Jorge Ferraris
Universidad de Buenos Aires, PEDIATRIA, Faculty Member
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Base de dados : LILACS. Pesquisa : 2583 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos... more
Base de dados : LILACS. Pesquisa : 2583 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 2583. ...
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Twenty three children aged 0.4 to 15 years, (x 7.5 years) with end-stage renal disease were treated with continuous ambulatory peritoneal dialysis (CAPD) over 46 months. The mean time of treatment for the group was 13 months (range 1.0 to... more
Twenty three children aged 0.4 to 15 years, (x 7.5 years) with end-stage renal disease were treated with continuous ambulatory peritoneal dialysis (CAPD) over 46 months. The mean time of treatment for the group was 13 months (range 1.0 to 31 months). Sixty five percent of the patients had readmission after catheter placement; 53% were for peritonitis. Nine out of 23 patients (39%), presented 20 episodes of peritonitis, an incidence of one episode per 15 patient months. Gram positive organisms were culture in 60% of these episodes. A total of 26 peritoneal catheters were placed in 23 patients. Of the five catheters that required replacement, three were for peritonitis. Seven out of 23 patients had nephrotic syndrome when admitted to CAPD, four of which develop peritonitis. Although no difference was seen between nephrotic and non nephrotic patients in relation to CAPD initiation and peritonitis development, nephrotic patients without peritonitis and non nephrotic had significantly higher initial growth index for height and iron binding capacity than those with nephrotic syndrome and peritonitis (-1.71 +/- 0.90 vs -2.29 +/- 0.27, P less than 0.05, and 265 +/- 50.5 vs 175 +/- 5.0 mg/dL, P less than 0.0005, respectively). No difference in mean plasma gamma globulin concentration was seen between patients with and without peritonitis. In 14 patients followed for a period greater than to 6 months, the delta growth index for weight and height and was: -0.13 +/- 0.31 and -0.31 +/- 0.46, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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Research Interests: Pharmacology, Kidney transplantation, Treatment Outcome, Adolescent, STEROIDS, and 15 moreMedicine, Transplantation, Tacrolimus, Humans, Child, Internal Medicine, Female, Male, Pediatric, Age Factors, Body Weight, Methylprednisolone, Dosing, Mycophenolic Acid, and Paediatrics and reproductive medicine
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Studies are increasingly recognizing health‐related quality of life (HRQOL) as a key pediatric outcome in both clinical and research settings and an essential health outcome measure to assess the effectiveness of medical treatment.... more
Studies are increasingly recognizing health‐related quality of life (HRQOL) as a key pediatric outcome in both clinical and research settings and an essential health outcome measure to assess the effectiveness of medical treatment. However, it has not yet been studied among the healthy siblings of kidney transplant recipients. The aim of this study, therefore, is to examine HRQOL among this population. We asked the following three groups to complete a validated measure of HRQOL among children (KIDSCREEN‐52): siblings of children who had received kidney transplants (n = 50), kidney transplant recipients (n = 43), and a healthy control group (n = 84). We found that siblings of kidney transplant patients exhibited lower scores for financial resources and autonomy than kidney transplant recipients. They also served lower on physical well‐being, financial resources, autonomy, and parent relations/home life than the control group. However, they scored higher on social acceptance than kidn...
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Serum creatine kinase (CK) and CK isoenzymes (CK-MM, CK-MB and CK-BB) were measured in 35 healthy and 25 children with hemolytic uremic syndrome (HUS) at 48 h, 7 and 15 days after admittance. Total serum CK activity was measured with a... more
Serum creatine kinase (CK) and CK isoenzymes (CK-MM, CK-MB and CK-BB) were measured in 35 healthy and 25 children with hemolytic uremic syndrome (HUS) at 48 h, 7 and 15 days after admittance. Total serum CK activity was measured with a commercially available kit ("CK-NAC", by Merck, cat 14327) and CK isoenzymes using the Helena laboratories method. The interassay coefficients of variation with these methods are the following: for the total CK activity, 10.95 and 9.15% for an enzyme activity of 42 and 142 U/L respectively; for the activity of the isoenzymes, 6.8, 8.0 and 15.1% for activities of 102, 67 and 30 U/L. Total CK activity at 48 h in HUS patients defined two groups, group 1 (G1) which is not different from the control group (CG) and group 2 (G2) which had a significantly higher activity, p less than 0.0005. The increase in total CK remained significant until the first week. Increase in total CK resulted from the increase in CK isoenzymes: CK-MM, CK-MB and CK-BB. Hi...
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Research Interests: Adolescent, Medicine, Humans, Child, Internal Medicine, and 15 moreBlood Pressure, Female, Male, Liver Transplantation, Pediatric, Ambulatory, Outpatients, Adult, Reproducibility of Results, Ambulatory Care, Ambulatory Blood Pressure, Postoperative care, Child preschool, Diastole, and Paediatrics and reproductive medicine
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Sorbitol accumulates in renal medullary cells by synthesis from glucose in a reaction catalyzed by aldose reductase. Medullary sodium and urea are high and vary with urinary concentration. Sorbitol varies similarly, consistent with its... more
Sorbitol accumulates in renal medullary cells by synthesis from glucose in a reaction catalyzed by aldose reductase. Medullary sodium and urea are high and vary with urinary concentration. Sorbitol varies similarly, consistent with its role as a compatible intracellular organic osmolyte. We measured renal medullary sodium, urea, sorbitol, aldose reductase (protein and activity), and aldose reductase mRNA in rats treated to change medullary sodium and urea. In untreated Brattleboro rats all measurements were low and increased after 7 days of treatment with arginine vasopressin. In contrast, when normal rats were water deprived for 3 days, urea increased out of proportion to sodium, and sorbitol, aldose reductase, and aldose reductase mRNA were unchanged. After 2 h of diuresis, normal rats had lower medullary sodium and urea and reduced mRNA and sorbitol; however aldose reductase did not change. These data are consistent with previous results from cultured cells in which altered extra...
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Base de dados : ADOLEC. Pesquisa : 34807 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 34807. Autor: Cortines... more
Base de dados : ADOLEC. Pesquisa : 34807 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 34807. Autor: Cortines ...
Low weight at birth may be due to intrauterine growth restriction or premature birth. Preterm birth is more common in low- and middle-income countries: 60% of preterm birth occur in sub-Saharan African or South Asian countries. However,... more
Low weight at birth may be due to intrauterine growth restriction or premature birth. Preterm birth is more common in low- and middle-income countries: 60% of preterm birth occur in sub-Saharan African or South Asian countries. However, in some higher-income countries, preterm birth rates appear to be increasing in relation to a reduction in the lower threshold of fetal viability. The cutoff is at 22–23 weeks, with a birth weight of approximately 500 g, although in developed countries such as Japan, the viability cutoff described is 21–22 weeks. There is evidence of the long-term consequences of prenatal programming of organ function and its relationship among adult diseases, such as hypertension (HT), central obesity, diabetes, metabolic syndrome, and chronic kidney disease (CKD). Premature delivery before the completion of nephrogenesis and intrauterine growth restriction leads to a reduction in the number of nephrons that are larger due to compensatory hyperfiltration and hypertr...
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BACKGROUND & PURPOSE It is well established that end-stage renal disease (ESRD) is associated with increased cardiovascular morbidity and mortality both in the adult and pediatric population. Although the underlying molecular... more
BACKGROUND & PURPOSE It is well established that end-stage renal disease (ESRD) is associated with increased cardiovascular morbidity and mortality both in the adult and pediatric population. Although the underlying molecular mechanisms are poorly understood, compromised nitric oxide (NO) bioactivity has been suggested as a contributing factor. With this in mind, we investigated the effects of hemodialysis on NO homeostasis and bioactivity in blood. METHODS & RESULTS Plasma and dialysate samples were obtained before and after hemodialysis sessions from adults (n = 33) and pediatric patients (n = 10) with ESRD on chronic renal replacement therapy, and from critically ill adults with acute kidney injury (n = 12) at their first sustained low-efficiency dialysis session. Levels of nitrate, nitrite, cyclic guanosine monophosphate (cGMP) and amino acids relevant for NO homeostasis were analyzed. We consistently found that nitrate and cGMP levels in plasma were significantly reduced after hemodialysis, whereas post-dialysis nitrite and amino acids coupled to NO synthase activity (i.e., arginine and citrulline) were only significantly reduced in adults with ESRD. The amount of excreted nitrate and nitrite during dialysis were similar to daily endogenous levels that would be expected from endothelial NO synthase activity. CONCLUSIONS Our results show that hemodialysis significantly reduces circulating levels of nitrate and cGMP, indicating that this medical procedure may impair NO synthesis and potentially NO signaling pathways.
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Resumo: La insuficiencia de crecimiento en talla en niños y adolescentes después del transplante renal exitoso, disminuye la autoestima y altera la rehabilitación. Los estudios sobre los patrones de crecimiento en niños que recibien... more
Resumo: La insuficiencia de crecimiento en talla en niños y adolescentes después del transplante renal exitoso, disminuye la autoestima y altera la rehabilitación. Los estudios sobre los patrones de crecimiento en niños que recibien prednisona diaria después del ...
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Nitric oxide (NO) contributes to maintaining normal cardiovascular and renal function. This bioactive signalling molecule is generally formed enzymatically by NO synthase in the vascular endothelium. NO bioactivity can also be attributed... more
Nitric oxide (NO) contributes to maintaining normal cardiovascular and renal function. This bioactive signalling molecule is generally formed enzymatically by NO synthase in the vascular endothelium. NO bioactivity can also be attributed to dietary intake of inorganic nitrate, which is abundant in our diet, especially in green leafy vegetables and beets. Ingested nitrate is reduced to nitrite by oral commensal bacteria and further to NO systemically. Previous studies have shown that dialysis, by means of removing nitrate and nitrite from the body, can reduce NO bioactivity. Hence, dietary intervention approaches aimed to boost the nitrate–nitrite–NO pathway may be of benefit in dialysis patients. The purpose of this study was to examine the kinetics of plasma nitrate and nitrite after a single intake of nitrate-rich concentrated beetroot juice (BJ) in adult hemodialysis (HD) patients and in age-matched healthy volunteers (HV). Eight HD patients and seven HV participated in this sing...
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La presion arterial (P.A.) en el sindrome de Batter (S.B.) dependeria de la accion de sustancias vasoactivas: prostaglandinas y bradiquininas que producen disminucion de la vasoconstriccion, de la P.A. y otras: angiotensina II (AII) y... more
La presion arterial (P.A.) en el sindrome de Batter (S.B.) dependeria de la accion de sustancias vasoactivas: prostaglandinas y bradiquininas que producen disminucion de la vasoconstriccion, de la P.A. y otras: angiotensina II (AII) y norepinefrina, que producen aumento de la vasoconstriccion y de la P.A. De acuerdo con este esquema, 1 mg/kg/dosis de captopril (inhibidor oral activo de la enzima convertidora de la angiotensina) causo una marcada disminucion de la P.A. y aumento en la actividad de la renina plasmatica (A.P.R.) en un paciente cono S.B. La infusion endovenosa de AII a 120 ng/kl/min., rapidamente aumento la P.A. en este paciente, a los niveles de P.A. pre-captopril. Conclusion: La hiperactividad del sistema reninaangiotensina juega un considerable papel en la regulacion de la P.A. en el S.B
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En las terapias intensivas neonatales, 1 de cada 4 pacientes tienen insuficiencia renal aguda. Las causas mas importantes son la hipoxia perinatal, la sepsis, las iatrogenicas y las cirugias (en especial, las cardiovasculares). En esta... more
En las terapias intensivas neonatales, 1 de cada 4 pacientes tienen insuficiencia renal aguda. Las causas mas importantes son la hipoxia perinatal, la sepsis, las iatrogenicas y las cirugias (en especial, las cardiovasculares). En esta revision definiremos la insuficiencia renal aguda en el recien nacido y los factores hemodinamicos que actuan sobre la funcion renal en estos pacientes. Se pondra especial enfasis en la insuficiencia renal aguda secundaria a hipoxia perinatal, en la que describiremos la fisiopatologia, la prevencion y su tratamiento.
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Eighteen records from children with renal trans- plants (RT) and classical haemolytic-uraemic syndrome (HUS) were reviewed. The mean oliguric period was 17.9 ___ 7.5 days; the interval between acute phase and end- stage renal disease... more
Eighteen records from children with renal trans- plants (RT) and classical haemolytic-uraemic syndrome (HUS) were reviewed. The mean oliguric period was 17.9 ___ 7.5 days; the interval between acute phase and end- stage renal disease (ESRD) was 9.3 + 5.2 years. HUS was the most frequent cause of renal transplantation (23.4%). There were no significant differences between patients with HUS and controls (children with RT but without HUS), regarding renal function, frequency of rejections, renal survival (HUS 65%, controls 57%) or patient survival (94.4% and 96.6%, respectively) after 9 years. None had clinical or histopathological evidence of HUS recurrence in the allograft. Of all children with living-related donors (LRD), renal survival after 3 years was longer for those who received cyclosporin A (CSA) (HUS and controls 86%) than for those who did not receive it (HUS 50%, controls 53%). Classical HUS is a frequent cause of ESRD in Argentina. The duration of the acute oliguric perio...
Research Interests: Kidney transplantation, Renal transplantation, Humans, Child, Female, and 15 moreMale, Infant, Cyclosporine, Pediatric Nephrology, Pediatric, Hemolytic Uremic Syndrome, Renal Function, Time Factors, Retrospective Studies, Chronic Kidney Failure, Renal disease, Postoperative Period, Child preschool, acute phase, and Paediatrics and reproductive medicine
Research Interests: Nephrology, Kidney transplantation, Adolescent, Medicine, Tacrolimus, and 14 moreHumans, Child, Internal Medicine, Chronic Disease, Female, Drug Resistance, Male, Cyclosporine, Pediatric Nephrology, Diabetes complications, Graft Rejection, Immunosuppressive Agents, Paediatrics and reproductive medicine, and Kidney function tests
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... Ferraris, Jorge R.2; Tambutti, Monica L.; Redal, Mariana; Ramirez, Jose A.; Carlin, Maria C.; Samaniego, Maria C.; Prigoshin, Norma. ... JR; Pasqualini, T; Alonso, G; Legal, S; Sorroche, P; Galich, A; Coccia, P; Ghezzi, L; Ferraris,... more
... Ferraris, Jorge R.2; Tambutti, Monica L.; Redal, Mariana; Ramirez, Jose A.; Carlin, Maria C.; Samaniego, Maria C.; Prigoshin, Norma. ... JR; Pasqualini, T; Alonso, G; Legal, S; Sorroche, P; Galich, A; Coccia, P; Ghezzi, L; Ferraris, V; Karabatas, L; Guida, C; Jasper, H Pediatric ...
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Research Interests: Kidney transplantation, Adolescent, Growth, Humans, Child, and 15 moreFemale, Male, Exploration, Infant, Pediatric Nephrology, Body Height, Growth Factor, Nino, Methylprednisolone, Child preschool, Immunosuppressive Agents, chronological age, Kidney Function, creatinine clearance, and Paediatrics and reproductive medicine
Research Interests: Immune response, Cytokines, Adolescent, Medicine, Humans, and 15 moreChild, Internal Medicine, Liver Transplantation, Cyclosporine, Pediatric, Time Factors, Renal Dysfunction, Liver function tests, Mycophenolate mofetil, Interleukin, Interferon Alpha, Interferon gamma, Immunosuppressive Agents, Paediatrics and reproductive medicine, and Kidney function tests
The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20... more
The Latin American Pediatric Nephrology Association (ALANEPE) reports the first regional kidney transplant registry in Latin America. A mean range of 75%, 30% to 100% renal transplant recipients under 21 yr old were included. Out of 20 countries invited to participate, 14 performed renal transplant, 11 had universal financial support from their governments. The centers included: Brazil (9), Argentina (4), Chile (4), Venezuela (3), Mexico (2), and one in: Cuba, Colombia, Costa Rica, Nicaragua, Guatemala, Ecuador, Honduras, Paraguay and Peru. The registry included 1458 patients, average of 291 per year, 55% male. Mean follow-up 23.4+/-17 months; mean age was 11.7+/-4.3 yr (1-21), 11% under five yr of age. uropathy/ reflux nephropathy 27%, glomerulopathies 24% (included 12% FSGS), hypo/dysplasia (11%), vascular (6%), congenital/hereditary (5%), unknown (19%). Induction therapy: 71% anti-IL2RAb, 13% ATG/TIMO, 14% non-induction. Maintenance therapy: Tacrolimus 64%, Cyclosporine 32%, MMF 54%, MPS 20%, noTORi 96%, steroids 90%, withdrawal or steroid avoidance 10%. Loss of graft 155/1458 (11%), death with functioning graft (3.4%), vascular thrombosis (2.8%), acute rejection (2.8%), recurrence of disease (1%). Forty-eight patients died (3.3%); infection was the main cause 23 (2.1%). Global patient survival rate at one, three, and five yr was 97%, 96%, and 96%. Graft survival rate at one, three, and five yr LRD was 96%, 93% and 89%; for DD 92%, 86% and 76% respectively. Both survival rates were higher in LRD (p<0.008 and p<0.001). A pediatric renal transplant study has started, making information available to be shared between the centers and the world.
Research Interests: Software Testing, Kidney transplantation, Adolescent, Medicine, Economía, and 14 moreLatin America, Renal transplantation, Humans, Child, Female, Male, Young Adult, Infant, Latin American, Registries, Graft Rejection, Child preschool, Immunosuppressive Agents, and Paediatrics and reproductive medicine
The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for... more
The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for monitoring the transplant rejection and the diagnosis of the associated nephropathies, in spite of the invasiveness of the procedure. Thus, it is of great interest to find alternative tools for diagnosis. The evaluation of regulatory cytokines is a simple procedure of low cost that could be useful to increase the sensitivity of the detection of polymorphic differences, to predict the graft acceptance and for the early detection of rejection. Recent studies suggest that the high production of pro-inflammatory mediators, such as Th1 cytokines, could be detrimental, whereas the production of anti-inflammatory regulatory cytokines, such as interleukin (IL)-10 and tumor necrosis factor (TGF)-beta, could be beneficial for graft survival. In the early stages, the ...
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1 Servicio de Diagnostico por Imagenes. 2 Unidad de Diagnostico y Tratamiento Fetal. 3 Servicio de Cirugia Infantil. 4 Servicio de Nefrologia Infantil. Hospital Italiano de Buenos Aires. El examen ecografico que se realiza rutinariamente... more
1 Servicio de Diagnostico por Imagenes. 2 Unidad de Diagnostico y Tratamiento Fetal. 3 Servicio de Cirugia Infantil. 4 Servicio de Nefrologia Infantil. Hospital Italiano de Buenos Aires. El examen ecografico que se realiza rutinariamente alrededor de la semana 20 de gestacion constituye uno de los controles basicos de salud fetal. Durante su transcurso no es infrecuente encontrar una dilatacion moderada de las pelvis renales. Su identificacion genera una serie de interrogantes acerca de: 1) ?Cual deberia ser el seguimiento prenatal? 2) ?En que sentido asesorar a los padres, teniendo en cuenta la carga emotiva que genera la comunicacion de una alteracion fetal, cualquiera que esta sea? 3) ?Cual es la conducta a seguir despues del nacimiento, una vez que tal alteracion ha sido observada in utero? Las investigaciones que se han centrado especificamente en la deteccion de hidronefrosis prenatal leve (HPL), considerando diametros anteroposteriores de pelvis renales de entre 3-5mm sin dil...
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The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for... more
The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for monitoring the transplant rejection and the diagnosis of the associated nephropathies, in spite of the invasiveness of the procedure. Thus, it is of great interest to find alternative tools for diagnosis. The evaluation of regulatory cytokines is a simple procedure of low cost that could be useful to increase the sensitivity of the detection of polymorphic differences, to predict the graft acceptance and for the early detection of rejection. Recent studies suggest that the high production of pro-inflammatory mediators, such as Th1 cytokines, could be detrimental, whereas the production of anti-inflammatory regulatory cytokines, such as interleukin (IL)-10 and tumor necrosis factor (TGF)-beta, could be beneficial for graft survival. In the early stages, the ...
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The syndrome of inappropriate secretion of antidiuretic hormone (ADH) or SIADH has been reported in various disorders. We report a pediatric patient with nasopharynx carcinoma who may have developed a clinical SIADH with severe... more
The syndrome of inappropriate secretion of antidiuretic hormone (ADH) or SIADH has been reported in various disorders. We report a pediatric patient with nasopharynx carcinoma who may have developed a clinical SIADH with severe hyponatremia and generalized seizure during the administration of intravenous hydration. We propose that the inappropriately high plasma level of ADH led to the inability to excrete sufficient amounts of free water during a hyperhydration protocol with a relatively hypotonic fluid, which resulted in acute hyponatremia and central nervous system involvement. To avoid this complication, intravenous hydration before chemotherapy in children with nasopharynx carcinoma should be performed at a slower infusion rate and with a sodium chloride concentration of more than half isotonic.
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Base de dados : ADOLEC. Pesquisa : 46013 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 46013. Autor:... more
Base de dados : ADOLEC. Pesquisa : 46013 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 46013. Autor: Ferraris, Jorge R; Ramírez, José A; Ruiz, Susana ...
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We assessed the long-term rehabilitation and quality of life after kidney transplantation in 17 recipients of transplants during their childhood who had reached 10 years or more after grafting. We found that all recipients considered... more
We assessed the long-term rehabilitation and quality of life after kidney transplantation in 17 recipients of transplants during their childhood who had reached 10 years or more after grafting. We found that all recipients considered themselves to be in good to excellent health, and 59% were completely satisfied with their life. Ninety-four percent of the recipients did not report any interference of their health with their family life. Only one recipient was unemployed, and five recipients have to miss work (n=2) and school (n=3) a few days a year due to their health status. Health seldom or never interfered with social life in 11 recipients, and in 6 of 9 sexually active recipients, their health status was not an obstacle in their sexual relationships. Two recipients expressed concerns about their short stature, and three were concerned with their body appearance. In conclusion, we describe a group of young adult recipients who presented a highly satisfactory rehabilitation and quality of life after their successful transplantation.
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Hemolytic uremic syndrome (HUS) isaninfectious disease caused by Shiga toxin-producing Escherichia coli. The objective of this study was to assess the risk of transmission and clinical course between siblings with typical HUS. Medical... more
Hemolytic uremic syndrome (HUS) isaninfectious disease caused by Shiga toxin-producing Escherichia coli. The objective of this study was to assess the risk of transmission and clinical course between siblings with typical HUS. Medical records of children with typical HUS between 1997 and 2012 were reviewed. Sibling pairs were established as inclusion criteria. A severity score was defined. A total of 133 patients with HUS were recorded; 40 had siblings and 4 progressed to HUS (10%). The mean age of the 4 sibling pairs was 29.3 months old (SD ± 11.5); 5 (62.5%) were girls. The mean time between each case was 5.7 days (SD ± 3). HUS was more severe in the siblings who became infected in the second place. The risk of HUS transmission between siblings was 10%, and the clinical course of the second sibling was less favorable.
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Research Interests: Pediatrics, Culture, Kidney transplantation, Adolescent, Humans, and 15 moreChild, Female, Male, Monoclonal Antibodies, Kidney Transplant, Donor, Combination drug therapy, Long Term, Calcineurin inhibitors, Antigen, immunoglobulin G, Nino, Methylprednisolone, Immunosuppressive Agents, and Paediatrics and reproductive medicine
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The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for... more
The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for monitoring the transplant rejection and the diagnosis of the associated nephropathies, in spite of the invasiveness of the procedure. Thus, it is of great interest to find alternative tools for diagnosis. The evaluation of regulatory cytokines is a simple procedure of low cost that could be useful to increase the sensitivity of the detection of polymorphic differences, to predict the graft acceptance and for the early detection of rejection. Recent studies suggest that the high production of pro-inflammatory mediators, such as Th1 cytokines, could be detrimental, whereas the production of anti-inflammatory regulatory cytokines, such as interleukin (IL)-10 and tumor necrosis factor (TGF)-beta, could be beneficial for graft survival. In the early stages, the cellular cytotoxicity is activated by the Th1 response and the detection of cytotoxic molecules is associated to the acute rejection. Later, the balance between pro and anti-inflammatory mediators and the regulation of their levels could be more important. In this regard, TGF-beta is also fibrogenic and a high local production can contribute to kidney damage. On the other hand, the increased production of IL-10 in response to the allogeneic stimuli could be, in most cases, an important marker of long-term acceptance.
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Base de dados : LILACS. Pesquisa : 26690 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos... more
Base de dados : LILACS. Pesquisa : 26690 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 26690. ...
In a prospective study, 10 children with congenital heart disease were studied before and after surgery (24-48 h). Mean age and weight, type of disease and surgery performed are described in Table 1. Six patients had acyanotic disease and... more
In a prospective study, 10 children with congenital heart disease were studied before and after surgery (24-48 h). Mean age and weight, type of disease and surgery performed are described in Table 1. Six patients had acyanotic disease and 4 were cyanotic. Before surgery, the acyanotic group (AG) showed hyperuricemia compared to normal children of the same chronological age (mean +/- SE: 5.53 +/- 0.42 vs 4.27 +/- 0.22, p less than 0.02). Initial seric creatinine (sCr), increased in 3 patients of the AC and in the 4 patients of the cyanotic group (CG) compared to normal values of sCr for height (AG: 0.47 +/- 0.05 vs 0.34 +/- 0.03, p less than 0.05; CG: 0.63 +/- 0.05 vs 0.38 +/- 0.05, p less than 0.01). Post-surgery, sCr and serum uric acid (sUA) increased significantly at 24 and 48 h in both groups (Fig 1); at 24 h the increment in sUA in the AG was higher than that in the CG (p less than 0.05). There was a direct and significant correlation between the increment in sUA and sCr in the AG (Fig. 2). The urine excretion of uric acid paralleled the increment of sUA in the CG (Table 2). Fractional excretion of, sodium (FENa) was less than 1% and greater than 1% in the AG and the CG, respectively, being the basal FENa of the AG significantly lower (Table 3).(ABSTRACT TRUNCATED AT 250 WORDS)
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Children with chronic renal disease may improve height with growth hormone (GH) treatment. We studied 2 groups of children with height below 1.8 SDS and/or height velocity (HV) below the 3rd centile: 1) 6 patients with end stage renal... more
Children with chronic renal disease may improve height with growth hormone (GH) treatment. We studied 2 groups of children with height below 1.8 SDS and/or height velocity (HV) below the 3rd centile: 1) 6 patients with end stage renal disease (ESRD) on dialysis, aged 12.2 +/- 4.4 years (x +/- sd), with bone age of 6.8 +/- 3.3 years, 3 with Tanner stage I and 3 Tanner II; and 2) 6 children with functioning renal transplants, aged 15.5 +/- 2.5 years, with bone age 10.0 +/- 2.3 years, Tanner II-IV. Maintenance dosage of orally administered methylprednisone (MP) was 0.16 +/- 0.04 mg/kg/day. 1) Children with ESRD received GH during 1 to 3.5 years. Height SDS and HV (x +/- sd) were: pre GH -3.8 +/- 0.6 SDS and 2.6 +/- 1.4 cm/y; at 1 year of GH therapy (n = 6) -3.9 +/- 0.4 SDS and 5.1 +/- 3.2 cm/y; at 2 years (n = 5) -4.2 +/- 0.5 SDS and 3.1 +/- 0.7 cm/y; at 3 years (n = 4) -4.1 +/- 0.7 SDS and 3.3 +/- 1.5 cm/y. Height SDS and HV were: pre GH -3.0 +/- 1.9 SDS and 3 +/- 1 cm/y; at 1 year -2.5 +/- 1.5 SDS (p < 0.05) (t paired test) and 6.9 +/- 2.3 cm/y (p < 0.01). Height SDS and HV increased; creatinine clearance remained stable; there was correlation between height SDS and serum creatinine r = -0.81, creatinine clearance and HV r = 0.92, MP dose and HV r = -0.85. Five of 6 patients reached adult height of -2.8 +/- 1.3 SDS, below their target height of -0,3 +/- 0.7 SDS (p < 0.005). In patients with ESRD, GH therapy did not improve significantly height SDS and HV. In pubertal transplanted patients height SDS and HV improved and renal function remained stable; final height remained below expected genetic height. Prolonged periods of GH therapy are necessary to evaluate if final height can be improved with GH.
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Deflazacort (DFZ) pharmacokinetics was evaluated in fifteen pediatric patients on chronic hemodialysis or after renal transplantation, and in three normal children. After overnight fasting, oral DFZ 0.26+/-0.01 mg/kg (mean +/- SEM) was... more
Deflazacort (DFZ) pharmacokinetics was evaluated in fifteen pediatric patients on chronic hemodialysis or after renal transplantation, and in three normal children. After overnight fasting, oral DFZ 0.26+/-0.01 mg/kg (mean +/- SEM) was given. Serial blood samples were collected for 360 min and analyzed by HPLC for 21-hydroxy-DFZ (21-HO-DFZ). Serum concentration profiles and pharmacokinetic parameters were similar in patients on hemodialysis, renal transplant recipients and normal children. Elimination half-life was longer in the 9 cyclosporine-treated subjects (108.0+/-13.6 min) than in the other nine (71.2+/-8.3 min; p <0.02). Our finding suggests that, from a pharmacokinetic point of view, DFZ dose adjustment for renal function is not necessary in children with chronic renal failure or after renal transplantation.
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Ferraris JR, Argibay PF, Costa L, Jimenez G, Coccia PA, Ghezzi LFR, Ferraris V, Belloso WH, Redal MA, Larriba JM. Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: Age... more
Ferraris JR, Argibay PF, Costa L, Jimenez G, Coccia PA, Ghezzi LFR, Ferraris V, Belloso WH, Redal MA, Larriba JM. Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: Age dependency and pharmacological interaction with steroids. Pediatr Transplantation 2011: 15: 525–532. © 2011 John Wiley & Sons A/S.Abstract: TAC, MMF and MP are used in pediatric kidney tx. The cytochrome P450 (CYP)3A5 enzyme appears to play a role in TAC metabolism. The aims of this study were to investigate CYP3A5 polymorphism’s effect on TAC dosing and the age dependency of TAC dosing by testing blood concentrations, and the interaction between steroids and TAC during the first year after tx. Genomic DNA was extracted and amplified with specific primers. CYP3A5 alleles were confirmed by direct sequencing of PCR products on an automated AB13100 capillary sequencer. We studied 48 renal transplant patients (age at tx 12 ± 0.5 yr, 22 boys) receiving TAC, MMF, ...
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Growth retardation is a prominent clinical manifestation in children with chronic renal failure (CRF). Nine children with CRF (3 on conservative treatment; 3 on dialysis and 3 after renal transplantation) aged 1.6 to 14.0 (x +/- SE: 8.1... more
Growth retardation is a prominent clinical manifestation in children with chronic renal failure (CRF). Nine children with CRF (3 on conservative treatment; 3 on dialysis and 3 after renal transplantation) aged 1.6 to 14.0 (x +/- SE: 8.1 +/- 1.4) years, were treated with twice daily subcutaneous injections of 26 +/- 2.4 micrograms/kg/day growth-hormone-releasing-hormone [GHRH (1-29) NH2 Serono (Geref)] during 3 to 6 months. Mean serum urea and creatinine remained stable, although 2 patients on conservative treatment showed a moderate increase in serum creatinine. At the start of the study, height SDS was -2.2 +/- 0.2 (x +/- SE), growth velocity was 4.5 +/- 1.0 cm/year (-2.3 +/- 0.6 DS for chronological age) and growth hormone (GH) response to acute GHRH test (1 microgram/kg IV) was 62 +/- 17.5 ng/ml. Five patients increased height velocity from 3.8 +/- 0.7 to 8.0 +/- 1.2 cm/year (paired t test, p < 0.05). The peak GH response to GHRH was significantly higher in the group of growth...
Research Interests: Anthropometry, Adolescent, Growth, Humans, Child, and 7 moreMedicina, Female, Male, Infant, Chronic Kidney Failure, Child preschool, and Sermorelin
The multicentric study of chronic renal failure, dialysis and transplant started in 1996 by the Nephrology Committee of the Argentine Pediatrics Society with the aim of knowing the development characteristics of children with this... more
The multicentric study of chronic renal failure, dialysis and transplant started in 1996 by the Nephrology Committee of the Argentine Pediatrics Society with the aim of knowing the development characteristics of children with this pathology. The study included children and adolescents on conservative treatment, dialysis or transplant who have registered any of the three modalities before being 19 year-old, since january 1996 to december 2003. The statistical analysis was made with the statistical software SAS; in order to calculate the survival curve, the method employed was Kaplan-Meier and the standardized height and weight z-scores were calculated. In this report, there is data related to 710 patients with chronic renal failure, under conservative treatment 34.2%, dialysis 57.6% and transplant 29.5%. The end-stage renal disease incidence was of 6.5/million inhabitants. The main etiologies were obstructive uropathy 18.3%, reflux nephropathy 15.1%, hemolytic uremic syndrome 14.4%, ...
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The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for... more
The outcome of the kidney allograft mainly depends on the immune response and on its complex regulation, where the cytokine network and other mediators play an important role. At present, kidney biopsy is the most useful tool for monitoring the transplant rejection and the diagnosis of the associated nephropathies, in spite of the invasiveness of the procedure. Thus, it is of great interest to find alternative tools for diagnosis. The evaluation of regulatory cytokines is a simple procedure of low cost that could be useful to increase the sensitivity of the detection of polymorphic differences, to predict the graft acceptance and for the early detection of rejection. Recent studies suggest that the high production of pro-inflammatory mediators, such as Th1 cytokines, could be detrimental, whereas the production of anti-inflammatory regulatory cytokines, such as interleukin (IL)-10 and tumor necrosis factor (TGF)-beta, could be beneficial for graft survival. In the early stages, the ...
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Many children with chronic renal insufficiency (CRI) show growth retardation. Our objective is to describe the natural history of growth in patients with CRI, its pathogenesis and its optimization. Final height remains below percentile 3... more
Many children with chronic renal insufficiency (CRI) show growth retardation. Our objective is to describe the natural history of growth in patients with CRI, its pathogenesis and its optimization. Final height remains below percentile 3 in 77% of male and 71% of female patients. The etiology of growth retardation in these children is multifactorial age at onset, primary renal disease, fluid and electrolyte abnormalities especially acidosis, renal osteodystrophy, inadequate caloric intake and perturbations of growth factors are all implicated. Post Tx, immunosuppressive corticoid therapy and reduced glomerular filtration rate have a significantly negative effect on final height. Growth retardation in both CRI and renal Tx patients is not the result of abnormal growth hormone secretion or decreased levels of IGF-I, but rather of elevated levels of IGF-I binding proteins inhibiting the bioavailability of the IGFs. Optimization of growth includes reduced corticoid dose, alternate-day i...
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Research Interests: Adolescent, Humans, Child, Hypertension, Female, and 6 moreMale, American, Dietary Supplements, Potassium, Clinical Sciences, and Adult
To analyze the relationship between IGF-I and growth in children with chronic renal failure, we studied 7 patients undergoing hemodialysis and 7 patients after successful renal transplantation. IGF-I was measured by acid chromatography... more
To analyze the relationship between IGF-I and growth in children with chronic renal failure, we studied 7 patients undergoing hemodialysis and 7 patients after successful renal transplantation. IGF-I was measured by acid chromatography using ODS silica columns. Hemodialyzed patients grew poorly (mean 1.5 cm/y), and although transplanted patients did significantly better (mean 3.3 cm/y), 4 out of 7 did not reach normal height velocity. IGF-I levels in transplanted patients (39.2 +/- 13.6 nM/l) were significantly higher than in hemodialyzed patients (13.4 +/- 3.0 before; 17.0 +/- 5.4, after dialysis, nM/l). Nevertheless, all individual values in both groups fell within normal limits. The mean logarithmic deviation of IGF-I values of hemodialyzed patients was not significantly different from normal. The logarithmic deviation of transplanted patients was significantly higher than normal, indicating a true, albeit slight, increase in the levels of this growth factor No significant correl...
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ABSTRACT
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Growth can be differently altered after liver and renal transplantation (Tx) in childhood. We compared graft function, linear growth, immunosuppression and serum IGF-I (RIA) and IGFBP3 (IRMA) concentrations in 15 liver (5.6+/-1.1 years... more
Growth can be differently altered after liver and renal transplantation (Tx) in childhood. We compared graft function, linear growth, immunosuppression and serum IGF-I (RIA) and IGFBP3 (IRMA) concentrations in 15 liver (5.6+/-1.1 years old) and 17 renal (7.4+/-0.1 years old) Tx patients who were followed for 4-6 years. Graft function was normal post-liver Tx, although in renal recipients creatinine clearance decreased significantly during follow-up. Liver Tx children presented an increase in mean height of 0.92+/-0.2 SDS (P&lt;0.01) beyond the 2nd year post-Tx, although in renal Tx patients height SDS did not improve. Immunosuppressive corticoid dosage could be decreased and discontinued in liver Tx patients, while in renal recipients it was maintained between 0.18+/-0.01 and 0.16+/-0.02 mg/kg/day. At 3.7+/-0.4 years post Tx, liver Tx patients presented higher mean serum IGF-I level, lower mean serum IGFBP3 value, leading to a higher mean IGF-I/IGFBP3 molar ratio, P&lt;0.001. We found that while catch up growth coud be achieved after liver Tx, height SDS did not improve after renal Tx. This may be related to a reduced renal graft function and/or to differences in immunosuppressive corticoid dosage. In children with renal transplants a challenge for the future will reside in making it possible to substitute steroid therapy without altering graft function.
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Research Interests: Kidney transplantation, Adolescent, Transplantation, Humans, Child, and 13 moreKidney, Hypertension, Female, Male, Young Adult, Adult, Reference Values, Cross Sectional Studies, Postoperative Period, Glomerular Filtration Rate, hyperhomocysteinemia, Antihypertensive agents, and Medical and Health Sciences
Background. Chronic rejection is the leading cause of graft failure. Both nonimmunological and immunological mechanisms contribute to this pathology. Methods. We studied changes in kidney function, mixed lymphocyte culture, cell-mediated... more
Background. Chronic rejection is the leading cause of graft failure. Both nonimmunological and immunological mechanisms contribute to this pathology. Methods. We studied changes in kidney function, mixed lymphocyte culture, cell-mediated lympholysis, serum HLA class ...
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Research Interests: Kidney transplantation, Adolescent, Renal transplantation, Prospective studies, Humans, and 13 moreFemale, Male, Cyclosporine, Pediatric, Combination drug therapy, Graft Rejection, Chronic Kidney Failure, Creatinine, Mycophenolate mofetil, Methylprednisolone, Immunosuppressive Agents, Mycophenolic Acid, and Paediatrics and reproductive medicine
Research Interests: Pediatrics, Culture, Kidney transplantation, Adolescent, Humans, and 15 moreChild, Female, Male, Monoclonal Antibodies, Kidney Transplant, Donor, Combination drug therapy, Long Term, Calcineurin inhibitors, Antigen, immunoglobulin G, Nino, Methylprednisolone, Immunosuppressive Agents, and Paediatrics and reproductive medicine
Research Interests: Pediatrics, Kidney transplantation, Cytokines, Adolescent, Dosage Form, and 15 moreHumans, Child, Conversion, Female, Male, FORMULATION, Immune system, Biological markers, Hemoglobins, Creatinine, Mycophenolate mofetil, Nino, Interferon gamma, Child preschool, and Paediatrics and reproductive medicine
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Research Interests: Kidney transplantation, Adolescent, Cardiovascular disease, Humans, Child, and 15 moreBlood Glucose, Fasting, Blood Pressure, Cholesterol, Female, Male, Infant, Cyclosporine, Adult, Cardiovascular Risk Factor, Cardiovascular Diseases, Mycophenolate mofetil, Acute rejection, Child preschool, and Immunosuppressive Agents
The aim of the present short-term study was to evaluate the use of a new HMG-CoA reductase inhibitor, atorvastatin, in the treatment of hyperlipidemia and the effect on blood pressure in a group of hypertensive stable renal transplant... more
The aim of the present short-term study was to evaluate the use of a new HMG-CoA reductase inhibitor, atorvastatin, in the treatment of hyperlipidemia and the effect on blood pressure in a group of hypertensive stable renal transplant recipients with hypercholesterolemia who received kidney grafts before 18 years of age. Eight patients (aged 10.8-30.1 years) with inadequately controlled total cholesterol (TC) levels by a lipid-lowering diet (8 weeks) were treated daily for 12 weeks with atorvastatin at an initial dose of 2.5 mg. The dose was increased monthly by 2.5 mg in order to lower TC levels to less than 200 mg/dl. Serum lipoprotein profile, cyclosporin A (CsA), serum creatinine (SCr), and liver and muscle enzyme levels were measured before starting the lipid-lowering diet, at the start of treatment (baseline), and during treatment. Ambulatory blood pressure monitoring (ABPM) (24-h) was carried out in each patient at both baseline and the end of the follow-up. During the lipid-lowering diet, no significant changes in lipoprotein parameters were observed. Atorvastatin was tolerated well and no clinical side effects were noted during the follow-up. The final dose of atorvastatin ranged from 2.5 to 7.5 mg/day. At the end of the study, TC was reduced by 32.2% ( P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05), low-density lipoprotein cholesterol (LDL-C) by 41.8% ( P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05), and apo B by 29.5% (…
Research Interests: Kidney transplantation, Adolescent, Prospective studies, Complication, Humans, and 15 moreChild, Blood Pressure, Female, Male, Exploration, Hypercholesterolemia, Pediatric Nephrology, Pediatric, Serum Creatinine, Enzyme, Lipoprotein a, Nino, Child preschool, Arterial pressure, and Paediatrics and reproductive medicine
Research Interests: Child Development, Kidney transplantation, Growth, Humans, Child, and 15 moreFemale, Body Composition, Leptin, Bone Density, Kidney Transplant, Bone Mineral Density, Bone Loss, Lipid Profile, Growth Factor, Insulin Like Growth Factor, Immunosuppressive Agents, Bone mineral content, Bone mass, Kidney Function, and creatinine clearance
Research Interests: Adolescent, Diarrhea, Echocardiography, Acute renal failure, Cardiac Hypertrophy, and 15 moreChild, Hemodynamics, Blood Pressure, Circadian Rhythm, Female, Exploration, Heart rate, Hemolytic Uremic Syndrome, Ambulatory, Children and Adolescents, Adult, Cross Sectional Studies, Child preschool, Arterial pressure, and Antihypertensive agents
Research Interests: Kidney transplantation, Renal transplantation, Humans, Child, Female, and 15 moreMale, Infant, Cyclosporine, Pediatric Nephrology, Pediatric, Hemolytic Uremic Syndrome, Renal Function, Time Factors, Retrospective Studies, Chronic Kidney Failure, Renal disease, Postoperative Period, Child preschool, acute phase, and Paediatrics and reproductive medicine
Research Interests: Kidney transplantation, Adolescent, Renal transplantation, Humans, Child, and 14 moreThyroid gland, Female, Male, Thyroxine, Thyroid Hormones, Pediatric Nephrology, Pediatric, Adult, Renal disease, Confidence Limit, Glucocorticoids, Thyroid Function, Thyroid hormone, and Paediatrics and reproductive medicine
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The effects of chronic renal failure on the pituitary-testicular axis of 31 males, aged 11.7 to 20.0 yr (mean, 16.0 yr) were studied. Nine patients not on hemodialysis (group I) had serum creatinines between 2.5 and 8.0 mg/dl, 10 patients... more
The effects of chronic renal failure on the pituitary-testicular axis of 31 males, aged 11.7 to 20.0 yr (mean, 16.0 yr) were studied. Nine patients not on hemodialysis (group I) had serum creatinines between 2.5 and 8.0 mg/dl, 10 patients were on hemodialysis (group II) and 12 patients had received a renal transplant (group III). The Tanner stage of pubertal development was delayed relative to chronologic age. Testosterone (T), delta 4-androstenedione (delta 4), and urinary 17-keto steroids were normal when related to pubertal stage in groups I and II; and dehydroepiandrosterone (DHEA) and DHEA sulfate (DS) were in the low normal range. In group III, adrenal androgens (delta 4, DHEA, DS) were decreased as a consequence of prednisone therapy whereas T was normal. Luteinizing hormone levels were normal in all. Follicle-stimulating hormone levels were normal in all. Follicle-stimulating hormone (FSH) was significantly increased in groups I and II. In group III, FSH was normal in 6 of 9 patients with serum creatinine concentrations &lt; 2 mg/dl. FSH levels were uniformly elevated in Tanner I-V patients with creatinines &gt; 2 mg/dl. The data shows that FSH is elevated in patients with chronic renal failure even in prepuberty and early adolescence. This may reflect damage to germinal epithelium prior to the advent of spermatogenesis, whereas Leydig cell function appears to remain intact.
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Deflazacort is an oxazoline compound derived from prednisolone with similar antiinflammatory effects but fewer side effects. We studied changes in kidney function, growth velocity, weight/height ratio, and growth hormone secretion before... more
Deflazacort is an oxazoline compound derived from prednisolone with similar antiinflammatory effects but fewer side effects. We studied changes in kidney function, growth velocity, weight/height ratio, and growth hormone secretion before and a year after substitution of deflazacort for methylprednisone in nine patients aged 9 to 15 years, 4 years after renal transplantation; all were in Tanner pubertal stage 1. Methylprednisone (mean +/- SEM: 0.2 +/- 0.02 mg/kg per day) was replaced by deflazacort (0.3 +/- 0.03 mg/kg per day) for a mean period of 15 months. Serum creatinine and calculated creatinine clearance did not change significantly during deflazacort treatment. Growth velocity increased from 1.5 +/- 0.3 to 3.2 +/- 0.5 cm/yr (p &amp;amp;amp;amp;lt; 0.005) in the nine patients. Weight/height ratio decreased from 28.4% +/- 8.5% to 16% +/- 6.7% (p &amp;amp;amp;amp;lt; 0.005). Cushingoid appearance decreased in all patients. Mean spontaneous growth hormone secretion increased from 2.5 +/- 0.4 to 4.4 +/- 1.2 ng/ml (p &amp;amp;amp;amp;lt; 0.05). Our findings indicate that immunosuppressive treatment with deflazacort is as effective as methylprednisone and is associated with fewer side effects.
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Research Interests: Pediatrics, Kidney transplantation, Adolescent, Humans, Child, and 15 moreFemale, Male, Cyclosporine, Apolipoprotein B, Adult, Lipoproteins, High Density Lipoprotein, Lipoprotein a, Creatinine, Methylprednisolone, Child preschool, Kidney Function, creatinine clearance, Paediatrics and reproductive medicine, and Hyperlipidemias
Four short pubertal boys were treated with LHRHa (leuprolide) and GH after renal transplantation, and followed until adult height. This combined therapy was not successful in increasing growth. Although this study must be considered... more
Four short pubertal boys were treated with LHRHa (leuprolide) and GH after renal transplantation, and followed until adult height. This combined therapy was not successful in increasing growth. Although this study must be considered preliminary because of the small number of patients and the lack of a matched control group, it shows for the first time that this combined therapy (GH + LHRHa) administered to short, pubertal boys after renal transplantation was not successful in increasing growth. Further studies are required to reach definitive conclusions.
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We had previously reported that serum sex hormone binding-globulin (SHBG) decreases and serum non-SHBG-bound testosterone (T) and free T increase significantly from infancy to late prepuberty in normal prepubertal children of both sexes.... more
We had previously reported that serum sex hormone binding-globulin (SHBG) decreases and serum non-SHBG-bound testosterone (T) and free T increase significantly from infancy to late prepuberty in normal prepubertal children of both sexes. We had also shown an age-related delay in these changes in hypopituitary boys, which was reversed by GH treatment. Stunted growth and delayed puberty are conspicuous features of chronic renal failure (CRF). As another model of delay of growth and development, serum SHBG and serum T fractions were determined in 13 boys with CRF on chronic dialysis. In CRF, mean serum SHBG was significantly higher (99.1 +/- 68.9 nmol/L; P less than 0.05) than in 31 control (C) children of similar ages (66.2 +/- 34.9 nmol/L), while serum non-SHBG-bound T and free T were significantly lower (0.16 +/- 0.12 in CRF vs. 0.24 +/- 0.12 in C and 0.010 +/- 0.005 in CRF vs. 0.016 +/- 0.01 in C, respectively). On the other hand, serum total T (1.31 +/- 0.88 in CRF vs. 1.08 +/- 0.56 in C) and serum insulin-like growth factor-I (IGF-I; 1.06 +/- 0.74 in CRF vs. 1.35 +/- 1.70 in C) were not significantly different. A significant negative correlation between serum SHBG and chronological age as well as a significant positive correlation between serum non-SHBG-bound T and chronological age were found. For a given age, serum SHBG was higher, while serum non-SHBG-bound T was lower in patients with CRF (by analysis of covariance, P less than 0.01). It is postulated that, as has been proposed for hypopituitary boys, this delayed increment in serum T fractions could be responsible for the delay in the onset of puberty reported in CRF. It is known that GH decreases serum SHBG, acting on hepatic cells either directly or through the action of IGF-I. Since it has been suggested that patients with CRF have peripheral resistance to GH or IGF-I, the high levels of SHBG that we have detected in prepubertal boys with CRF could be taken as an additional evidence of this biological resistance.
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Research Interests: Immunology, Kidney transplantation, Adolescent, Renal transplantation, Humans, and 13 moreChild, Hemodialysis, Immunosuppression, Statistical Significance, Cyclosporine, Kidney Transplant, Adult, Human Immunology, Graft Rejection, Azathioprine, Acute rejection, Methylprednisolone, and Child preschool
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Research Interests: Kidney transplantation, Adolescent, Renal transplantation, Progesterone, Humans, and 14 moreProlactin, Child, Puberty, Female, Haemodialysis, Clinical Sciences, Chronic Renal Failure, Ovary, Chronic Kidney Failure, Luteinizing Hormone, Estradiol, Follicle stimulating hormone, Renal Dialysis, and Paediatrics and reproductive medicine
. We studied the effects of chronic renal failure on the pituitary-cortisol axis and adrenal androgen function in 26 patients (16 male and 10 female), aged 6.5 to 22.5 years (mean 14.5). Ten patients were prepubertal, 8 pubertal, and 8... more
. We studied the effects of chronic renal failure on the pituitary-cortisol axis and adrenal androgen function in 26 patients (16 male and 10 female), aged 6.5 to 22.5 years (mean 14.5). Ten patients were prepubertal, 8 pubertal, and 8 post-pubertal. All of them were on chronic hemodialysis. Pubic hair development was delayed in 56% of the patients. Serum cortisol was increased in 15 out of the 26 patients. Serum Δ4-androstenedione was high in 11 out of 15 patients in…
Research Interests:
Research Interests:
... Dres. Diego Elias 1-2 , Francisco de Badiola 3 y Jorge R. Ferraris 4. ... Con el fin de mejorar la capacidad pronóstica del método se ha intentado establecer un punto de corte adecuado a través del cual se pueda diferenciar entre un... more
... Dres. Diego Elias 1-2 , Francisco de Badiola 3 y Jorge R. Ferraris 4. ... Con el fin de mejorar la capacidad pronóstica del método se ha intentado establecer un punto de corte adecuado a través del cual se pueda diferenciar entre un hallazgo fisiológico de uno patológico. ...
Research Interests:
The distribution of trace elements in kidney cortex and medulla and in their subcellular fractions was studied by inductively coupled plasma mass spectrometry (ICP-MS). This technology allows the analysis of almost all the elements of the... more
The distribution of trace elements in kidney cortex and medulla and in their subcellular fractions was studied by inductively coupled plasma mass spectrometry (ICP-MS). This technology allows the analysis of almost all the elements of the periodic table, along with their isotopes, in the same experiment. Acid digestion of the tissue (samples) was required before ICP-MS elemental analysis. Mineralization in 8 N nitric acid for 2 min in a Parr microwave acid digestion bomb, inside a regular microwave oven working at medium power, gave good sensitivity and reproducible results. Trace element determinations could be precisely performed, despite the presence of a considerable amount of organic matter. Cortex/plasma and medulla/plasma inorganic ratios were taken as indicators of the inorganic bioaccumulation. The highest enrichment factors of elements found in the cortex were Mn > Co > Tl > Zn > Rb > Mo > Cu and the highest element enrichments of the medulla were Tl >...
Research Interests:
... A. Exeni. Centro Médico OSECAC, San Juan, Dr. J. García. Centro de Nefrología y Diálisis, Rosario (Santa Fe), Dres. ... A. Scarafía. Hospital de Niños Santísima Trinidad, Córdoba, Dra. ... Dr. JP Garrahan&amp;amp;quot;, Ciudad de... more
... A. Exeni. Centro Médico OSECAC, San Juan, Dr. J. García. Centro de Nefrología y Diálisis, Rosario (Santa Fe), Dres. ... A. Scarafía. Hospital de Niños Santísima Trinidad, Córdoba, Dra. ... Dr. JP Garrahan&amp;amp;quot;, Ciudad de Buenos Aires, Dres. E. Sojo, M. Turconi, L. Briones, M. Adragna. ...
Research Interests:
Research Interests:
We have studied the growth of 144 children after treatment of brain tumours distant from the hypothalamo-pituitary axis. All had cranial irradiation and 87 spinal irradiation. In 56 patients observed without intervention for 3 years,... more
We have studied the growth of 144 children after treatment of brain tumours distant from the hypothalamo-pituitary axis. All had cranial irradiation and 87 spinal irradiation. In 56 patients observed without intervention for 3 years, height SDS in the cranial (CR) group (n = 20) declined from 0.02 to -0.44 and in the craniospinal (CS) group (n = 36) from -0.28 to -1.11. Failure of spinal growth had a marked effect in the CS group. The onset of puberty was slightly but not significantly advanced; median ages at onset of puberty were 10.3 years in girls and 12.1 years in boys. Of the total group 86.4% had clinical and biochemical evidence of growth hormone insufficiency. Fifty-two children, 33 (28 CS; 5 CR) of whom were prepubertal, received biosynthetic human growth hormone, in a dose of 15 mU/m2/week by daily injection for a period of one year. Height velocity SDS increased significantly in both groups from -2.74 to +1.90 (CS) and from -1.0 to +4.26 (CR). Spinal response to GH treatment was restricted in the craniospinal group.
Research Interests:
Research Interests:
Abstract: Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has proven to have better reproducibility than office blood pressure (BP) and is increasingly used for the study of hypertension in children and adolescents. The aim... more
Abstract: Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has proven to have better reproducibility than office blood pressure (BP) and is increasingly used for the study of hypertension in children and adolescents. The aim of our study was to assess 24-...
Research Interests: Adolescent, Humans, Child, Blood Pressure, Female, and 13 moreMale, Liver Transplantation, Pediatric, Outpatients, Adult, Time Factors, Retrospective Studies, Reproducibility of Results, Ambulatory Care, Ambulatory Blood Pressure, Postoperative care, Child preschool, and Paediatrics and reproductive medicine
Abstract: Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has proven to have better reproducibility than office blood pressure (BP) and is increasingly used for the study of hypertension in children and adolescents. The aim... more
Abstract: Twenty-four-hour ambulatory blood pressure monitoring (ABPM) has proven to have better reproducibility than office blood pressure (BP) and is increasingly used for the study of hypertension in children and adolescents. The aim of our study was to assess 24-...
Research Interests: Adolescent, Humans, Child, Blood Pressure, Female, and 13 moreMale, Liver Transplantation, Pediatric, Outpatients, Adult, Time Factors, Retrospective Studies, Reproducibility of Results, Ambulatory Care, Ambulatory Blood Pressure, Postoperative care, Child preschool, and Paediatrics and reproductive medicine
Research Interests: Kidney transplantation, Growth, Humans, Child, Low Dose, and 15 moreFemale, Body Composition, Male, Bone Density, Body Mass Index, Body Fat, Lipid Profile, Graft Rejection, Acute rejection, lumbar vertebrae, Methylprednisolone, Child preschool, Immunosuppressive Agents, creatinine clearance, and Paediatrics and reproductive medicine
Research Interests: Kidney transplantation, Growth, Humans, Child, Low Dose, and 15 moreFemale, Body Composition, Male, Bone Density, Body Mass Index, Body Fat, Lipid Profile, Graft Rejection, Acute rejection, lumbar vertebrae, Methylprednisolone, Child preschool, Immunosuppressive Agents, creatinine clearance, and Paediatrics and reproductive medicine
Five characteristics of neonate renal physiology, namely glomerular hypofiltration, low renal blood flow and alterations in water, sodium and potassium management, disappear during the first year of life but reoccur during senescence.... more
Five characteristics of neonate renal physiology, namely glomerular hypofiltration, low renal blood flow and alterations in water, sodium and potassium management, disappear during the first year of life but reoccur during senescence. However, the underlying mechanisms are different during the two periods.
Research Interests:
Research Interests:
We evaluated the relationship between the acute phase and the development of end-stage renal disease (ESRD) and the outcome of renal transplant in patients with Shiga toxin-associated hemolytic uremic syndrome (Stx-HUS). A 20-year... more
We evaluated the relationship between the acute phase and the development of end-stage renal disease (ESRD) and the outcome of renal transplant in patients with Shiga toxin-associated hemolytic uremic syndrome (Stx-HUS). A 20-year retrospective study was performed of 66 renal transplants in 62 patients with Stx-HUS compared with 189 renal allografts in 178 children with other diseases. Of 62 patients, 61 had &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;7 days of oliguria during the acute phase. Stx-HUS patient survival was not different from controls (92% vs. 83% 15 years after renal transplantation). In the cyclosporine (CsA) era, survival of grafts from living related (LRD) and cadaver (CD) donors in Stx-HUS and control patients was 83% versus 70% ( P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.03) and 77% versus 49% ( P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05) at 10 years. Graft survival in Stx-HUS and dysplasia/obstructive uropathy patients was 79% versus 76% ( P=NS), but it was different from that of other diseases (79% vs. 58%, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). There was no clinical or histopathological evidence of Stx-HUS recurrence. In conclusion, in Stx-HUS patients the duration of the acute oliguric period was a good predictor for the progression to ESRD. Use of CsA and the absence of recurrence of the disease influenced the excellent prognosis in Stx-HUS patients after renal transplantation. The development of ESRD in Stx-HUS could be mediated by non-immunological factors.
Research Interests: Kidney transplantation, Treatment Outcome, Adolescent, Renal transplantation, Humans, and 16 moreChild, End Stage Renal Disease, Female, Male, Follow-up studies, Pediatric Nephrology, Pediatric, Hemolytic Uremic Syndrome, Recurrence, Adult, Shiga Toxin, Disease Progression, Graft Rejection, Retrospective Study, Chronic Kidney Failure, and Glomerulonephritis
Titania Pasqualini MD a, b, c, Corresponding Author Contact Information, Debora Zantielfer MD a, b, c, Marta Balzaretti PhD a, b, c, Elsa Granillo MD a, b, c, Patricia Fainstein-Day MD a, b, c, Jose Ramirez MD a, b, c, Susana Ruiz MD a,... more
Titania Pasqualini MD a, b, c, Corresponding Author Contact Information, Debora Zantielfer MD a, b, c, Marta Balzaretti PhD a, b, c, Elsa Granillo MD a, b, c, Patricia Fainstein-Day MD a, b, c, Jose Ramirez MD a, b, c, Susana Ruiz MD a, b, c, Raul Gutman MD a, b, c, Jorge ...