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Article
Open AccessPD-L1 expression in ovarian clear cell carcinoma using the 22C3 pharmDx assay
Ovarian clear cell carcinoma (OCCC), well known for its chemoresistance to platinum-based chemotherapy, exhibited a good response in clinical trials of anti–PD-1/PD-L1 inhibitors. By assessing PD-L1 expression...
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Article
Open AccessLife disturbance and hospital visit experiences among Chinese patients with benign prostatic hyperplasia: a qualitative study
The impact of lower urinary tract symptoms (LUTS) on the quality of life of patients with benign prostatic hyperplasia (BPH) has been rarely reported. Additionally, the challenges faced by these patients in se...
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Article
Claudin18.2 expression in pulmonary mucinous adenocarcinoma
Pulmonary invasive mucinous adenocarcinoma (IMA) is a unique type of lung adenocarcinoma with a high recurrence rate and limited treatment strategies. The tight-junction-associated protein claudin18.2 is a new...
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Article
China Health Related Outcomes Measures (CHROME): development of a descriptive system to support cardiovascular disease specific preference-based measure for the Chinese population
Preference-based measures have been increasingly recommended to measure health outcomes for economic evaluation. However, none of existing cardiovascular disease (CVD)-specific health-related quality of life (...
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Article
Open AccessPhysicians’ use and perceptions of genetic testing for rare diseases in China: a nationwide cross-sectional study
Genetic testing can facilitate the diagnosis and subsequent therapeutic management of rare diseases. However, there is a lack of data on the use of genetic testing for rare diseases. This study aims to describ...
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Article
Open AccessRobot-assisted percutaneous balloon compression for trigeminal neuralgia- preliminary experiences
This study aims to discuss the availability of robot-assisted percutaneous balloon compression (PBC) for trigeminal neuralgia (TN) and share our preliminary experiences.
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Article
miR-339-3p inhibits cell growth and epithelial–mesenchymal transition in nasopharyngeal carcinoma by modulating the KAT6A/TRIM24 axis
To explore the effect and mechanism of the miR-339-3p/KAT6A/TRIM24 axis in nasopharyngeal carcinoma (NPC) cell growth and epithelial–mesenchymal transition (EMT) progression.
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Article
China Health Related Outcomes Measures (CHROME): Development of a New Generic Preference-Based Measure for the Chinese Population
Existing generic preference-based measures were all developed in Western countries. Evidence shows that the Chinese population may have different perceptions about health and health-related quality of life. Th...
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Article
Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts
The extent of myocardial fibrosis is closely related to the prognosis of diabetic cardiomyopathy (DCM). Low-intensity pulsed ultrasound (LIPUS) has been reported to have multiple biological effects. However, t...
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Article
Open AccessNovel LTBP3 mutations associated with thoracic aortic aneurysms and dissections
Thoracic aortic aneurysm and dissection (TAAD) is a hidden-onset but life-threatening disorder with high clinical variability and genetic heterogeneity. In recent years, an increasing number of genes have been...
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Article
Development and validation of a novel metabolic signature for predicting prognosis in patients with laryngeal cancer
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Article
Prognostic nomograms based on immune scores for head–neck squamous cell carcinoma patients
We aim to develop an immune-score nomograms for predicting overall survival (OS) of patients with HNSCC and assess the association of immune scores with prognosis.
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Article
Open AccessKLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy
Cardiovascular diseases have become the leading cause of death worldwide, and cardiac hypertrophy is the core mechanism underlying cardiac defect and heart failure. However, the underlying mechanisms of cardia...
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Article
Development and validation of a novel metabolic signature for predicting prognosis in patients with laryngeal cancer
Despite advances in the development of treatments for laryngeal cancer (LC), including surgical treatments and radio-chemotherapy, the survival rate of LC remains low. Therefore, novel metabolic signatures are...
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Article
HTA methodology and value frameworks for evaluation and policy making for cell and gene therapies
This last decade has been marked by significant advances in the development of cell and gene (C&G) therapies, such as gene targeting or stem cell-based therapies. C&G therapies offer transformative benefits to...
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Article
Open AccessClassification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas
The limited molecular classifications and disease signatures of osteoarthritis (OA) impede the development of prediagnosis and targeted therapeutics for OA patients. To classify and understand the subtypes of ...
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Article
Open AccessTargeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas
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Chapter
Ensuring Food and Drug Safety
“Food safety is a big issue, and drug safety is a matter of life.” The security of food and drug (including five types of products: food, medicine, health food, medical equipment, cosmetics and so on, hereinaf...
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Chapter
The Overall Deepening of Medical and Health System Reform
Deepening the reform of medical and health system, greatly focused on by the Party Central Committee and the State Council, is an important part of comprehensively deepening reform and a major livelihood proje...
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Chapter
Intensifying International Exchanges and Cooperation
The “Outline for Strengthening International Exchanges and Cooperation” has made in-depth expositions on strengthening international exchanges and cooperation and actively participating in global health govern...