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      PeruDengue VirusBiological SciencesHumans
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      MathematicsBiological SciencesHumansMathematical Sciences
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      Biological SciencesHumansYellow feverVaccine
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      GeneticsImmune responseClinical TrialHuman Development
No abstract
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      Infectious DiseasesDengue VirusDengue feverDengue Hemorrhagic Fever
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      Optimal ControlDengue VirusBiological SciencesDisease Outbreaks
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      BrazilBiological SciencesHumansVaccine
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      Dengue VirusBiological SciencesVirusMice
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      Flow CytometryDengue VirusBiological SciencesEscherichia coli
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      Immune responseDengue VirusBiological SciencesCell line
Dengue is a viral pandemic caused by four dengue virus serotypes (DENV-1, 2, 3, and 4) transmitted by Aedes mosquitoes. Reportedly, there has been a 2-fold increase in dengue cases every decade. An efficacious tetravalent vaccine, which... more
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      Dengue VirusCell lineMiceAnimals
Dengue is an important and well-documented public health problem in the Asia-Pacific and Latin American regions. However, in Africa, information on disease burden is limited to case reports and reports of sporadic outbreaks, thus... more
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      Research DesignAfricaPublic HealthAdolescent
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      Dengue VirusHumansMiceAnimals
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      VirologyBiological SciencesMacacaAnimals
Recombinant fusion protein containing domain III of the dengue envelope protein fused to capsid protein from dengue 2 virus was immunogenic and conferred protection in mice against lethal challenge in previously report. Here, the... more
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      Medical MicrobiologySurvival AnalysisHumansMice
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      MathematicsBiological SciencesHumansMathematical Sciences
Dengue (DF) and dengue hemorrhagic fevers (DHF) are present in urban and suburban areas in the Americas, South-East Asia, the Eastern Mediterranean and the Western Pacific, but dengue fever is present mainly in the rural areas of Africa.... more
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      Global HealthEgyptTravelHumans
The global occurrence of viral infectious diseases poses a significant threat to human health. Dengue virus (DENV) infection is one of the most noteworthy of these infections. According to a WHO survey, approximately 400 million people... more
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      Drug DiscoveryDengue VirusHumansDengue
Un récent vaccin contre la dengue suscite d'importantes réserves de la part de la communauté scientifique. Sa diffusion en 2016 aux Philippines semble répondre autant à des enjeux de santé publique qu'à des intérêts diplomatiques et... more
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      Clinical TrialsVaccine developmentDengue Vaccines
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      MicrobiologyImmunologyMedical MicrobiologyDengue Virus
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      Dengue VirusBiological SciencesMathematical SciencesDengue
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      Dengue VirusBiological SciencesEscherichia coliMolecular cloning
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      MathematicsBiological SciencesHumansMathematical Sciences
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      MicrobiologyMedical MicrobiologyVirologyMedicine
Background: Dengue is a global arboviral threat to humans; causing 390 million infections per year. The availability of safe and effective tetravalent dengue vaccine is a global requirement to prevent epidemics, morbidity, and mortality... more
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    • Dengue Vaccines
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      VirologyDengue VirusBiological SciencesCercopithecus aethiops
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      Treatment OutcomeAdolescentHumansChild
 Dengue viruses (DENV) infect over 300 million people annually causing 96 million cases of dengue disease and 22,000 deaths [1]. A safe vaccine which protects against DENV disease is a global health priority [2].  We enrolled 72... more
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      Infectious DiseasesAdolescentMedicineDengue Virus
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      Global HealthEgyptTravelHumans
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      Infectious DiseasesAdolescentDengue VirusBiological Sciences
A live-attenuated tetravalent dengue virus (DENV) vaccine candidate has been well tolerated and immunogenic in healthy, US flavivirus naive adult volunteers. We conducted a pilot, safety, and immunogenicity trial of the vaccine candidate... more
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      Immune responseClinical TrialTropical MedicinePublic Health
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      GeneticsDengue VirusBiological SciencesHumans
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      ImmunologyDengue VirusVirulenceCercopithecus aethiops
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    •   57  
      MicrobiologyImmunologyMedical MicrobiologyVirology
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      Public HealthDengue VirusBiological SciencesHumans
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      Survival AnalysisDengue VirusBiological SciencesHumans
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      Dengue VirusBiological SciencesHumansMice
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      ImmunologyMedical MicrobiologyAdolescentDengue Virus
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    •   16  
      Treatment OutcomeAdolescentDengue VirusTravel
Abstract. A live-attenuated tetravalent dengue virus (DENV) vaccine candidate has been well tolerated and im-munogenic in healthy, US flavivirus naive adult volunteers. We conducted a pilot, safety, and immunogenicity trial of the vaccine... more
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      Immune responseClinical TrialPublic HealthMedicine
Background In efficacy trials of a tetravalent dengue vaccine (CYD-TDV), excess hospitalizations for dengue were observed among vaccine recipients 2 to 5 years of age. Precise risk estimates according to observed dengue serostatus could... more
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      Treatment OutcomeAdolescentDengue VirusHumans
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      HumansDengueVaccinationDengue Vaccines
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      MalaysiaBiological SciencesSafetyHumans
A live-attenuated dengue-2 virus strain S16803 vaccine candidate that is immunogenic and safe in humans was derived by 50 passages in primary dog kidney (PDK) cells. To identify mutations associated with attenuation of the dengue-2 PDK50... more
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      Growth KineticsDengue VirusBiological SciencesVirulence
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      EngineeringPhysicsChemistryImmune response
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      Clinical TrialDengue VirusBiological SciencesPrimates
Dengue is a mosquito borne infection, which in recent years has become a major international public health concern. Annually, 100 million dengue virus infections are reported worldwide. The nonstruc-tural protein 1 (NS1) of dengue virus... more
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      PharmacyDengue VirusPharmaceutical BiotechnologyDengue Transmission
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      Dengue VirusBiological SciencesHumansGeneral
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      Tropical MedicineThailandPreventionHumans
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      BioinformaticsComputational BiologyDengue VirusBiological Sciences