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Limited access to safe transportation is one of the greatest challenges to labor force participation faced by women in developing countries. This paper quantifies the causal impacts of improved urban transport systems in women ́s... more
Limited access to safe transportation is one of the greatest challenges to labor force participation faced by women in developing countries. This paper quantifies the causal impacts of improved urban transport systems in women ́s employment outcomes, looking at Bus Rapid Transit (BRT) and elevated light rail investments in the metropolitan region of Lima, Perú. We find large gains in employment and earnings per hour among women, and not for men, due to these investments. Most of the gains arise on the extensive margin, with more women being employed, but employment does not appear to be of higher quality than that for comparison groups. We find also evidence of an increase in the use of public transport. Results are robust to alternative specifications and we do not find evidence that they are driven by neighborhood composition changes. Overall, these findings suggest that infrastructure investments that make it more convenient and safer for women to use public transport can generat...
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Poster: "ECR 2011 / C-1247 / Duane Syndrome: Correlation between clinical and MRI Findings" by: "D. Rodriguez Martinez1, V. Valdivielso1, A. Carvajal1, J. Visa 1, S. PEREZ1, M. Prenafeta Moreno2, A. Zugazaga1, A.... more
Poster: "ECR 2011 / C-1247 / Duane Syndrome: Correlation between clinical and MRI Findings" by: "D. Rodriguez Martinez1, V. Valdivielso1, A. Carvajal1, J. Visa 1, S. PEREZ1, M. Prenafeta Moreno2, A. Zugazaga1, A. Torremade3; 1Sabadell/ES, 2Arenys de Munt-Barcelona/ES, 3Sabadell (Barcelona)/ES"
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The 7th Asia-Pacific Workshop on Structural Health Monitoring (APWSHM 2018), Hong Kong, China, 12-15 November 2018
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Poster: "ECR 2015 / C-2254 / Efficient radiology reporting using the script editor Autohotkey" by: "J. Garcia-Bennett, A. Conejero Olesti, P. Palana, C. Serrano Burgos, D. Rodriguez Martinez; Reus/ES"
Objetivos DocentesLa exploracion retrobulbar con ecografia doppler color se realiza con sonda lineal multifrecuencia de 18 a 7 MHz .El paciente se coloca en decubito supino, con los ojos cerrados y la cabeza levemente elevada , unos 20-30... more
Objetivos DocentesLa exploracion retrobulbar con ecografia doppler color se realiza con sonda lineal multifrecuencia de 18 a 7 MHz .El paciente se coloca en decubito supino, con los ojos cerrados y la cabeza levemente elevada , unos 20-30 o aproximadamente, y con la mirada al frente. ( Fig 1).Los vasos arteriales parten de la arteria oftalmiva, promer rama de la carotida interna, que penetra en la orbita por el orificio optico, junto al nervio. De ella parten las ciliares posteriores , que se situan paralelas al nervio optico, y la central de la retina que lo acompana. ( Fig 2)Tomamos como referencia el nervio optico, que en la ecografia se identifica como una estructura anecoica, lineal, en el polo posterior del globo ocular ( Fig 3). La arteria y vena central de la retina se identifican en su trayecto (Fig 4), mientras que las ciliares postreiores estan situadas en el lado nasal y temporal del nervio ( Fig 5).La arteria oftalmica se situa en el margen nasal del nervio , entre 1-2 ...
Poster: "ECR 2018 / C-3056 / Pulmonary asymmetry in pediatrics: which is the good side? " by: " M. PITARCH DIAGO 1, C. Martin Martinez1, V. P. Beltran Salazar1, C. Duran Feliubadalo1, D. Rodriguez Martinez1, B. Del Rio2, F.... more
Poster: "ECR 2018 / C-3056 / Pulmonary asymmetry in pediatrics: which is the good side? " by: " M. PITARCH DIAGO 1, C. Martin Martinez1, V. P. Beltran Salazar1, C. Duran Feliubadalo1, D. Rodriguez Martinez1, B. Del Rio2, F. Bosch Barragan1, A. Gonzalez Lopez1, A. B. A. B. CASTRO GARCIA2; 1Sabadell/ES, 2Terrassa/ES"
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Background: Photoreceptors, light-sensing neurons in retina, are central to vision. Photoreceptor cell death (PCD) is observed in most inherited and acquired retinal dystrophies. But the underlying molecular mechanism of PCD is unclear.... more
Background: Photoreceptors, light-sensing neurons in retina, are central to vision. Photoreceptor cell death (PCD) is observed in most inherited and acquired retinal dystrophies. But the underlying molecular mechanism of PCD is unclear. Photoreceptors are sturdy neurons that survive high oxidative and phototoxic stress, which are known threats to genome stability. Unexpectedly, DNA damage response in mice photoreceptors is compromised; mainly due to loss of crucial DNA repair proteins, ATM and 53BP1. We tried to understand the molecular function of ATM and 53BP1 in response to oxidative stress and how suppression of DNA repair response in mice retina affect photoreceptor cell survival. Methods: We use the state of art cell biology methods and structure-function analysis of mice retina. RNA:DNA hybrids (S9.6 antibody and Hybrid-binding domain of RNaseH1) and DNA repair foci (gH2AX and 53BP1) are quantified by confocal microscopy, in retinal sections and cultured cell lines. Oxidative...
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This paper examines how international development funding and accountability requirements are implicated in the so-called disarticulation of a social movement. Based on field studies in Guatemala and El Salvador, we show and explain the... more
This paper examines how international development funding and accountability requirements are implicated in the so-called disarticulation of a social movement. Based on field studies in Guatemala and El Salvador, we show and explain the way accountability requirements, which encompass management and accounting, legal, and financial technologies, constitute the field of international development through the regulation of heterogeneous social movement organizations. We highlight how accountability enables a form of governance that makes possible the emergence of entities (with specific attributes), while restricting others. Our analysis has implications for governmentality studies that have examined the interrelation of assemblages by analyzing how these interrelations are operationalized at the field level through the Deleuze-and-Guattari-inspired processes of territorialization, coding, and overcoding.
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Retinitis pigmentosa (RP) is the most common cause of inherited blindness in adults. Mutations in the PRPF31 gene produce autosomal dominant RP (adRP). To date there are no effective treatments for this disease. The purpose of this study... more
Retinitis pigmentosa (RP) is the most common cause of inherited blindness in adults. Mutations in the PRPF31 gene produce autosomal dominant RP (adRP). To date there are no effective treatments for this disease. The purpose of this study was to design an efficient non-viral vector for human PRPF31 gene delivery as an approach to treat this form of adRP. Span based nanoparticles were developed to mediate gene transfer in the subretinal space of a mouse model of adRP carrying a point mutation (A216P) in the Prpf31 gene. Funduscopic examination, electroretinogram, optomotor test and optical coherence tomography were conducted to further in vivo evaluate the safety and efficacy of the nanosystems developed. Span-polyarginine (SP-PA) nanoparticles were able to efficiently transfect the GFP and PRPF31 plasmid in mice retinas. Statistically significant improvement in visual acuity and retinal thickness were found in Prpf31(A216P/+) mice treated with the SP-PA-PRPF31 nanomedicine.
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Hypoxia inducible factor 1-α (HIF-1α) and peroxisome proliferator-activated receptor γ (PPARγ) are transcription factors that activate genes involved in cellular metabolism. Physiological cardiac hypertrophy induced by pregnancy initiates... more
Hypoxia inducible factor 1-α (HIF-1α) and peroxisome proliferator-activated receptor γ (PPARγ) are transcription factors that activate genes involved in cellular metabolism. Physiological cardiac hypertrophy induced by pregnancy initiates compensatory changes in metabolism. However, the contributions of HIF-1α and PPARγ to this physiological status and to its reversible, metabolic process (postpartum) in the heart are not well-defined. Therefore, the aim of the present study was to evaluate the transcriptional activities of HIF-1α and PPARγ in the left ventricle of rats before, during, and after pregnancy. Furthermore, the effects of pregnancy on target genes of glycolysis and glycerol-lipid biosynthesis, key regulatory enzymes, and metabolic intermediates were evaluated. The activities of HIF-1α and PPARγ increased 1.2- and 1.6-fold, respectively, during pregnancy, and decreased to basal levels during postpartum. Expressions of mRNA for glucose transport 1 (GLUT1), enzymes of glycolysis (HK2, PFKM, and GAPDH) and glycerol-lipid biosynthesis (GPAT and GPD1) increased 1.6- to 14-fold during pregnancy and returned to basal levels postpartum. The increase in GPD1 expression translated to an increase in its activity, but such was not the case for GAPDH suggesting that post-translational regulation of these proteins is differential during pregnancy. Glycolytic (glucose, lactate, and DHAP) and glycerol-lipid biosynthesis (G3P and FFA) intermediates increased with pregnancy and were maintained postpartum. The results demonstrate that pregnancy-induced, physiological cardiac hypertrophy activates the expression of genes involved in glycolytic and glycerol-lipid biosynthesis suggesting that the shift in cardiac metabolism is mediated by the activation of HIF-1α and PPARγ.
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Erectile dysfunction has plagued humanity for millennia. For years, treatment had been in the hands of mental health professionals. It was not until the 1970s that urologists created a modality that was marketable, reproducible, and... more
Erectile dysfunction has plagued humanity for millennia. For years, treatment had been in the hands of mental health professionals. It was not until the 1970s that urologists created a modality that was marketable, reproducible, and consistently successful at treating impotence, the Small-Carrion Penile Prosthesis. We present the evolution of the malleable/semi-rigid penile prosthesis, concentrating our efforts reviewing and critiquing the pivotal article published by Drs. Michael P. Small, Hernan M. Carrion, and Julian A. Gordon. We then discuss its continued advancement, current-day utilization, and the future of the malleable prosthesis. From the early 1900s, surgeons have been toying with the idea of creating a penile implant. These initial attempts utilized rib cartilage, and eventually synthetic materials, including acrylic, silicone, and polyethylene. In 1975, Drs. Carrion and Small presented their initial experience of 31 patients utilizing their silicone implant. In their m...
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The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. It is a progressive disease that can lead to the need for blood transfusion, hospitalizations, and... more
The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. It is a progressive disease that can lead to the need for blood transfusion, hospitalizations, and surgical interventions. This tends to affect the quality of life of these patients, and management can at times be difficult. We have evaluated the GreenLight Xcelerated Performance System (XPS) with TruCoag, although primarily used for management of benign prostatic hypertrophy (BPH), for the treatment of radiation-induced hemorrhagic cystitis. After International Review Board (IRB) approval, a retrospectivechart review was performed in addition to a literature search. A series of four male patients, mean age of 81 years, with radiation-induced hemorrhagic cystitis secondary to radiotherapy for pelvic malignancies (3 prostate cancer, 1 rectal cancer) were successfully treated with the GreenLight laser after unsuccessful treatment with current therapies...
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PURPOSE/AIM To show the classic and specific sign of intravaginal testicular torsion known as the “whirlpool sign”. CONTENT ORGANIZATION Testicular torsion is a surgical emergency that calls for quick and accurate management.... more
PURPOSE/AIM To show the classic and specific sign of intravaginal testicular torsion known as the “whirlpool sign”. CONTENT ORGANIZATION Testicular torsion is a surgical emergency that calls for quick and accurate management. Ultrasonography has proven accurate in confirming or ruling out testicular torsion. We reviewed the sonograms of 21 patients (age range, 12-31 years) with surgically proven testicular intravaginal torsion studied between October 2003 and March 2010, analyzing the size, appearance, time from the onset of symptoms, and ultrasonographic findings. The whirlpool sign was clearly visible in all cases. SUMMARY The “whirlpool sign” is a specific ultrasonographic sign of intravaginal testicular torsion. We consider it vitally important to increase social awareness of the importance of referring boys with scrotal pain to a hospital to enable early diagnosis and treatment of torsion and reduce its sequelae.
Book review.
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Despite advances in penile prosthetic surgery, risk of infection is not negligible and the results are catastrophic. Men with infection interested in remaining sexually active are traditionally either salvaged immediately, carrying a high... more
Despite advances in penile prosthetic surgery, risk of infection is not negligible and the results are catastrophic. Men with infection interested in remaining sexually active are traditionally either salvaged immediately, carrying a high risk of reinfection, or salvaged in a delayed fashion, resulting in corporal fibrosis and loss of penile length and girth. The “Carrion Cast” provides another option for patients who are not candidates for an immediate salvage procedure (i.e., presenting with septicemia, complicated medical/surgical history, or failed prior salvage). As is standard of care all infected implant components are removed, and the surgical site vigorously irrigated following a “Mulcahy salvage protocol.” Then, 2-0 Vicryl sutures are preplaced in preparation for “watertight” closure of the corporotomies. Open corporotomy in infected corpus implant has been removed Three Possible Treatment Strategies
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Aneurysmal dilatation of the corpora cavernosa can occur because of recurrent priapism in the setting of sickle cell disease. We present the first case of a successful implementation of the reduction corporoplasty technique for treatment... more
Aneurysmal dilatation of the corpora cavernosa can occur because of recurrent priapism in the setting of sickle cell disease. We present the first case of a successful implementation of the reduction corporoplasty technique for treatment of a phallus that was "too large for…
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Polycations possessing substantial buffering capacity below physiological pH, are intrinsically efficient transfection agents. These vectors have been shown to deliver genes as well as oligonucleotides, both in vitro and in vivo, by... more
Polycations possessing substantial buffering capacity below physiological pH, are intrinsically efficient transfection agents. These vectors have been shown to deliver genes as well as oligonucleotides, both in vitro and in vivo, by protecting DNA from inactivation by blood components. Their efficiency relies on extensive endosome swelling and rupture that provides an escape mechanism for the polycation/DNA complexes. Recently, biocompatible cationic cholesteric liquid-crystal polymers (ChLCP) have proved able to condense and successfully transfect DNA, acting as non-viral vectors. Here the radius of gyration of the new ChLCPs is determined by SANS as a function of pH, the ultimate aim being to correlate changes in polymer conformation with membrane activity. With increasing pH the polymers apparent radii of gyration increased to a maximum, before subsequently decreasing. This molecular expansion, on passing from acidic pH environment (cf., lysosome pH 3.5- 4, late endosome pH 5- 6,...
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Traumatic brain injury (TBI) increases susceptibility to Alzhei- mer's disease (AD), but it is not known how TBI contributes to the onset or progression of this common late life dementia. To address this question, we studied... more
Traumatic brain injury (TBI) increases susceptibility to Alzhei- mer's disease (AD), but it is not known how TBI contributes to the onset or progression of this common late life dementia. To address this question, we studied neuropathological and be- havioral consequences of single versus repetitive mild TBI (mTBI) in transgenic (Tg) mice (Tg2576) that express mutant human A precursor protein, and we demonstrate elevated brain A levels and increased A deposition. Nine-month-old Tg2576 and wild-type mice were subjected to single (n 15) or repetitive (n 39) mTBI or sham treatment (n 37). A t2da nd 9 and 16 weeks after treatment, we assessed brain A deposits and levels in addition to brain and urine isoprostanes generated by lipid peroxidation in these mice. A subset of mice also was studied behaviorally at 16 weeks after injury. Repetitive but not single mTBI increased A deposition as well as levels of A and isoprostanes only in Tg mice, and repetitive mTBI alone in- duced cognit...
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Purpose: The aim of this study was to analyze patient-reported health issues and levels of engagement, discussion of needed lifestyle changes, and goal setting with the patient's intern or staff doctor before and after a brief... more
Purpose: The aim of this study was to analyze patient-reported health issues and levels of engagement, discussion of needed lifestyle changes, and goal setting with the patient's intern or staff doctor before and after a brief intervention to increase health-promoting activities in the clinic. Methods: Patient surveys were developed and administered to outpatients before and after a brief intervention aimed at increasing staff and intern engagement with patients on health promotion measures. Patients self-reported areas of need and levels of engagement by their doctor or intern. Data were analyzed as pre- and postintervention independent, cross-sectional samples. Frequencies and chi-square assessments were performed. Results: One hundred twenty-eight preintervention surveys and 162 postintervention surveys were collected. Back pain was the most common reason for being seen in the clinic (60% of patients) and most patients were white. More than 10% were smokers in both samples. M...
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Research Interests: Biological Chemistry, Transcription Factors, Biological Sciences, Beta-Catenin, Phosphorylation, and 9 moreCHEMICAL SCIENCES, Protein Conformation, Structure activity Relationship, Recombinant Proteins, DNA binding proteins, Site-directed Mutagenesis, Tyrosine, Tyrosine Phosphorylation, and Medical and Health Sciences
For a weighted, undirected graph G = (V,E), the single most vital edge in a network with respect to shortest paths is the edge that, when removed, results in the greatest increase in the shortest distance between two nodes s and t. We... more
For a weighted, undirected graph G = (V,E), the single most vital edge in a network with respect to shortest paths is the edge that, when removed, results in the greatest increase in the shortest distance between two nodes s and t. We give a sequential algorithm for the Single Most Vital Edge problem on weighted and undirected graphs. Our
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The purpose of this study was to investigate the impact of recombinant human growth hormone (rhGH) on patella tendon (PT), medial collateral ligament (MCL), and lateral collateral ligament (LCL) on collagen growth and maturational changes... more
The purpose of this study was to investigate the impact of recombinant human growth hormone (rhGH) on patella tendon (PT), medial collateral ligament (MCL), and lateral collateral ligament (LCL) on collagen growth and maturational changes in dwarf GH-deficient rats. Twenty male Lewis mutant dwarf rats, 37 days of age, were randomly assigned to Dwarf + rhGH (n = 10) and Dwarf + vehicle (n = 10) groups. The GH group received 1.25 mg rhGH/kg body wt twice daily for 14 days. rhGH administration stimulated dense fibrous connective tissue growth, as demonstrated by significant increases in hydroxyproline specific activity and significant decreases in the non-reducible hydroxylysylpyridinoline (HP) collagen cross-link contents. The increase in the accumulation of newly accreted collagen was 114, 67, and 117% for PT, MCL, and LCL, respectively, in 72 h. These findings suggest that a short course rhGH treatment can affect the rate of new collagen production. However, the maturation of the tendon and ligament tissues decreased 18-25% during the rapid accumulation of de novo collagen. We conclude that acute rhGH administration in a dwarf rat can up-regulate new collagen accretion in dense fibrous connective tissues, while causing a reduction in collagen maturation.
Research Interests: Physiology, Growth Hormone, Humans, Human Growth Hormone, Collagen, and 14 moreAnimals, Male, Connective tissue, Dwarfism, Rats, Specific Activity, Hydroxyproline, Recombinant Proteins, Ligaments, Tendons, Recombinant Human Growth Hormone, Biochemistry and cell biology, Medial Collateral Ligament, and Medical biochemistry and metabolomics
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Research Interests: Engineering, Biology, Medicine, Biological Sciences, Cell Differentiation, and 13 moreMice, Bone, Animals, Glycosaminoglycan, Morphological Variation, Chondrocytes, Chondrogenesis, Cell Proliferation, Growth Plate, Autosomal Dominant, bone development, Heparan Sulfate, and Medical and Health Sciences
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Research Interests: Anthropology, Censorship, Anthropology of Music, Border Studies, Anthropology of Gender, and 15 moreBorder Crossing, Anthropology Of Consumption, Anthropology of Borders, Border Theory, Anthropology of Law, Borderlands Studies, Anthropology of Finance, Black Markets, Anthropology of Money, Border Security, Anthropology of Violence, Borders and Borderlands, Anthropology of Everyday Life, Anti Money laundering, and Anthropology of Religion
Research Interests: Engineering, Adolescent, Elasticity, Humans, Collagen, and 15 moreChronic Disease, Female, Male, Fascia, Mechanical Testing, Pressure, Middle Aged, Adult, Elastic Modulus, Hydroxyproline, Control Group, Biomechanical Phenomena, Mechanical Property, Medical and Health Sciences, and In Vitro Techniques
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How our minds work, and how we make decisions. Why is there more chance we'll believe something if it's in a bold type face? Why are judges more likely to deny parole before lunch? Why do we assume a good-looking person will be... more
How our minds work, and how we make decisions. Why is there more chance we'll believe something if it's in a bold type face? Why are judges more likely to deny parole before lunch? Why do we assume a good-looking person will be more competent? The answer lies in the two ways we make choices: fast, intuitive thinking, and slow, rational thinking.