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Article
Open AccessInhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
The aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood brain barrier (BBB) dysfunction caused by NMDAR activation.
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Article
Open AccessType-printable photodetector arrays for multichannel meta-infrared imaging
Multichannel meta-imaging, inspired by the parallel-processing capability of neuromorphic computing, offers considerable advancements in resolution enhancement and edge discrimination in imaging systems, exten...
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Article
Open AccessUncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal development. Dynamic changes in DNA methylation occur during preimplantation development and are critical for cell f...
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Article
Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections. However, FcγR is a member of FcRs family, whose structure and fu...
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Article
Open AccessPrognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma
The ramifications of necroptosis on the prognostication of clear cell renal cell carcinoma (ccRCC) remain inadequately expounded.
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Article
Open AccessAmlodipine inhibits Synaptotagmin-4’s oncogenic activity on gastric cancer proliferation by targeting calcium signaling
Background: Gastric cancer (GC) remains a leading cause of cancer mortality globally. Synaptotagmin-4 (SYT4), a calcium-sensing synaptic vesicle protein, has been implicated in the oncogenesis of diverse malig...
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Article
High-performance carbon-electrode-based self-powered optoelectronic synaptic devices
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Clinical Analysis of the Application of Anatomical Silicone Gel Implants in Augmentation Mammaplasty via the Inframammary Fold Approach for the Treatment of Mild Mastoptosis
The aim of this study is to explore the effectiveness and indications of using an anatomical implant through an inframammary fold incision for the treatment of breast ptosis. A retrospective analysis was condu...
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Article
Attitudes of medical professionals toward fragile X carrier screening and genetic counseling in China
Fragile X syndrome is the most common inherited cause of intellectual disability. Considering China’s low prevalence, distinct healthcare system, middle-income economic status, and unique culture, China cannot...
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The Impact of Dipyridamole on Disease-Associated Microglia Phenotypic Transformation in White Matter Lesions Induced by Chronic Cerebral Hypoperfusion
White matter lesions (WMLs) resulting from chronic cerebral hypoperfusion (CCH) are the leading cause of vascular dementia (VaD). This study aimed to investigate whether dipyridamole could alleviate WMLs by re...
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Article
Ferroelectric-controlled graphene plasmonic surfaces for all-optical neuromorphic vision
Artificial visual systems can recognize desired objects and information from complex environments, and are therefore highly desired for pattern recognition, object detection, and imaging applications. However,...
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Article
Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion
Neuroinflammation is assumed as the critical pathophysiologic mechanism of white matter lesions (WMLs), and infiltrated peripheral monocyte-derived macrophages are implicated in the development of neuroinflamm...
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Article
Open AccessProteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape of 272 soft tissue sarcomas representing 12 major subtypes. Hi...
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Article
Open AccessTwo-fold symmetric superconductivity in the Kagome superconductor RbV3Sb5
The recently discovered kagome superconductors offer a promising platform for investigating intertwined orders and novel states, including topology, superconductivity, charge density waves, and more. The inter...
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Article
Open AccessDynamic evolution and spatial difference of public health service supply in economically developed provinces of China: typical evidence from Guangdong Province
The outbreak of the COVID-19 pandemic has drawn attention from all sectors of society to the level of public health services. This study aims to investigate the level of public health service supply in the fou...
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Article
Quantitative Almost Reducibility and Möbius Disjointness for Analytic Quasiperiodic Schrödinger Cocycles
Sarnak’s Möbius disjointness conjecture states that Möbius function is disjoint to any zero entropy dynamics. We prove that Möbius disjointness conjecture holds for one-frequency analytic quasi-periodic cocycl...
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Article
Open AccessConcurrent fabry disease and immunoglobulin a nephropathy: a case report
Fabry disease (FD) is an X-linked, hereditary dysfunction of glycosphingolipid storage caused by mutations in the GLA gene encoding alpha-galactosidase A enzyme. In rare cases, FD may coexist with immunoglobulin ...
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Article
Two-dimensional metallic alloy contacts with composition-tunable work functions
Heterostructures made using two-dimensional semiconducting transition metal dichalcogenides could be used to build next-generation electronic devices. However, their performance is limited by low-quality metal...
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Article
Open AccessPH13 improves soybean shade traits and enhances yield for high-density planting at high latitudes
Shading in combination with extended photoperiods can cause exaggerated stem elongation (ESE) in soybean, leading to lodging and reduced yields when planted at high-density in high-latitude regions. However, t...
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Open AccessInhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood–Brain Barrier Disruption and Neuronal Damage
The disruption of the blood–brain barrier (BBB) is hypothesized to be involved in the progression of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, but its mechanism is still unclear. Recently, the phos...
