Silver (Ag) thin films have garnered significant attention due to their unique optical properties. This paper systematically investigates the optical characteristics of Ag films prepared using the electron beam evaporation method. The... more
Silver (Ag) thin films have garnered significant attention due to their unique optical properties. This paper systematically investigates the optical characteristics of Ag films prepared using the electron beam evaporation method. The investigation was conducted using spectroscopic ellipsometry and covers a broad wavelength range of 1679 nm to 36 µm (0.738–0.034 eV), spanning from near-infrared to far-infrared regions. Optical and dispersion models were developed to analyze the impacts of Ag nanostructures on the complex refractive indices, dielectric functions, and reflectance. The results indicate that Ag particles and coalescence films exhibit non-metallic and low absorption properties, while Ag percolation and continuous films present a typical Drude model. The reflectance of Ag films increases as the film coverage ratio increases, and it can reach close to 100% in continuous film. Additionally, a non-destructive, non-contact, and vacuum-free means of confirming the percolation ...
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A synergetic strategy was proposed to address the critical issue in the brand characterization of Colla corii asini (Ejiao, CCA), a precious traditional Chinese medicine (TCM). In all brands of CCA, Dong’e Ejiao (DEEJ) is an intangible... more
A synergetic strategy was proposed to address the critical issue in the brand characterization of Colla corii asini (Ejiao, CCA), a precious traditional Chinese medicine (TCM). In all brands of CCA, Dong’e Ejiao (DEEJ) is an intangible cultural heritage resource. Seventy-eight CCA samples (including forty DEEJ samples and thirty-eight samples from other different manufacturers) were detected by laser-induced breakdown spectroscopy (LIBS) and near-infrared spectroscopy (NIR). Partial least squares discriminant analysis (PLS-DA) models were built first considering individual techniques separately, and then fusing LIBS and NIR data at low-level. The statistical parameters including classification accuracy, sensitivity, and specificity were calculated to evaluate the PLS-DA model performance. The results demonstrated that two individual techniques show good classification performance, especially the NIR. The PLS-DA model with single NIR spectra pretreated by the multiplicative scatter c...
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Background: Homologous recombination repair gene mutations are associated with increased platinum-based chemosensitivity, whereas few studies have reported the predictive value of family history of cancer for breast cancer in the... more
Background: Homologous recombination repair gene mutations are associated with increased platinum-based chemosensitivity, whereas few studies have reported the predictive value of family history of cancer for breast cancer in the neoadjuvant setting. This study aimed to construct a brief and effective novel family history scoring system and explore its association with pathological complete response (pCR), survival outcomes, and safety for locally advanced breast cancer receiving platinum-based neoadjuvant chemotherapy.Methods: A total of 262 patients treated with neoadjuvant cisplatin and paclitaxel were included. Neo-Family History Score (NeoFHS) was calculated according to cancer type, age at diagnosis, kinship, and number of affected relatives. Logistic regression was performed to analyze the association between pCR and NeoFHS. Survival rates were compared by Kaplan-Meier curves, examined by log-rank test and Cox proportional hazard regressions.Results: For all patients enrolled...
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A hybrid of N-doped carbon encapsulated ultrasmall Mo2C nanodots on Ti3C2TxMXene exhibits excellent HER performance in the entire pH range.
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ObjectiveLinc00665 is a novel long non-coding RNA that can promote the progression of breast cancer, but its value in predicting the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer has not been reported. We aim to analyze the... more
ObjectiveLinc00665 is a novel long non-coding RNA that can promote the progression of breast cancer, but its value in predicting the efficacy of neoadjuvant chemotherapy (NAC) for breast cancer has not been reported. We aim to analyze the correlation between Linc00665 expression and pathological complete response (pCR) in breast cancer patients.Materials and MethodsThe present study examined the predictive role of Linc00665 expression in pCR after NAC using both univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) curve and area under curve (AUC) were utilized to evaluate the performance of Linc00665 in predicting pCR. The Kyoto Encyclopedia of Gene and Genome (KEGG) analysis and Gene Set Enrichment Analysis (GSEA) were also conducted to determine the biological processes where Linc00665 may participate in.ResultsThe present study study totally enrolled 102 breast cancer patients. The univariate analysis showed that Linc00665 level, human...
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The effect of CYP2D6 genotype on the dose-exposure relationship for atomoxetine has not been well characterized in children. Children 6-17 years of age diagnosed with ADHD were stratified byCYP2D6 genotype into groups with 0 (PM, n=4),... more
The effect of CYP2D6 genotype on the dose-exposure relationship for atomoxetine has not been well characterized in children. Children 6-17 years of age diagnosed with ADHD were stratified byCYP2D6 genotype into groups with 0 (PM, n=4), 0.5 (IM, n=3), one (EM1, n=8) or two (EM2, n=8) functional alleles) and administered a single 0.5 mg/kg oral dose of atomoxetine. Plasma and urine samples were collected for 24 (IM, EM1 and EM2) or 72 hours (PMs). Dose-corrected atomoxetine systemic exposure (AUC00-∞ ) varied 29.6-fold across the study cohort, ranging from 4.4±2.7 µM*h in EM2s to 5.8±1.7 µM*h, 16.3±2.9 µM*h and 50.2±7.3 µM*h in EM1s, IMs and PMs, respectively (p<0.0001). Simulated steady state profiles at the maximum FDA-recommended dose suggest that most patients are unlikely to attain adequate ATX exposures. These data support the need for individualized dosing strategies for more effective use of the medication. This article is protected by copyright. All rights reserved.
Research Interests: Pharmacology, Pharmacokinetics, Adolescent, Medicine, Humans, and 15 moreChild, Female, Male, Longitudinal Studies, Genotype, Biotransformation, Atomoxetine, Precision Medicine, Area Under Curve, Cohort Studies, Attention deficit disorder with hyperactivity, Dosing, alleles, Clinical Pharmacology and Therapeutics, and Pharmacology and pharmaceutical sciences
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The aim of this study was to explore the role and effect of ginsenosides Rg1 on osteoblasts cultured with Ti particles. Osteoblasts from neonatal rats were cultured with particles and different doses of Rg1, the main active ingredient in... more
The aim of this study was to explore the role and effect of ginsenosides Rg1 on osteoblasts cultured with Ti particles. Osteoblasts from neonatal rats were cultured with particles and different doses of Rg1, the main active ingredient in ginsenosides Rg1. We found that the COX-2, PGE2, TNF-α, IL-1, and IL -6 concentrations in the medium of cells cultured with Ti particles significantly increased as compared with that of the control cells (p<0.05 or p<0.01). In addition, cells cultured with Ti particles alone exhibited the highest concentrations of these molecules. The PGE2, TNF-α, IL-1, and IL-6 levels in the medium of cells cultured with Rg1 were in between those of the control cells and the cells cultured with Ti particles alone. The IL-1ra level in the group cultured with Ti and medium-dose Rg1 was the highest followed by the cells cultured with Ti and high-dose Rg1 and those cultured with Ti and low-dose Rg1 (p<0.05). In conclusion, ginsenosides can reduce the levels of...
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Research Interests: Algorithms, Chemistry, Biomedical Engineering, Magnetic Resonance Imaging, Nuclear Magnetic Resonance, and 15 moreMagnetic Resonance Spectroscopy, Medicine, Brain, Humans, Female, Male, Glutathione, Filter, Human Brain, Head, High Resolution, Adult, Reproducibility of Results, Sensitivity and Specificity, and Metabolite
Support vector machines (SVM) represent a promising development in machine learning research that is not widely used within the remote sensing community. This paper reports the results of two experiments in which multi‐class SVMs are... more
Support vector machines (SVM) represent a promising development in machine learning research that is not widely used within the remote sensing community. This paper reports the results of two experiments in which multi‐class SVMs are compared with maximum likelihood (ML) and artificial neural network (ANN) methods in terms of classification accuracy. The two land cover classification experiments use multispectral (Landsat‐7
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Research Interests: Colorimetry, Biology, Industrial Biotechnology, Comparative Study, Food Microbiology, and 15 moreDiarrhea, Humans, Liver, Europe, HPLC, Animals, Bioassay, Contamination, Great Britain, Marine toxin, Food Sciences, Biological Assay, Enzyme Linked Immunosorbent Assay, Foodborne diseases, and HPLC Chromatography
A procedure for the quantification of the PCB marker congeners 28, 52, 101, 138, 153, 180 in plastic waste form the recycling of cables in the range of content between 0.1 mgkg(-1) and 20 mgkg(-1) was validated. Representative reference... more
A procedure for the quantification of the PCB marker congeners 28, 52, 101, 138, 153, 180 in plastic waste form the recycling of cables in the range of content between 0.1 mgkg(-1) and 20 mgkg(-1) was validated. Representative reference materials for laboratory analyses were produced using granulates from different recycling processes. The method development included aspects of grinding, sieving, homogenising as well as the comparison of extraction methods and chromatographic conditions. The validated procedure foresees grinding of the technical sample to an upper particle size limit of 0.50mm followed by extraction with an unpolar solvent such as n-hexane and gas chromatographic determination. LOD and LOQ for individual congeners ranged between 0.01 mgkg(-1) and 0.08 mgkg(-1). Electron capture detection (ECD) and mass selective detection (MS) were equivalent if chromatographic conditions were appropriately selected. The application of MS was advantageous in presence of significant amounts of interfering components which have been found in some cables. Three reference materials containing the marker congeners in the range of 0.1 mgkg(-1)-5 mgkg(-1) were submitted to a final validation intercomparison with 23 selected field laboratories using the developed method. Relative reproducibility standard deviations varied between 15% and 33%.
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Research Interests: Engineering, Mathematics, Computer Science, Optimal Control, Model Predictive Control, and 15 moreMathematical Sciences, Automatica, Feedback Control, Horizon, Linear System, Constrained System, Constrained systems, Bound States, Optimal Control Problem, Linear Time, Autom, Affine Transformation, Expected Value, Discrete time, and convex function
Research Interests: Mathematics, Applied Mathematics, Computer Science, System Dynamics, Statistical Physics, and 12 moreLinear Model, First-Order Logic, Dynamical Systems Theory, Romantic Relationship, Time Dependent, Nonlinear system, Numerical Analysis and Computational Mathematics, Differential equation, Nonlinear Model, Time varying, Time Varying Systems, and dynamic model
We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP)... more
We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit.
Research Interests: Algorithms, Electrophysiology, Anesthesiology, Molecular Biology, Membrane Proteins, and 15 moreMedicine, Biological Sciences, Cercopithecus aethiops, Cell line, Humans, Animals, Anesthesia, Clinical Sciences, CHEMICAL SCIENCES, Amides, KIR, Diazoxide, Adenosine Triphosphate, Clonidine, and Medical and Health Sciences
1This paper was the basis of a talk at the NIPS*98 Workshop on Large Margin Classi ers, Breckenridge CO, December 5, 1998 and is submitted for `Advances in Large Margin Classi ers&amp;#x27;, A. Smola, P. Bartlett, B. Scholkopf and D.... more
1This paper was the basis of a talk at the NIPS*98 Workshop on Large Margin Classi ers, Breckenridge CO, December 5, 1998 and is submitted for `Advances in Large Margin Classi ers&amp;#x27;, A. Smola, P. Bartlett, B. Scholkopf and D. Schurmans, Eds. This replaces an earlier version ...
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In this paper we study the numerical method and the convergence for solving the time-dependent Maxwell-Schr\"{o}dinger equations under the Lorentz gauge. An alternating Crank-Nicolson finite element method for solving the problem is... more
In this paper we study the numerical method and the convergence for solving the time-dependent Maxwell-Schr\"{o}dinger equations under the Lorentz gauge. An alternating Crank-Nicolson finite element method for solving the problem is presented and the optimal error estimate for the numerical algorithm is obtained by a mathematical inductive method. Numerical examples are then carried out to confirm the theoretical results.
Research Interests: Mathematics, Applied Mathematics, Computer Science, Physics, Finite element method, and 15 morePure Mathematics, Medicine, Algorithm, Controllability, Discretization, Finite Volume Method, Convection Diffusion Equation, Exponential Function, Amplitude, Basis Pursuit, Ideal Ethics, Rate of Convergence, Polynomial, Terminal sliding mode, and Sobolev space
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The object of this paper is to investigate the convergence of finite-element approximations to solutions of parabolic and hyperbolic integrodifferential equations, and also of equations of Sobolev and viscoelasticity type. The concept of... more
The object of this paper is to investigate the convergence of finite-element approximations to solutions of parabolic and hyperbolic integrodifferential equations, and also of equations of Sobolev and viscoelasticity type. The concept of Ritz–Volterra projection will be seen to unify much of the analysis for the different types of problems. Optimal order error estimates are obtained in $L_p $ for $2 \leqq p < \infty $, and almost optimal order pointwise results given.
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The identification of the source control $q = q(t)$ of one-dimensional quasilinear parabolic equations is considered via additional information on the solution of integral type. Existence, uniqueness, and continuous dependence of the... more
The identification of the source control $q = q(t)$ of one-dimensional quasilinear parabolic equations is considered via additional information on the solution of integral type. Existence, uniqueness, and continuous dependence of the solution upon the data are demonstrated by employing some a priori estimates, compactness arguments, and the strong maximum principle.
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... 1. Introduction In this paper we consider the following parabolic system of finding U = (u 1 (x; t); u 2 (x; t)) such that u 1 t \Gamma c 1 u 1 xx = b 1 l 1 d dt maxfI(U); 0g ; in Q 1 T = (0; l 1 ) \Theta J; (1.1) u 2 t \Gamma c 2 u 2... more
... 1. Introduction In this paper we consider the following parabolic system of finding U = (u 1 (x; t); u 2 (x; t)) such that u 1 t \Gamma c 1 u 1 xx = b 1 l 1 d dt maxfI(U); 0g ; in Q 1 T = (0; l 1 ) \Theta J; (1.1) u 2 t \Gamma c 2 u 2 xx = b 2 1 \Gamma l 2 d dt maxfI(U); 0g ; in Q 2 T = (l 2 ; 1 ...
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Page 1. MORTAR F1N1TE VOLUME ELEMENT APPROX1MAT1ONS OF SECOND ORDER ELL1PT1C PROBLEMS RICHARD EWING' RAYTCHO LAZAROV' TAO LIN' AND YANPING LIN Abstract. Application of domain decomposition ...
ABSTRACT This paper discusses the multiscale method for the time-dependent Maxwell&#39;s equa-tions with memory effects in composite materials. The main difficulty is that one cannot use the usual multiscale asymptotic method (cf.... more
ABSTRACT This paper discusses the multiscale method for the time-dependent Maxwell&#39;s equa-tions with memory effects in composite materials. The main difficulty is that one cannot use the usual multiscale asymptotic method (cf. [25, 4]) to solve this problem, due to the complication of the memory terms. The key steps addressed in this paper are to transfer the original integro-differential equations to the stationary Maxwell&#39;s equations by using the Laplace transform, to employ the multiscale asymptotic method to solve the stationary Maxwell&#39;s equations, and then to obtain the computational solution of the original problem by employing a quadrature formula for computing the inverse Laplace transform. Numerical simulations are then carried out to validate the multiscale numerical algorithm in the present paper.
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ABSTRACT In this paper, a box approximation scheme is proposed using the lumped mass numerical integration technique on piecewise linear finite element spaces for a coupled nonlinear thermistor system. Existence and uniqueness of the... more
ABSTRACT In this paper, a box approximation scheme is proposed using the lumped mass numerical integration technique on piecewise linear finite element spaces for a coupled nonlinear thermistor system. Existence and uniqueness of the proposed box approximation scheme are proved via a fixed point theorem, and H 1 -error analysis is presented. AMS(MOS) subject classification : 35J65, 35K65, 65N12, 65N30. 1. Introduction In this paper we study the numerical approximation by a box method of the following nonlinear elliptic-parabolic coupled system u t Gamma r(k(u)ru) = oe(u)jrOEj 2 ; inOmega Theta (0; T ]; (1.1) Gammar(oe(u)rOE) = 0; inOmega Theta (0; T ]; (1.2) with u(x; 0) = u 0 (x) inOmega and u = 0; OE = g on @ OmegaGamma whereOmega ae R 2 is a bounded convex polygonal domain. This system models the electric heating of a conducting body with u being the temperature, OE the electrical potential, oe and k the temperature- dependent electrical and thermal conductivities r...
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Background Brugada syndrome (Brs) and long QT syndrome (LQTs) are the most observed “inherited primary arrhythmia syndromes” and “channelopathies”, which lead to sudden cardiac death. Methods Detailed clinical information of Brs and LQTs... more
Background Brugada syndrome (Brs) and long QT syndrome (LQTs) are the most observed “inherited primary arrhythmia syndromes” and “channelopathies”, which lead to sudden cardiac death. Methods Detailed clinical information of Brs and LQTs patients was collected. Genomic DNA samples of peripheral blood were conducted for whole-exome sequencing on the Illumina HiSeq 2000 platform. Then, we performed bioinformatics analysis for 200 genes susceptible to arrhythmias and cardiomyopathies. Protein interaction and transcriptomic co-expression were analyzed using the online website and GTEx database. Results All sixteen cases of Brs and six cases of LQTs were enrolled in the current study. Four Brs carried known pathogenic or likely pathogenic of single-point mutations, including SCN5A p.R661W, SCN5A p.R965C, and KCNH2 p.R692Q. One Brs carried the heterozygous compound mutations of DSG2 p.F531C and SCN5A p.A1374S. Two Brs carried the novel heterozygous truncated mutations (MAF < 0.001) of ...
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Background: The gut microbial ecosystem is an important factor that regulates host health and the onset of chronic diseases, such as inflammatory bowel diseases, obesity, hyperlipidemia, and diabetes mellitus, which are important risk... more
Background: The gut microbial ecosystem is an important factor that regulates host health and the onset of chronic diseases, such as inflammatory bowel diseases, obesity, hyperlipidemia, and diabetes mellitus, which are important risk factors for atherosclerosis. However, the links among diet, microbiota composition, and atherosclerotic progression are unclear. Methods and results: Four-week-old mice (-/- mice, C57Bl/6) were randomly divided into two groups, namely, supplementation with culture medium (control, CTR) and Bacteroides fragilis (BFS), and were fed a high-fat diet. The gut microbiota abundance in feces was evaluated using the 16S rDNA cloning library construction, sequencing, and bioinformatics analysis. The atherosclerotic lesion was estimated using Oil Red O staining. Levels of CD36, a scavenger receptor implicated in atherosclerosis, and F4/80, a macrophage marker in small intestine, were quantified by quantitative real-time PCR. Compared with the CTR group, the BFS g...
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Time-critical scheduling in real-time database systems has two components: real-time transaction scheduling, which is related to task scheduling in real-time operating systems, and concurrency control, which can be considered as operation... more
Time-critical scheduling in real-time database systems has two components: real-time transaction scheduling, which is related to task scheduling in real-time operating systems, and concurrency control, which can be considered as operation level scheduling. Most current research in ...
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Background Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is associated with ventricular arrhythmia, heart failure (HF), and sudden death. Thromboembolism is also an important and serious complication of ARVC/D.... more
Background Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is associated with ventricular arrhythmia, heart failure (HF), and sudden death. Thromboembolism is also an important and serious complication of ARVC/D. However, the etiology of ARVC/D and thromboembolism and their association with genetic mutations are unclear. Methods Genomic DNA samples of peripheral blood were conducted for whole-exome sequencing (WES) and Sanger sequencing in the ARVC/D family. Then, we performed bioinformatics analysis for genes susceptible to cardiomyopathies and arrhythmias. Further, we analyzed how the potential pathogenic mutations were affecting the hydrophobicity and phosphorylation of amino acids and their joint pathogenicity by ProtScale, NetPhos and ORVAL algorisms. Results We discovered a Chinese Han family of ARVC/D with right ventricular HF (RVHF), cerebral thromboembolism, arrhythmias (atrial fibrillation, atrial standstill, multifocal ventricular premature, complete ri...
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Self-serving leadership is a typical example of destructive leadership that has negative effects on its subordinates and organization. According to social identity theory, we propose a theoretical model that self-serving leadership... more
Self-serving leadership is a typical example of destructive leadership that has negative effects on its subordinates and organization. According to social identity theory, we propose a theoretical model that self-serving leadership induces employee interpersonal deviance and organizational deviance through organization identification, and we explore the moderating role of moral identity in this relationship. Based on survey data collected from 377 questionnaires by using a three-wave time lagged design, structural equation modeling results showed that (1) there was a significant positive correlation between self-serving leadership and employees’ deviant behavior, (2) organizational identification partially mediates the relationship between self-serving leadership and employees’ deviant behavior, and (3) employees’ moral identity negatively moderates the relationship between self-serving leadership and employees’ organizational identification. The findings further extend the research...
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Abstract. We present existence of solutions and other results for the partial dif-ferential equation system with memory which models amorphous silicon devices and related problems in R3. Our approach employs only classical estimates and... more
Abstract. We present existence of solutions and other results for the partial dif-ferential equation system with memory which models amorphous silicon devices and related problems in R3. Our approach employs only classical estimates and Degree Theory; it shows the existence of C;=2 solutions for some > 0. In view of the mixed boundary conditions, this is the maximum regularity that can be expected. 1.
Background Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis and identified... more
Background Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis and identified CARMN as a downregulated lncRNA which is lowest expressed in TNBC. We aimed to identify the potential role and molecular mechanisms of CARMN in TNBC. Methods Predictive value of CARMN was explored in breast cancer cohorts. TNBC cell lines with CARMN overexpression or CARMN silence and were used for in vitro and in vivo experiments. RNA-seq of CARMN overexpressed cells was performed for exploring downstream of CARMN. Results CARMN is downregulated at different phase of malignant transformation of breast tissue. CARMN can predict both better prognosis and higher response rate of cisplatin-based neoadjuvant chemotherapy in breast cancer. A nomogram is built to predict cisplatin-based chemotherapy response in breast cancer. Through in vitro and in vivo stu...
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This paper deals positive steady state for predator-prey microorganisms in a flow reactor with diffusion and flow. The coexistence conditions for the predator-prey populations are established. The main method used here is the fixed point... more
This paper deals positive steady state for predator-prey microorganisms in a flow reactor with diffusion and flow. The coexistence conditions for the predator-prey populations are established. The main method used here is the fixed point index theory.
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Senile osteoporosis (SOP) is a common disease that has decreased bone strength as its main symptom. There is currently no medication that can treat SOP, and traditional Chinese medicine has advantages in slowing down bone aging. The... more
Senile osteoporosis (SOP) is a common disease that has decreased bone strength as its main symptom. There is currently no medication that can treat SOP, and traditional Chinese medicine has advantages in slowing down bone aging. The present study aimed to observe the effects of Qing’e decoction on leptin, leptin receptor, sex hormone, and biochemical markers of bone metabolism in naturally aging rats and to explore its mechanism in regulating bone metabolism. The results revealed that, with the increase in age, the bone mineral density (BMD), bone strength, bone trabecula sparse, serum levels of leptin receptor (LEP-R), estradiol (E2), testosterone (T), core binding-factor α-1 (Cbfα-1), collagen-I (COL-I) and osteocalcin (OC), and the mRNA levels of leptin (LEP) and LEP-R in bone tissue decreased, while serum LEP levels increased in the female and male NS groups. The serum levels of LEP, LEP-R, E2, T, osteoprotegerin, Cbfα-1, COL-I, OC and bone alkaline phosphatase, and the mRNA lev...