Flavonoids are groups of polyphenolic compounds which are found in fruits, flowers, seeds & vegetable.
(named from the Latin word flavus meaning yellow, their colour in nature)
Turmeric is obtained from the dried rhizomes of the plant Curcuma longa. It contains the yellow chemical curcumin, which makes up 50-60% of turmeric. Curcumin can be isolated from turmeric powder through extraction with alcohol or hexane followed by acetone. Curcumin is identified through chemical tests where it produces a crimson color with sulfuric acid or a reddish brown color with boric acid that turns greenish blue with alkali. Curcumin content can be analyzed using methods like HPLC, where it shows peaks at specific retention times when separated using a Nucleosil NH2 column with ethanol mobile phase and UV detection at 254nm.
Terpenoids are a class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are volatile essential oils found in many plants and flowers which give them their distinctive fragrances. There are many different classes of terpenoids classified based on the number of isoprene units they contain, such as monoterpenoids, sesquiterpenoids, and diterpenoids. Common terpenoids include limonene, menthol, and camphor. Spectroscopic techniques such as UV, IR, NMR and mass spectrometry are used to determine terpenoid structures and functional groups.
This document provides an overview of flavonoids including their introduction, classification, isolation, purification, and methods for structural determination. Flavonoids are polyphenolic plant secondary metabolites with a C6-C3-C6 carbon skeleton found in flowers, leaves, bark, fruits, grains and nuts. They can be isolated from plant material by extracting with hot water or alcohol. Purification involves fractional crystallization or separation in solvent mixtures. Structural determination of flavonoids is done by observing their degradation products when fused with alkali, which produces identifiable phenols and aromatic acids.
Shikimic acid is an important biochemical metabolite found in plants and microorganisms. It was first isolated from the Japanese star anise plant in 1885. The shikimate pathway is a seven step metabolic route used by plants and microbes to synthesize the aromatic amino acids phenylalanine, tyrosine, and tryptophan. This pathway is not present in animals. Shikimic acid is the starting point for the biosynthesis of many important phenolic compounds like flavonoids, tannins, lignin, and gallic acid. It is also a precursor for indole derivatives and the psychedelic compound DMT. Glyphosate herbicide works by inhibiting the shikimate pathway in plants
This document provides information about alkaloids. It begins with definitions and classifications of alkaloids. It then discusses two specific alkaloids - ephedra and colchicum. For ephedra, it describes the plant source, chemical constituents including ephedrine, uses, and chemical tests. For colchicum, it provides the plant source, chemical constituents including colchicine, and geographical sources.
- Taxol is a potent anticancer compound obtained from the Pacific yew tree. It was first isolated in 1971 and has the generic name paclitaxel.
- Due to the tree's slow growth, industrial production of taxol involves extraction from tree bark or semi-synthesis from related compounds like 10-deacetylbaccatin III from European yew.
- Taxol is used to treat cancers like ovarian cancer, breast cancer, and lung cancer. It works by stabilizing microtubules to inhibit cancer cell growth. While initially challenging to source, taxol production is now sustainable through extraction and semi-synthesis.
This document discusses drugs derived from marine organisms. It begins by defining marine drugs as those obtained from marine life, such as shark and cod-liver oils. Marine organisms represent a potential source for drug discovery due to the chemical and biological diversity in the oceans. Harsh marine conditions cause organisms to produce unique molecules and compounds with various biological activities. Many marine natural products have been isolated from sponges, corals, tunicates, echinoderms, and microorganisms. These drugs are classified based on their pharmacological actions such as cytotoxic, cardiovascular, antimicrobial, antibiotic, anti-inflammatory, and more. Several examples of compounds are provided for each category.
The document discusses the chemistry and biosynthesis of various glycosides. It begins by defining glycosides as molecules composed of a sugar molecule (glycone) linked to a non-sugar molecule (aglycone). It then discusses the chemistry and sources of several classes of glycosides - cardiac glycosides, sennosides, steroidal saponin glycosides like diosgenin, hecogenin and sarsapogenin. The biosynthesis of these glycosides involves the transfer of a sugar molecule from a UDP-sugar to the aglycone, catalyzed by glycosyltransferases. Key cardiac glycosides discussed are digoxin and digitoxin. Sennosides are anthraquinone glycos
This presentation provides information on different types of volatile oils and their medicinal values. Volatile oils are also known as ethereal or essential oils, and evaporate at ordinary temperatures. They provide scents to plants and protect them from animals. There are various classifications of volatile oils including hydrocarbons, alcohols, aldehydes, ketones, phenols, and esters. Methods to obtain volatile oils include distillation, solvent extraction, and mechanical expression. Volatile oils have many medicinal uses such as for aromatherapy, as antiseptics, and to treat conditions like spasms. The presentation examines properties, chemical constituents, extraction methods, and applications of these important plant-derived oils
This document discusses flavonoids, which are polyphenolic compounds found in plants. It provides an introduction to flavonoids, including their structure, occurrence in plants, and functions. It also describes methods for isolating, extracting, and determining the structures of flavonoids, such as using chromatography, ultraviolet and infrared spectroscopy, and nuclear magnetic resonance spectroscopy. Key tests for detecting flavonoids include the Shinoda test and sodium hydroxide test.
This document provides information about terpenoids, which are a large and diverse class of organic compounds derived from isoprene units. It discusses that terpenoids are commonly found in plants and have various important uses and properties. The document classifies terpenoids based on their carbon content, including monoterpenes which contain two isoprene units. It provides examples of important acyclic, monocyclic, and bicyclic monoterpenes and discusses their structures, natural sources, and significance.
Here are short answers to your questions on carotenoids:
1. Carotenoids are yellow, orange or red pigments found in plants and algae. They are lipophilic and soluble in oils. Upon heating, acid or light, they may isomerize.
2. Carotenoids are classified into carotenes and xanthophylls. Carotenes like alpha-carotene and beta-carotene contain no oxygen. Xanthophylls like lutein and zeaxanthin contain oxygen.
3. Alpha- and beta-carotene are carotenes. They are antioxidants and beta-carotene can be converted to vitamin A.
4. Lyc
- Alkaloids are basic nitrogenous plant compounds with physiological effects. They contain heterocyclic nitrogen structures derived from amino acids.
- Atropine is an alkaloid obtained from plants like belladonna. It acts as an anticholinergic and is used to treat conditions like nausea, vomiting, Parkinson's disease, and as a pre-anesthetic.
- Reserpine is obtained from Rauwolfia serpentina and works by depleting catecholamines. It is used to treat psychosis, anxiety, hypertension, and aggression.
- Ephedrine is a sympathomimetic alkaloid obtained from Ephedra that stimulates alpha and beta receptors. It is
The document discusses primary and secondary metabolites, alkaloids, glycosides, and tannins. It defines these compounds and outlines their key properties. Alkaloids are nitrogen-containing compounds that have physiological effects. They are classified based on biosynthetic pathways, pharmacology, taxonomy, and heterocyclic ring structures. Glycosides are compounds containing a sugar and non-sugar moiety. They are classified by the type of sugar or aglycone. Tannins are polyphenolic compounds that can combine with proteins. They are classified as hydrolysable or condensed based on their chemical structures. Extraction and isolation methods are also presented.
This presentation included the general intro of herb,
its collection and cultivation,
chemical constituents,
uses,
mechanism of action;
dosage form and doses;
side effects, toxicity;
precautions,
interaction with other drugs an herbs
Flavonoid adalah senyawa fenolik yang berperan sebagai antioksidan dan ditemukan pada berbagai tumbuhan. Terdapat tiga jenis flavonoid utama yaitu antosianin yang memberi warna merah/biru, antoksanin yang memberi warna kuning, dan tanin yang tidak berwarna. Semua jenis flavonoid bermanfaat sebagai antioksidan dan antiinflamasi.
Flavonoid adalah senyawa fenol yang banyak ditemukan di alam yang memberikan warna merah, ungu, dan kuning pada tumbuhan. Struktur dasar flavonoid terdiri atas 15 atom karbon yang membentuk susunan C6-C3-C6. Flavonoid memiliki berbagai jenis seperti flavon, flavonol, antosianidin yang dapat diisolasi dari ekstrak tumbuhan melalui fraksinasi.
Roles of Flavonoids in Human Health (Seminar presentation)Kayode Kolawole
This document summarizes a student presentation on the roles of flavonoids in human health. It discusses the sources of flavonoids, their structure, biosynthesis pathway, and various pharmacological activities including antioxidant, cardio-protective, anti-carcinogenic, gastro-protective, anti-microbial, anti-inflammatory, and anti-thrombotic effects. It provides examples of specific flavonoids and their effects. The presentation concludes that flavonoids show therapeutic potential but their use requires validation through biochemical testing, and their safety depends on appropriate dosing.
This document discusses flavonoids, a class of polyphenolic compounds found in plants. It notes that over 4,000 flavonoids have been identified in foods and beverages, and that they have antioxidant and anti-inflammatory properties. Flavonoids are categorized into subclasses including flavonols, flavones, flavanones, and isoflavones. The document explores the antioxidant activities and health benefits of specific flavonoids like quercetin and xanthohumol. High intake of flavonoids from foods is associated with reduced risk of diseases like cancer and heart disease.
The document discusses plant phenolic compounds. It notes that thousands of phenolic structures are known, accounting for 40% of organic carbon in the biosphere. Phenolic compounds are primarily derived from the phenylpropanoid and acetate pathways and play important roles in plant cell walls, defense, wood/bark features, and flower color/flavor. Phenolic compounds can be classified into flavonoids and non-flavonoids. Key flavonoids discussed include quercetin, naringenin, and isoflavonoids like genistein and daidzein. Non-flavonoids include hydroxycinnamates, stilbenes like resveratrol, and tannins.
Flavonoids are polyphenolic compounds found in plants. They have 15 carbon atoms arranged in two benzene rings connected by a 3 carbon chain. There are over 4,000 known flavonoids which serve important functions in plants like pigmentation and protecting against environmental toxins. The main classes of flavonoids include flavones, flavonols, flavanones, and anthocyanidins. Flavonoids act as antioxidants and have various health benefits like antiviral, anti-inflammatory, and antitumor properties. They can be identified through color reactions with acids or lead acetate and purified through chromatography techniques.
The document discusses flavonoids, a large group of plant metabolites that include flavones, flavonols, flavanones, isoflavonoids, anthocyanidins, and flavan-3-ols. Flavonoids are found naturally in plants and have various functions like pigments, growth regulators, and antimicrobial properties. They also have therapeutic uses like antioxidant, anticancer, antiviral, and hepatoprotective effects. The document describes the isolation, identification, and properties of various flavonoid subclasses and compounds like hesperidin, rutin, catechins, and silymarin. It provides information on the source, structure, and pharmacological activities of important flavonoids.
The document summarizes extraction methods for alkaloids from plants. It describes two main methods - solvent extraction under alkaline conditions, which extracts alkaloids as free bases using organic solvents, and extraction under acidic conditions, which extracts alkaloid salts into aqueous extracts that can then be made basic to recover the free bases. Both methods involve defatting the plant material first before extraction. The document provides details on the steps involved in each extraction method and notes that no universal quantification method exists for all alkaloids due to their chemical diversity.
Flavonoids are polyphenolic compounds found in plants that act as antioxidants. They have 15 carbon atoms arranged in two benzene rings connected by a 3 carbon chain. Over 4,000 flavonoids have been identified, commonly found as flower pigments but also throughout plants. Major classes include flavones, flavonols, flavanones, and anthocyanidins. Key flavonoids like quercetin and kaempferol are studied for their health benefits such as antiviral and anti-inflammatory properties. Their structures can be elucidated through various chemical tests and reactions.
This document provides information on flavonoids. Some key points:
- Flavonoids are polyphenolic compounds found in plants that act as antioxidants. They have 15 carbon atoms arranged in two benzene rings connected by a 3 carbon chain.
- Over 4,000 flavonoids have been identified. They are commonly found in flowers but also in other plant parts. Major classes include flavones, flavonols, flavanones, and isoflavonoids.
- Common flavonoids include quercetin, kaempferol, and naringenin. Quercetin occurs naturally as the glycoside quercetin-3-rhamnoside and has the molecular formula C
Flavonoids are polyphenolic compounds found in plants that act as antioxidants. They have 15 carbon atoms arranged in two benzene rings connected by a 3 carbon chain. Over 4,000 flavonoids have been identified, commonly found as flower pigments but also throughout plants. Major classes include flavones, flavonols, flavanones, and anthocyanidins. Key flavonoids like quercetin and kaempferol are studied for their health benefits such as antiviral and anti-inflammatory properties. Their structures can be elucidated through chemical reactions and chromatography techniques.
content
Flavonoids (importance, Physiological role and Therapeutic uses).
Flavonoids biosynthesis, General Properties and Tests for identity.
Flavone Glycosides (Diosmin and Apiin)
Flavonol Glycosides (rutin and Quercetrin)
Flavanone Glycosides (Hesperidin)
Silymarin (flavonolignans)
Isoflavonoids (Genistein)
Coumarin Glycosides
This document provides an overview of polyphenol subclasses including flavonoids, phenolic acids, and stilbenoids. It discusses their plant sources and potential health benefits. Flavonoids are the largest subclass and can be further divided into flavones, isoflavones, flavanones, flavonols, flavanols, anthocyanidins, and chalcones. Phenolic acids are derived from benzoic or cinnamic acids. Stilbenoids mainly include resveratrol. While polyphenols have powerful antioxidant effects in vitro, their roles in human health benefits are complex and uncertain due to various factors like low bioavailability.
This document discusses techniques used to study biosynthetic pathways in plants. It describes the shikimic acid pathway and mevalonate pathway, which are important for producing aromatic compounds and terpenes respectively. It also summarizes several techniques used in biogenic studies including the use of isolated organs, grafting, mutant strains, tracer techniques, and enzymatic studies. Tracer techniques involve using radioactive isotopes or stable isotopes to trace metabolic pathways and locate compounds. Proper labeling and introduction of tracers is required.
The document provides an overview of flavonoids, a class of secondary plant metabolites. It discusses the composition, structures, subclasses and properties of flavonoids. Key points include: flavonoids are polyphenolic compounds found in many plants; they have antioxidant effects and play roles in plant growth and pollination; major subclasses include flavones, flavonols, flavanones and anthocyanidins; glycosylation and other substitutions lead to diversity in flavonoid structures. The document also reviews the structures and properties of related subclasses like lignans and isoflavones.
Unit I Metabolic pathways in
higher plants & their determination
Pharmacognosy & Phytochemistry II
B. Pharm. Vth Semester
Biosynthetic Pathways
Metabolic pathways
Separation of L-Phenylalanine by Solvent Sublation and Solvent Extraction MethodBRNSS Publication Hub
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# Quercetin is the most abundant dietary flavonoid. It has been linked to improved exercise performance and reduced inflammation, blood pressure, and blood sugar level.
# Flavonoids any of large class of plant pigments having a structure based on or similar to that of flavone.
This document discusses cytochrome P450 enzymes (CYP) which are involved in drug metabolism in the human liver. CYP1A2 is one of the main CYP enzymes. Several drug substrates of different CYP isoenzymes are provided as examples. The document also discusses sources of interindividual variation in CYP enzymes including genetic polymorphisms and environmental factors. Phase I and Phase II drug metabolism reactions are described in detail.
Xenobiotics are foreign compounds to our body. They are more lipophilic and less hydrophilic . So it is quite tough to excrete them out from the body. Hence metabolism of xenobiotic is important.
This document discusses biotransformation, or the metabolism of drugs in the body. It covers the key topics of:
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Lect. No. 14 & 15 Detoxification & Biotrasformation of Xenobiotics.pptShambhudeoKharde
1. Detoxification involves metabolizing xenobiotics like drugs and chemicals through phase I and phase II reactions to make them more water soluble and easily excreted.
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Flavonoids, Definition, Classification, General Methods for the Structural determination of Flavonoids, Structural Elucidation of Quercetin, References.
This document discusses the metabolism of xenobiotics, or foreign chemicals, in the body. It notes that xenobiotics are mostly lipophilic and cannot be easily cleared from the body. Their metabolism involves two phases - in the first phase enzymes like cytochrome P450 modify xenobiotics through reactions like hydroxylation and oxidation, while the second phase involves conjugating the substances to make them more water soluble and able to be excreted, through processes like glucuronidation and sulfation. Factors like genetic variability and drug interactions can impact an individual's ability to metabolize different xenobiotics. The document provides many examples of common xenobiotics and discusses how their metabolism can sometimes produce toxic effects.
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Is Email Marketing Really Effective In 2024?Rakesh Jalan
Slide 1
Is Email Marketing Really Effective in 2024?
Yes, Email Marketing is still a great method for direct marketing.
Slide 2
In this article we will cover:
- What is Email Marketing?
- Pros and cons of Email Marketing.
- Tools available for Email Marketing.
- Ways to make Email Marketing effective.
Slide 3
What Is Email Marketing?
Using email to contact customers is called Email Marketing. It's a quiet and effective communication method. Mastering it can significantly boost business. In digital marketing, two long-term assets are your website and your email list. Social media apps may change, but your website and email list remain constant.
Slide 4
Types of Email Marketing:
1. Welcome Emails
2. Information Emails
3. Transactional Emails
4. Newsletter Emails
5. Lead Nurturing Emails
6. Sponsorship Emails
7. Sales Letter Emails
8. Re-Engagement Emails
9. Brand Story Emails
10. Review Request Emails
Slide 5
Advantages Of Email Marketing
1. Cost-Effective: Cheaper than other methods.
2. Easy: Simple to learn and use.
3. Targeted Audience: Reach your exact audience.
4. Detailed Messages: Convey clear, detailed messages.
5. Non-Disturbing: Less intrusive than social media.
6. Non-Irritating: Customers are less likely to get annoyed.
7. Long Format: Use detailed text, photos, and videos.
8. Easy to Unsubscribe: Customers can easily opt out.
9. Easy Tracking: Track delivery, open rates, and clicks.
10. Professional: Seen as more professional; customers read carefully.
Slide 6
Disadvantages Of Email Marketing:
1. Irrelevant Emails: Costs can rise with irrelevant emails.
2. Poor Content: Boring emails can lead to disengagement.
3. Easy Unsubscribe: Customers can easily leave your list.
Slide 7
Email Marketing Tools
Choosing a good tool involves considering:
1. Deliverability: Email delivery rate.
2. Inbox Placement: Reaching inbox, not spam or promotions.
3. Ease of Use: Simplicity of use.
4. Cost: Affordability.
5. List Maintenance: Keeping the list clean.
6. Features: Regular features like Broadcast and Sequence.
7. Automation: Better with automation.
Slide 8
Top 5 Email Marketing Tools:
1. ConvertKit
2. Get Response
3. Mailchimp
4. Active Campaign
5. Aweber
Slide 9
Email Marketing Strategy
To get good results, consider:
1. Build your own list.
2. Never buy leads.
3. Respect your customers.
4. Always provide value.
5. Don’t email just to sell.
6. Write heartfelt emails.
7. Stick to a schedule.
8. Use photos and videos.
9. Segment your list.
10. Personalize emails.
11. Ensure mobile-friendliness.
12. Optimize timing.
13. Keep designs clean.
14. Remove cold leads.
Slide 10
Uses of Email Marketing:
1. Affiliate Marketing
2. Blogging
3. Customer Relationship Management (CRM)
4. Newsletter Circulation
5. Transaction Notifications
6. Information Dissemination
7. Gathering Feedback
8. Selling Courses
9. Selling Products/Services
Read Full Article:
https://digitalsamaaj.com/is-email-marketing-effective-in-2024/
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Facilitatory techniques
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Flavonoids classification, isolation and identification
2. Definition:
Group of polyphenolic compounds which
are found in fruits, flowers, seeds &
vegetable.
They are more common in higher plants being
abundant in families, Polygonaceae,
Rutaceae, Leguminosae, Umbelliferae &
Compositae.
Flavonoids (named from the Latin word
flavus meaning yellow, their colour in
nature) are a class of plant secondary
metabolites.
3. Physiological role:
1- Role in plant defense mechanism:-
They have a very limited role in this respect
due to their low toxicity when compared with
other plant secondary metabolites such as
alkaloids.
2- They are the pigments of flowers and
attract pollinating insects.
3- They play a role in plant growth control
by inhibiting & activating enzymes.
4. Structure of flavonoids
The flavonoids are possessing 15 carbon
atoms; two benzene rings joined by a
linear three carbon chain the skeleton
can be represented as the C6 - C3 - C6
system.
5. The three-carbon (-C3-) may be included through an
oxygen bond between the two phenyl rings into:
1- A five-membered heterocyclic ring (furan)
as in aurones.
2- A six-membered heterocyclic ring (pyran) to
give flavonoids which constitute the largest
group.
6. Flavonoids occur as aglycones, glycosides
and methylated derivatives.
The flavonoid aglycone consists of a benzene ring
(A) condensed with a six membered ring (C) pyran
ring , which in the 2-position carries a phenyl ring
(B) as a substituent.
7. The flavonoid glycosides:
Glycosides → aglycone (non sugar part)+glycone (sugar
part)
When glycosides are formed, the glycosidic linkage can be
located in positions 3 or 7 and may be L-rhamnose, D-
glucose, galactose or arabinose .
8. Classification:
They are classified accorrding to chemical structure into:
1-
Flavones:
2-phenylchromen-4-one examples:-
1- Apigenin.
2- Luteolin.
3- Tangeritin.
4- Diosmetin.
20. Actions of flavonoids
1-Flavonoids as antioxidants:
The flavones and catechins seem to be the most powerful flavonoids for
protecting the body against reactive oxygen species (ROS).
Flavonoids are oxidized by radicals, resulting in a more stable,
less-reactive radical.
Because of the high reactivity of the hydroxyl group of the
flavonoids, radicals are made inactive. Epicatechin and
rutin are also powerful radical scavengers.
2- Anti ulcer effect:
Majority of peptic ulcers are associated with helicobacter
pylori, a spiral-shaped bacterium that lives in the acidic
environment of the stomach. Quercetin seems to play a
very important role in the prevention and treatment of
peptic ulcer. It acts by promoting mucus secretion, thereby
serves as gastroprotective agent, also quercetin has been
shown to inhibit the growth of helicobacter pylori
bacterium in-vitro studies.
21. 3- Anti atherosclerotic effects:
Atherosclerosis is a condition that results from the gradual
build-up of fatty substances, including cholesterol, on the
walls of the arteries. This build-up, called plaque, reduces
the blood flow to the heart, brain and other tissues and can
progress to cause a heart attack or stroke. This process is
commonly referred to as hardening of the arteries. An
elevated plasma low density lipoprotein (LDL)
concentration is a primary risk factor for the development
of atherosclerosis and coronary artery disease. Flavonoids
seems to suppress LDL oxidation and inflammatory
progression in the artery wall. A Japanese study reported
an inverse correlation between flavonoid intake and total
plasma cholesterol concentrations, other clinical studies, as
mentioned earlier, stated that flavonoid intakes protect
against coronary heart disease.
22. 4- Anti-inflammatory effect:
Cyclooxygenase (COX) is an enzyme that plays an
important role as inflammatory mediator and is involved
in the release of arachidonic acid, which is a precursor for
biosynthesis of eicosanoids like prostaglandins and
prostacyclin. The release of arachidonic acid can be
considered starting point for a general inflammatory
response. Select flavonoids like quercetin are shown to
inhibit the cyclooxygenase pathway. This inhibition
reduces the release of arachidonic acid.
23. 5-Hepatoprotective activity:
Many flavonoids have also been found to possess
hepato-protective activity e.g silymarin, apigenin,
quercetin and naringenin.
The results of several clinical investigations showed
the efficacy and safety of flavonoids in the
treatment of hepato-biliary dysfunction and
digestive complaints, such as sensation of
fullness, loss of appetite, nausea and abdominal
pain.
24. Isolation of flavonoids
*Glycosides are polar due to sugar moiety and
extractable with alcohol, water and
hydroalcoholic solution.
*Aglycones are extracted with less polar
solvents e.g ether, chloroform and ethyl acetate.
25. 1-Plant preparation:
Flavonoids (particularly glycosides) can be degraded by
enzyme action when collected plant material is fresh or
non dried. It is advisable to use dry, lyophilized, or
frozen samples. dry plant material is used, it is generally
ground into a powder.
2-Solvent choosing:
For extraction, the solvent is chosen as a function of the type
of flavonoid required. Less polar flavonoids (e.g.,
isoflavones, flavanones, methylated flavones, and
flavonols) are extracted with chloroform,
dichloromethane, diethyl ether, or ethyl acetate.
while flavonoid glycosides are more polar and are extracted
with alcohols or alcohol–water mixtures.
26. The extractions of flavonoid-containing material are still
performed by simple direct solvent extraction, can also be
extracted in a Soxhlet apparatus, first with hexane,to
remove lipids and then with ethyl acetate or ethanol to
obtain phenolics. This approach is not suitable for heat-
sensitive compounds.
A convenient and frequently used procedure is sequential
solvent extraction. A first step,with dichloromethane, for
example, will extract flavonoid aglycones and less polar
material. A subsequent step with an alcohol will extract
flavonoid glycosides and polar constituents.
28. The crude flavonoid extract could be purified by one of the
following methods:-
1- Shaking with Na2CO3 or NaHCO3 in case of
compounds contaning strong acidic OH groups at C-7
and or C-4`followed by acidification.
B-Preliminary
Purification
29. 2- Precipitation with Pb-acetate:
The lead acetate procedure is often
unsatisfactory since some phenolics do not
precipitate; other compounds may co-precipitate
and it is not always easy to remove the lead salt.
3- Chromatographic techniques e.g PC, TLC or
CC.
A short polyamide column, a Sephadex LH-20
column, or an ion exchange resin can be used.
30. Preparative Methods
The major problems with the preparative
separation of flavonoids:-
sparing solubility in solvents employed in
chromatography.
Poor solubility in the mobile phase used for a
chromatographic separation can induce
precipitation at the head of the column, leading
to poor resolution, decrease in solvent flow, or
even blockage of the column.
31. In the separation of anthocyanins and
anthocyanin-rich fractions, it is advisable to
avoid acetonitrile and formic acid
Acetonitrile is difficult to evaporate and there is
a risk of ester formation with formic acid.
The choice of method depends on the polarity of
the compounds and the quantity of sample
available.
32. Conventional open-column chromatography is still
widely used because of its simplicity and its value
as an initial separation step.
Support materials include polyamide, cellulose,
silica gel, Sephadex LH-20, and Sephadex G-10, G-25,
and G-50.
Sephadex LH-20 is recommended for the separation
of proanthocyanidins.
Methanol and ethanol can be used as eluents for
proanthocyanidins, acetone is better for displacing
the high molecular weight polyphenols.
33. Several preparative pressure liquid chromatographic
methods are available. These can be classified according
to the pressure employed for the separation:
1- High-Performance Liquid Chromatography:-
HPLC is becoming by far the most popular technique for
the separation of flavonoids, both on preparative and
analytical scales.
The difference between the analytical and preparative
methodologies is that analytical HPLC does not rely on
the recovery of a sample, while preparative HPLC is a
purification process and aims at the isolation of a pure
substance from a mixture.
35. 2- Medium-Pressure Liquid Chromatography:-
MPLC is a closed column (generally glass) connected to
a compressed air source or a reciprocating pump.
MPLC columns have a high loading capacity — up to a
1:25 sample-to-packing-material ratio — and are
ideal for the separation of flavonoids.
3- Centrifugal Partition Chromatography:-
Countercurrent chromatography is a separation
technique that relies on the partition of a sample
between two immiscible solvents.
The relative proportions of solute passing into each of
the two phases determined by the partition
coefficients of the components of the solute.
36. Absence of a solid support has the following
advantages over other chromatographic
techniques:-
1-No irreversible adsorption of the sample.
2-Quantitative recovery of the introduced sample.
3- Reduced risk of sample denaturation.
4-Low solvent consumption.
5-Favorable economics.
37. Identification and
characterization
A- Test for identification:-
The different types of flavonoides can be characterized by their
colored response to different tests (visible light ) or colored
fluorescence in UV light.
1- Reaction with aluminum chloride:
The different classes of flavonoids give yellow color with AlCl3
but fluoresce differently in UV as shown in the following table .
FlavanonesFlavonolsFlavoneslight
YellowYellowYellowVisible
Pale-brownishYellowish to
Yellowish-green
GreenUV
38. 2- Lead subacetate test:-
all flavonoids give yellowish precipitate with Pb
subacetate.
3-Shinoda´s test for flavanones and
flavonols:-
alcoholic solution + Mg metal ⁄ Hcl , an orange , red or
violet color is produed.
4- Antimony pentachloride test for
chalcones:
alcoholic solution + SbCl5⁄ CCl4 , red or violet color is
produced.
39. B- Chromatographic characterization by
PC and ⁄ or TLC:-
One or more of the following procedures can be
used for location of flavonoid spots:
1- Under UV before and after spraying with AlCl3
and/or exposure to ammonia vapors.
2- In visible light: e.g. chalcones and aurones
appear bright yellow and turns to orange red on
exposure to ammonia vapor.
3-After spraying with FeCl3, p-anisaldehyde ,
diazotized sulphanilic acid.