomes remains unknown, especially as a function of their maturation in immune cells. Here, we show using mass spectrometry based quantitative lipidomics that the ceramide class of lipids, especially very long chain ceramides, are enriched on maturing phagosomes with a concomitant decrease in the biosynthetic precursors of ceramides. We thus posit a new function for the enzyme ceramide synthase during phagocytosis in mammalian macrophages. Biochemical assays, cellular lipid feeding experiments, and pharmacological blockade of ceramide synthase together show that this enzyme indeed controls the flux of ceramid...
Research Interests: Biochemistry, Evolutionary Biology, Genetics, Microbiology, Biophysics, and 15 moreChemistry, Inorganic Chemistry, Immunology, Mental Health, Mass Spectrometry, Cancer, Biology, Cell Biology, Medicine, Biological Sciences, Lipidomics, Ceramide, CHEMICAL SCIENCES, Lipid Profile, and Biochemical assays
We report 250–800 nm UV-Vis monomeric protein absorption originating from protein backbone–sidechain and sidechain–sidechain charge transfer transitions involving Lys/Glu residues.
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Pregabalin is an anti-epileptic drug which has been used for the treatment of diabetic peripheral neuropathy. Earlier, it was more prescribed as an adjuvant therapy for treating the partial seizures with or without secondary... more
Pregabalin is an anti-epileptic drug which has been used for the treatment of diabetic peripheral neuropathy. Earlier, it was more prescribed as an adjuvant therapy for treating the partial seizures with or without secondary generalization in adults. It is an antagonist of voltage sensitive calcium ion channel on the presynaptic neuron. Pregabalin has a very good pharmacokinetic profile, possesses linear pharmacokinetics with low inter-variability of subjects. It does not show protein binding and does not interfere with the metabolism of other drugs because pregabalin undergoes very less metabolism. This factor has confirmedly shown that its benefits outweigh the risk. Different clinical trials and case reports have confirmed the fact that is reduces the pain involved in peripheral neuropathy. Though, more drugs have come like tricyclic antidepressant to manage the pain but due to their adverse effects, they are less used. This reappraisal is all about the pregabalin, its role, and ...
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In this present work, a microstrip low pass filter has been developed with wide stop band. In this work, in order to achieve sharp cut-off and high attenuation in stop band, two techniques namely CSRR (Complementary Split Ring Resonator)... more
In this present work, a microstrip low pass filter has been developed with wide stop band. In this work, in order to achieve sharp cut-off and high attenuation in stop band, two techniques namely CSRR (Complementary Split Ring Resonator) and SRR. (Split Ring Resonator) are used. In this work both of the above mentioned techniques are used at a time in the same patch. Comparison between normal and enhanced responses have been shown.
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Research Interests:
In recent years, relay feedback method has found a new lease of life in the automatic tuning of PID controllers and in the initialization of other sophisticated adaptive controllers. This tuner is based on the approximate estimation of... more
In recent years, relay feedback method has found a new lease of life in the automatic tuning of PID controllers and in the initialization of other sophisticated adaptive controllers. This tuner is based on the approximate estimation of the critical point on the process frequency response from relay oscillations. A continuous cycling of the controlled variable is generated from a relay feedback experiment and the important process information, ultimate gain and ultimate period can be extracted directly from the experiment. This is a very efficient way, i.e., a one shot solution, to generate sustained oscillations. The success of this auto tuner is due to the fact that the identification and tuning mechanism is simple so that process operators understand how it works. Moreover, it works well even in slow and non-linear processes.
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Proteins are playing a vital role in maintaining the cellular integrity and function, as well as for brain cells. Protein intake and supplementation of individual amino acids can affect the brain functioning and mental health, and many of... more
Proteins are playing a vital role in maintaining the cellular integrity and function, as well as for brain cells. Protein intake and supplementation of individual amino acids can affect the brain functioning and mental health, and many of the neurotransmitters in the brain are made from amino acids. The amino acid supplementation has been found to reduce symptoms, as they are converted into neurotransmitters which in turn extenuate the mental disorders. The biosynthesis of amino acids in the brain is regulated by the concentration of amino acids in plasma. The brain diseases such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder (OCD), and Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HD) are the most common mental disorders that are currently widespread in numerous countries. The intricate biochemical and molecular machinery contributing to the neurological disorders is still unknown, and in this chapter, we revealed the invo...