- Centurion University of Technology and Management
School of Pharmacy
Pitamahal
Rayagada-765002
- Maharajahs College Of Pharmacy, Pharmaceutical Chemistry, Faculty Memberadd
- Dr. Gopal Krishna Padhy obtained his M.Pharm. degree in Pharmaceutical chemistry from Poona College of Pharmacy, Bhar... moreDr. Gopal Krishna Padhy obtained his M.Pharm. degree in Pharmaceutical chemistry from Poona College of Pharmacy, Bharati Vidyapeeth University, in 2007. He had carried out his Ph.D. work under joint supervision of Dr. Ajaya Kumar behera and Dr. Jagadeesh Panda in Sambalpur University. He worked as Asst.Professor in Maharajah's College of Pharmacy, Vizianagaram, Andhra Pradesh from 2007-2019. Currently he is working as an associate professor in Centurion University of Technology and Management, Rayagada, Odisha, India.edit
Research Interests:
The advance progression in the pharmaceuticals brought a new era in human health. These pharmaceutical preparations might serve their envisioned solitary if they're free from impurities and as long as are administered in suitable... more
The advance progression in the pharmaceuticals brought a new era in human health. These pharmaceutical preparations might serve their envisioned solitary if they're free from impurities and as long as are administered in suitable quantity. With intensifying regulatory stringency on the control of medicines, impurities and their degradation constituents in unadulterated and formulated products, a strong emphasis is being placed on the need of the stability viewing systems/methods to measure the drugs and their impurities by utilizing assortment of common analytical instrumental strategies. Every single procedure has its one unique impact in assessing the pharmaceutical preparations, and investigating their impurities, which could have a hazard to human existence. In the drug manufacturing an impurity is measured, characterized any other organic substances in addition to the drug substance or pharmaceutical ingredients. The impurity can be fashioned in the course of the drug prepa...
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A novel series of 2-Benzyl substituted benzimidazole acetohydrazone derivatives was synthesized by multistep reaction sequences. The synthesized compounds were characterized using IR, 1H NMR, mass and elemental analysis. Antibacterial... more
A novel series of 2-Benzyl substituted benzimidazole acetohydrazone derivatives was synthesized by multistep reaction sequences. The synthesized compounds were characterized using IR, 1H NMR, mass and elemental analysis. Antibacterial activities of the compounds were evaluated against selective gram positive and gram negative bacteria. Compound 7 was found to be most active among the series.
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Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: “Zero crossing... more
Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: “Zero crossing technique” was chosen for quantitative determination. The zero-crossing points (ZCP’s) were found to be 209 nm where metoprolol succinate was quantified and 211 nm where ramipril was quantified. This method was then subjected to accuracy, linearity, sensitivity and reproducibility according to ICH guidelines to ensure and confirm its validity. Results: The method was found to be obeying Beer’s law in the range of 10-50 µg/ml and 5-25 µg/ml for metoprolol succinate and ramipril, respectively. The % recoveries were observed between the range of 99.2-100.2 for metoprolol succinate and 99.57-99.86 for ramipril. The intra-day and inter-day results showed reproducibility. Conclusion: It can be concluded that the developed third-order UV derivative spectro...
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A new HPLC stability indicating method was developed and optimized by using a statistical tool, design expert 13.0.1.0 (Stat-Ease) for simultaneous quantitation of bilastine and montelucast sodium in marketed tablet dosage form.... more
A new HPLC stability indicating method was developed and optimized by using a statistical tool, design expert 13.0.1.0 (Stat-Ease) for simultaneous quantitation of bilastine and montelucast sodium in marketed tablet dosage form. Randomized response surface methodology with two factor central composite design was utilized for mobile phase optimization and the effect of the independent variables, flow rate and volume of organic phase on critical quality attributes, resolution and retention time was studied. The analytes were resolved on a inertsil C18 (150 × 4.6 mm) column with 5 μm particle size. Within the design space the optimum chromatographic condition chosen was 0.1% orthophosphoric acid with acetonitrile at 60:40 (%v/v) having a flow rate of 1 min/mL for 10 min. The retention time (Rt) for bilastine and montelucast sodium was 2.445 and 3.787 min, respectively. The method was completely validated as per the current ICH guidelines. Forced degradation was carried out in acidic, b...
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Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is... more
Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to present the literature on 2-acetylbenzimidazole chemistry and provide valuable and up-to-date information for its applications. The present review is carried out by compiling literature from 1964 to 2020 concerning the synthesis and biological aspects of various heterocyclic compounds derived from 2-acetylbenzimidazole. Literature was collected from various online search engines viz. Google Scholar, PubMed, Science Direct, Core, and Semantic scholar. 2-acetylbenzimidazole has been successfully employed as a synthon to obtain heterocyclic system viz. oxirane, pyrazoline, thiazole, pyrazole, isoxazoline, isoxazole, pyridine, pyrimidine, ...
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Spathodea campanulata P. Beauv., belonging to the family Bignoniaceae, is a big erect tree with an ancient history of medicinal use in Africa. In the traditional system, it is mentioned for the treatment of malaria, diabetes, stomach... more
Spathodea campanulata P. Beauv., belonging to the family Bignoniaceae, is a big erect tree with an ancient history of medicinal use in Africa. In the traditional system, it is mentioned for the treatment of malaria, diabetes, stomach ulcers, wounds, skin infections and viral diseases. The aim of the review is to make available the current information that exists on the traditional uses, phytochemistry, pharmacology, and toxicology of S. campanulata. Additionally, the potential uses of this plant to treat various diseases and to bring in a foundation for further research are emphasized. The present review is carried out by compiling literature from 1972 to 2021, concerning the morphology, traditional uses, phytochemistry, pharmacological activities, and toxicological aspects of S. campanulata. Literatures were collected from various online search engines, viz. Google Scholar, PubMed, Science Direct, Core, and Semantic Scholar. Diverse chemical compounds including iridoids, terpenoids, steroids, cinnamic acid derivatives, cerebrosides, flavonoids, and carotenoids have been isolated from this plant. Mostly in-vivo models have indicated several evidences of the use of this plant particularly to cure malaria. Few in-vivo studies have also proved the usefulness of this plant in inflammation, wound healing, diabetes, and convulsion. In some in-vitro studies, the anticancer, antibacterial, antiviral insecticidal, larvicidal, and anti-oxidant potential has been proved. Preclinical studies have demonstrated remarkable activity which supports the conventional use of the plant as an antimalarial, wound healing, antidiabetic, antimicrobial, and anti-inflammatory agent for years without any adverse effects. Based on the results obtained from a combination of in vivo and in vitro potency and toxicity studies reported, S. campanulata is a promising agent in the development of nutraceuticals against malaria and diabetes. Although few phytochemicals isolated (ursolic acid, tomentosolic acid, 20β-hydroxyursolic acid, verminoside, specioside, spathoside, kaempferol, and β-sitosterol-3-acetate) from the plant exhibited remarkable biological activity, it was only confined to preclinical study. The only clinical study documented is for curing malaria, but with crude extract only. With its current extensive traditional use, there is a need for additional studies of the isolated compounds, clinical trials, and product development to take full advantage of this widely distributed medicinal plant.
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ã2020 Published by HOPE on behalf of RJPLS This is an open access article under the CC-BY-NC-ND License. ______________________ * Corresponding author: Gopal Krishna Padhy, Department of Pharmaceutical Chemistry, School of Pharmacy,... more
ã2020 Published by HOPE on behalf of RJPLS This is an open access article under the CC-BY-NC-ND License. ______________________ * Corresponding author: Gopal Krishna Padhy, Department of Pharmaceutical Chemistry, School of Pharmacy, Centurion University of Technology and Management, Pitamahal, Rayagada, Odisha-765002, India. E mail ID: gopalmedchem@gmail.com Introduction Aspirin (ASP), a non-steroidal antiinflammatory (NSAID) medication indicated to cure pain, inflammation and fever ( Figure 1). Due to it’s antithrombotic action, aspirin is also given to decreases the incidence of heart failure and used in long term basis to prevent strokes and heart attacks. Omeprazole (OME, Figure 2), a selective and irreversible proton pump inhibitor indicated in the treatment of peptic ulcer and Zollinger–Ellison syndrome.
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The present study was under taken to evaluate anthelmintic activity of ethanolic extract of leaves and roots of vitex negundo and leaves of moringa olifera and roots of tamarindus indica on Indian earthworm pheritima posthuma . Various... more
The present study was under taken to evaluate anthelmintic activity of ethanolic extract of leaves and roots of vitex negundo and leaves of moringa olifera and roots of tamarindus indica on Indian earthworm pheritima posthuma . Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10mg/ml) is used as reference standard and saline water as control group.
Research Interests:
The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause... more
The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the commercially available anti helminthiasis becomes a severe problem worldwide. The present study was under taken to evaluate antihelmenthic activity of ethanol extract of seeds of Cucurbita maxima, Moringa olifera and fruits of Solanum surattense on Indian earthworm pheritima phosthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10 mg/ml) is used as reference standard and saline water as control.
Research Interests:
Drugs are the most important elements in healthcare and must be manufactured to the highest quality levels. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Process validation performs this... more
Drugs are the most important elements in healthcare and must be manufactured to the highest quality levels. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Process validation performs this task ensuring that the process does what it purports to do. The process validation is establishing documented evidence which provides high degree on assurance that a specific process consistently produced a product meeting its predetermined specifications and quality characteristic. Validation is the art of designing and practicing the designed steps alongside with the documentation. Process validation emphasize on process design elements and maintaining process control during commercialization and communicate that process validation is an ongoing program and align process validation activities with product lifecycle. According to GMP validation studies are essential part of GMP and required to be done as per predefined protocols. Process validatio...
A simple, efficient and green methodology has been developed for the synthesis of N-(2-oxoindolin-3- ylidene)benzohydrazide derivatives using D-glucose as catalyst. All the compounds were synthesized under solid phase synthesis by simple... more
A simple, efficient and green methodology has been developed for the synthesis of N-(2-oxoindolin-3- ylidene)benzohydrazide derivatives using D-glucose as catalyst. All the compounds were synthesized under solid phase synthesis by simple physical grinding of reactants. All the synthesized compounds were evaluated for their antimicrobial activity, where compounds 3(d-f) shown moderate activity and others with none.
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Background: Aristolochia indica L. of the family Aristolochiaceae is a twining perennial herbs with an ancient history of medicinal use. In the Indian Ayurvedic system, it is mentioned for the treatment of snake venom, scorpion venom,... more
Background: Aristolochia indica L. of the family Aristolochiaceae is a twining perennial herbs with an ancient history of medicinal use. In the Indian Ayurvedic system, it is mentioned for the treatment of snake venom, scorpion venom, pimple, fever and worm infection.
Objective: To make accessible the current information that is existing on the traditional uses, phytochemistry, pharmacology and toxicology of Aristolochia indica . Additionally, to emphasize the potential uses of this plant to treat various diseases and to bring in a foundation for further research.
Methods: The present review is carried out by compiling literature from 1935 to 2020, concerning the morphology, tradional uses, phytochemistry, pharmacological activities and toxicological aspects of Aristolochia indica.
Results: Diverse chemical compounds including Aristolochic acids, aristolactam, Phenanthrenes, alkaloids, lignans, steroids and terpenes have been isolated from this plant. Mostly in-vivo models indicated several evidence in the use of this plant particularly to regulate fertility. Few in-vivo studies also proved usefulness of this plant in inflammation and diabetis. In some in-vitro studies the anti-snake venom, larvicidal, and anti-oxidant potential has been proved.
Conclusion: Preclinical studies have demonstrated remarkable activity which support the conventional use of the plant as an antivenum, antifertility, antimicrobial and anti-inflammatory agent. Although few phytochemicals isolated (Aristolic acid, (12S)-7,12-secoishwaran-12-ol, Aristololactam-I N-β-D-glucoside, Aristolochic acids, β-sitosterol, (-) Hinokinin and Aristolactam-I) from the plant exhibited remarkable biological activity, it was only confined to preclinical study. Even though, the isolated aristolochic acids showed significant anti-snake venom activity but it was found to be nephrotoxic and mutagenic. More detailed safety data pertaining to dose of crude extracts or pure compounds needs to be generated.
Objective: To make accessible the current information that is existing on the traditional uses, phytochemistry, pharmacology and toxicology of Aristolochia indica . Additionally, to emphasize the potential uses of this plant to treat various diseases and to bring in a foundation for further research.
Methods: The present review is carried out by compiling literature from 1935 to 2020, concerning the morphology, tradional uses, phytochemistry, pharmacological activities and toxicological aspects of Aristolochia indica.
Results: Diverse chemical compounds including Aristolochic acids, aristolactam, Phenanthrenes, alkaloids, lignans, steroids and terpenes have been isolated from this plant. Mostly in-vivo models indicated several evidence in the use of this plant particularly to regulate fertility. Few in-vivo studies also proved usefulness of this plant in inflammation and diabetis. In some in-vitro studies the anti-snake venom, larvicidal, and anti-oxidant potential has been proved.
Conclusion: Preclinical studies have demonstrated remarkable activity which support the conventional use of the plant as an antivenum, antifertility, antimicrobial and anti-inflammatory agent. Although few phytochemicals isolated (Aristolic acid, (12S)-7,12-secoishwaran-12-ol, Aristololactam-I N-β-D-glucoside, Aristolochic acids, β-sitosterol, (-) Hinokinin and Aristolactam-I) from the plant exhibited remarkable biological activity, it was only confined to preclinical study. Even though, the isolated aristolochic acids showed significant anti-snake venom activity but it was found to be nephrotoxic and mutagenic. More detailed safety data pertaining to dose of crude extracts or pure compounds needs to be generated.
Research Interests:
Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is... more
Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to present the literature on 2-acetylbenzimidazole chemistry and provide valuable and up-to-date information for its applications. The present review is carried out by compiling literature from 1964 to 2020 concerning the synthesis and biological aspects of various heterocyclic compounds derived from 2-acetylbenzimidazole. Literature was collected from various online search engines viz. Google Scholar, PubMed, Science Direct, Core, and Semantic scholar. 2-acetylbenzimidazole has been successfully employed as a synthon to obtain heterocyclic system viz. oxirane, pyrazoline, thiazole, pyrazole, isoxazoline, isoxazole, pyridine, pyrimidine, thiazine, diazepine, and other miscellaneous rings. 2-acetylbenzimidazole has shown promise for the convenient synthesis of various heterocyclic compounds. The reactions can be carried out on various reactive sites of 2-acetylbenzimidazole, which are the carbonyl group and the amino group. This review will help to explore various heterocyclic compounds and particularly in the synthesis of biologically useful compounds.
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Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and... more
Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and spectral studies (IR, 1D/2D NMR techniques and mass spectrometry). The synthesized compounds were screened for their antimicro-bial activity against selected Gram-positive and Gram-negative bacteria, and fungi strain. The compounds with halo substituted phenyl group at C5 of the 1-phenyl pyrazoline ring (15, 16 and 17) showed significant antibacterial activity. Among the screened compounds, 17 showed most potent inhibitory activity (MIC = 64 µg mL-1) against a bacterial strain. The tested compounds were found to be almost inactive against the fungal strain C. albicans, apart from pyrazoline-1-carbothiomide 21, which was moderately active.
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Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have... more
Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Material and Methods: A hybrid approach has been used, in which core structure of potentially active N-benzyl benzimidazole and pyrimidine derivatives are brought together in to a single molecule. The desired compounds were prepared by the condensation of N-benzyl benzimidazole chalcones with guanidine hydrochloride. The synthesized compounds were characterized using spectral studies (IR, 1H, 13C-NMR techniques and mass spectrometry). All the compounds were screened for their anticancer activity against human breast cancer cell line MDA-MB-231. Results: The spectral data’s are in well agreement with the synthesized compounds 5a-e. Compounds 5b (GI50 = 39.6 μM) and 5a (GI50=84.0 μM) exhibited significant anticancer activity. Conclusion: Owing to the anticancer activity, compound 5b can be used as lead structure in the development of yet more potent anticancer agents.
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Efficient synthesis of some new N-Benzyl substituted benzimidazole chalcone derivatives were performed by multistep reaction sequences. The synthesized compounds were characterized using IR, 1 H NMR, mass spectrometry and elemental... more
Efficient synthesis of some new N-Benzyl substituted benzimidazole chalcone derivatives were performed by multistep reaction sequences. The synthesized compounds were characterized using IR, 1 H NMR, mass spectrometry and elemental analysis. The synthesized compounds were screened for their antibacterial activity against selective gram positive and gram negative bacteria. Compound 10 was found to be most active among the series.
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An efficient synthesis of some new benzimidazole derivatives linked to various heterocyclic scaffolds was performed by multistep reaction sequences. The structures of synthesized compounds were elucidated by spectral studies (infrared,... more
An efficient synthesis of some new benzimidazole derivatives linked to various heterocyclic scaffolds was performed by multistep reaction sequences. The structures of synthesized compounds were elucidated by spectral studies (infrared, nuclear magnetic resonance [ 1 H NMR], 13 C NMR, and mass spectrometry). The compounds were evaluated for their antibacterial activity against few Gram-positive and Gram-negative bacteria. Among the screened compounds, compound 7 showed the most potent inhibitory activity.
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A novel series of 2-Benzyl substituted benzimidazole acetohydrazone derivatives was synthesized by multistep reaction sequences. The synthesized compounds were characterized using IR, 1 H NMR, mass and elemental analysis. Antibacterial... more
A novel series of 2-Benzyl substituted benzimidazole acetohydrazone derivatives was synthesized by multistep reaction sequences. The synthesized compounds were characterized using IR, 1 H NMR, mass and elemental analysis. Antibacterial activities of the compounds were evaluated against selective gram positive and gram negative bacteria. Compound 7 was found to be most active among the series.
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A reverse phase HPLC method was successfully developed and validated for concurrent assessment of omeprazole and aspirin for bulk and pharmaceutical formulation. The method was developed employing a reversed phase C 18 column. A optimized... more
A reverse phase HPLC method was successfully developed and validated for concurrent assessment of omeprazole and aspirin for bulk and pharmaceutical formulation. The method was developed employing a reversed phase C 18 column. A optimized mobile phase having a composition of acetonitrile-methanol (20:80 v/v) was used. The experiment was carried out at flow rate of 0.6 ml/min and wavelength of 233 nm. Retention times for omeprazole and aspirin were found at 2.667 and 1.720 min respectively. Across a concentration span of 10-50 µg/ml and 5-25 µg/ml the method was linear for aspirin and omeprazole, respectively. The proposed method have potential for the regular quality scrutiny of this combination in bulk and pharmaceutical dosage form.
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A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ritonavir in pharmaceutical dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a symmetry C18 column at... more
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ritonavir in pharmaceutical dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a symmetry C18 column at ambient temperature. The mo bile phase consisted of acetonitrile: methanol: buffer 50:35:15 (V/V). The UV detection wavelength was at 252 nm. Linearity was observed in concentra tion range of 5-150 ppm. The retention time for Ritonavir was 5.32 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Ritonavir in pharmaceutical dosage forms.
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Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: "Zero crossing... more
Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: "Zero crossing technique" was chosen for quantitative determination. The zero-crossing points (ZCP's) were found to be 209 nm where metoprolol succinate was quantified and 211 nm where ramipril was quantified. This method was then subjected to accuracy, linearity, sensitivity and reproducibility according to ICH guidelines to ensure and confirm its validity. Results: The method was found to be obeying Beer's law in the range of 10-50 µg/ml and 5-25 µg/ml for metoprolol succinate and ramipril, respectively. The % recoveries were observed between the range of 99.2-100.2 for metoprolol succinate and 99.57-99.86 for ramipril. The intra-day and inter-day results showed reproducibility. Conclusion: It can be concluded that the developed third-order UV derivative spectroscopic method for the simultaneous determination of metoprolol succinate and ramiprilcan be recommended for routine quantitative analysis.
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A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λmax of valsartan in methanol and water was found to be 248.21 nm. Methanol... more
A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λmax of valsartan in methanol and water was found to be 248.21 nm. Methanol and water is used as diluent in equal proportion. The drug exhibited the linearity in the concentration range of 2-20μg/ml with correlation coefficient of 0.999. The % recovery of the drug for the proposed was found to be 99.2%. The limit of detection and limit of quantification was found to be 0.15% and 0.45% respectively. No interference was observed in the presence of common pharmaceutical excipient. The method was validated as per ICH guidelines. The developed method was successfully employed for the estimation of valsartan in pharmaceutical dosage form.
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Drugs are the most important elements in healthcare and must be manufactured to the highest quality levels. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Process validation performs this... more
Drugs are the most important elements in healthcare and must be manufactured to the highest quality levels. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Process validation performs this task ensuring that the process does what it purports to do. The process validation is establishing documented evidence which provides high degree on assurance that a specific process consistently produced a product meeting its predetermined specifications and quality characteristic. Validation is the art of designing and practicing the designed steps alongside with the documentation. Process validation emphasize on process design elements and maintaining process control during commercialization and communicate that process validation is an ongoing program and align process validation activities with product lifecycle. According to GMP validation studies are essential part of GMP and required to be done as per predefined protocols. Process validation also emphasizes the role of objective measures and statistical tools and analyses and emphasizes knowledge, detection, and control of variability and gives assurance on consistent of quality/productivity throughout life cycle of product. Thus the validation is an essential part of the quality assurance. Lending importance to validation is increasingly profound in recent years. Hence, an emphasis made on this review that gives a detailed, overview of process validation concept
The present study was undertaken to evaluate Anthelmintic activity of petroleum ether and alcoholic extracts of whole plant of Tephrosia purpurea against Pheretima posthuma and Ascardi galli. Various concentrations (10, 25 and 50 mg/ml)... more
The present study was undertaken to evaluate Anthelmintic activity of petroleum ether and alcoholic extracts of whole plant of Tephrosia purpurea against Pheretima posthuma and Ascardi galli. Various concentrations (10, 25 and 50 mg/ml) of extracts were evaluated and results were expressed in terms of time of paralysis (P) and time of death (D) for both types of worms. Piperazine citrate was used as a s tandard Anthelmintic drug and distilled water was used as control. The results of present study indicated that the alcoholic and petroleum ether extract exhibited paralysis and death of worms. Further studies are in process to isolate the active principles responsible for the activity.
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The present study was under taken to evaluate anthelmintic activity of ethanolic extract of leaves and roots of vitex negundo and leaves of moringa olifera and roots of tamarindus indica on Indian earthworm pheritima posthuma. Various... more
The present study was under taken to evaluate anthelmintic activity of ethanolic extract of leaves and roots of vitex negundo and leaves of moringa olifera and roots of tamarindus indica on Indian earthworm pheritima posthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10mg/ml) is used as reference standard and saline water as control group.
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The present study was undertaken to evaluate the Anthelmintic activity of ethanol extracts of Zingiber officinalis (Zingiberacae), Zingiber zerumbet (Zingiberacae) and Curcuma longa on Indian earthworm, Pheretima posthuma.Various... more
The present study was undertaken to evaluate the Anthelmintic activity of ethanol extracts of Zingiber officinalis (Zingiberacae), Zingiber zerumbet (Zingiberacae) and Curcuma longa on Indian earthworm, Pheretima posthuma.Various concentrations (10ug/ml, 25ug/ml, 50ug/ml) of all extracts were tested and results were expressed in terms of time of paralysis and time of death of the earthworm. Piperazine citrate (10ug/ml) was used as reference standard and sterile water as control group
Research Interests:
The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause... more
The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the commercially available anti helminthiasis becomes a severe problem worldwide. The present study was under taken to evaluate antihelmenthic activity of ethanol extract of seeds of Cucurbita maxima, Moringa olifera and fruits of Solanum surattense on Indian earthworm pheritima phosthuma. Various concentrations (10, 25, 50 mg/ml) of extracts
were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10mg/ml) is used as reference standard and saline water as control.
were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10mg/ml) is used as reference standard and saline water as control.