Peter Adriaensens
Universiteit Hasselt, Faculty of Science, Faculty Member
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An aqueous precursor solution, containing citrato-VO2+ complexes, is synthesized for the formation of monoclinic VO2.
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Research Interests: Materials Science, Chemistry, Technology, Medicine, Pharmaceutics, and 15 moreComposite Material, Dissolution, Oral Drug Delivery, Compression, Hot Melt Extrusion, Carbamazepine, Polyvinyl alcohol, Poly Vinyl Alcohol, Compaction, Extrusion, Solid Dispersions, Technology and Engineering, RELEASE, Elastic Recovery, and Pharmacology and pharmaceutical sciences
Research Interests: Algorithms, Materials Science, Crystallization, Amylopectin, Magnetic Resonance Spectroscopy, and 15 moreExperimental Design, Medicine, Amylose, Cellulose, Excipient, Granulation, European, Particle Size, Extrusion, Drug Carriers, Excipients, Drug Release, Aspect Ratio, Microcrystalline Cellulose, and friability
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Acrylate‐endcapped urethane‐based precursors constituting a poly(D,L‐lactide)/poly(ε‐caprolactone) (PDLLA/PCL) random copolymer backbone are synthesized with linear and star‐shaped architectures and various molar masses. It is shown that... more
Acrylate‐endcapped urethane‐based precursors constituting a poly(D,L‐lactide)/poly(ε‐caprolactone) (PDLLA/PCL) random copolymer backbone are synthesized with linear and star‐shaped architectures and various molar masses. It is shown that the glass transition and thus the actuation temperature could be tuned by varying the monomer content (0–8 wt% ε‐caprolactone, Tg,crosslinked = 10—42 °C) in the polymers. The resulting polymers are analyzed for their physico‐chemical properties and viscoelastic behavior (G′max = 9.6–750 kPa). The obtained polymers are subsequently crosslinked and their shape‐memory properties are found to be excellent (Rr = 88–100%, Rf = 78–99.5%). Moreover, their potential toward processing via various additive manufacturing techniques (digital light processing, two‐photon polymerization and direct powder extrusion) is evidenced with retention of their shape‐memory effect. Additionally, all polymers are found to be biocompatible in direct contact in vitro cell assa...
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Inpresenceofwater, therehabilitees ofXLPE are greatly influenced bytheformation ofwatertrees. In this papertheXLPEinsulation degraded bywatertrees bywaterinception through external cracks inthePVC sheath hasbeenstudied by different... more
Inpresenceofwater, therehabilitees ofXLPE are greatly influenced bytheformation ofwatertrees. In this papertheXLPEinsulation degraded bywatertrees bywaterinception through external cracks inthePVC sheath hasbeenstudied by different techniques. Classical techniques hasbeenusedas theoptical microscope examination ofwatertrees after coloration, FT-IR mapping ofcutthinfilms butalsowithother methods ofinvestigation asspacecharges measurement bythethermal stepmethodandMagnetic Resonance Imaging (MRI) for waterpenetration. A 2D MRItransversal mapping ofthewaterinthe insulation showthree regions: an external one full of watertreestill thethird ofthedepth explaining the electrical breakdown, thereafter aregion ofvoids dueto anoldsteamextrusion andathird without watertrees. The degradation of thecables arises froma simultaneous presenceofbothdipoles andinjected spacecharges which create a non linear internal field. Therefore thespacecharge profile infunction ofthe depth hasbeenstudied on awet...
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Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the... more
Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the foreign body response. In this work, phosphodiester‐crosslinked hydrogels are produced by a simple free‐radical polymerization of a phosphotriester crosslinker. In a second step, this material is transformed to the phosphodiester, by heating it up to 60 °C in phosphate‐buffered saline. Compared to earlier methods, there is no need for acids, bases, or oxidizing agents to achieve this final conversion to the phosphodiester. This method thus reduces the risk to damage or degrade any sensitive biomolecules that might be of interest to tissue engineers, such as various growth factors or other proteins. The phosphotriester crosslinker is readily synthesized out of common laboratory chemicals in multigram quantities with good yield and easy workup and purifi...
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For paper coatings with organic nanoparticles of poly(styrene‐co‐maleimide), dispersive Raman spectroscopy and confocal Raman microscopy are applied for qualitative and quantitative analyses of the lateral distribution of chemical... more
For paper coatings with organic nanoparticles of poly(styrene‐co‐maleimide), dispersive Raman spectroscopy and confocal Raman microscopy are applied for qualitative and quantitative analyses of the lateral distribution of chemical moieties as a function of different coating grades (degree of imidization) and thermal curing temperatures (120–250 °C). Raman mapping with band intensity ratios, single band intensities, and average spectral intensities illustrates that surface locations with imide moieties are sensitive to the thermal curing temperature due to the reactivity of an amount of ammonolyzed (nonimidized) maleic anhydride, whereas the styrene moieties are not sensitive to the thermal curing. A maximum in imide functionalities at the surface occurs after curing at 135–150 °C depending on the coating grade. The surface coverage of the coating moieties is complementary to the cellulose components, but local variations in specific Raman bands for the latter suggest interactions du...
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The synthesis of polymers from radical polymerization of dialkyl muconates, a renewable monomer that is readily available from biofermentation, is described. Polymuconates are scarcly described in literature, and were previously believed... more
The synthesis of polymers from radical polymerization of dialkyl muconates, a renewable monomer that is readily available from biofermentation, is described. Polymuconates are scarcly described in literature, and were previously believed to polymerize only sluggishly. In here we demonstrate the optimized polymerization that yields materials that are analoguous to classical oil-based polyacrylates. Thermal properties of the polymers are explored, and the abaility to control the polymerization via reversible deactivation radical polymerization is showcased.
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Oxaliplatin is a platinum (Pt)containing antineoplastic agent that is applied in current clinical practice for the treatment of colon and appendiceal neoplasms. A fully validated, highly sensitive, high throughput inductively coupled... more
Oxaliplatin is a platinum (Pt)containing antineoplastic agent that is applied in current clinical practice for the treatment of colon and appendiceal neoplasms. A fully validated, highly sensitive, high throughput inductively coupled plasma mass spectrometry (ICP-MS) method is provided to quantify the total Pt content in plasma, plasma ultrafiltrate, urine and peritoneal fluid. In this ICP-MS approach, the only step of sample preparation is a 1000-fold dilution in 0.5% nitric acid, allowing the analysis of 17 samples per hour. Detection of Pt was achieved over a linear range of 0.01-100 ng/mL. The limit of quantification was 18.0 ng/mL Pt in plasma, 8.0 ng/mL in ultrafiltrate and 6.1 ng/mL in urine and peritoneal fluid. The ICP-MS method was further validated for inter-and intraday precision and accuracy (≤15%), recovery, robustness and stability. Short-term storage of the biofluids, for 14 days, can be performed at -4 °C, -24 °C and -80 °C. As to long-term stability, up to 5 months...
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Site-specific functionalization of nanobodies after introducing bioorthogonal groups offers the possibility to biofunctionalize surfaces with a uniformly oriented layer of nanobodies. In this paper, expressed protein ligation (EPL) was... more
Site-specific functionalization of nanobodies after introducing bioorthogonal groups offers the possibility to biofunctionalize surfaces with a uniformly oriented layer of nanobodies. In this paper, expressed protein ligation (EPL) was used for site-specific alkynation of the model nanobody NbBcII10. In contrast to EPL constructs, which are typically expressed in the cytoplasm, nanobodies are expressed in the periplasm where its oxidizing environment ensures a correct folding and disulfide bond formation. Different pathways were explored to express the EPL constructs in the periplasm but simultaneously, the effect of cytoplasmic expression on the functionality of NbBcII10 was also evaluated. By using Escherichia coli SHuffle(®)T7 cells, it was demonstrated that expression of the EPL complex in the cytoplasm was readily established and that site-specifically mono-alkynated nanobodies can be produced with the same binding properties as the non-modified NbBcII10 expressed in the peripl...
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Research Interests: Chemistry, Amylopectin, Pharmaceutical Chemistry, Medicine, Pharmaceutics, and 15 moreInsulin, Animals, FORMULATION, Bioavailability, Mixtures, Freeze Drying, Delivery, Influenza Vaccine, Powders, Intranasal Administration, Medicine and Health Sciences, Drug Carriers, Biological Availability, Metoprolol, and Pharmacology and pharmaceutical sciences
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ABSTRACT An acid-induced conversion method for dithiocarbamate precursor poly(thienylenevinylene) (PTV) and poly(phenylenevinylene) (PPV) derivatives is presented, which has the advantage that it can be executed at moderate temperatures.... more
ABSTRACT An acid-induced conversion method for dithiocarbamate precursor poly(thienylenevinylene) (PTV) and poly(phenylenevinylene) (PPV) derivatives is presented, which has the advantage that it can be executed at moderate temperatures. The lower conversion temperature avoids possible thermal degradation of the polymer chromophore structure, and therefore conjugated polymers with a higher effective conjugation length can be obtained. This process was studied using UV−vis and FTIR spectroscopy. The obtained results indicate that trifluoroacetic acid yields a more defect-free structure as compared to benzenesulfonic acid which induces degradation after prolonged reaction times. A tentative mechanism is proposed in which the formation of an intermediate carbenium ion is part of the rate-limiting step. It also implicates a competition between elimination and substitution reactions depending on specific reaction conditions.
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The development of stimuli-responsive nanomaterials, that possess tailored functional properties for the release of specific compounds, is of particular interest.
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Abstract A novel class of polystyrene-based gel-type resins (SPACeR, SP), containing the large 1,4-bis(4-vinylphenoxy)benzene cross-linker, is introduced; SP-immobilized 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and triethylamine (TEA)... more
Abstract A novel class of polystyrene-based gel-type resins (SPACeR, SP), containing the large 1,4-bis(4-vinylphenoxy)benzene cross-linker, is introduced; SP-immobilized 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and triethylamine (TEA) bases are synthesized and characterized in terms of their structural, thermal and morphological features, and their catalytic efficiency in a series of fundamental chemical transformations under solvent-free conditions is investigated.
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Research Interests: Chemistry, NMR Spectroscopy, Polysaccharides, Cytotoxicity, Hydrogels, and 13 moreMedicine, Optimization, In Vitro, Sequence, Derivatization, Substitution, Acid, Biological Macromolecules, Hydrolysis, Sodium Alginate, Biochemistry and cell biology, Nuclear Magnetic Resonance Spectroscopy, and degree of substitution
The chemical regeneration of exhausted granular activated carbon (GAC) from a water treatment plant to produce dialysis water used in hemodialysis treatments for chronic renal disease patients from a general Hospital of Ciego de Avila... more
The chemical regeneration of exhausted granular activated carbon (GAC) from a water treatment plant to produce dialysis water used in hemodialysis treatments for chronic renal disease patients from a general Hospital of Ciego de Avila province, Cuba, was investigated. Activated carbon (AC) exhausted mainly by inorganics (Ca (Ca-chelates), Mg and Na) was regenerated using hydrochloric acid and acetic acid (one regeneration cycle). Solutions of 5%, 10%, 15% and 20%(v/v) as well as four contact times (2 h, 4 h, 6 h and 48 h) for hydrochloric acid and three contact times (2 h, 4 h and 6 h) for acetic acid at 25°C and 1 atm in a dosage of 1 g GAC/10 mL were used. Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES), thermogravimetric analysis (TGA), X-ray absorption technique (XRA) and Scanning Electronic Microscopy (SEM) were used to evaluate the effect of the regeneration on exhausted GAC. Batch and scaled column experiments were developed. Breakthrough curves were obtaine...
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In this study, a new cost-benefit economic model for hemodialyzer reuse has been developed considering all of the direct costs (dialyzer price, disinfection fluid price, reverse osmosis water cost, personnel, and miscellaneous) as well as... more
In this study, a new cost-benefit economic model for hemodialyzer reuse has been developed considering all of the direct costs (dialyzer price, disinfection fluid price, reverse osmosis water cost, personnel, and miscellaneous) as well as the number of disinfections applied to the hemodialyzer. The maximum number of disinfections/reuses for different models of hemodialyzer was estimated using statistical analysis based on the information obtained from a total of 60 adult patients on maintenance hemodialysis for approximately 4 years; from a hospital in Santiago de Cuba province, Cuba. An equal number of treatments (100) was evaluated for each hemodialyzer including 2,800 total reuses. The total cost savings for reuse/disinfection using the new economic approach is compared with the single-use modality. Obtained results by applying the proposed model indicated that the correlation between the economic advantages of the reuse/disinfection process in the total cost of the hemodialysis ...
Research Interests: Hemodialysis and Reuse
In oncology, Positron Emission Tomography (PET) is frequently performed for cancer staging and treatment monitoring. Metabolic active tumor volume (MATV) as well as total MATV (TMATV - including primary tumor, lymph nodes and metastasis)... more
In oncology, Positron Emission Tomography (PET) is frequently performed for cancer staging and treatment monitoring. Metabolic active tumor volume (MATV) as well as total MATV (TMATV - including primary tumor, lymph nodes and metastasis) derived from PET images have been identified as prognostic factor or for evaluating treatment efficacy in cancer patients. To this end a segmentation approach with high precision and repeatability is important. Moreover, to derive TMATV, a reliable segmentation of the primary tumor as well as all metastasis is essential. However, the implementation of a repeatable and accurate segmentation algorithm remains a challenge. In this work, we propose an artificial intelligence based segmentation method based on textural features (TF) extracted from the PET image. From a large number of textural features, the most important features for the segmentation task were selected. The selected features are used for training a random forest classifier to identify voxels as tumor or background. The algorithm is trained, validated and tested using a lung cancer PET/CT dataset and, additionally, applied on a fully independent test-retest dataset. The approach is especially designed for accurate and repeatable segmentation of primary tumors and metastasis in order to derive TMATV. The segmentation results are compared with conventional segmentation approaches in terms of accuracy and repeatability. In summary, the TF segmentation proposed in this study provided better repeatability and accuracy than conventional segmentation approaches. Moreover, segmentations were accurate for both primary tumors and metastasis and the proposed algorithm is therefore a good candidate for PET tumor segmentation.
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BackgroundRadiomics refers to the extraction of a large number of image biomarker describing the tumor phenotype displayed in a medical image. Extracted from positron emission tomography (PET) images, radiomics showed diagnostic and... more
BackgroundRadiomics refers to the extraction of a large number of image biomarker describing the tumor phenotype displayed in a medical image. Extracted from positron emission tomography (PET) images, radiomics showed diagnostic and prognostic value for several cancer types. However, a large number of radiomic features are nonreproducible or highly correlated with conventional PET metrics. Moreover, radiomic features used in the clinic should yield relevant information about tumor texture. In this study, we propose a framework to identify technical and clinical meaningful features and exemplify our results using a PET non‐small cell lung cancer (NSCLC) dataset.Materials and methodsThe proposed selection procedure consists of several steps. A priori, we only include features that were found to be reproducible in a multicenter setting. Next, we apply a voxel randomization step to identify features that reflect actual textural information, that is, that yield in 90% of the patient scan...